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20.02.2015

Herpes vaccine research 2014, how to treat herpes simplex virus on lips - Try Out

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One of the most difficult aspects of living with herpes is the knowledge that it’s with you forever. Antiviral drugs are most often prescribed to treat herpes today, such as acyclovir and famciclovir, while they effectively suppress the symptoms of an active herpes infection, the medications do little to inhibit viral shedding.
However, the advent of research and latest technology has helped experts to have finally aced the possible cure for herpes – with better and promising treatment of existing herpes infections, and experimental vaccines to prevent infections from occurring. Additionally, since this drug works differently than antivirals already approved for use, it may provide a weapon against drug-resistant herpes viruses. At Duke University, studies have focused on the herpes virus’ unique ability to lie dormant in the body for extended periods of time, and then reactivate.
The key to making this research into a viable herpes treatment, according to researchers, will be in learning how to use single strands of RNA, called microRNA, to activate the dormant virus, thereby making them vulnerable to antiviral drugs.
Researchers at the University of Florida are taking a similar approach to combatting viral infection.
Using a specially created RNA enzyme called a hammerhead ribozyme, researchers were able to keep the virus from reactivating in test animals.
In this rather complex study, researchers at Albert Einstein College of Medicine of Yeshiva University addressed the process of viral cell penetration – a step earlier in the infection process than either viral replication or shedding.
These innovative cures for herpes are encouraging, but what’s truly exciting is the possibility of a herpes vaccine. Much like pritelivir, the experimental vaccine HerpV focuses on viral shedding as the crucial function to suppress. Perhaps even more interesting are the results of early clinical trials for a vaccine currently called GEN-003.
Reports from Genocea, the company developing the vaccine, also indicate measurable increases in the immune response of T-cells, which are known to be instrumental in fighting off various diseases and infections. While classified as vaccines by their developers, HerpV and GEN-003 are still mostly targeted at responding to the symptoms of an active infection. The first of these trial vaccines is currently called HSV529, and it’s being developed by the National Institute of Allergy and Infectious Diseases (NIAID). What’s different about the Coridon vaccine, though, is the way that response is being created.
Many of these natural remedies have proven to be highly effective when used to heal herpes sores and decrease the number and frequency of herpes outbreaks.
The connection between the amino acids lysine and arginine and herpes activity is fairly well documented. Taking liquid Siberian ginseng extract is a great way reduce the duration and intensity of genital herpes outbreaks. Another standby of Chinese herbal medicine, licorice root has long been used to treat herpes, shingles, and cold sores. While it may be risky to ingest high doses of zinc regularly, in a cream or ointment zinc (often sold as zinc oxide cream) is a well-known and effective treatment for herpes sores. Melissa officinalis, or lemon balm as it’s commonly called, is a versatile and proven antiviral and one of the most effective topical treatments for herpes sores.
A relative newcomer to the herpes treatment scene, red marine algae (Gigartina) has shown the ability to stimulate immune response, lessening the intensity and frequency of herpes outbreaks.
Long used as a home remedy for burns and cuts, aloe vera has also shown promise as a topical treatment for genital herpes, especially for men. When you’re suffering from a painful, itchy genital herpes outbreak, one of the most soothing remedies possible is a simple bath in warm water infused with Epsom salts. Along with Epsom salts, baking soda is a safe, inexpensive way to dry out herpes lesions, relieve pain and itching, and speed healing. New research has found that sending an email to a love interest is more effective at creating arousal than leaving a voicemail.
Research finds we have strong associations with Monday and Friday, while we have weaker associations with the middle days, leading us to confuse them more. A biotechnology company in Australia is now recruiting participants to test a herpes vaccine aimed to both prevent and cure herpes simplex 2 infections.


Coridon, a biotechnology company that started out of University of Queensland, has received approval to begin early-stage, Phase I human trials for its herpes simplex 2 (HSV-2) vaccine, which would be used as both a preventative vaccine and a therapeutic vaccine for those who already carry the virus. Herpes simplex 2, also known as genital herpes, is a viral infection that can infect skin cells of a certain area of the body, such as the mouth and genital area, resulting in periodic outbreaks.
The only treatments for herpes is Valtrex, which is a pill that is not completely covered by U.S.
Genital herpes affects more than one in six Americans between the ages of 14 and 49, according to the Centers for Disease Control and Prevention (CDC). Genital herpes is a highly contagious STD caused by herpes simplex virus 2 or, in some cases, herpes simplex virus 1. In other herpes vaccine news, on November 5, 2013, Agenus, a pharmaceutical company reported positive mid-stage finds in a clinical trial for another vaccine called HerpV. On January 15, 2014, HealthDay News announced that they have come out with an experimental drug which could offer new treatment for those with genital herpes.
While there is still no cure for genital herpes, all of this research being done in herpes news gives patient with this disease hope that one day there will be. We suggest the Ultimate Herpes Protocol, an eBook describing how author Melanie Addington stopped her herpes outbreaks for good using all-natural, holistic methods.
Positive Singles is a dating site for those with herpes who want romance while avoiding the awkward "herpes talk"! During the study minor adverse events (AEs) were reported but considered unrelated to the vaccine. While there are many ways to treat the symptoms of the herpes simplex virus (HSV), there are no cures yet. Their work also focuses on the herpes virus’ ability to reactivate and recur over time. If the technique works equally well for humans, this gene therapy will keep the virus from causing repeated herpes outbreaks. By inhibiting the body’s production of Akt, they were able to significantly reduce herpes infections in human cells exposed to the virus. A vaccine has the potential to nearly eradicate a disease, by helping the body to develop an immunity to a specific infection. This vaccine also demonstrated positive reductions in viral shedding – in some cases shedding was reduced by as much as 50%. There are, however, two vaccines in the very early stages of clinical trials that are aimed directly at preventing a herpes infection from ever taking hold in the body.
The vaccine is the result of a 10-year partnership between doctors at Harvard Medical School and the NIAID.
Research for the vaccine is being conducted by Coridon, an Australian biotech company working in conjunction with the University of Queensland. Instead of introducing a weakened version of the herpes virus, this vaccine uses a small section of DNA to produce T-cells and stimulate the immune response. Researchers at Coridon, however, emphasize that even in the most ideal of circumstances, they’ll need between 6 and 10 years of further studies before their vaccine becomes commercially available. But those who are already dealing with a herpes infection understand the importance of living in the present.
Arginine seems to promote the formation of herpes sores, while lysine tends to prevent herpes breakouts and also helps to heal existing sores quickly.
Just brew a cup of black tea, let the tea bag cool until you can touch it comfortably, and apply the tea bag directly to a herpes lesion. Ginseng is known to have the ability to strengthen the immune response, which may make it helpful in fighting off the effects of an active herpes episode.
Liquid extract of licorice root can be applied directly to herpes sores; you can also make a paste with powdered licorice root and almond oil. It reduces healing time dramatically, and can also lower the stress levels that incite herpes outbreaks.
The Epsom salts ease the pain of inflamed tissues and dry out herpes sores, helping them to heal faster.


We have seen very encouraging results from animal studies and we expect pivotal data showing that our vaccine, which incorporates our patented optimisation technology, to produce similar immune responses in the clinic," said Professor Frazer who founded Coridon in 2000 and is leading the study. Phase I trials usually use doses of drugs or vaccines that are meant to test the safe dosing range and may confer protection to those who participate in the trial. Anna Wald, a professor of medicine and laboratory medicine at the University of Washington’s School of Medicine and a professor of epidemiology in the School of Public Health has made herpes news.
That’s why many medical researchers consider the search for a herpes cure to be akin to the search for the Holy Grail.
Rather than seeking to activate the latent herpes virus, however, this study seeks to keep it dormant and thereby eliminate the possibility of recurring infection. But widespread use of vaccinations gradually decreased incidences of this disease, and the last known case of polio in the U.S. Study of the vaccine is in the early trial stage, and researchers hope to complete this initial phase some time in 2016. As a topical treatment for herpes lesions, propolis has proven to be a quick and effective healer.
The recommended dosage is one-half to a full tablespoon three times daily during a herpes outbreak.
There’s not a lot of evidence, however, that echinacea is effective when used as a herpes treatment.
She announced that there have been positive results for a therapeutic vaccine candidate to treat patients with genital herpes. These results showed a clear dose response over the 3 injections and illustrated that patients confirmed to be sero-negative for HSV-2 had generated an immune response to the vaccine.The DTH response is a cell mediated response. Bonus: black tea is a great source of caffeine, so enjoy a little pick-me-up by drinking the tea while treating a herpes sore with the tea bag.
The drug trial for this vaccine is taking place at six other centers across the United States.
They tested how much of the virus each of the patients were releasing 45 days before they were given 3 doses of the HerpV or the placebo. The cell mediated immunity response shown in this study, where the study subjects had no previous HSV-2 infection, demonstrates utility of this vaccine.
The cascade of events initiated by the T cells leads to hardening (induration) and redness (erythema) at the injection site, which was clearly evident in these study subjects.The safety profile and the detected immune response provides the basis for the company to select appropriate vaccine doses to progress the therapeutic vaccine into a Phase II study in individuals suffering recurrent genital lesions. For this reason, scientists and doctors are working on vaccines that reduce the contagiousness of the virus as well as reduce the frequency of herpes outbreaks.
The results showed that there was a 15% reduction in the release of the virus by patients who received the vaccines. These findings were also reported on January 16, 2014 in the New England Journal of Medicine. Over the course of the study, the 3 intradermal injections of the vaccine were found to be safe and well tolerated with some local redness being observed post injection which dissipated over time. With this T cell vaccine, scientists are trying to find a way to bring on this protective reaction. This medical trial enlisted 143 volunteers who suffer from moderate to severe genital herpes. This drug works in a different way as those that are already being used to treat genital herpes. They are doing a double blind, placebo controlled study to measure the immune response generated by the vaccine and also to study the safety measure of the vaccine. Half of the patients in this study were given the actual vaccine through an arm muscle injection and the other half were given a placebo through an arm muscle injection. After patients were given three doses of the vaccine, 51% of them showed reduction in the viral shedding which makes it possible to spread this disease.



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