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12.03.2015

Herpes vaccine news, lupus alternative medicine - How to DIY

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While current treatment options for genital herpes have been successful in limiting the number of outbreaks the patient experiences over time, there is still no cure for this highly infectious sexually transmitted infection (STI). According to the Centers for Disease Control and Prevention, each year 776,000 people in the United States develop new genital herpes infections, caused by either the herpes simplex virus type 1 (HSV 1) or type 2 (HSV 2). Genital herpes can be spread from person to person through anal, vaginal, or oral sex when HSV 1 or HSV 2 escapes from soars in the groin area. Researchers working on this genital herpes vaccine recruited 156 patients who had tested positive for HSV 2. Health care professionals urge people affected by genital herpes to abstain from sex during an outbreak of genital herpes sores. Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes.
Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept. The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M.
Agenus Inc said a trial of its experimental genital herpes vaccine reduced the rate at which patients released the virus, reducing the likelihood of infecting others, sending its shares up 32 percent in premarket trading. The 15 percent reduction in the release of the virus by patients receiving the vaccine in a mid-stage trial compared to those on a placebo, who showed no reduction.


The mid-stage trial had 80 patients with a history of 1-9 herpes recurrences within the prior 12 months. The trial tested the efficacy of the vaccine by measuring the release of the virus by patients 45 days before and after three injections of HerpV. Genital herpes, a highly contagious sexually transmitted infection, is usually caused by the herpes simplex virus (HSV). The company's partners are also testing the QS-21 Stimulon adjuvant in combination with other vaccines. A study funded by the pharmaceutical company AiCuris has produced a new drug known as pritelivir that shows promise as a future treatment option for type 2 genital herpes. Considering signs and symptoms of herpes can go unnoticed or can be mistaken for another skin condition, HSV 2 carriers can be unaware of their condition. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. T cell vaccine research is trying to find safe, effective ways to spur this protective reaction.
However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus.


A majority of the patients also received a booster injection, given 6 months after the first vaccination. There are two types of HSV and Agenus's vaccine targets HSV type 2, which most often causes genital herpes. Centers for Disease Control and Prevention, 776,000 people in the United States get new herpes infections annually and one out of six people aged 14 to 49 years has genital HSV-2 infection.
Throughout the study each participant was asked to record instances of genital herpes signs and symptoms.
Three of the major antiviral drugs meant to keep genital herpes outbreaks at bay include acyclovir (Zovirax), famciclovir (Famvir), and valacyclovir (Valtrex).
Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases. People with a compromised immune system are especially at risk for developing genital herpes.



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