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12.07.2015

Alternative medicine for pancreatic cancer, healing herpes ulcers - Reviews

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Washington, May 20: Researchers at the Kimmel Cancer at Jefferson in Philadelphia have found that a herb used in traditional medicine by many Middle Eastern countries might help in the fight against pancreatic cancer.
They found that thymoquinone, an extract of nigella sativa seed oil, blocked pancreatic cancer cell growth and killed the cells by enhancing the process of programmed cell death. The studies are in the initial stages, but the findings suggest that thymoquinone could eventually have some use as a preventative strategy in patients who have gone through surgery and chemotherapy or in individuals who are at a high risk of developing cancer.
Previous studies also have shown anticancer activity in prostate and colon cancers, as well as antioxidant and anti-inflammatory effects. Using a human pancreatic cancer cell line, Arafat and her team found that adding thymoquinone killed approximately 80 percent of the cancer cells. Researchers also found that thymoquinone caused ‘epigenetic’ changes in pancreatic cancer cells, modifying the cells’ DNA. This ‘acetylation’ process can be important for genes to be read and translated into proteins.
At the same time, adding thymoquinone to pancreatic cancer cells reduced the production and activity of enzymes called histone deacetylases (HDACs), which remove the acetyl groups from the histone proteins, halting the gene transcription process.
Researchers found that HDAC inhibitors are a new class of drugs that interfere with the function of histone deacetylases, and is being studied as a treatment for cancer and neurodegenerative diseases.
Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer. Liver fibrosis and mechanisms of the protective action of medicinal plants targeting inflammation and the immune response.


Tolerance and effect of an add-on treatment with a cough medicine containing ivy leaves dry extract on lung function in children with bronchial asthma. Role of herbal bioactives as a potential bioavailability enhancer for Active Pharmaceutical Ingredients. Roles of Natural Compounds from Medicinal Plants in Cancer Treatment: Structure and Mode of Action at Molecular Level. Natural flavonoids as potential herbal medication for the treatment of diabetes mellitus and its complications. Effects of a traditional herbal medicine on peripheral blood flow in women experiencing peripheral coldness: a randomized controlled trial.
Recreational drugs: a new health hazard for patients with concomitant chronic liver diseases. For the year of 2012, the estimate for those who will be diagnosed with Pancreatic Cancer is approximately 44,000.
For information on endocrine pancreatic cancer, see the PDQ summary on Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment. For information on pancreatic cancer in children, see the PDQ summary on Unusual Cancers of Childhood Treatment.
Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. Laparoscopy : A surgical procedure to look at the organs inside the abdomen to check for signs of disease.


Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer. The process used to find out if cancer has spread within the pancreas or to other parts of the body is called staging. Having a risk factor does not mean that you will get cancer; not having risk factors doesn’t mean that you will not get cancer. Certain substances are linked to specific types of cancer when found in increased levels in the body. It does not respond well to either chemotherapy or radiotherapy, due partly to apoptotic resistance (AR) of the cancer cells.
The results of some of the tests used to diagnose pancreatic cancer are often also used to stage the disease.
In pancreatic cancer, significant mutations of K-ras and p53, constitutive activation of NF?B, over-expression of heat shock proteins (Hsp90, Hsp70), histone deacetylase (HDACs) and the activities of other proteins (COX-2, Nrf2 and bcl-2 family members) are closely linked with resistance to apoptosis and invasion.



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