The paleo diet book loren cordain,free fatty acid titration method,reverse dieting layne - PDF Review

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Robb Wolf, a former research biochemist, is the New York Times Best Selling author of The Paleo Solution – The Original Human Diet. Robb Wolf’s 30 Day Paleo Transformation is a complete guide to your first 30 days on the Paleo diet, much like our own 30 Day Challenge. I started Ultimate Paleo Guide to help people get healthy through simple paleo principles and great paleo recipes.
Here is an interview with Loren from 2010, where he explains the biochemistry of why autoimmune diseases such as MS, arthritis and Type 1 diabetes might be made worse by grains, beans, dairy, and in some people, egg whites and tomatoes.
The second mechanism is the transcellular pathway, where these elements are going through the cell itself.
The luminal side of the intestine doesn’t have a whole lot of receptors that we know about. But the M cells we don’t believe are exploited by dietary antigens and most of the bacterial gut pathogens. So our hypothesis is, the gut becomes damaged by certain dietary elements, which strips the glycocalyx, which exposes the epidermal growth factor receptor, which allows these certain dietary elements, along with these viral and bacteria peptides, to get into the bloodstream. So one problem is that the foods that you’re implicating have an easy way, they tend to damage the glycocalyx. So it has a high affinity for bacterial cell wall proteins, and there’s a bacterial cell wall protein called LPS, lipopolysaccharide. I’m picturing it like a sticky lollypop stick, and what it grabs to be the top of the lollypop is unfortunately quite often a bacteria.
That’s right, it gets carried along whatever is stuck to it, and this is the universal mechanism. The T lymphocytes lose the ability to recognize themselves in a foreign bacteria because the confirmation of what it sees is so similar to a foreign molecule and itself.
When we were first trying to make vaccines to prevent diseases, like the polio vaccine that Jonas Salk won the Nobel Prize for back in the ’40s or ’50, they tried to simply get the virus and make a weakened version of the virus, dry it out, whatever, inject it into the body’s system. If you buy canned legumes, part of the process of preventing horrible bacterial contamination is to pressure cook them, so most canned foods are pressure cooked, and if you’re eating beans you don’t have to worry about it if they are canned, typically. The information that we have is that the fermentation process does not significantly reduce the lectin content of bread. The concentration of WGA in white flour is about 3 to 4 milligrams per 100 grams, whereas in whole wheat it’s 10 times that, it’s an order of magnitude higher. It sounds like if somebody actually has a sensitivity or a vulnerability to this WGA, it may be an all-or-nothing food for them. But once somebody’s sensitized, once their immune system is hypervigilant for this protein, it may not take very much.
And that’s the very first step, to show definitively that in healthy, normal people without gut disease, which is what our subjects were, that with the consumption of these foods, we see lectin appear in the bloodstream. However, there’s an exception to this, and there’s a very, very stubborn hormone called betacellulin, which is the body’s own endogenous ligand for the receptor. But the thing about tomato lectin is that if you put it in these little Petri dishes with white blood cells, it doesn’t cause an inflammatory response. Now, none of this has been shown in humans as of yet, except for the tomato and the peanut agglutinin. And go ahead and add some of the other autoimmune diseases that you increase the risk for if you drink milk. Here in Fort Collins, we get more days of sunshine than they do in San Diego, but what’s important is the height of the sun relative to the latitude, because in the tropics, you get direct sunlight, and the direct exposure of UV causes a greater synthesis of vitamin D. The foods that you’re choosing to say are problems are ones that have been traditionally chosen also by naturopathic physicians, by acupuncturists, by people who study those alternative fields. I think that people that are in the trenches, making careful observations with naturopaths and some of these others, they see hundreds if not thousands or tens of thousands of patients, and they have at least anecdotal evidence from their experience that there’s something going on. So I think that if you triangulate it, and you look at the evolutionary perspective, we seem to be focusing in on these same types of foods. Whether you’ve been following a Paleo-friendly diet and want to take it to the next level or are just discovering the benefits of going Paleo, this book will help you follow the Paleo path to the fullest-for lifelong health, increased energy, better sleep, lower stress and weight loss. The material on this web site is provided for educational purposes only and is not to be used for medical advice, diagnosis or treatment. I recently started the paleo diet for a few reasons:  health, weight loss, and an answer as to whether or not I have celiac disease. In regards to sleep, melatonin supplements may be helpful at first, but again make sure they are free of wheat, soy and other additives that are non-Paleo.  A long term strategy to improve sleep will not require melatinin supplements, as you body will naturally manufacture sufficient melatonin to elicit peaceful, long and uninterrupted sleep.
The paleo diet is a great option for those diagnosed with coeliac as it is naturally gluten free and very healthy but you really should get properly diagnosed.
Reading your comments about health insurance I am so thankful for our NHS and sincerely hope that the more US citizens begin to embrace healthcare reform.
If we are following the paleo diet ( which we should all be) then there is no need to be tested for celiac. I recommend that before you eliminate gluten altogether from your diet, you should consult with a gastroenterologist and be tested for Celiac disease if you think that you may have it. If your doctor confirms that you have Celiac disease, then gluten should be eliminated from your diet altogether. The only way to be tested with 100% certainty is through a biopsy of your small intestine done from an endoscope. Put Paleo into action with The Paleo Diet Cookbook and eat your way to weight loss, increased energy, and lifelong health-while enjoying delicious meals.
With 174 scientific references, The Dietary Cure for Acne thoroughly documents and clearly explains the ultimate causes of acne.
The Dietary Cure for Acne will help you understand the scientific basis of why diet matters in keeping your skin acne free.
Until the publication of my paper, “Acne Vulgaris: A Disease of Western Civilization,” in 2002, the medical and dermatological communities generally discounted diet as a causative agent in the development of acne. The clue to unraveling the link between diet and acne first came from our study showing that acne was completely absent in non-westernized populations such as the Ache hunter gatherers of Paraguay and the Kitavan Islanders.
These results led my research team and I to the conclusion that environmental factors absent in the Ache hunter gatherers and the Kitavan islanders, but present in the western world likely represented the underlying causes of acne. We were then able to deduce how the typical western diet caused hormonal and physiological changes that elicited these four known causes of acne.
After reading The Dietary Cure for Acne, you’ll understand how the right foods can prevent the pore blockage, excess oil production, inflammation, and bacterial infection that characterize acne.
You will receive an email from The Paleo Diet confirming your purchase of The Dietary Cure for Acne eBook with instructions to access and download the eBook.
Cardiovascular Disease Resulting From A Diet And Lifestyle At …THE IDEAL HUMAN DIET Perhaps no scientific topic has generated more controversy and confusion in recent times than the question of the ideal human diet. Following The Paleo Diet With Rowing Sensation Ursula Grobler …Following the Paleo Diet with Rowing Sensation Ursula Grobler Nikki Young Interviews Ursula Grobler In 2003, Ursula Grobler recreated her life in Seattle. PALEO DIET AUTOIMMUNE IMPLEMENTATION TIPSPALEO DIET AUTOIMMUNE IMPLEMENTATION TIPS Eating Paleo is really easy once you make the decision, and get the hang of it. DisclaimerThe Paleo Diet The paleo diet is one of the most intriguing diets that have come out in recent years.
Paleo Meal PlanThe meal plan also gives you a great example of what day to day eating often looks like on a Paleo diet. Raw Veganism – Wikipedia, The Free EncyclopediaRaw veganism is a diet that combines veganism and raw foodism. Pros And Cons Of The Paleo DietPros and cons of the Paleo or Paleolithic Diet, also called the Cave Man Diet, Hunter-Gatherer diet, Stone Age diet, Neanderthin and others. Concise Paleo DietConcise Paleo Diet The 15 minute guide for people wanting to know what the paleo diet is all about. Paleo Parents PamphletNo longer willing to be morbidly obese and in pain she discovered Dr.
2012 Brings Out The Diet In UsIt’s the number one resolution of most Americans lose weight andor get healthy. The Dietary Cure for Acne addresses all four known causes of acne, and is the only program shown to clear acne blemishes in a human clinical trial. Loren Cordain, and check out Loren Cordain on Wikipedia, Youtube, Google News, Google Books, and Twitter on Digplanet. Loren Cordain (born October 24, 1950) is an American scientist who specializes in fields of nutrition and exercise physiology. Cordain L, Eaton SB, Brand Miller J, Lindeberg S, Jensen C, "An evolutionary analysis of the etiology and pathogenesis of juvenile-onset myopia".
Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J, "Acne vulgaris: a disease of Western civilization".
Sledge, along with his wife, Shauna, founded the Fort Collins-based the Paleo Diet Foods , which just launched its initial product, the Paleo Diet Bar.
When he's not eating 80% paleo, he's challenging himself to do the impossible and build other Impossible Ventures. In addition to the audio interview, this now includes a written transcript of the interview.  Thanks to Sandy Grabowski for transcribing. So with multiple sclerosis, we chose that because there is epidemiologic evidence that implicates diet in multiple sclerosis. This is an unusual receptor, because the way the body works its that when we secret hormones, hormones bind to receptors at cells, and that causes the cell to express genes and make proteins and do all kinds of things.
When you lick an open wound, the hormone, epidermal growth factor, in the saliva promotes healing. So even if these bacterial peptides were to get past the gut, and even if they were to get into cells, cells have an enzyme called lysozyme. It’s like you have somebody speaking English and somebody speaking Chinese and you have somebody in the middle that’s doing the translation.
The HLA system is what’s called a polymorphic molecule, and there’s more than 3,000 different versions of this. What they wanted to do was to build an immune response so that the T cells and the B cells and the rest of the system would mount an attack on this weakened version of the polio virus. The WGA that’s found in cooked bread or even roasted peanuts is the same concentration as what you find in raw, uncooked. What does do it is that the WGA that we find in bread is primarily found in the germ and the bran.

How they specifically get through the gut is not completely clear, but those individuals can’t have any wheat. In the animal models where it’s been done, it’s been done at typically higher values in which ___ wheat comprises 20% to 30% or more for the energy.
And after that, then hopefully in the ensuing years we’ll be able to measure this inflammatory response that we see in vitro, in tissue models, we want to do it in vivo, to show that if we give people a big dose of lectin from kidney beans or wheat germ, that it causes an in vivo inflammatory response, and then the next step is to do what are called Elisas , a kind of an immune-type way of looking at these complexes, so we can identify these molecules to see if they are actually getting in the bloodstream as well. And then if you throw WGA into the mix, you can get even potentially more of these monster molecules.
One of my colleagues, Pedro Bastos from Portugal, is the man to talk to about that, but apparently there are different ways in which the whey is separated from the rest of the milk proteins. And so we believe that if tomato lectin binds specific antigens in the gut, then those antigens can gain access. In the body’s own cells, it has these very, very powerful enzymes that bind bacteria and destroy them. Having spoken with multiple sclerosis patients who have come into remission on a wheat- and a dairy-free-type diet, a couple of them have told me that egg whites exacerbate their symptoms. With type 1 diabetes, we not only have epi studies, we also have animal studies, just like those little rats where we fed them increased wheat diets and they had and increased incidence of type 1 diabetes, the same thing is true. And the reason for it is because we need to look at the foods that were traditionally in the human diet. And vitamin D really isn’t a vitamin, it’s a hormone, because it acts in every cell of the body. So in terms of the blood concentrations of vitamin D, we are significantly lower here in Colorado than we would be in the tropics.
But in support of these folks are part of the medical community that are concerned with allergies, particularly food allergies. Loren Cordain, the world’s leading expert on Paleolithic eating styles and internationally regarded as the founder of the modern day Paleo Diet movement.
Loren Cordain is Professor Emeritus of the Department of Health and Exercise Science at Colorado State University in Fort Collins, Colorado. Loren Cordain’s The Real Paleo Diet Cookbook with 250 Paleo recipes prove following The Paleo Diet is as delicious and inspiring as it is healthy.
Loren Cordain demonstrates how, by eating your fill of satisfying and delicious meats and fish, fresh fruits, snacks, and non-starchy vegetables, you can lose weight and prevent and treat heart disease, cancer, osteoporosis, metabolic syndrome, and many other illnesses.
Unfortunately this dogma had persisted for at least the past 30 years, despite little or no good scientific evidence supporting its conclusion. Diet seemed to be the most obvious element, as neither the Ache nor the Kitavans had access to western foods such as refined sugars, dairy products, cereal grains, vegetable oils or processed foods.
With 174 scientific references, I thoroughly document and clearly explain the ultimate causes of acne.
Loren Cordain and world renowned triathlon coach Joe Friel for more information on endurance specific Paleo Nutrition.
Exactly which items do and do not fit into the Paleo diet food list is not always an easy answer to follow. My doctor and so many books I hold to a greater regard say that to eating too many grains and starchy carbs (bread, pasta, potatoes) will hurt my effort to lose fat. Each organ, and even the bloodstream, contains a part of our immune system, which uses inflammation to protect us from bacteria, viruses, parasites, molds and foreign proteins as well as to heal wounds. This is your essential step-by-step guide to starting the Paleo Diet, loosing weight and feeling great. Loren Cordain has extensively studied the crucial role that diet plays in causing acne and has made invited presentations of his findings to the largest, most prestigious dermatology organization in the United States, the Society for Investigative Dermatology (SID) and its equivalent in Europe, the European Society of Dermatology and Venerology (EADV).
Loren Cordain, a global leading expert on paleolithic diets and founder of the paleolithic movement, believes that the culprits of our obesity epidemics and health problems are whole grains, dairy, and processed foods. We think that in order for the immune system to lose the ability to recognize self and non-self, which is what autoimmune disease is, there has to be peripheral antigenic stimulation, meaning that there has to be antigens or proteins that come in constant contact with the immune system that we believe enter into the immune system from the gut. The proteins are broken into peptide fragments, and peptides are broken into amino acid sequences. One is what’s called the paracellular pathway, which is whereby these peptide fragments are leaking through the cell-to-cell connections. People who have rheumatoid arthritis tend to have inflammations of the joints occur at the same time the gut occurs.
We believe that there are receptors in the gut that are acting as Trojan horses that are allowing these molecules to get through. So the crazy thing about the gut is, the inside of the gut that’s exposed to the food and so forth, is actually the outside of your body. We know that from animal studies in which we’ve prevented animals from licking their wounds, or we’ve taken their own saliva and swabbed it onto the open wound.
The way that T and B cells operate in conjunction with these M cells is, the T and the M cells don’t allow much antigenic material to bypass the gut, or what we have is, we have another part of our immune system called the gamma globulins, and the gamma globulins form complexes that prevent any of these proteins from doing any damage to our system. Most receptors have one or two endogenous ligands, but the way this thing work is what’s called a dimer.
And what an HLA molecule is, it’s just simply a little molecule that spans the cell membrane and it presents proteins from within the cell to circulating white blood cells, or T lymphocytes. But the problem is, the immune system was smart, and the immune system says—it’s like going fishing.
What we take are little Petri dishes and we put in white blood cells, and then we also put in WGA.
When a dietary antigen gets into your system, it’s causing a low level of inflammation, and that’s not a good thing, to have chronic low-level inflammation. So if you look at the concentration of WGA in whole wheat, it is significantly higher than what it is in white bread. We know from tissue studies, these in vitro studies, that cells respond at nanogram concentrations, so nanogram concentrations can easily be achieved by consuming 4 to 7 milligrams per 100 grams.
The problem with dairy is that dairy doesn’t contain lectins per se, so you would think that if this is how lectins are dragging these gut molecules through, dairy shouldn’t be a problem. These are the most likely candidates that cause this three-way molecular mimicry and peripheral antigenic stimulation in the gut. For instance, if you look at your conjunctiva, if you look at the tissues that line your eye, the eye is constantly exposed to bacteria in the air, so we’ve got this open, as it were, reservoir that can potentially get infected every day of your life.
My colleague Frazier Scott in Canada has shown that if you feed them more milk, they also have an increased incidence of type 1 diabetes. So even if you had the susceptibility haplotype and you started to get the disease, then the exposure was very, very short, whereas in the modern world, we eat grains and legumes and dairy products almost every single day.
If you look at the scientific peer review journals in the allergy field, the same picture is painted: milk, wheat, corn, dairy, tomatoes, and so forth often are the same foods that are allergenic.
And even though they seem like staples and they seem like everybody eats them and there’s no problems with it, if you look at the incidence of celiac disease, we know now the roughly 1 in 100 people have celiac disease in the U.S. People, when they look at autoimmune disease or any other disease, they look at an allopathic treatment.
In The Paleo Answer, he shows you how to supercharge the Paleo diet for optimal lifelong health and weight loss. His research emphasis over the past 20 years has focused upon the evolutionary and anthropological basis for diet, health and well being in modern humans. As I pointed out in my article, “Implications for the role of diet in acne,” the notion that diet didn’t cause acne was based solely upon two poorly controlled studies conducted more than 30 years ago. Mann’s group at the Royal Melbourne Institute of Technology in Australia has published a series of recent papers showing how high protein, low glycemic load diets (which in essence define both the Ache and Kitavan diets) cause remission of acne symptoms. The dietary program I suggest in this book works by preventing the four immediate causes of acne, and will quickly result in great improvements or complete remission of your acne symptoms.
So normally what we end up with are amino acid fragments that we absorb, and what we think is going on is, we think that these larger peptide fragments, as well as amino acid sequences that may be 10 to 15 bases long, can also get in. The glycocalyx is kind of this wavy series of carbohydrate molecules that prevent anything from binding this receptor.
So at least in theory, the M cells, combined with the gamma globulin system, prevent any of this from going on.
We know that WGA, when it gets into the gut, causes the glycocalyx to be stripped, which opens the door to bind the epidermal growth factor. So even if you do get bacteria in your bloodstream, the lysozyme in the cells breaks it down and there’s not a problem. We believe there are multiple HLA haplotypes that can combine with multiple dietary lectins, which can combine with multiple gut antigens to express a disease. When the circulating T lymphocytes see a molecule that’s foreign to the body’s own self, it mounts an attack on not just the molecule that it sees here, but any other place in the body where it encounters that foreign molecule, it will mount an attack. What the HLA molecule does is, it sees that chimeric molecule that’s digested, and the HLA molecule then presents this monster molecule at its cell surface. If we put WGA into a Petri dish with white blood cells, the white blood cells, which are called macrophages, elicit an inflammatory response. As a matter of fact, if you take dry kidney beans and boil them for two or three hours, there’s still physiologically significant lectins after boiling for two or three hours. So white bread, even though it’s not necessarily a good food because of the high glycemic load, has a lower lectin content.
Animal models tell us that these legume lectins get across the gut very easily, just like wheat germ agglutinin. But dairy contains something else, the body’s own endogenous ligand for the epidermal growth factor. But it also contains a profile of many of the hormones that circulate in a cow’s blood, because milk is essentially filtered blood. I don’t know that we have any experiments to date that show what the betacellulin content is of these various separation processes. Our idea is that people with autoimmune disease, there’s a variety of foods that they ought to eliminate initially and then carefully monitor their symptoms.
But what happens is that the tears in your eye contain a very, very high concentration of lysozyme. If you look at the epidemiology of milk-drinking and multiple sclerosis, for the last 30 or 40 years we know that there’s a very good epidemiologic association. And once again, from animal models, there’s an animal model of a multiple sclerosis EAE that can be prevented simply by dosing the animals on high levels of vitamin D before implication of the disease.

And we have in the allergy community IGG responses, which are considered more valid than an IGA response.
In contrast, we found no acne in the entire Kitavan population including about 300 adolescents.
Similarly, scientists at the Harvard School of Public Health have linked acne to dairy consumption in large epidemiological studies.
It mimics the diets of our hunter-gatherer ancestors – consisting of lean meats, seafood, vegetables, fruits, nuts and seeds.
Lazarus will compare and contrast convential wisdom regarding a healthy diet and how to achieve and maintain true wellness. He coaches athletes at the highest levels of competition and consults with Olympians and world champions in MMA, motocross, rowing and triathlon.
We think that this content leaking of antigenic peptides and proteins from the gut into circulation primes the immune system to do nasty things in certain generally predisposed individuals.
In nature we believe that inflammation of the gut is associated with inflammation of other tissue. What happens is, when the gut becomes damaged, either through mechanical damage or through GI tract irritation or whatever, that information causes the glycocalyx to be shed and it allows the receptor to bind its normal ligand.
So we believe that’s what’s going on in the gut, that the epidermal growth factor receptor is there on an evolutionary basis to help us heal our own wounds. And the way the gut actually makes the immune system aware of the contents of the gut, because the immune system needs to know that, is through what we call M cells. So it binds this whole series of things, and it has to do with the structure of the receptor.
So when you eat meat, that gets broken down into its peptides and amino acid components in the same way as the bacteria. However, WGA is resistant to this enzyme lysozyme, so WGA, when it’s bound to the bacterial peptide, it’s like putting a Superman invulnerable shield around itself.
When the adjuvant molecule is tacked onto the weakened virus or bacteria, that adjuvant serves like red pepper.
The only way that you can remove lectins, because of their molecular confirmation, they are such sturdy molecules the way they’re built, that they’re resistant to not only proteases that are found in these bacteria that cause fermentation, they are resistant to heat.
We currently have conducted an experiment here at CSU where we fed wheat germ agglutinin into humans as well as peanut agglutinin to humans, and we’re in the process of measuring blood concentrations of these lectins to see if it gets through.
With a disease like multiple sclerosis, basically there’s different versions of it, but the most common version is relapsing and remitting, where people have these symptoms that come on and go off, come on and go off. Lysozyme busts up these gram-positive bacteria, as well as gram-negative bacteria, and it destroys them. When it busts them up, it forms these fragments of lysozyme, because lysozyme is resistant to the gut’s proteases, it forms these complexes of lysozyme plus bacteria. When it sticks to bacteria, it forms a complex, the lysozyme can bind that receptor, and then it can drag this stuff through.
And having gone through the biochemistry of lysozyme to see how it actually works, lysozyme in theory has the potential to act like a lectin and get into circulation. Milk has only been around for 6,000, and if a human generation is 30 years, we’re looking at a very, very small time for milk to be in the human diet. We believe, then, that these are diseases of civilization, these autoimmune diseases, had they been present two and a half million years ago, natural selection would have weeded them out by now, and that’s why they haven’t been weeded out, because they have such short exposure to the human genome.
And from a fundamental perspective to understand the disease processes, we can perhaps build better drugs, if that’s an option, but perhaps it’s better to use the system the way it was designed genetically, and that’s my bias. C-reactive protein’s generally used in the medical community to check for inflammatory conditions related to heart disease . Cordain’s scientific publications have examined the nutritional characteristics of worldwide hunter-gatherer diets as well as the nutrient composition of wild plant and animal foods consumed by foraging humans. The tide has now turned, and many dermatologists now agree with the notion that diet represents the major factor underlying acne. Wolf has provided seminars in nutrition and strength & conditioning to various entities including NASA, Naval Special Warfare, the Canadian Light Infantry and the United States Marine Corps. Normally these large-size peptides and proteins simply would not be able to get through, so we’ve hypothesized that there’s one of three potential mechanisms whereby they can get through.
So the dimensions of the tight junctions actually increase, allowing for a larger molecule to get through. These are specialized cells that line Peyer’s patches in the gut, bumps that are found in certain parts of the gut, and within those Peyer’s patches are M cells. Because it binds so many endogenous ligands, it has the potential for binding everything, and that’s the problem, that it has the potential to bind lots and lots of factors that at least in the Western diet are very, very common. How we know this is, there are animal models where we take insulin and we bind insulin to WGA, so we have a complex.
So bacterial cell wall gets broken down, and if you have WGA in the gut, it binds these bacterial cell wall proteins, and it then binds the epidermal growth factor receptor, acting like a Trojan horse, and bringing WGA plus this antigenic bacterial molecule into plasma.
The peptide remains intact, and then it can be transported to any other cell in the body that expresses the epidermal growth factor. Cops are trying to catch speeders, and the companies that build radar detectors build a better radar detector, they build a better radar gun, and there’s this one-ups-manship. It totally inflames the immune system, and now the immune system will make an immunologic response to that antigen.
Most of the hormones have very, very rapid half-lives, like any other hormones, so by the time the cow’s milk is pasteurized and process, three days later it appeared on the grocery shelf, most of the hormones are degraded. At least to date, it seems somewhere serendipitous how it happens, although there’s an association once again with inflammation.
Tomato lectin in 1972 was shown, when they labeled tomato juice with a radioactive isotopic tracer, a person drank tomato juice, and a half hour later the isotope was in their bloodstream. But once again, tomato lectin doesn’t just nicely bind the receptor, shut the door, and go in. What we do have is a dietary trial going on right now in Ireland where people are going on diets that are wheat-, grain-, dairy-free. Because lysozyme can bind the epidermal growth factor receptor, then lysozyme, just like tomato lectin, even though in vivo it doesn’t do anything by itself, when it’s drawn through the gut, it can potentially cause an immune reaction. The human genome would normally, through negative selection, get rid of these things, because they’re killing us at a younger and younger age.
If the system is genetically designed to operate under these conditions, maybe that’s what we should be doing if it’s practical rather than continuing to try to operate it under conditions under which the genome wasn’t selective. He is the world’s leading expert on Paleolithic diets and has lectured extensively on the Paleolithic nutrition worldwide. Their function is to sample tiny amounts of the bacteria and the pathogens and everything that’s in the gut so we can tell the immune system what’s going on.
We have an insulin WGA molecule, and what happens is, WGA, because it has an affinity for the epidermal growth factor receptor, binds that receptor, and in rats, it lowers the blood glucose. What we believe is, through a process of three-way molecular mimicry, the T lymphocytes become confused. The same thing has happened over the course of hundreds of millions of years with the immune system. We know then if you put WGA into a Petri dish with white blood cells, the inflammatory response is even greater than if you would put bacterial cell walls, this LPS protein I talked about. So we hope to have this information shortly, and this will represent the first human studies to show that these lectins get through.
So when they get viral diseases or bacterial diseases, they seem to have a flare-up of their symptoms.
Even though we call them the staff of life and the staple of all civilizations, on an evolutionary time scale, they’ve only recently been domesticated and adopted.
So it allows the key to bind the receptor, and the body’s endogenous key is epidermal growth factor. And how they become confused is through a process that we call monster molecules, these chimeric molecules, which you’ve called the lectins attached to the bacterial cell walls.
So the HLA molecule slightly changes the confirmation this monster molecule, and when it does that, it totally confuses the immune system, and the immune system loses the ability to recognize self and non-self. But frequently we eat our legumes and beans from the dried form, we just soak them and boil them, and they are still significant sources of WGA. So when you drink milk, whether it’s been pasteurized, processed, whether it’s goat’s milk, cow’s milk or anything, you’re get a big shot of betacellulin, which then has the capacity to bind the epidermal growth factor receptor. So we believe that these dietary antigens also potentially can cause flare-ups in relapsing and remitting MS patients. Had that been going on for hundreds of thousands or millions of years, we would no longer have multiple sclerosis, or we would have it at a very, very low percentage of the population.
And I suspect that when we finally do, maybe not in my lifetime, I’m getting to be old here, I would suspect in maybe the next generation that we will see autoimmune disease unlocked. Cordain is the author of six popular bestselling books including The Real Paleo Diet Cookbook, The Paleo Diet, The Paleo Answer, and The Paleo Diet Cookbook, summarizing his research findings.
We call those chimeric or monster molecules, and when they come in, they look a lot like the bacteria, but they also look a little bit like the tissue that’s being attacked. That would make it a possible, though fuzzy, test of the need to be even kinder to the digestive tract.
So when we swallow our own saliva, if the receptor has been exposed at the glycocalyx, then the hormone, epidermal growth factor, the key, can bind it’s receptor, epidermal growth factor receptor, and when it does that, it causes tissues to be healed inside the gut. Not only does betacellulin get in, these other peptide fragments that are found in the casein fragment, the whey side of milk, they also get through as well. We don’t believe that this is a cure-all for everybody, but we think that in certain people, dependent upon how long they’ve had the disease, they can improve the symptoms. The longer they’ve had the disease, they may stabilize, but the less likely it is they will ever regain function.
If they have had the disease for a short period, within one to three years, there’s a good chance that they can go into complete remission, not all people, but some people, and many people can have an improvement of symptoms.

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