mVox USB Speakerphone
Perfect (except for the form factor)
This is a great speakerphone.  It really works well.  No configuration necessary with Skype (haven't tried other uses).  The plug and play is real!  The best part is the full duplex capability (each side can talk at the same time and hear each other). <br /> <br />Could shrink the form factor.  It's very light so it seems like they could slim it down even further if they tried.  One other improvement could be to put a simple volume control for the speaker and a mute button.  You have to use softkey controls on your computer to do these things (e.g., on your Skype controls).  The quality of the speaker and mic and simplicity over rule these things and qualify for 5 stars from me.