!Source "The Drug Repurposing Hub, Broad Institute" !URL http://www.broadinstitute.org/repurposing !File_date 3/27/17 !Table_name drug information !API_available We suggest using the available data API and/or custom web export function for additional annotation fields and database source information. !Disclaimer For research use only. Do not use the Repurposing Hub to make clinical treatment decisions. BROAD DOES NOT GUARANTEE OR WARRANT THE ACCURACY OF THE DATA WITHIN THE REPURPOSING HUB. RELIANCE ON THE REPURPOSING HUB IS AT THE USER’S SOLE RISK. !Restrictions The Drug Repurposing Hub data is provided for non-commercial use only. !Citation "Please cite usage as: Corsello SM, et al. Nature Medicine. 23 (2017)." !Contact repurposing@broadinstitute.org pert_iname clinical_phase moa target (1E)-1-(2-hydroxy-5-methylphenyl)-1-dodecanone oxime Preclinical A-317491 Preclinical purinergic receptor antagonist P2RX3 A-33903 Phase 2 A-366 Preclinical histone lysine methyltransferase inhibitor EHMT1|EHMT2 A-674563 Preclinical AKT inhibitor AKT1|PKIA|PRKACA A-7 Preclinical calmodulin antagonist A-769662 Preclinical AMPK activator A-803467 Preclinical sodium channel blocker SCN10A abacavir Launched nucleoside reverse transcriptase inhibitor abafungin Phase 3 sterol methyltransferase inhibitor abamectin Launched benzodiazepine receptor agonist GABBR1|GABBR2 abametapir Phase 3 metalloproteinase inhibitor MMP9 ABC-294640 Phase 1/Phase 2 sphingosine kinase inhibitor SPHK2 abiraterone Launched androgen biosynthesis inhibitor CYP11B1|CYP17A1 abiraterone-acetate Launched androgen biosynthesis inhibitor CYP17A1 ABT-202 Phase 1 acetylcholine receptor agonist ABT-239 Phase 1 histamine receptor antagonist HRH1|HRH2|HRH3 ABT-491 Phase 1 platelet activating factor receptor antagonist PTAFR ABT-639 Phase 2 calcium channel blocker CACNA1G|CACNA1H|CACNA1I ABT-702 Preclinical adenosine kinase inhibitor ADK ABT-724 Phase 2 dopamine receptor agonist DRD4 ABT-737 Phase 1/Phase 2 BCL inhibitor BCL2|BCL2L1|BCL2L2 ABT-751 Phase 2 tubulin polymerization inhibitor TUBB AC-264613 Preclinical PAR agonist F2RL1 AC-55541 Preclinical PARP inhibitor PARP2 AC-55649 Preclinical retinoid receptor agonist RARA|RARB AC-7954-(+/-) Preclinical urotensin receptor agonist UTS2R acadesine Phase 3 AMPK activator acalabrutinib Phase 3 Bruton's tyrosine kinase (BTK) inhibitor BTK acalisib Phase 1 PI3K inhibitor PIK3CB|PIK3CD acamprosate Launched glutamate receptor antagonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B|GRM5 acarbose Launched glucosidase inhibitor AMY2A|GAA|MGAM|SI ACDPP Preclinical glutamate receptor antagonist GRM5 acebutolol Launched adrenergic receptor antagonist ADRB1|ADRB2 acecainide Phase 3 polarization inhibitor SCN5A aceclidine Launched acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 aceclofenac Launched prostanoid receptor antagonist PTGS2 acedapsone Launched acedoben Phase 2 acefylline Launched adenosine receptor agonist ADORA1 aceglutamide Launched acemetacin Launched cyclooxygenase inhibitor PTGS1|PTGS2 aceneuramic-acid Phase 3 AZGP1|CES1|MBL2|REG1A|SELE|SELP|SIGLEC1 acenocoumarol Launched vitamin K antagonist VKORC1 acepromazine Launched dopamine receptor antagonist ADRA1A|ADRA1B|DRD1|DRD2|HTR1A|HTR2A acesulfame-potassium Phase 3 acetanilide Preclinical hydrogen peroxide decomposition inhibitor acetarsol Launched acetazolamide Launched carbonic anhydrase inhibitor AQP1|CA1|CA12|CA14|CA2|CA3|CA4|CA7 acetohexamide Launched ATP channel blocker ABCC8|KCNJ1|KCNJ10|KCNJ11 acetohydroxamic-acid Launched urease inhibitor MMP12 acetophenazine Launched dopamine receptor antagonist DRD1|DRD2 acetriazoic-acid Preclinical acetyl-farnesyl-cysteine Launched methyltransferase inhibitor PPARG acetyl-l-leucine Launched acetyl-11-keto-beta-boswellic-acid Phase 2 lipoxygenase inhibitor HSD11B1|HSD11B2 acetylcholine Launched acetylcholine receptor agonist ACHE|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|CHRNA2 acetylcysteine Launched mucolytic agent ACY1|CHUK|GRIN1|GRIN2A|GRIN2B|GRIN2D|GRIN3A|GSS|IKBKB|RELA|SLC7A11 acetylsalicylsalicylic-acid Preclinical cyclooxygenase inhibitor acexamic-acid Launched 5 alpha reductase inhibitor GAST acifran Phase 3 cholesterol inhibitor HCAR2|HCAR3 acipimox Launched cholesterol inhibitor HCAR2 acitazanolast Launched mediator release inhibitor acitretin Launched retinoid receptor agonist RARA|RARB|RARG|RBP1|RXRA|RXRB|RXRG|STAT3 acivicin Phase 2 gamma glutamyltransferase Inhibitors CTPS1 aclarubicin Launched topoisomerase inhibitor TOP1|TOP2A aclidinium Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 ACPC Phase 1 glutamate receptor antagonist acriflavine Launched hypoxia inducible factor inhibitor HIF1A acriflavinium Launched hypoxia inducible factor inhibitor HIF1A acrisorcin Launched other antifungal acrivastine Launched histamine receptor antagonist HRH1 acrylate Phase 3 mucus protecting agent ACT-132577 Launched endothelin receptor antagonist EDNRA|EDNRB ACT-462206 Phase 1 orexin receptor antagonist HCRTR1|HCRTR2 actarit Launched interleukin receptor agonist ACTB-1003 Phase 1 FGFR inhibitor|VEGFR inhibitor KDR|TEK actinomycin-d Launched RNA polymerase inhibitor actinoquinol Preclinical ACY-1215 Phase 1/Phase 2 HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC6|HDAC8 acyclovir Launched DNA polymerase inhibitor PNP AC1NDSS5 Phase 1 AD-5467 Phase 2 aldose reductase inhibitor AKR1B1 adapalene Launched retinoid receptor agonist RARA|RARB|RARG|RXRA|RXRB|RXRG adaprev Phase 3 TGF beta receptor inhibitor IGF2R|M6PR adaptavir Phase 2 CC chemokine receptor antagonist CCR5 adarotene Phase 1 retinoid receptor agonist RARB|RARG adatanserin Phase 2 serotonin receptor agonist|serotonin receptor antagonist HTR1A|HTR2A ADD-233089 Phase 1 benzodiazepine receptor agonist adefovir Launched DNA polymerase inhibitor adefovir-dipivoxil Launched DNA polymerase inhibitor adelmidrol Phase 2/Phase 3 anti-inflammatory agent ademetionine Launched methyltransferase stimulant|phosphodiesterase inhibitor AMD1|CBS|COMT|GNMT|MAT1A|MAT2A adenine Preclinical protein synthesis stimulant ACACB|ACP1|APRT|MTAP|PECR|SRPK2 adenosine Launched adenosine receptor agonist ADORA1|ADORA2A|ADORA2B|ADORA3|PI4K2A|PI4K2B|TRPM4 adenosine-phosphate Launched adenosine receptor agonist ACSL1|ACSS1|ACSS2|ADCY1|ADK|CREB1|FBP1|HINT1|PDE4B|PDE4D|PIM1|PRKAA1|PRKAB1|PRKAB2|PYGL|TRPM4 adenosine-triphosphate Phase 2 adenosine receptor agonist ABCA1|ABCB1|ABCB11|ABCC2|ABCC8|ABCC9|ABCG1|ABL1|ABL2|ACSL1|ACSS1|ACSS2|ACVR1|ACVR1B|ACVRL1|ADCY1|ADRBK1|ADRBK2|AFG3L2|AKT1|ALK|AMHR2|APAF1|ARAF|ASNA1|ASNS|ASS1|CDK15|GPR17|ITPR1|NAE1|NT5C2|P2RY1|P2RY11|P2RY13|P2RY2|P2RY4|PRKAA1|RYR1|RYR2|RYR3|SLC25A4|TNK2|TRPM4|TRPM7 adiphenine Launched acetylcholine receptor antagonist CHRNA1 adipic-acid Preclinical solute carrier family member inhibitor SLC22A6 adiporon Preclinical adiponectin receptor agonist ADIPOR1|ADIPOR2 ADL5859 Phase 2 opioid receptor agonist OPRD1 adoprazine Phase 2 dopamine receptor antagonist|serotonin receptor agonist DRD2|HTR1A adrafinil Launched adrenergic receptor agonist adrenalone Launched adrenergic receptor agonist ADRA1A adrenosterone Preclinical 11-beta hydroxysteroid dehydrogenase inhibitor HSD11B1|HSD11B2 ADX-47273 Preclinical glutamate receptor modulator GRM5 AEE788 Phase 1/Phase 2 EGFR inhibitor|VEGFR inhibitor EGFR|ERBB2|ERBB4|FGFR2|FGFR3|KDR AEG3482 Preclinical HSP inducer afalanine Phase 3 dopamine receptor agonist DRD2 afatinib Launched EGFR inhibitor EGFR|ERBB2|ERBB4 afimoxifene Phase 2 estrogen receptor antagonist ESR1|ESR2|ESRRG|PLD1|PRKCD|PRKCE|PRKCQ|PRKCZ afloqualone Launched acetylcholine receptor antagonist AFN-1252 Phase 2 FABI inhibitor afobazole Launched anxiolytic AF38469 Preclinical sortilin inhibitor SORT1 AG-1024 Preclinical insulin growth factor receptor inhibitor IGF1R AG-14361 Preclinical PARP inhibitor PARP1 AG-490 Preclinical EGFR inhibitor|JAK inhibitor EGFR|JAK2|JAK3 AG-555 Preclinical tyrosine kinase inhibitor CDK2 AG-556 Preclinical tyrosine kinase inhibitor AGI-5198 Preclinical isocitrate dehydrogenase inhibitor IDH1 AGI-6780 Preclinical isocitrate dehydrogenase inhibitor IDH2 AGM-1470 Phase 2 cell cycle inhibitor METAP2 agmatine Phase 3 nitric oxide synthase inhibitor ADRA2C|ASIC3|CACNA1B|CHRNA1|GRIN1|KCNJ1|NISCH AGN-192403 Preclinical imidazoline receptor ligand NISCH AGN-194310 Phase 3 retinoid receptor antagonist RXRA|RXRB|RXRG AGN-195183 Phase 1/Phase 2 retinoid receptor agonist RARA agomelatine Launched melatonin receptor agonist|serotonin receptor antagonist HTR2A|HTR2B|HTR2C|MTNR1A|MTNR1B AGP-103 Launched membrane permeability inhibitor AH11110 Preclinical adrenergic receptor ligand ADRA1B AH6809 Preclinical prostanoid receptor antagonist PTGDR|PTGER1|PTGER2|PTGER3 AI-10-49 Preclinical core binding factor inhibitor CBFB ajmaline Launched sodium channel blocker SCN5A AJ76-(+) Preclinical dopamine receptor antagonist DRD2|DRD3|DRD4 AKBA Phase 3 lipoxygenase inhibitor ALOX5 aklomide Launched alacepril Launched angiotensin converting enzyme inhibitor ACE alafosfalin Phase 1 bacterial cell wall synthesis inhibitor alagebrium Phase 2/Phase 3 glycosylation inhibitor alanine Launched AARS|AARS2|ABAT|AGXT|AGXT2|GPRC6A|GPT|GPT2|KYNU|NFS1|PHYKPL|SLC1A4|SLC36A1|SLC7A8 alaproclate Phase 2 serotonin receptor antagonist SLC6A4 alarelin Launched gonadotropin releasing factor hormone receptor antagonist GNRH1 albendazole Launched tubulin polymerization inhibitor TUBA1A|TUBB|TUBB4B albendazole-oxide Launched anthelmintic agent albuterol Launched adrenergic receptor agonist ADRB1|ADRB2 alcaftadine Launched histamine receptor antagonist HRH1 alclofenac Launched cyclooxygenase inhibitor PTGS1 alclometasone-dipropionate Launched glucocorticoid receptor agonist CYP3A4|NR3C1|SERPINA6 alcuronium Launched muscle relaxant CHRM1|CHRM2|CHRM3|CHRM4|CHRNA7 aldoxorubicin Phase 3 topoisomerase inhibitor TOP2A alectinib Launched ALK tyrosine kinase receptor inhibitor ALK|MET alendronate Launched bone resorption inhibitor ATP6V1A|FDPS|PTPN4|PTPRE|PTPRS alexidine Preclinical phosphatidylglycerophosphatase inhibitor PTPMT1 alfacalcidol Launched vitamin D receptor agonist CYP27B1|VDR alfadolone-acetate Phase 2 benzodiazepine receptor agonist alfaxalone Launched chloride channel agonist|benzodiazepine receptor agonist GABBR1 alfuzosin Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|KCNH2 algestone-acetophenide Launched alibendol Launched antispasmodic alimemazine Launched histamine receptor agonist HRH1 alisertib Phase 3 Aurora kinase inhibitor AURKA aliskiren-hemifumarate Launched renin inhibitor REN alizapride Launched dopamine receptor antagonist DRD2 alizarin Preclinical allantoin Launched cosmetic allicin Phase 2 cytokine production inhibitor TRPA1|TRPV1 allopurinol Launched xanthine oxidase inhibitor XDH allopurinol-riboside Phase 2 anti-leishmanial agent allylestrenol Launched steroidal progestin ESR1|PGR|SLC6A9 allylisothiocyanate Preclinical TRPV agonist TRPA1 allylthiourea Preclinical nitrification inhibitor almitrine Launched neurotransmitter agonist ATP1A1 almorexant Phase 3 orexin receptor antagonist HCRTR1|HCRTR2 almotriptan Launched serotonin receptor agonist HTR1B|HTR1D aloe-emodin Preclinical anticancer agent CASP8 alogliptin Launched dipeptidyl peptidase inhibitor DPP4 aloin Preclinical angiogenesis inhibitor aloperine Preclinical alosetron Withdrawn serotonin receptor antagonist HTR3A aloxistatin Phase 3 protease inhibitor CTSG alpelisib Phase 3 PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG alpha-Asarone Preclinical cytochrome P450 inhibitor|HMGCR inhibitor HMGCR alpha-D-glucopyranose Preclinical alpha-linolenic-acid Phase 3 omega 3 fatty acid stimulant ELOVL4|FADS1|FADS2|FFAR1|FFAR4|PTGS2|SLC8A1|TRPV1 alpha-methylhistamine-dihydrobromide-(R)-(-) Preclinical histamine receptor agonist HRH3 alpha-methylhistamine-dihydrobromide-(S)-(+) Preclinical histamine receptor agonist HRH3 alpha-methylserotonin Preclinical serotonin receptor agonist HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR4 alpha-tochopherol Launched antioxidant alpha-tochopheryl-acetate Launched antioxidant alpidem Withdrawn benzodiazepine receptor agonist GABRA1 alprenolol Launched adrenergic receptor antagonist ADRB1|ADRB2|HTR1A alprostadil Launched prostanoid receptor agonist CATSPER1|CATSPER2|CATSPER3|CATSPER4|PTGDR|PTGER1|PTGER2|PTGER4|PTGIR alrestatin Preclinical aldose reductase inhibitor AKR1B1 ALS-8176 Phase 1 RNA polymerase inhibitor altanserin Phase 2 serotonin receptor antagonist HTR2A althiazide Launched diuretic altinicline Phase 2 nicotinic receptor agonist CHRNA4|CHRNB2 altiratinib Phase 1 VEGFR inhibitor|MET inhibitor KDR|MET|TEK altrenogest Launched progestogen hormone PGR altretamine Launched DNA synthesis inhibitor alverine Launched muscle relaxant HTR1A alvespimycin Phase 2 HSP inhibitor HSP90AA1 alvimopan Launched opioid receptor antagonist OPRD1|OPRK1|OPRM1 alvocidib Phase 2 CDK inhibitor CDK1|CDK2|CDK4|CDK5|CDK6|CDK7|CDK8|CDK9|EGFR|PYGM ALX-5407 Phase 1 Glycine transporter 1 inhibitor SLC6A9 AM-1241 Preclinical cannabinoid receptor agonist CNR1|CNR2 AM-24 Phase 2 lipoxygenase inhibitor ALOX5 AM-251 Preclinical cannabinoid receptor antagonist CNR1|GPR18|GPR55 AM-281 Preclinical cannabinoid receptor antagonist CNR1|CNR2|GPR55 AM-404 Preclinical cyclooxygenase inhibitor|FAAH inhibitor|TRPV antagonist CNR1|CNR2|FAAH|TRPV1 AM-580 Preclinical retinoid receptor agonist RARA AM-630 Preclinical cannabinoid receptor antagonist CNR1|CNR2 AM-92016 Preclinical potassium channel blocker GRIN1 amantadine Launched glutamate receptor antagonist DRD2|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A ambazone Phase 1 DNA damage inducer ambenonium Launched cholinesterase inhibitor ACHE ambrisentan Launched endothelin receptor antagonist EDNRA|EDNRB ambroxol Launched sodium channel blocker CYP3A4 amcinonide Launched glucocorticoid receptor agonist ANXA1|NR3C1 amdinocillin Launched bacterial cell wall synthesis inhibitor AMD11070 Phase 1/Phase 2 CC chemokine receptor antagonist CXCR4 ameltolide Preclinical anticonvulsant amezinium Launched adrenergic receptor agonist ADRB2 amfenac Launched cyclooxygenase inhibitor PTGS1|PTGS2 amfepramone Launched adrenergic receptor agonist SLC6A2|SLC6A3 amflutizole Phase 2 xanthine oxidase inhibitor XDH AMG-208 Phase 1 tyrosine kinase inhibitor MET AMG-232 Phase 1/Phase 2 MDM inhibitor MDM2 AMG-319 Phase 2 PI3K inhibitor PIK3CD AMG-337 Phase 2 MET inhibitor MET AMG-487 Phase 2 CC chemokine receptor antagonist CXCR3 AMG-517 Phase 1 TRPV antagonist TRPV1 AMG-548 Phase 1 MAP kinase inhibitor MAPK11|MAPK12|MAPK13|MAPK14 AMG-837 Phase 1 free fatty acid receptor agonist FFAR1 AMG-925 Phase 1 CDK inhibitor|FLT3 inhibitor CDK4|CDK6|FLT3 AMG-9810 Preclinical TRPV antagonist TRPV1 AMG319 Phase 2 PI3K inhibitor PIK3CD AMG458 Preclinical MET inhibitor MET AMG900 Phase 1 Aurora kinase inhibitor AURKA|AURKB|AURKC AMI-1 Preclinical protein arginine N-methyltransferase inhibitor PRMT1 amibegron Phase 3 adrenergic receptor agonist ADRB3 amidopyrine Launched analgesic agent amifampridine Launched potassium channel blocker amiflamine Phase 1 monoamine oxidase inhibitor MAOA|SLC6A2 amifostine Launched reducing agent ALPPL2|ENPP1 amikacin Launched bacterial 30S ribosomal subunit inhibitor amiloride Launched sodium channel blocker AOC1|ASIC1|ASIC2|ASIC3|PKD2|PKD2L1|PLAU|SCNN1A|SCNN1B|SCNN1D|SCNN1G|SLC9A1|TRPC7|TRPV2 amineptine Withdrawn dopamine receptor agonist SLC6A2|SLC6A4 aminocaproic-acid Launched plasminogen activator inhibitor LPA|PLAT|PLG aminoglutethimide Launched glucocorticoid receptor antagonist CYP11A1|CYP19A1 aminoguanidine Phase 3 nitric oxide synthase inhibitor NOS2 aminohydroxybutyric-acid Launched aminolevulinic-acid-benzyl-ester Phase 1 aminomethyltransferase Preclinical nitric oxide synthase inhibitor NOS2 aminopentamide Launched acetylcholine receptor antagonist CHRM1 aminophylline Launched adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3|HDAC2|PDE3A|PDE3B|PDE4A|PDE4B|PDE4C|PDE4D aminopterin Phase 3 dihydrofolate reductase inhibitor DHFR|SLC46A1 aminopurvalanol-a Preclinical CDK inhibitor|tyrosine kinase inhibitor CDK1|CDK2|CDK5|CDK6 aminosalicylate Launched cyclooxygenase inhibitor ALOX5|CHUK|PLA2G2E|PTGS1|PTGS2 aminothiadiazole Phase 2 inosine monophosphate dehydrogenase inhibitor ADORA3|IMPDH1 aminothiazole Preclinical cyclin D inhibitor NOS2 amiodarone Launched potassium channel blocker ADRB1|CACNA1H|CACNA2D2|KCNA7|KCNH2 amiprilose Phase 3 CD antagonist amisulpride Launched dopamine receptor antagonist DRD2|DRD3|HTR2A|HTR7 amitifadine Phase 3 serotonin transporter (SERT) inhibitor SLC6A2|SLC6A3|SLC6A4 amitraz Launched adrenergic receptor agonist ADRA1A|ADRA2A amitriptyline Launched norepinephrine inhibitor|norepinephrine reuptake inhibitor|serotonin receptor antagonist|serotonin–norepinephrine reuptake inhibitor (SNRI) ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRB1|ADRB2|ADRB3|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HRH1|HRH2|HRH4|HTR1A|HTR1B|HTR1D|HTR2A|HTR2C|HTR6|HTR7|KCNA1|KCND2|KCND3|KCNQ2|KCNQ3|NTRK1|NTRK2|OPRD1|OPRK1|OPRM1|SIGMAR1|SLC6A2|SLC6A4 amlexanox Launched histamine receptor modulator FGF1|IL3|PDE4A|PDE4B|PDE4C|PDE4D|S100A12|S100A13 amlodipine Launched calcium channel blocker CA1|CACNA1B|CACNA1C|CACNA1D|CACNA1F|CACNA1S|CACNA2D1|CACNA2D3|CACNB1|CACNB2|SMPD1 ammonium-glycyrrhizinate Launched thrombin inhibitor HSD11B1|HSD11B2|SLCO1B1|SLCO1B3 ammonium-lactate Launched HCAR1 ammonium-perfluorocaprylate Phase 1 Pim kinase inhibitor PIM1 AMN-082 Preclinical glutamate receptor modulator GRM7 amodiaquine Launched histamine receptor agonist HNMT amonafide Phase 3 topoisomerase inhibitor TOP2A|TOP2B amorolfine Launched membrane integrity inhibitor amoxapine Launched norepinephrine reputake inhibitor ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|HRH1|HRH4|HTR1A|HTR1B|HTR2A|HTR2B|HTR2C|HTR3A|HTR6|HTR7|SLC6A2|SLC6A3|SLC6A4 amoxicillin Launched penicillin binding protein inhibitor CYP2C19|SLC15A1|SLC15A2|SLC22A6 AMPA-(RS) Preclinical glutamate receptor agonist GRIN1 AMPA-(S) Preclinical glutamate receptor agonist GRIN1 ampalex Phase 2 glutamate receptor agonist GRIA1|GRIA2|GRIA3|GRIA4 amperozide Launched dopamine receptor antagonist FAAH|HTR2A amphotericin-b Launched membrane permeability enhancer ampicillin Launched bacterial cell wall synthesis inhibitor ampiroxicam Launched cyclooxygenase inhibitor PTGS1|PTGS2 amprenavir Launched HIV protease inhibitor amprolium Launched thiamine uptake blocker ampyrone Preclinical cyclooxygenase inhibitor amrinone Launched phosphodiesterase inhibitor PDE3A|PDE3B|PDE4B|TNF amrubicin Launched topoisomerase inhibitor TOP2A|TOP2B amsacrine Launched topoisomerase inhibitor KCNH2|TOP2A amthamine Preclinical histamine receptor agonist HRH2 amtolmetin-guacil Launched cyclooxygenase inhibitor PTGS1|PTGS2 amuvatinib Phase 2 FLT3 inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|RAD51 inhibitor|RET tyrosine kinase inhibitor KIT|MET amygdalin Phase 2 caspase activator CASP3 amyl-nitrite Preclinical atrial natriuretic peptide receptor agonist NPR1 amyleine Preclinical local anesthetic amylene-hydrate Preclinical local anesthetic AMZ30 Preclinical protein phosphatase inhibitor AM679 Preclinical cannabinoid receptor agonist|lipoxygenase inhibitor ALOX5AP|CNR1|CNR2 anabasine Preclinical acetylcholine receptor agonist anacetrapib Phase 3 cholesteryl ester transfer protein inhibitor CETP anagliptin Launched dipeptidyl peptidase inhibitor DPP4 anagrelide Launched phosphodiesterase inhibitor PDE3A anamorelin Phase 3 growth hormone secretagogue receptor agonist GHSR anandamide Phase 2 cannabinoid receptor agonist CACNA1G|CACNA1H|CACNA1I|CNR1|CNR2|GLRA1|GPR18|GPR55|KCNA2|KCNK3|KCNK9|TRPM8|TRPV1 anastrozole Launched aromatase inhibitor CYP19A1 andarine Phase 1 androgen receptor modulator AR andrographolide Phase 2 tumor necrosis factor production inhibitor NFKB1 androstenone Preclinical steroid androsterone Preclinical androgen receptor agonist anecortave-acetate Launched angiogenesis inhibitor anethole Launched glutathione transferase stimulant anethole-trithione Launched glutathione transferase stimulant anguidine Phase 2 protein synthesis inhibitor SLC5A1 anidulafungin Launched "fungal 1,3-beta-D-glucan synthase inhibitor" aniracetam Launched glutamate receptor agonist DRD2|GRIA1|GRIA2|GRIA3|GRIA4|HTR2A anisindione Launched vitamin K antagonist GGCX anisodamine Phase 3 lipid peroxidase inhibitor ADRA1A anisomycin Preclinical DNA synthesis inhibitor NHP2L1|RPL10L|RPL11|RPL13A|RPL15|RPL19|RPL23|RPL23A|RPL26L1|RPL3|RPL37|RPL8|RSL24D1 anisotropine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3 anlotinib Phase 2/Phase 3 VEGFR inhibitor|PDGFR tyrosine kinase receptor inhibitor KDR|PDGFRB anpirtoline Phase 1 serotonin receptor agonist HTR1B ansamitocin-p-3 Preclinical apoptosis stimulant antagonist-g Phase 1 neuropeptide receptor antagonist MAPK8 antazoline Launched antihistamine HRH1 anthralin Launched DNA synthesis inhibitor anthranilic-acid Preclinical anthraquinone Preclinical CDC inhibitor CDC25B antimony-potassium Phase 2 antimonyl Phase 1 antimycin-a Preclinical ATP synthase inhibitor CYCS antioxine Launched AN2718 Phase 1 leucyl-tRNA synthetase inhibitor apabetalone Phase 3 apolipoprotein expression enhancer BRD3 apafant Phase 3 platelet activating factor receptor antagonist PTAFR apatinib Phase 3 RET tyrosine kinase inhibitor CSK|KDR|KIT|RET APC-100 Phase 1/Phase 2 anti-inflammatory agent|androgen receptor antagonist AR APD597 Phase 1 glucose dependent insulinotropic receptor agonist GPR119 APD668 Phase 1 glucose dependent insulinotropic receptor agonist GPR119 aphidicolin Phase 1 RNA synthesis inhibitor API-001 Phase 2 sigma receptor antagonist SIGMAR1 apigenin Preclinical casein kinase inhibitor|cell proliferation inhibitor AKR1B1|AR|CDK6|CFTR|CYP19A1|CYP1B1|HSD17B1 apixaban Launched coagulation factor inhibitor F10 apocynin Phase 1 NADPH oxidase inhibitor NOX4 apoptosis-activator-II Preclinical carboxylesterase inhibitor BCHE|CES1 APR-246 Phase 1/Phase 2 p53 activator TP53 apraclonidine Launched adrenergic receptor agonist ADRA1A|ADRA2A|ADRA2B|ADRA2C apramycin Launched bacterial 30S ribosomal subunit inhibitor apratastat Phase 2 matrix metalloprotease inhibitor|tumor necrosis factor production inhibitor ADAM17|MMP1|MMP13|MMP9 apremilast Launched phosphodiesterase inhibitor PDE4A|PDE4B|PDE4C|PDE4D aprepitant Launched tachykinin antagonist TACR1 apricitabine Phase 3 nucleoside reverse transcriptase inhibitor aprindine Launched voltage-gated sodium channel blocker CALM1|SCN5A aptiganel Phase 3 glutamate receptor antagonist GRIN1 APTO-253 Phase 1 krüppel-like factor expression enhancer KLF4 APY0201 Preclinical phosphoinositide dependent kinase inhibitor IL12A|IL12B|PIKFYVE AP1903 Phase 1/Phase 2 AP26113 Phase 2 ALK tyrosine kinase receptor inhibitor ALK|EGFR AQ-RA741 Preclinical acetylcholine receptor antagonist CHRM2 AR-A014418 Preclinical glycogen synthase kinase inhibitor GSK3B AR-C155858 Preclinical monocarboxylate transporter inhibitor SLC16A1|SLC16A7 AR-12 Phase 1 phosphoinositide dependent kinase inhibitor PDPK1 AR-42 Phase 1 HDAC inhibitor HDAC1 arachidonic-acid Phase 1 cytochrome P450 inhibitor CLCN2|KCNJ4|KCNK10|KCNK18|KCNK2|PRKCZ|PTGS1|TRPC6|TRPM2 arbidol Launched cytochrome P450 inhibitor CYP3A4 arbutin Phase 2/Phase 3 melanin inhibitor TYR ARC-239 Preclinical adrenergic receptor antagonist ADRA2A|ADRA2B|ADRA2C arctigenin Preclinical MEK inhibitor CHUK|MAP2K1 arcyriaflavin-a Preclinical CDK inhibitor CCND1|CDK4 ardeparin Withdrawn thrombin inhibitor SERPINC1|SERPIND1 arecaidine-but-2-ynyl-ester Preclinical acetylcholine receptor agonist CHRM2 arecaidine-propargyl-ester Preclinical acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4 arecoline Phase 1 acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4 argatroban Launched thrombin inhibitor F2 arglabin Launched farnesyltransferase inhibitor FNTA|NFKB1 aripiprazole Launched serotonin receptor agonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2C|HTR3A|HTR6|HTR7 armodafinil Launched adrenergic receptor agonist SLC6A3 ARN-509 Phase 3 androgen receptor antagonist AR arofylline Phase 3 phosphodiesterase inhibitor PDE4A arotinolol Launched adrenergic receptor antagonist ADRB3 ARQ-092 Phase 1 AKT inhibitor AKT2 ARQ-621 Phase 1 kinesin-like spindle protein inhibitor KIF11 ARRY-334543 Phase 2 EGFR inhibitor ERBB2 arsanilic-acid Phase 1 LYZ arsenic-trioxide Launched apoptosis stimulant AKT1|CCND1|IKBKB|JUN|MAPK1|MAPK3|TXNRD1 artemether Launched antimalarial agent ATP1A1 artemisinin Launched DNA synthesis inhibitor CYP2B6 artemotil Launched artesunate Launched DNA synthesis inhibitor articaine Launched local anesthetic arundic-acid Phase 2/Phase 3 astrocyte modulating agent PTGS2|S100B ARV-825 Preclinical bromodomain inhibitor BRD4 AS-1949490 Preclinical SHIP2 phosphatase inhibitor INPP5D AS-252424 Preclinical PI3K inhibitor PIK3CG AS-604850 Preclinical PI3K inhibitor PIK3CA|PIK3CG AS-703026 Phase 2 MEK inhibitor MAP2K1|MAP2K2 AS-77 Preclinical potassium channel blocker KCNA3|KCNA5|KCNN4 ASA-404 Phase 3 angiogenesis inhibitor asaraldehyde Preclinical cyclooxygenase inhibitor PTGS2 ASC-J9 Phase 2 androgen receptor enhancer AR ascomycin Preclinical calcineurin inhibitor FKBP1A ascorbic-acid Launched antioxidant ALKBH2|ALKBH3|BBOX1|DBH|EGLN1|EGLN2|EGLN3|KDM5D|LCT|OGFOD1|OGFOD2|P3H1|P3H2|P3H3|P4HA1|P4HTM|PAM|PHYH|PLOD1|PLOD2|PLOD3|SLC23A1|SLC23A2|TMLHE asenapine Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|DRD1|DRD2|DRD3|DRD4|HRH1|HRH2|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|HTR7 asiatic-acid Preclinical apoptosis stimulant PYGM ASP-2535 Phase 1 glycine transporter inhibitor SLC6A9 aspartame Launched TAS1R2|TRPV1 aspirin Launched cyclooxygenase inhibitor AKR1C1|ASIC3|EDNRA|HSPA5|IKBKB|NFKB1|NFKB2|NFKBIA|PRKAA1|PRKAA2|PRKAB1|PRKAB2|PRKAG1|PRKAG2|PRKAG3|PTGS1|PTGS2|RPS6KA3|TP53 ASP3026 Phase 1 ALK tyrosine kinase receptor inhibitor ALK AST-1306 Phase 1 EGFR inhibitor EGFR|ERBB2 astaxanthin Launched antioxidant astemizole Withdrawn histamine receptor antagonist HRH1|KCNH1|KCNH2 astragaloside-a Preclinical antiinflammatory agent asunaprevir Phase 3 HCV inhibitor asymmetrical-dimethylarginine Phase 1 nitric oxide synthase inhibitor NOS2|NOS3 AT-7519 Phase 2 CDK inhibitor CDK1|CDK2|CDK4|CDK5|CDK6|CDK9 AT-9283 Phase 2 Aurora kinase inhibitor|JAK inhibitor AURKA|AURKB|JAK2|JAK3|RPS6KA6|STK17A ataluren Launched CFTR channel agonist|dystrophin stimulant DMD atazanavir Launched HIV protease inhibitor ATB-346 Phase 2 cyclooxygenase inhibitor PTGER2 atenolol-(+/-) Launched adrenergic receptor antagonist ADRB1|ADRB2 atenolol-(-) Preclinical adrenergic receptor antagonist atglistatin Preclinical adipose triglyceride lipase inhibitor atipamezole Launched adrenergic receptor antagonist atiprimod Phase 2 JAK inhibitor|STAT inhibitor JAK2|STAT3 atizoram Phase 2 phosphodiesterase inhibitor PDE4A|PDE4B|PDE4C|PDE4D ATN-161 Phase 2 integrin antagonist ITGA5|ITGAV|ITGB1|ITGB3 atomoxetine Launched norepinephrine transporter inhibitor GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B|SLC6A2|SLC6A3|SLC6A4 atorvastatin Launched HMGCR inhibitor AHR|DPP4|HMGCR atosiban Launched oxytocin receptor antagonist AVPR1A|AVPR1B|AVPR2|OXTR atovaquone Launched mitochondrial electron transport inhibitor DHODH ATPA Preclinical glutamate receptor agonist GRIA2|GRIK1 atracurium Launched acetylcholine receptor antagonist CHRNA2 atrasentan Phase 3 endothelin receptor antagonist EDNRA atropine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 atropine-oxide Preclinical acetylcholine receptor antagonist AT13148 Phase 1 protein kinase inhibitor AKT1|AKT2|AKT3|ROCK1|ROCK2|SGK3 AT13387 Phase 2 HSP antagonist HSP90AA1 AT7867 Preclinical AKT inhibitor AKT2|GSK3B|PKIA|PRKACA auranofin Launched NFkB pathway inhibitor IKBKB|PRDX5|TRPA1 aurora-a-inhibitor-i Preclinical Aurora kinase inhibitor AURKA aurothioglucose Launched PKC inhibitor PRKCI autotaxin-modulator-1 Preclinical autotaxin inhibitor ENPP2 AV-412 Phase 1 protein tyrosine kinase inhibitor EGFR|ERBB2 AV-608 Phase 2 tachykinin antagonist TACR1 avagacestat Phase 2 gamma secretase inhibitor PSEN1 avanafil Launched phosphodiesterase inhibitor PDE5A avasimibe Phase 3 ACAT inhibitor CES1 avatrombopag Phase 3 thrombopoietin receptor agonist MPL AVE-0991 Preclinical angiotensin receptor agonist MRGPRX1 avibactam Launched beta lactamase inhibitor AVL-292 Phase 2 Bruton's tyrosine kinase (BTK) inhibitor BTK|YES1 AVN-944 Phase 2 inosine monophosphate dehydrogenase inhibitor IMPDH1|IMPDH2 avobenzone Launched UV blocker TYR avridine Preclinical immunostimulant axitinib Launched PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor CSF1|FLT1|FLT4|KDR|PLK4 AY-9944 Preclinical hedgehog pathway modulator AZ-10417808 Preclinical caspase inhibitor CASP3 AZ-628 Preclinical RAF inhibitor BRAF|RAF1 azacitidine Launched DNA methyltransferase inhibitor DNMT1|DNMT3A azacyclonol Preclinical histamine receptor antagonist HRH1 azaguanine-8 Preclinical purine antagonist PNP azalomycin-b Preclinical bacterial 50S ribosomal subunit inhibitor azaperone Launched dopamine receptor antagonist DRD2|DRD3 azapropazone Withdrawn cyclooxygenase inhibitor PTGS2 azaserine Preclinical purine antagonist azasetron Launched serotonin receptor antagonist HTR3A|HTR3B azatadine Launched histamine receptor antagonist HRH1 azathioprine Launched dehydrogenase inhibitor HPRT1|IMPDH1|PPAT AZD1080 Phase 1 glycogen synthase kinase inhibitor GSK3A|GSK3B AZD1208 Phase 1 Pim kinase inhibitor PIM1|PIM2|PIM3 AZD1283 Preclinical purinergic receptor antagonist P2RY12 AZD1446 Phase 2 acetylcholine receptor agonist CHRNA4|CHRNB2 AZD1480 Phase 1 JAK inhibitor JAK1|JAK2|JAK3 AZD1981 Phase 2 CRTH receptor antagonist PTGDR2 AZD2014 Phase 2 mTOR inhibitor MTOR AZD2461 Phase 1 PARP inhibitor AZD2858 Preclinical glycogen synthase kinase inhibitor GSK3B AZD3264 Preclinical IKK inhibitor IKBKB AZD3463 Preclinical ALK tyrosine kinase receptor inhibitor|insulin growth factor receptor inhibitor ALK|IGF1R AZD3514 Phase 1 androgen receptor modulator AR AZD3759 Phase 1 EGFR inhibitor EGFR AZD3839 Phase 1 beta-secretase inhibitor BACE1 AZD3965 Phase 1 monocarboxylate transporter inhibitor SLC16A1 AZD4282 Phase 1 glutamate receptor antagonist AGXT|AGXT2|ALAS1|ALAS2|BAAT|GARS|GATM|GCAT|GCSH|GLDC|GLRA1|GLRA2|GLRA3|GLRB|GLYAT|GLYATL1|GLYATL2|GNMT|GPR18|GPRC6A|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3B|GSS|PIPOX|SHMT1|SHMT2|SLC32A1|SLC36A1|SLC6A5|SLC6A9 AZD4547 Phase 2/Phase 3 FGFR inhibitor FGFR1|FGFR2|FGFR3|FGFR4|IGF1R|KDR AZD5069 Phase 2 CC chemokine receptor antagonist CXCR2 AZD5363 Phase 2 AKT inhibitor AKT1|AKT2|AKT3 AZD5438 Phase 1 CDK inhibitor KCNH2 AZD5582 Preclinical XIAP inhibitor BIRC2|BIRC3|XIAP AZD6482 Phase 1 PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG AZD6738 Phase 1/Phase 2 ATR kinase inhibitor ATR AZD6765 Phase 2 glutamate receptor antagonist GRIN1 AZD7545 Phase 1 pyruvate dehydrogenase kinase inhibitor PDK1 AZD7687 Phase 1 diacylglycerol O acyltransferase inhibitor DGAT1 AZD7762 Phase 1 CHK inhibitor CHEK1|CHEK2 AZD8055 Phase 1 mTOR inhibitor MTOR AZD8186 Phase 1 PI3K inhibitor PIK3CB|PIK3CD AZD8330 Phase 1 MEK inhibitor AZD8835 Phase 1 PI3K inhibitor PIK3CA|PIK3CD AZD8931 Phase 2 EGFR inhibitor EGFR|ERBB2|ERBB3 AZD9496 Phase 1 estrogen receptor agonist ESR1 AZD9668 Phase 2 elastase inhibitor ELANE azelaic-acid Launched tyrosinase inhibitor AKR1D1|SRD5A2|TYR azelastine Launched histamine receptor antagonist HRH1 azeliragon Phase 3 RAGE receptor antagonist AGER azelnidipine Launched calcium channel blocker CACNA1C azilsartan Launched angiotensin receptor antagonist AGTR1|AGTR2 azilsartan-medoxomil Launched angiotensin receptor antagonist AGTR1|AGTR2 azimilide Phase 3 potassium channel blocker KCNA5|KCNE1|KCNH2|KCNQ1 azithromycin Launched bacterial 50S ribosomal subunit inhibitor MLNR azlocillin Launched bacterial cell wall synthesis inhibitor azodicarbonamide Phase 2 DNA synthesis inhibitor azomycin-(2-nitroimidazole) Preclinical protein synthesis inhibitor azosemide Launched electrolyte reabsorption inhibitor SLC12A1|SLC12A2 aztreonam Launched bacterial cell wall synthesis inhibitor AZ191 Preclinical DYRK inhibitor DYRK1B AZ20 Preclinical ATR kinase inhibitor ATR|MTOR AZ3146 Preclinical monopolar spindle 1 kinase inhibitor AZ505 Preclinical histone lysine methyltransferase inhibitor SMYD2 AZ5104 Preclinical EGFR inhibitor EGFR AZ960 Preclinical JAK inhibitor JAK2 A0001 Phase 2 A205804 Preclinical ICAM1 expression inhibitor ICAM1|SELE A61603 Preclinical adrenergic receptor agonist ADRA1A A66 Preclinical PI3K inhibitor PIK3CA A740003 Preclinical purinergic receptor antagonist P2RX7 A77636 Preclinical dopamine receptor agonist CALY A922500 Preclinical diacylglycerol O acyltransferase inhibitor DGAT1 bacampicillin Launched bacterial cell wall synthesis inhibitor bacitracin Launched bacterial cell wall synthesis inhibitor A2M|IDE bacitracin-zinc Launched bacterial cell wall synthesis inhibitor baclofen Launched benzodiazepine receptor agonist GABBR1|GABBR2|KCTD12|KCTD16|KCTD8 baclofen-(R) Preclinical benzodiazepine receptor agonist GABBR1|GABBR2 BADGE Preclinical PPAR receptor antagonist PPARG bafetinib Phase 2 Bcr-Abl kinase inhibitor|LYN tyrosine kinase inhibitor ABL1|BCR|LYN baicalein Preclinical lipoxygenase inhibitor ALOX5|GLO1|PREP|SELL|SELP|TNF|XDH baicalin Launched beta glucuronidase inhibitor PREP bakuchiol Phase 2 DNA polymerase inhibitor HIF1A balaglitazone Phase 3 insulin sensitizer|PPAR receptor partial agonist PPARG balapiravir Phase 2 RNA polymerase inhibitor balicatib Phase 2 cathepsin inhibitor CTSK balofloxacin Launched bacterial DNA gyrase inhibitor balsalazide Launched cyclooxygenase inhibitor ALOX5|PPARG|PTGS1|PTGS2 bambuterol Launched adrenergic receptor agonist ADRB2|BCHE BAM7 Preclinical BAX activator BAX BAN-ORL-24 Preclinical nociceptin/orphanin FQ receptor antagonist OPRL1 barasertib Phase 2/Phase 3 Aurora kinase inhibitor AURKA|AURKB barasertib-HQPA Phase 2/Phase 3 Aurora kinase inhibitor AURKB barbital Launched sedative CHRNA4|CHRNA7|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GRIA2|GRIK2 bardoxolone Phase 1 nuclear factor erythroid derived|like (NRF2) activator NOS2|PPARG bardoxolone-methyl Phase 3 nuclear factor erythroid derived|like (NRF2) activator PPARG|STAT3 baricitinib Phase 3 JAK inhibitor JAK1|JAK2 barnidipine Launched calcium channel blocker basic-fuchsin Preclinical basimglurant Phase 2 glutamate receptor antagonist GRM5 batimastat Phase 3 matrix metalloprotease inhibitor ADAM28|ADAMTS5|MMP12|MMP16|MMP2|MMP8 bavisant Phase 2 histamine receptor antagonist HRH3 BAX-channel-blocker Preclinical cytochrome C release inhibitor BAX BAY-K-8644-(+/-) Preclinical L-type calcium channel activator BAY-K-8644-(s)-(-) Preclinical L-type calcium channel activator CACNA1C bay-w-9798 Phase 2 antioxidant BAY-11-7082 Preclinical NFkB pathway inhibitor RELA BAY-11-7085 Preclinical NFkB pathway inhibitor NFKBIA bay-60-7550 Preclinical phosphodiesterase inhibitor PDE2A BAY-61-3606 Preclinical syk inhibitor SYK BAY-85-8050 Phase 1 BAY-87-2243 Phase 1 hypoxia inducible factor inhibitor HIF1A bazedoxifene Launched selective estrogen receptor modulator (SERM) ESR1|ESR2 BCI-540 Phase 2 glutamate receptor agonist BCX-1470 Phase 1 serine protease inhibitor|complement inhibitor CFD BD-1008 Preclinical sigma receptor antagonist BD-1047 Preclinical adrenergic receptor antagonist SIGMAR1 BD-1063 Preclinical sigma receptor antagonist SIGMAR1 BE-2254 Phase 2 adrenergic receptor antagonist ADRA1A beclamide Launched anticonvulsant beclomethasone Launched glucocorticoid receptor agonist NR3C1|SERPINA6 beclomethasone-dipropionate Launched glucocorticoid receptor agonist GPR97|NR3C1 bedaquiline Launched ATPase inhibitor befuraline Phase 2 begacestat Phase 1 gamma secretase inhibitor PSEN1 bekanamycin Launched bacterial 30S ribosomal subunit inhibitor belinostat Launched HDAC inhibitor HDAC1|HDAC10|HDAC11|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9 bemegride Launched chemoreceptor agonist GABRA1 bemesetron Phase 3 serotonin receptor antagonist HTR3A|HTR3B bemotrizinol Launched benaxibine Phase 1 benazepril Launched angiotensin converting enzyme inhibitor ACE bendamustine Launched DNA inhibitor bendazac Launched cyclooxygenase inhibitor PTGS1|PTGS2 bendroflumethiazide Launched sodium/potassium/chloride transporter inhibitor CA1|CA2|CA4|KCNMA1|SLC12A1|SLC12A3 benethamine Preclinical benfluorex Withdrawn gluconeogenesis inhibitor HMGCR benfluralin Phase 3 CYP1A1|CYP1A2|CYP2B6|CYP3A4|ESR1|MMP1|SULT2A1|UGT1A1 benfotiamine Launched antioxidant AGER benidipine Launched calcium channel blocker CACNA1C|CACNA1G benperidol Launched dopamine receptor antagonist DRD2 benproperine Launched antitussive SCN5A benserazide Launched DOPA decarboxylase inhibitor DDC bentazepam Launched benzodiazepine receptor agonist bentiromide Launched HPN benurestat Phase 1 urease inhibitor benzalkonium Launched Cationic surfactant benzamil Phase 2 sodium channel blocker ASIC1|PKD2L1|SCNN1A|SCNN1B|SCNN1D|SCNN1G|SLC8A1 benzbromarone Launched chloride channel blocker ABCC1 benzethonium Launched sodium channel blocker SCN10A benznidazole Launched DNA synthesis inhibitor benzo[d]thiazole-2(3h)-thione Phase 1 benzocaine Launched sodium channel blocker SCN10A benzoclidine Preclinical benzofenac Phase 1 benzoic-acid Launched food preservative DAO|HRSP12|PRDX5|RAB9A benzoin Preclinical CES1 benzonatate Launched local anesthetic SCN5A benzoquinonium-dibromide Preclinical cholinergic receptor antagonist CHRNA1 benzotript Phase 1 CCK receptor antagonist CCKAR|CCKBR benzoxiquine Preclinical antiinfective drug benzoyl-peroxide Launched oxidizing agent benzoylpas Preclinical benzthiazide Launched carbonic anhydrase inhibitor CA1|CA12|CA2|CA4|CA9|SLC12A3 benztropine-mesylate Launched acetylcholine receptor antagonist CHRM1|HRH1|SLC6A3 benzydamine Launched prostanoid receptor antagonist benzyl-alcohol Launched local anesthetic benzyl-benzoate Launched lipase inhibitor LIPE benzyl-isothiocyanate Preclinical methylazoxymethanol acetate inhibitor benzyldimethylhexadecylammonium Preclinical cationic surfactant benzyldimethyloctylammonium Preclinical benzylpenicillin Launched penicillin binding protein inhibitor bephenium-hydroxynaphthoate Launched anthelmintic agent bepotastine Launched histamine receptor antagonist HRH1 bepridil Launched calcium channel blocker ATP1A1|CACNA1A|CACNA1H|CACNA2D2|CALM1|KCNQ1|KCNQ4|PDE1A|PDE1B|TNNC1 berberine Phase 2/Phase 3 LDL receptor activator LDLR bergapten Preclinical bergenin Preclinical interleukin inhibitor IL1B|TNF besifloxacin Launched bacterial DNA gyrase inhibitor BET-BAY-002 Preclinical bromodomain inhibitor beta-amyloid-synthesis-inhibitor Preclinical beta amyloid synthesis inhibitor APP beta-carotene Launched beta-CCB Launched benzodiazepine receptor ligand GABRA1|GABRG2 beta-elemene Launched apoptosis stimulant MMP2|MMP9 beta-funaltrexamine Preclinical opioid receptor antagonist OPRD1|OPRK1|OPRM1 beta-glycerophosphoric-acid Preclinical beta-hydroxy-beta-methylbutyrate Phase 2/Phase 3 protein synthesis stimulant MTOR beta-Hydroxybutyrate Phase 1 HCAR2 beta-lapachone Phase 2 topoisomerase inhibitor TOP1 beta-naphthol Preclinical betahistine Launched histamine receptor agonist|histamine receptor antagonist HRH1|HRH3 betaine Launched nitric oxide donor betamethasone Launched glucocorticoid receptor agonist NR3C1 betamethasone-acetate Launched glucocorticoid receptor agonist NR3C1 betamethasone-dipropionate Launched anti-inflammatory agent betamethasone-valerate Launched glucocorticoid receptor agonist NR3C1 betamipron Launched panipenem uptake inhibitor betaxolol Launched adrenergic receptor antagonist ADRB1|ADRB2 betazole Launched histamine receptor agonist HRH2 bethanechol Launched acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4 betrixaban Phase 3 coagulation factor inhibitor KCNH2 betulinic-acid Phase 1/Phase 2 apoptosis stimulant|NFkB pathway inhibitor GPBAR1 bevantolol Launched adrenergic receptor antagonist ADRA1A|ADRB1|ADRB2 bevirimat-dimeglumine Phase 2 HIV capsid assembly inhibitor bexarotene Launched retinoid receptor agonist RXRA|RXRB|RXRG bezafibrate Launched PPAR receptor agonist PPARA|PPARD|PPARG BF2.649 Phase 3 histamine receptor antagonist HRH3 BGT226 Phase 1/Phase 2 PI3K inhibitor MTOR|PIK3CA|PIK3CB|PIK3CG BHQ Preclinical ATPase inhibitor ATP2A1 BI-D1870 Preclinical ribosomal protein inhibitor RPS6KA1|RPS6KA2|RPS6KA3|RPS6KA6 BI-224436 Phase 1 HIV integrase inhibitor BI-2536 Phase 2 PLK inhibitor BRD4|PLK1|PLK2|PLK3 BI-78D3 Preclinical JNK inhibitor MAPK8 BI-847325 Phase 1 MEK inhibitor|Aurora kinase inhibitor AURKA|AURKB|AURKC|MAP2K1|MAP2K2 biapenem Launched bacterial cell wall synthesis inhibitor BIBN4096 Phase 2 calcitonin antagonist CALCA|CALCRL|RAMP1 BIBR-1532 Preclinical telomerase inhibitor TERT BIBU-1361 Preclinical EGFR inhibitor EGFR BIBX-1382 Phase 1 EGFR inhibitor EGFR|ERBB2 bicalutamide Launched androgen receptor antagonist AR bicuculline-(+) Preclinical GABA receptor antagonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|KCNN1 bicuculline-methochloride-(-) Preclinical GABA receptor antagonist bicyclol Launched NFkB pathway inhibitor HSPA1A|HSPB1 bifemelane Launched acetylcholine release enhancer MAOA|MAOB bifendate Launched bifonazole Launched sterol demethylase inhibitor CYP2B6 BIIB021 Phase 2 HSP inhibitor HSP90AA1 bilastine Launched histamine receptor antagonist HRH1 bilobalide Preclinical GABA receptor modulator GLRA1|GLRA2|GLRB|HTR3A|HTR3B bimatoprost Launched prostanoid receptor agonist AKR1C3|PTGER1|PTGER3|PTGFR bindarit Phase 2 NFkB pathway inhibitor CCL2|CCL7|CCL8 BIO-1211 Phase 2 integrin antagonist ITGA4|ITGB1 biotin Launched vitamin B ACACA|ACACB|HLCS|MCCC1|MCCC2|PC|PCCA|PCCB|SLC5A6 bipenamol Phase 2 dipeptidyl peptidase inhibitor CTSC biperiden Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|CHRNA2 birinapant Phase 2 XIAP inhibitor BIRC2|XIAP bis(maltolato)oxovanadium(IV) Phase 2 tyrosine phosphatase inhibitor PTPN1 bisacodyl Launched laxative bisindolylmaleimide-ix Preclinical PKC inhibitor AKT1|GSK3B|LCK|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|PRKCA|ROCK1|RPS6KB1|SIRT1 bismuth(iii)-trifluoromethanesulfonate Preclinical direct substitution catalyst bismuth-oxalate Preclinical bismuth-subcitrate-potassium Launched bismuth-subgallate Launched nitric oxide synthase inhibitor NOS1 bismuth-subsalicylate Launched antacid bisoctrizole Phase 2 bisoprolol Launched adrenergic receptor antagonist ADRB1|ADRB2 bisphenol-a Phase 1 synthetic estrogen AR|ESR1|ESR2|ESRRG|PPARG bithionol Withdrawn autotaxin inhibitor ESR1|ESR2|MCL1 bitopertin Phase 3 glycine transporter inhibitor|GlyT-1 inhibitor SLC6A5|SLC6A9 bitoscanate Preclinical anthelmintic agent bivalirudin Launched thrombin inhibitor F2 BIX-01294 Preclinical histone lysine methyltransferase inhibitor EHMT1|EHMT2 BIX-02188 Preclinical MEK inhibitor MAP2K5 BIX-02189 Preclinical MEK inhibitor MAP2K5|MAPK7 BL-5583 Preclinical hypercalcaemic agent blebbistatin-(+/-) Preclinical ATPase inhibitor MYH2 blebbistatin-(-) Preclinical ATPase inhibitor bleomycetin Phase 2 EGFR expression inhibitor bleomycin Launched DNA synthesis inhibitor LIG1|LIG3 blonanserin Launched dopamine receptor antagonist|serotonin receptor antagonist DRD2|HTR2A BLU9931 Preclinical FGFR inhibitor FGFR4 BML-190 Preclinical cannabinoid receptor inverse agonist CNR2 BML-284 Preclinical WNT agonist BMS-182874 Phase 2 endothelin receptor antagonist EDNRA BMS-191011 Preclinical potassium channel activator KCNMA1 BMS-191095 Phase 1 KATP activator|potassium channel agonist BMS-265246 Preclinical CDK inhibitor CDK1|CDK2 BMS-299897 Phase 1 gamma secretase inhibitor BMS-345541 Preclinical IKK inhibitor CHUK|IKBKB BMS-387032 Phase 1 CDK inhibitor|cell cycle inhibitor|MCL1 inhibitor CDK2|CDK7|CDK9 BMS-536924 Preclinical IGF-1 inhibitor AKT1|CCNE1|CDK2|CYP3A4|ERBB2|IGF1R|KDR|LCK|MAPK1|MET|PDGFRA|PDGFRB BMS-587101 Phase 2 integrin antagonist ITGAL|ITGB2 BMS-599626 Phase 1 EGFR inhibitor|protein tyrosine kinase inhibitor EGFR|ERBB2|ERBB4 BMS-626529 Phase 3 HIV attachment inhibitor BMS-649 Preclinical retinoid receptor agonist RXRA BMS-688521 Preclinical leukocyte function-associated antigen receptor antagonist|ICAM1 antagonist ICAM1 BMS-690514 Phase 2 EGFR inhibitor|VEGFR inhibitor EGFR|ERBB2|FLT3|KDR BMS-707035 Phase 2 HIV integrase inhibitor BMS-754807 Phase 2 IGF-1 inhibitor AKT1|IGF1R BMS-777607 Phase 1/Phase 2 AXL kinase inhibitor|c-Met inhibitor|FLT3 inhibitor|hepatocyte growth factor receptor inhibitor|macrophage migration inhibiting factor inhibitor|tyrosine kinase inhibitor AXL|MERTK|MET|MST1R|TYRO3 BMS-806 Phase 1 HIV attachment inhibitor BMS-817378 Phase 1 c-Met inhibitor|VEGFR inhibitor KDR|MET BMS-833923 Phase 2 smoothened receptor antagonist SMO BMS-863233 Phase 1/Phase 2 CDC inhibitor CDC7|PIM1 BMS-927711 Phase 2 calcitonin antagonist CALCA BMS-983970 Phase 1 notch signaling inhibitor BMS-986020 Phase 2 lysophosphatidic acid receptor antagonist LPAR1 BMY-14802 Phase 2 sigma receptor antagonist HTR1A BMY-45618 Phase 2 PKC activator PRKCE BMY-45778 Preclinical IP1 prostacyclin receptor agonist PTGIR BMY-7378 Preclinical adrenergic receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|HTR1A BNC105 Phase 2 tubulin polymerization inhibitor BNTX Preclinical opioid receptor antagonist OPRD1|OPRK1|OPRM1 boceprevir Launched HCV inhibitor CMA1|CTSA|CTSF|CTSK|CTSL|CTSS bonaphthone Phase 3 bopindolol Launched adrenergic receptor antagonist ADRB1|ADRB2|ADRB3|HTR1A|HTR1B bornyl-acetate Preclinical boronophenylalanine Phase 2 bortezomib Launched NFkB pathway inhibitor|proteasome inhibitor PSMA1|PSMA2|PSMA3|PSMA4|PSMA5|PSMA6|PSMA7|PSMA8|PSMB1|PSMB10|PSMB11|PSMB2|PSMB3|PSMB4|PSMB5|PSMB6|PSMB7|PSMB8|PSMB9|PSMD1|PSMD2|RELA bosentan Launched endothelin receptor antagonist EDNRA|EDNRB bosutinib Launched Abl kinase inhibitor|Bcr-Abl kinase inhibitor|src inhibitor ABL1|BCR|CAMK1D|CAMK2G|CDK2|FRK|FYN|HCK|LYN|MAP2K1|MAP2K2|MAP3K2|MAP4K5|SRC|STK10|STK24|STK4|TNK2|TXK BP-554 Preclinical serotonin receptor agonist HTR1A BP-897 Phase 2 dopamine receptor agonist ADRA1A|ADRA1D|ADRA2A|DRD1|DRD2|DRD3|DRD4|HTR1A|HTR2B BQ-123 Phase 2 endothelin receptor antagonist EDNRA BQ-788 Phase 1 endothelin receptor antagonist EDNRB BQU57 Preclinical Ras GTPase inhibitor RALA|RALB BRD4770 Preclinical histone lysine methyltransferase inhibitor EHMT2 brefeldin-a Preclinical protein synthesis inhibitor ARF1|CYTH2 bremelanotide Phase 3 melanocortin receptor agonist MC1R|MC2R|MC3R|MC4R|MC5R brequinar Phase 2 dihydroorotate dehydrogenase inhibitor DHODH bretazenil Phase 2 GABA benzodiazepine site receptor partial agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6 bretylium Launched norepinephrine inhibitor ATP1A1 brexpiprazole Launched dopamine receptor partial agonist DRD2 briciclib Phase 1 cyclin D inhibitor CCND1 brigatinib Phase 3 ALK tyrosine kinase receptor inhibitor|EGFR inhibitor ALK|EGFR brilliant-green Launched brimonidine Launched adrenergic receptor agonist ADRA2A|ADRA2B|ADRA2C brinzolamide Launched carbonic anhydrase inhibitor CA1|CA12|CA14|CA2|CA4|CA5A|CA7 brivanib Phase 3 FGFR inhibitor|VEGFR inhibitor CYP3A4|FGFR1|FLT1|KCNH2|KDR brivanib-alaninate Phase 3 FGFR inhibitor|VEGFR inhibitor FGFR3 brivaracetam Launched voltage-gated sodium channel blocker SV2A brivudine Launched DNA directed DNA polymerase inhibitor BRL-15572 Preclinical serotonin receptor antagonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR6 BRL-26314 Phase 1 cholesterol inhibitor LPL BRL-37344 Phase 2 adrenergic receptor agonist ADRB1|ADRB2|ADRB3 BRL-44408 Preclinical adrenergic receptor antagonist ADRA2A|ADRA2B|ADRA2C BRL-50481 Preclinical phosphodiesterase inhibitor PDE7A|PDE7B BRL-52537 Preclinical opioid receptor agonist OPRK1 BRL-54443 Preclinical serotonin receptor agonist HTR1E|HTR1F brolitene Launched muscle relaxant RYR1 bromantan Launched dopamine reuptake inhibitor|serotonin reuptake inhibitor bromebric-acid Preclinical purine antagonist|DNA synthesis inhibitor bromfenac Withdrawn cyclooxygenase inhibitor PTGS1|PTGS2 bromhexine Launched mucolytic agent bromindione Phase 2 anticoagulant bromocriptine Launched dopamine receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR6|HTR7 bromopride Launched dopamine receptor antagonist DRD2 bromosporine Preclinical bromodomain inhibitor bromperidol Launched dopamine receptor antagonist DRD2 brompheniramine Launched histamine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HRH1 bronopol Launched bropirimine Phase 3 interferon inducer broxaldine Preclinical broxaterol Phase 3 adrenergic receptor agonist ADRB2 broxuridine Phase 2 antimetabolite broxyquinoline Phase 1 antiprotozoal agent bruceantin Phase 2 protein synthesis inhibitor brucine Preclinical glycine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 BS-181 Preclinical CDK inhibitor CDK7 BTB06584 Preclinical ATPase inhibitor ATP5F1 BTS Preclinical BTS-54505 Withdrawn dopamine reuptake inhibitor SLC6A2|SLC6A3|SLC6A4 BTS-72664 Phase 1 GABA receptor antagonist GABBR1 BTZ043-racemate Preclinical DPRE1 inhibitor BU-224 Preclinical imidazoline receptor ligand MAOA|MAOB BU-239 Preclinical imidazoline receptor ligand|imidazoline receptor agonist bucetin Withdrawn analgesic agent bucillamine Launched immunosuppressant bucladesine Launched adenosine receptor agonist|cAMP stimulant PRKACA buclizine Launched histamine receptor antagonist CHRM1|HRH1 budesonide Launched glucocorticoid receptor agonist NR3C1 budipine Launched glutamate receptor antagonist GRIN1 bufexamac Withdrawn cyclooxygenase inhibitor HDAC10|HDAC6 buflomedil Launched adrenergic receptor antagonist|calcium channel blocker ADRA1A bumetanide Launched solute carrier family member inhibitor CFTR|GPR35|SLC12A1|SLC12A2|SLC12A4|SLC12A5 bunazosin Launched adrenergic receptor antagonist ADRA1A buparlisib Phase 3 PI3K inhibitor PIK3CA|PIK3CG buparvaquone Launched antiprotozoal agent buphenine Launched adrenergic receptor agonist ADRB2 bupicomide Phase 1 adrenergic receptor antagonist ADRB1 bupivacaine Launched sodium channel blocker KCNA5|PTGER1|SCN10A|SCN4A bupranolol Launched adrenergic receptor antagonist ADRB1|ADRB2|ADRB3 bupropion Launched dopamine uptake inhibitor CHRNA3|SLC6A2|SLC6A3 buramate Preclinical antiepileptic buspirone Launched serotonin receptor agonist DRD2|HTR1A busulfan Launched DNA inhibitor butabindide Preclinical tripeptidyl peptidase inhibitor TPP2 butacaine Launched local anesthetic butaclamol Phase 2 dopamine receptor antagonist DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR2A butalbital Launched GABA receptor antagonist CHRNA4|CHRNA7|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIA2|GRIK2 butamben Withdrawn sodium channel blocker butein Preclinical EGFR inhibitor|src inhibitor ACE butenafine Launched fungal squalene epoxidase inhibitor SQLE buthionine-sulfoximine Phase 1 glutathione transferase inhibitor GCLM butibufen Withdrawn cyclooxygenase inhibitor butoconazole Launched bacterial cell wall synthesis inhibitor butofilolol Phase 2 adrenergic receptor antagonist butorphanol-(+)-tartrate Launched opioid receptor agonist|opioid receptor antagonist OPRD1|OPRK1|OPRM1 butyl-paraben Preclinical DNA synthesis inhibitor butylated-hydroxyanisole Preclinical antioxidant butylated-hydroxytoluene Phase 1 carbonic anhydrase inhibitor CA2 butylphthalide Launched potassium channel antagonist KCNK2 butylscopolamine-bromide Launched cholinergic receptor antagonist BU226 Preclinical imidazoline receptor ligand BVD-523 Phase 1/Phase 2 MAP kinase inhibitor BVT-2733 Preclinical 11-beta hydroxysteroid dehydrogenase inhibitor HSD17B1 BVT-948 Preclinical tyrosine phosphatase inhibitor PTPN1|PTPN11|PTPN2 BW-A4C Phase 1 lipoxygenase inhibitor ALOX5 BW-B70C Preclinical lipoxygenase inhibitor ALOX5 BW-180C Phase 2 opioid receptor agonist OPRD1|OPRM1 BW-373U86 Preclinical opioid receptor agonist OPRD1 BW-616U Preclinical monoamine oxidase inhibitor MAOA BW-723C86 Preclinical serotonin receptor agonist HTR2A|HTR2B|HTR2C BX-795 Preclinical IKK inhibitor CDK2|CHEK1|GSK3B|KDR|PDK1|PDPK1 BX-912 Preclinical pyruvate dehydrogenase kinase inhibitor CDK2|CHEK1|GSK3B|KDR|PDK1|PDPK1 BYK-204165 Preclinical PARP inhibitor PARP1 C-1 Preclinical protein kinase inhibitor PRKCA C-751 Preclinical cabagin Launched cabaletta Phase 2 pharmacological chaperone cabazitaxel Launched microtubule inhibitor TUBA4A|TUBB|TUBB1 cabergoline Launched dopamine receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR7 cabotegravir Phase 2/Phase 3 HIV integrase inhibitor cabozantinib Launched RET tyrosine kinase inhibitor|VEGFR inhibitor KDR|MET cadralazine Launched adrenergic receptor antagonist cafestol Launched pregnane X receptor agonist caffeic-acid Preclinical HIV integrase inhibitor|lipoxygenase inhibitor|nitric oxide production inhibitor|tumor necrosis factor production inhibitor ALOX5|MIF caffeic-acid-phenethyl-ester Preclinical HIV integrase inhibitor RELA caffeine Launched adenosine receptor antagonist|phosphodiesterase inhibitor ADORA1|ADORA2A|ADORA2B|ADORA3|ATM|ITPR1|ITPR2|ITPR3|PDE10A|PDE11A|PDE1A|PDE1B|PDE1C|PDE2A|PDE3A|PDE3B|PDE4A|PDE4B|PDE4C|PDE4D|PDE5A|PDE6A|PDE6B|PDE6C|PDE7A|PDE7B|PDE8A|PDE8B|PDE9A|PIK3CA|PIK3CB|PIK3CD|PRKDC|RYR1|RYR2|RYR3 calcifediol Launched vitamin D receptor agonist VDR calcipotriol Launched vitamin D receptor agonist VDR calcitriol Launched vitamin D receptor agonist VDR calcium-gluceptate Launched calcium-levofolinate Launched calpeptin Preclinical calpain inhibitor camicinal Phase 2 motilin receptor agonist MLNR CaMKII-IN-1 Preclinical calcium/calmodulin dependent protein kinase inhibitor AKT1|CAMK2A|CAMK4|MYLK camostat-mesilate Launched protease inhibitor PRSS1 camphor-(+) Phase 2 TRPV1 camphor-(1r) Phase 1 TRPV activator camptothecin Phase 3 topoisomerase inhibitor TOP1 camylofine-chlorhydrate Launched canagliflozin Launched sodium/glucose cotransporter inhibitor SLC5A1|SLC5A2 candesartan Launched angiotensin receptor antagonist AGTR1 candesartan-cilextil Launched angiotensin receptor antagonist AGTR1|AGTR2 candicidin Launched fungal ergosterol inhibitor canertinib Phase 3 EGFR inhibitor AKT1|EGFR|ERBB2|ERBB4 canrenone Withdrawn mineralocorticoid receptor antagonist NR3C2 cantharidin Launched protein phosphatase inhibitor capadenoson Phase 2 adenosine receptor agonist ADORA1 capecitabine Launched DNA synthesis inhibitor|thymidylate synthase inhibitor TYMS capobenic-acid Preclinical capreomycin Launched protein synthesis inhibitor caprylic-acid Launched capsaicin Launched TRPV agonist CFTR|TRPV1 capsazepine Preclinical TRPV agonist TRPV1|TRPV4 captamine Preclinical captan Phase 1 captopril Launched angiotensin converting enzyme inhibitor ACE|LTA4H|MMP2|MMP9 caracemide Phase 2 ribonucleotide reductase inhibitor RRM1 caramiphen Launched cholinergic receptor antagonist CHRM1|CHRM2 carazolol Launched adrenergic receptor antagonist ADRB1|ADRB2|ADRB3 carbachol Launched cholinergic receptor agonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|CHRNA2 carbadox Launched other antibiotic carbamazepine Launched carboxamide antiepileptic SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A carbaril Launched acetylcholinesterase inhibitor carbarsone Launched antiprotozoal agent carbazochrome Launched carbendazim Launched microtubule inhibitor|tubulin polymerization inhibitor TP53|TUBB carbenicillin Launched bacterial cell wall synthesis inhibitor carbenoxolone Launched 11-beta hydroxysteroid dehydrogenase inhibitor GJA1|GJA10|GJA3|GJA4|GJA5|GJA8|GJA9|GJB1|GJB2|GJB3|GJB4|GJB5|GJB6|GJB7|GJC1|GJC2|GJC3|GJD2|GJD3|GJD4|GJE1|HSD11B1|PANX1|PANX2|PANX3 carbetapentane Launched acetylcholine receptor antagonist CHRM2 carbetocin Launched oxytocin receptor agonist OXTR carbidopa Launched aromatic L-amino acid decarboxylase inhibitor DDC carbimazole Launched antithyroid agent TPO carbinoxamine Launched histamine receptor antagonist HRH1 carboplatin Launched DNA alkylating agent|DNA inhibitor carboxyamidotriazole Phase 3 calcium channel blocker CXCL8 carboxylosartan Phase 1 angiotensin antagonist AGTR1 carboxypyridine-disulfide Phase 2 cardiogenol-c Preclinical cardiomyogenesis inducer carebastine Phase 1 histamine receptor antagonist HRH1 carfilzomib Launched proteasome inhibitor PSMA1|PSMA2|PSMA3|PSMA4|PSMA5|PSMA6|PSMA7|PSMA8|PSMB1|PSMB10|PSMB11|PSMB2|PSMB3|PSMB4|PSMB5|PSMB6|PSMB7|PSMB8|PSMB9 carglumic-acid Launched carbamoyl phosphate synthase activator CPS1 caricotamide Phase 2 NADPH quinone oxidoreductase inhibitor NQO2 cariporide Phase 3 sodium/hydrogen exchanger inhibitor SLC9A1 cariprazine Launched dopamine receptor antagonist DRD2|DRD3 carisoprodol Launched acetylcholine receptor antagonist CYP2C19 carmofur Launched thymidylate synthase inhibitor TYMS carmoterol Phase 2 adrenergic receptor agonist ADRB2 carmoxirole Phase 2 dopamine receptor agonist DRD2 carmustine Launched DNA alkylating agent|DNA inhibitor GSR carnitine-(D/L) Phase 3 carnosine Phase 2 antiglycating agent caroverine Launched glutamate receptor antagonist|calcium channel blocker caroxazone Withdrawn monoamine oxidase inhibitor MAOA|MAOB carprofen Launched cyclooxygenase inhibitor PTGS1|PTGS2 carsalam Preclinical analgesic agent carteolol Launched adrenergic receptor antagonist ADRB1|ADRB2 carumonam Launched bacterial cell wall synthesis inhibitor carvedilol Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|GJA1|HIF1A|KCNH2|NDUFC2|NPPB|SELE|VCAM1|VEGFA carzenide Preclinical CA1|CA12|CA14|CA2|CA6|CA9 casanthranol-variant Launched caspofungin Launched "fungal 1,3-beta-D-glucan synthase inhibitor|bacterial cell wall synthesis inhibitor" caspofungin-acetate Launched "fungal 1,3-beta-D-glucan synthase inhibitor" castanospermine Phase 2 glucosidase inhibitor GAA|GBA catharanthine Preclinical tubulin polymerization inhibitor cathepsin-inhibitor-1 Preclinical cathepsin inhibitor CTSB|CTSL|CTSV CAY10505 Preclinical PI3K inhibitor PIK3CG CB-03-01 Phase 3 androgen receptor antagonist AR CB-10-277 Phase 1 DNA synthesis inhibitor CB-5083 Phase 1 valosin-containing protein inhibitor VCP CB-839 Phase 1/Phase 2 glutaminase inhibitor GLS CBS-1114 Phase 1 lipoxygenase inhibitor ALOX5 CC-115 Phase 1 mTOR inhibitor|DNA protein kinase inhibitor MTOR CC-223 Phase 1/Phase 2 mTOR inhibitor MTOR CC-401 Phase 1 JNK inhibitor MAPK8 CC-930 Phase 2 JNK inhibitor CCG-50014 Preclinical G protein signaling inhibitor RGS4|RGS8 CCG-63802 Preclinical G protein signaling inhibitor RGS4 CCG-63808 Preclinical G protein signaling inhibitor RGS4 CCMI Preclinical acetylcholine receptor allosteric modulator CHRNA7 CCMQ Preclinical homoquinolinic acid binding inhibitor CCT018159 Preclinical HSP inhibitor HSP90AA1|HSP90AB1 CCT128930 Preclinical AKT inhibitor PKIA|PRKACA CCT129202 Preclinical Aurora kinase inhibitor AURKA|AURKB|AURKC CCT137690 Preclinical Aurora kinase inhibitor AURKA|AURKB|AURKC CD-1530 Preclinical retinoid receptor agonist RARG CD-437 Preclinical retinoid receptor agonist RARG CDBA Phase 3 CDK1-5-inhibitor Preclinical CDK inhibitor|glycogen synthase kinase inhibitor CDK1|CDK5|GSK3B CDK9-IN-6 Preclinical CDK inhibitor CDK9 cebranopadol Phase 3 opioid receptor agonist OPRL1|OPRM1 cediranib Phase 3 KIT inhibitor|VEGFR inhibitor CSF1R|FLT1|FLT3|FLT4|KDR|KIT|PDGFRA|PDGFRB cedrol Phase 2 cedrol-(+) Phase 2 sedative cefaclor Launched bacterial cell wall synthesis inhibitor cefadroxil Launched bacterial cell wall synthesis inhibitor SLC15A1|SLC15A2|SLC22A6|SLC22A8 cefalonium Launched bacterial cell wall synthesis inhibitor cefamandole Launched bacterial cell wall synthesis inhibitor cefamandole-nafate Launched bacterial cell wall synthesis inhibitor cefathiamidine Launched bacterial cell wall synthesis inhibitor cefazolin Launched bacterial cell wall synthesis inhibitor PON1 cefcapene-pivoxil Launched bacterial cell wall synthesis inhibitor cefdinir Launched bacterial cell wall synthesis inhibitor MPO cefditoren-pivoxil Launched bacterial cell wall synthesis inhibitor cefepime Launched bacterial cell wall synthesis inhibitor cefetamet Launched bacterial cell wall synthesis inhibitor cefetamet-pivoxil Launched bacterial cell wall synthesis inhibitor cefixime Launched bacterial cell wall synthesis inhibitor cefmenoxime Launched bacterial cell wall synthesis inhibitor cefmetazole Launched bacterial cell wall synthesis inhibitor cefminox Launched bacterial cell wall synthesis inhibitor cefodizime Launched bacterial cell wall synthesis inhibitor cefonicid Launched bacterial cell wall synthesis inhibitor cefoperazone Launched bacterial cell wall synthesis inhibitor ceforanide Launched penicillin binding protein inhibitor cefoselis Launched bacterial cell wall synthesis inhibitor cefotaxime Launched bacterial cell wall synthesis inhibitor cefotetan Launched bacterial cell wall synthesis inhibitor cefotiam Launched bacterial cell wall synthesis inhibitor cefotiam-cilexetil Launched bacterial cell wall synthesis inhibitor cefoxitin Launched bacterial cell wall synthesis inhibitor cefozopran Launched bacterial cell wall synthesis inhibitor cefpiramide Launched bacterial cell wall synthesis inhibitor cefpirome Launched bacterial cell wall synthesis inhibitor cefpodoxime Launched bacterial cell wall synthesis inhibitor cefprozil Launched bacterial cell wall synthesis inhibitor cefradine Launched bacterial cell wall synthesis inhibitor CYP3A4 cefsulodin Launched bacterial cell wall synthesis inhibitor ceftaroline-fosamil Launched bacterial cell wall synthesis inhibitor ceftazidime Launched bacterial cell wall synthesis inhibitor ceftibuten Launched bacterial cell wall synthesis inhibitor ceftiofur Launched bacterial cell wall synthesis inhibitor ceftizoxim Launched bacterial cell wall synthesis inhibitor ceftriaxone Launched bacterial cell wall synthesis inhibitor cefuroxime Launched bacterial cell wall synthesis inhibitor cefuroxime-axetil Launched bacterial cell wall synthesis inhibitor celecoxib Launched cyclooxygenase inhibitor CA12|PDPK1|PTGS2 celiprolol Launched adrenergic receptor antagonist ADRA2A|ADRB1|ADRB2 centazolone Phase 1 monoamine oxidase inhibitor centpropazine Phase 3 inositol monophosphatase inhibitor CEP-32496 Phase 1/Phase 2 RAF inhibitor BRAF|RAF1 CEP-33779 Preclinical JAK inhibitor JAK2 CEP-37440 Phase 1 ALK tyrosine kinase receptor inhibitor ALK cephalexin Launched bacterial cell wall synthesis inhibitor cephalomannine Preclinical DNA polymerase inhibitor cephalosporin-c-zn Preclinical bacterial cell wall synthesis inhibitor cephalothin Launched bacterial cell wall synthesis inhibitor cephapirin Launched bacterial cell wall synthesis inhibitor cepharanthine Phase 2 NFkB pathway inhibitor cephradine Launched bacterial cell wall synthesis inhibitor ceramide Launched phosphoenolpyruvate carboxylase activator|serine/threonine protein phosphatase activator ceritinib Launched ALK tyrosine kinase receptor inhibitor ALK|FLT3|IGF1R|INSR|TSSK1B cerulenin Launched fatty acid synthase inhibitor FASN cetaben Phase 2 cholesterol inhibitor|ACAT inhibitor PPARA cetilistat Phase 3 triacylglycerol lipase inhibitor PNLIP cetirizine Launched histamine receptor antagonist HRH1 cetrimonium Launched cetrorelix Launched gonadotropin releasing factor hormone receptor antagonist GNRHR|LHCGR cetylpyridinium Launched cevimeline Launched acetylcholine receptor agonist CHRM1|CHRM3 cevipabulin Phase 1 microtubule stimulant|tubulin polymerization inhibitor TUBB CFM-1571 Preclinical guanylate cyclase activator CFM-2 Preclinical glutamate receptor antagonist CFTRinh-172 Preclinical chloride channel blocker CFTR CF102 Phase 2 adenosine receptor agonist ADORA1|ADORA2A|ADORA2B|ADORA3 CG-400549 Phase 2 FABI inhibitor CGH2466 Preclinical adenosine receptor antagonist ADORA1|ADORA2B|ADORA3 CGK-733 Preclinical ATM kinase inhibitor|ATR kinase inhibitor ATM|ATR CGM097 Phase 1 MDM inhibitor MDM2 CGP-12177 Phase 1 adrenergic receptor agonist ADRB1|ADRB2|ADRB3 CGP-13501 Preclinical GABA receptor modulator GABBR1 CGP-20712A Preclinical adrenergic receptor antagonist ADRB1|ADRB3 CGP-37157 Preclinical mitochondrial Na+/Ca2+ exchanger antagonist|sodium/calcium exchange inhibitor SLC8A1 CGP-37849 Phase 1 glutamate receptor antagonist GRIN2A|GRIN2B|GRIN2C|GRIN2D CGP-52411 Preclinical EGFR inhibitor EGFR CGP-53353 Preclinical EGFR inhibitor|PKC inhibitor EGFR|PRKCB CGP-54626 Preclinical GABA receptor antagonist GABBR1|GABBR2|KCTD12|KCTD16|KCTD8 CGP-55845 Preclinical GABA receptor antagonist GABBR1|GABBR2|KCTD12|KCTD16|KCTD8 CGP-57380 Preclinical MAP kinase inhibitor AURKB|LCK|MKNK1|MKNK2|SGK1 CGP-71683 Preclinical neuropeptide receptor antagonist NPY5R CGP-78608 Preclinical glutamate receptor antagonist CGP-7930 Preclinical GABA receptor modulator GABBR1 CGS-15943 Preclinical adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 CGS-20625 Phase 1 benzodiazepine receptor agonist|GABA benzodiazepine site receptor partial agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6 CGS-21680 Preclinical adenosine receptor agonist ADORA1|ADORA2A|ADORA2B|ADORA3 CGS-9896 Preclinical GABA receptor antagonist GABRA1|GABRB2|GABRG2 CH-170 Phase 1 CH-5183284 Phase 1 fibroblast growth factor inhibitor FGFR1|FGFR2|FGFR3 chenodeoxycholic-acid Launched 11-beta hydroxysteroid dehydrogenase inhibitor|FXR agonist NR1H4 chenodiol Launched 11-beta hydroxysteroid dehydrogenase inhibitor HSD11B1 CHF5074 Phase 2 gamma secretase modulator PSEN1 chicago-sky-blue-6b Preclinical glutamate inhibitor|macrophage migration inhibiting factor inhibitor MIF chidamide Launched HDAC inhibitor HDAC10|HDAC3 chiniofon Launched antiprotozoal agent CHIR-124 Preclinical CHK inhibitor CHEK1 CHIR-98014 Preclinical glycogen synthase kinase inhibitor GSK3A|GSK3B CHIR-99021 Preclinical glycogen synthase kinase inhibitor CDK1|GSK3A|GSK3B|MAPK1 chloralose Preclinical chlorambucil Launched DNA inhibitor chloramine-t Launched chloramphenicol Launched bacterial 50S ribosomal subunit inhibitor CD55 chloramphenicol-palmitate Launched protein synthesis inhibitor chloramphenicol-sodium-succinate Launched protein synthesis inhibitor chlorazanil Preclinical chlorcyclizine Launched histamine receptor antagonist HRH1 chlorfenson Phase 2 other antifungal chlorhexidine Launched membrane integrity inhibitor chlorindanol Preclinical chlorindione Preclinical chlorisondamine-diiodide Preclinical acetylcholine receptor antagonist CHRNA1 chlormadinone-acetate Launched 5 alpha reductase inhibitor PGR chlormezanone Withdrawn GABA receptor modulator GABRA1|TSPO chlormidazole Launched fungal lanosterol demethylase inhibitor chlorobutanol Launched chlorocresol Launched ryanodine receptor activator chlorogenic-acid Launched antioxidant SLC37A4 chlorophyllide-cu-complex-na-salt Preclinical chlorophyllin Preclinical chlorophyllin-copper Phase 1 cytochrome P450 inhibitor chloroprocaine Launched sodium channel blocker ATP1A1|CHRNA10|GRIN3A|HTR3A|SCN10A|SLC6A3 chloropyramine Launched histamine receptor antagonist HRH1 chloroquine Launched antimalarial agent GSTA2|MRGPRX1|TLR9|TNF chlorothiazide Launched diuretic CA1|CA2|CA4|SLC12A3 chlorothymol Launched chlorotrianisene Launched estrogenic hormone ESR1|ESR2 chloroxine Launched opioid receptor antagonist OPRK1 chloroxoquinoline Launched chloroxylenol Launched ATP synthase inhibitor chlorphenamine Launched histamine receptor antagonist HRH1|SLC6A2|SLC6A3|SLC6A4 chlorphenesin Launched muscle relaxant chlorphensin-carbamate Preclinical muscle relaxant chlorproguanil Launched dihydrofolate reductase inhibitor DHFR chlorpromazine Launched dopamine receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CALM1|CHRM1|CHRM3|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HRH4|HTR1A|HTR2A|HTR2B|HTR2C|HTR6|HTR7|KCNH2|ORM1|ORM2|SMPD1|TRPC5 chlorpropamide Launched ATP channel blocker ABCC8|KCNJ10|KCNJ11 chlorpropham Phase 1 antiviral chlorprothixene Launched dopamine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|HRH1|HTR2A|HTR2B|HTR2C chlorpyrifos Launched acetylcholinesterase inhibitor ACHE chlorquinaldol Launched other antibiotic chlortetracycline Launched protein synthesis inhibitor chlorthalidone Launched carbonic anhydrase inhibitor CA1|CA12|CA14|CA4|CA7|SLC12A1|SLC12A3 chlorzoxazone Launched bacterial 30S ribosomal subunit inhibitor KCNMA1|KCNN4 cholecalciferol Launched VDR cholesterol Preclinical RORA cholic-acid Launched bile acid ADH1C|CES1|COX4I1|COX5A|COX5B|COX6A2|COX6B1|COX6C|COX7A1|COX7B|COX7C|COX8A|ESRRG|FABP6|FECH|GPBAR1|MT-CO1|MT-CO2|MT-CO3|PLA2G1B choline Phase 3 acetylcholine precursor ACHE|BCHE|CHRNA2|PCYT1A|PCYT1B|PHOSPHO1|PLD1|PLD2 choline-alfoscerate Launched acetylcholine precursor GM2A CHPG Preclinical glutamate receptor agonist GRM5 CHR-6494 Preclinical serine/threonine kinase inhibitor GSG2 chromanol-(+/-) Preclinical potassium channel blocker chromocarb Launched antispasmodic chrysin Phase 1 breast cancer resistance protein inhibitor AKR1B1|CDK6|CYP19A1|CYP1B1 chrysophanic-acid Preclinical EGFR inhibitor EGFR|MTOR chuanxiongzine Phase 2 CH223191 Preclinical aryl hydrocarbon receptor antagonist AHR CH5132799 Phase 1 PI3K inhibitor MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG CH55 Preclinical retinoid receptor binder RARA|RARB CI-844 Phase 2 CI-923 Phase 1 acetylcholine receptor antagonist CI-966 Phase 1 GAT inhibitor SLC6A1 CI-976 Phase 1 ACAT inhibitor ACAT1|CES1 ciaftalan-zinc Phase 1 reactive oxygen species stimulant cianidanol Withdrawn fatty acid synthase inhibitor PTGS1 cibenzoline Launched sodium channel blocker ciclesonide Launched glucocorticoid receptor agonist NR3C1|SERPINA6 ciclopirox Launched membrane integrity inhibitor ATP1A1 cicloprofen Preclinical cyclooxygenase inhibitor PTGS1|PTGS2 CID-5458317 Preclinical MAP kinase phosphatase inhibitor MAPK3 cidofovir Launched DNA polymerase inhibitor ciglitazone Phase 2 PPAR receptor agonist PPARG cilastatin Launched dehydropeptidase inhibitor DPEP1 cilazapril Launched angiotensin converting enzyme inhibitor ACE cilengitide Phase 3 integrin antagonist ITGAV|ITGB3 cilnidipine Launched calcium channel blocker CACNA1B cilomilast Phase 3 phosphodiesterase inhibitor PDE4A|PDE4B|PDE4D cilostamide Preclinical phosphodiesterase inhibitor PDE3A|PDE3B cilostazol Launched phosphodiesterase inhibitor PDE3A|PDE3B cimaterol Preclinical adrenergic receptor agonist ADRB1|ADRB2|ADRB3 cimetidine Launched histamine receptor antagonist HRH2|SLC29A4|SLC47A1|SLC47A2 cimetropium Launched acetylcholine receptor antagonist CHRM1 cinacalcet Launched calcium channel activator CASR cinaciguat Phase 2 guanylate cyclase activator GUCY1A3|GUCY1B3 cinalukast Phase 2 leukotriene receptor antagonist CYSLTR1 cinanserin Preclinical serotonin receptor antagonist HTR2A cinchocaine Launched sodium channel blocker CALM1|SCN10A|SCN5A cinchonidine Phase 1 P glycoprotein inhibitor cinchonine Preclinical P glycoprotein inhibitor CYP2D6 cinchophen Launched analgesic agent cinepazet Launched vasodilator cinepazide Withdrawn calcium channel activator cinflumide Phase 2 muscle relaxant cinnamaldehyde Preclinical aldose reductase inhibitor|TRPV agonist TRPA1 cinnarazine Launched calcium channel blocker cinoctramide Preclinical cinoxacin Launched topoisomerase inhibitor cinoxate Launched cinromide Phase 3 cintriamide Preclinical cipemastat Phase 3 metalloproteinase inhibitor ADAM17|MMP1|MMP13|MMP2|MMP3|MMP8|MMP9 ciprofibrate Launched PPAR receptor agonist PPARA ciprofloxacin Launched bacterial DNA gyrase inhibitor TOP2A ciproxifan Preclinical histamine receptor antagonist ADRA2A|ADRA2C|HRH3|HRH4|HTR3A cirazoline Preclinical adrenergic receptor agonist ADRA1A cis-aconitic-acid Preclinical ACO2 cis-ACPD Preclinical glutamate receptor agonist GRM2|GRM3|GRM6|GRM7|GRM8 cis-urocanic acid Phase 2 serotonin receptor agonist HTR2A cis-urocanic-acid Phase 2 serotonin receptor agonist HTR2A cisapride Withdrawn serotonin receptor agonist HTR2A|HTR3A|HTR4|KCNH2 cisplatin Launched DNA alkylating agent|DNA synthesis inhibitor XIAP citalopram Launched selective serotonin reuptake inhibitor (SSRI) SLC6A2|SLC6A4 CITCO Preclinical constitutive androstane receptor (CAR) agonist NR1I3 citicoline Launched membrane permeability enhancer|glutathione transferase stimulant ACHE|SLC1A2 citiolone Preclinical lipotropic|mucolytic agent citric-acid Preclinical coagulation factor inhibitor AKR1B1|ANG|APRT|BHMT|C8G|CA4|CPB1|CS|CTDSP1|GNMT|HGS|HS3ST3A1|IL4I1|ITPA|LSM6|MDH2|MIF|PDE5A|PKD2L1|PLEKHA1|RNASE1|RNASE3|SRC|TNFSF13B|UCK2 CK-636 Preclinical actin related protein inhibitor ACTR2|ACTR3|ARPC1B|ARPC2|ARPC3|ARPC4|ARPC5 CKD-712 Phase 1 NFkB pathway inhibitor JAK2|STAT1 CL-218872 Phase 1 benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3|GABRA5|GABRB2|GABRG2 CL-225385 Phase 2 cladribine Launched adenosine deaminase inhibitor|ribonucleotide reductase inhibitor ADA|PNP|POLA1|POLE|POLE2|POLE3|POLE4|RRM1|RRM2|RRM2B clarithromycin Launched bacterial 50S ribosomal subunit inhibitor CYP3A4 clavulanate Launched beta lactamase inhibitor clebopride Launched dopamine receptor antagonist ACHE|DRD2 clemastine Launched histamine receptor antagonist HRH1 clemizole Launched HCV inhibitor clenbuterol Launched adrenergic receptor agonist ADRB1|ADRB2|ADRB3|NGF|TNF cleviprex Launched calcium channel blocker CACNA1C|CACNA1D|CACNA1F|CACNA1S clevudine Launched DNA polymerase inhibitor clidinium Launched acetylcholine receptor antagonist CHRM1|CHRM3 climbazole Launched enzyme inducer clinafloxacin Phase 3 bacterial DNA gyrase inhibitor clindamycin Launched protein synthesis inhibitor clindamycin-palmitate Launched bacterial 50S ribosomal subunit inhibitor clindamycin-phosphate Launched protein synthesis inhibitor clinofibrate Launched lipase clearing factor inhibitor LPL clioquinol Withdrawn chelating agent OPRK1 clobazam Launched GABA benzodiazepine site receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ clobenpropit Preclinical histamine receptor antagonist HRH1|HRH2|HRH3|HRH4 clobetasol-propionate Launched glucocorticoid receptor agonist NR3C1|PLA2G1B clobetasone-butyrate Launched corticosteroid agonist NR3C1 clobutinol Withdrawn antitussive clocortolone-pivalate Launched steroid NR3C1|PLA2G1B clodronic-acid Launched bone resorption inhibitor SLC25A4|SLC25A5|SLC25A6 clofarabine Launched ribonucleotide reductase inhibitor POLA1|POLD1|POLE|RRM1|RRM2|RRM2B clofazimine Launched GK0582 inhibitor clofedanol Launched histamine receptor antagonist HRH1 clofibrate Launched PPAR receptor agonist LPL|PPARA clofibric-acid Launched PPAR receptor agonist PPARA clofilium Phase 2 potassium channel blocker KCNA5|KCNH1 clofoctol Launched protein synthesis inhibitor clomesone Phase 1 DNA inhibitor clomethiazole Launched GABA receptor antagonist|GABA receptor modulator GABRA1 clomifene Launched estrogen receptor antagonist ESR1 clomipramine Launched serotonin transporter (SERT) inhibitor GSTP1|HTR2A|HTR2B|HTR2C|SLC6A2|SLC6A3|SLC6A4 clonazepam Launched GABA benzodiazepine site receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|TSPO clonidine Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C clonixin-lysinate Launched cyclooxygenase inhibitor clopamide Launched sodium/chloride cotransporter inhibitor cloperastine Launched antitussive clopidogrel Launched purinergic receptor antagonist P2RY12 clopidol Launched cloprostenol-(+/-) Launched prostaglandin receptor agonist PTGDR|PTGER1|PTGER3|PTGFR|TBXA2R cloranolol Launched adrenergic receptor antagonist ADRB1|ADRB2|ADRB3 clorgiline Phase 2 monoamine oxidase inhibitor MAOA clorotepine Launched dopamine receptor antagonist|adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|DRD2|HRH1|HTR2C|HTR6 clorprenaline Launched adrenergic receptor agonist ADRB1|ADRB2 clorsulon Launched glycolysis inhibitor closantel Launched chitinase inhibitor|NFkB pathway inhibitor clotiapine Launched clotrimazole Launched cytochrome P450 inhibitor|imidazoline receptor ligand CYP3A4|KCNN4|NR1I2|NR1I3|TRPM2|TRPM4|TRPM8 cloxacillin Launched bacterial cell wall synthesis inhibitor cloxyquin Preclinical potassium channel activator KCNK18 clozapine Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CALY|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HRH4|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR3A|HTR5A|HTR6|HTR7 CL316243 Phase 2 adrenergic receptor agonist ADRB3|UCP1|UCP2|UCP3 CMPD-1 Preclinical p38 MAPK inhibitor GNRHR|MAPK14 CNQX Phase 1 glutamate receptor antagonist GRIA1|GRIA2|GRIA3|GRIA4 CNX-2006 Preclinical EGFR inhibitor EGFR CNX-774 Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK CO-101244 Preclinical glutamate receptor antagonist GRIN2B co-102862 Phase 1 SCN4A|SCN9A cobicistat Launched cytochrome P450 inhibitor CYP3A4|CYP3A43|CYP3A5|CYP3A7 cobimetinib Launched MEK inhibitor coenzyme-a Launched ACAT2|CRAT|CS|DBI|HMGCR|KAT2A|KAT2B|KAT5 coenzyme-i Phase 2 AASS|ACADS|ADH1A|ADH1B|ADH1C|ADH4|ADH5|ADH7|AKR1B1|AKR1C1|AKR1C2|AKR1C3|AKR1C4|ALDH1A1|ALDH1A2|ALDH1A3|ALDH1B1|ALDH2|ALDH3A1|ALDH3A2|ALDH3B1|ALDH3B2|ALDH4A1|ALDH5A1|ALDH6A1|ALDH7A1|ALDH9A1|AMT|BDH1|BLVRA|BLVRB|CDO1|CYB5R3|CYP17A1|CYP4A11|DHCR7|DHFR|DLAT|DLD|EHHADH|GAPDH|GAPDHS|GLUD1|GLUD2|GPD1|GSR|H6PD|HADH|HADHA|HIBADH|HMGCR|HMOX1|HMOX2|HPGD|HSD11B1|HSD11B2|HSD17B1|HSD17B10|HSD17B2|HSD17B3|HSD17B4|HSD17B7|HSD17B8|HSD3B1|HSD3B2|IDH3A|IDH3B|IDH3G|IMPDH1|IMPDH2|LDHA|LDHAL6A|LDHAL6B|LDHB|LDHC|MDH1|MDH2|ME1|ME2|ME3|MSMO1|MT-ND1|MT-ND2|MT-ND3|MT-ND4|MT-ND4L|MT-ND5|MT-ND6|MTHFD1|MTHFD2|NDUFA1|NDUFA10|NDUFA11|NDUFA12|NDUFA13|NDUFA2|NDUFA3|NDUFA4|NDUFA4L2|NDUFA5|NDUFA6|NDUFA7|NDUFA8|NDUFA9|NDUFAB1|NDUFB1|NDUFB10|NDUFB2|NDUFB3|NDUFB4|NDUFB5|NDUFB6|NDUFB7|NDUFB8|NDUFB9|NDUFC1|NDUFC2|NDUFS1|NDUFS2|NDUFS3|NDUFS4|NDUFS5|NDUFS6|NDUFS7|NDUFS8|NDUFV1|NDUFV2|NDUFV3|NNT|NQO2|NSDHL|OGDH|PDHA1|PDHA2|PDHB|PHGDH|PYCR1|PYCR2|QDPR|RDH5|SORD|TSTA3|TYR|UGDH coenzyme-q10 Launched colchicine Launched microtubule inhibitor GLRA1|GLRA2|TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA3D|TUBA3E|TUBA4A|TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8 colesevalam Preclinical colforsin Phase 2 adenylyl cyclase activator ADCY2|ADCY5 colforsin-daproate Launched adenylyl cyclase activator colfosceril-palmitate Launched pulmonary surfactant colistimethate Launched bacterial permeability inducer colistin Launched bacterial permeability inducer colistin-b-sulfate Launched bacterial permeability inducer colistin-sulfate Launched bacterial permeability inducer combretastatin-A-4 Phase 2 tubulin polymerization inhibitor compound-w Preclinical beta-secretase inhibitor BACE1 compound-401 Preclinical DNA dependent protein kinase inhibitor MTOR|PRKDC compound-58112 Preclinical conivaptan Launched vasopressin receptor antagonist AVPR1A|AVPR2 copanlisib Phase 3 PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG copper-histidine Phase 3 HAL|HARS|HDC|SLC15A3|SLC15A4|SLC38A3|SLC38A5 cordycepin Phase 1/Phase 2 DNA inhibitor corosolic-acid Phase 2 PKC inhibitor|protein tyrosine kinase inhibitor HSD11B1|PTPN1 corticosterone Preclinical mineralocorticoid receptor agonist HSD11B1|NCOA1|NR3C2 cortisone Launched glucocorticoid receptor agonist NR3C1 cortisone-acetate Launched glucocorticoid receptor agonist NR3C1 cortodoxone Phase 3 androgen receptor antagonist AR costunolide Preclinical telomerase inhibitor cot-inhibitor-1 Preclinical MAPK-interacting kinase inhibitor MAP3K8 cot-inhibitor-2 Preclinical MAPK-interacting kinase inhibitor MAP3K8 cotinine Phase 2 nicotine metabolite coumarin Launched vitamin K antagonist CA1|CA12|CA14|CA2|CA4|CA6|CA9|CYP2A6 coumophos Preclinical cholinesterase inhibitor CP-339818 Preclinical potassium channel blocker KCNA3 CP-376395 Phase 1 corticosteroid releasing factor receptor antagonist CRHR1 CP-532623 Phase 1 cholesteryl ester transfer protein inhibitor CETP CP-640186 Preclinical acetyl-CoA carboxylase inhibitor ACACA|ACACB CP-673451 Preclinical PDGFR tyrosine kinase receptor inhibitor KIT|PDGFRA|PDGFRB CP-724714 Phase 2 EGFR inhibitor|protein tyrosine kinase inhibitor ERBB2 CP-91149 Preclinical glycogen phosphorylase inhibitor PYGL CP-93129 Preclinical serotonin receptor agonist HTR1A CP-94253 Preclinical serotonin receptor agonist HTR1B CPA-inhibitor Preclinical carboxypeptidase inhibitor CPA1|CPA2 CPCCOEt Preclinical glutamate receptor antagonist GRM1 CPI-0610 Phase 1 bromodomain inhibitor BRD4 CPI-1189 Phase 2 tumor necrosis factor release inhibitor TNF CPI-169 Preclinical histone lysine methyltransferase inhibitor EZH2 CPI-203 Preclinical bromodomain inhibitor BRD4 CPI-360 Preclinical histone lysine methyltransferase inhibitor EZH2 CPI-613 Phase 2 pyruvate dehydrogenase inhibitor PDHA1 CPP Phase 2 glutamate receptor antagonist GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D creatine Launched CKB|CKM|CKMT1A|CKMT2|GAMT|SLC6A8 creatinine Preclinical creatinol-phosphate Launched crenolanib Phase 2 PDGFR tyrosine kinase receptor inhibitor CSF1R|FLT3|KIT|PDGFRA|PDGFRB cresol Launched cresopirine Preclinical cridanimod Launched progesterone receptor agonist PGR crisaborole Phase 3 phosphodiesterase inhibitor PDE4B crizotinib Launched ALK tyrosine kinase receptor inhibitor ALK|MET crizotinib-(S) Preclinical MTH1 inhibitor NUDT1 croconazole Launched bacterial cell wall synthesis inhibitor cromoglicic-acid Launched immunosuppressant KCNMA1|S100P crotamiton Launched antipruritic CRT0044876 Preclinical cryptotanshinone Preclinical acetylcholinesterase inhibitor|STAT inhibitor STAT3 crystal-violet Launched other antibiotic CR8-(R) Preclinical CDK inhibitor CCNA2 CS-110266 Preclinical dopamine receptor agonist SLC6A3 CS-917 Phase 2 fructose biphosphate inhibitor FBP1 CT-7758 Phase 2 integrin antagonist ITGA4 CTEP Preclinical glutamate receptor antagonist GRM5 CTS-1027 Phase 2 metalloproteinase inhibitor MMP1|MMP13|MMP2|MMP3|MMP9 CTS21166 Phase 1 beta-secretase inhibitor BACE1 CUDC-101 Phase 1 EGFR inhibitor EGFR|ERBB2 CUDC-427 Phase 1 apoptosis inhibitor XIAP CUDC-907 Phase 2 PI3K inhibitor HDAC2|PIK3R1 CUR-61414 Phase 1 smoothened receptor antagonist DHH|IHH|SMO curcumin Launched cyclooxygenase inhibitor|histone acetyltransferase inhibitor|lipoxygenase inhibitor|NFkB pathway inhibitor APP|CA1|CA12|CA14|CA2|CA4|CA6|CA9|CYP3A4|DNMT3B|EP300|MMP13|MMP9|NOS2|PTGS1|PTGS2|XDH curcumol Phase 1 JAK inhibitor JAK1|JAK2|JAK3 cutamesine Phase 2 sigma receptor agonist SIGMAR1 CV-1808 Preclinical adenosine receptor agonist ADORA2A CVT-10216 Phase 1 aldehyde dehydrogenase inhibitor ALDH2 CX-4945 Phase 1/Phase 2 casein kinase inhibitor CSNK2A1|CSNK2A2|DAPK3|HIPK3 CX-516 Phase 2/Phase 3 glutamate receptor modulator CX-5461 Phase 1 RNA polymerase inhibitor cyacetacide Preclinical cyamemazine Launched serotonin receptor antagonist HTR1A|HTR2A|HTR2C|HTR7 cyanocobalamin Launched methylmalonyl CoA mutase stimulant|vitamin B MMAA|MMACHC|MTHFR|MTR|MTRR|MUT cyanopindolol Phase 2 adrenergic receptor antagonist ADRB1|HTR1A|HTR1D cyclamic-acid Preclinical cyclandelate Launched calcium channel blocker CACNA2D1|CES1 cyclic-AMP Preclinical CNGA3|HCN2|PRKAR1A|PRKAR2B|TRPM7 cyclizine Launched histamine receptor modulator HRH1|SULT1E1 cyclobenzaprine Launched adrenergic receptor agonist|serotonin receptor agonist HTR2A cyclocreatine Phase 1 creatine kinase substrate cyclocytidine Preclinical DNA synthesis inhibitor|RNA synthesis inhibitor cycloheximide Preclinical protein synthesis inhibitor RPL3 cyclopenthiazide Launched thiazide diuretic cyclopentolate Launched acetylcholine receptor antagonist CHRM1 cyclophosphamide Launched DNA alkylating agent CYP2A6|CYP2B6|CYP2C18|CYP2C19|CYP2C8|CYP2C9|CYP2D6|CYP3A4|CYP3A5|CYP3A7 cyclopiazonic-acid Preclinical ATPase inhibitor ATP2A1 cycloserine-(d) Launched bacterial cell wall synthesis inhibitor GRIN1 cyclosporin-a Launched calcineurin inhibitor PPP3CA cyclosporine Launched calcineurin inhibitor ABCB11|CAMLG|FPR1|PPIA|PPIF|PPP3R2|SLC10A1|SLCO1B1|SLCO1B3 cyclothiazide Launched glutamate receptor modulator CA1|CA2|CA4|FXYD2|GRIA1|GRIA2|GRIA3|GRIA4|SLC12A3 cyclovalone Launched breast cancer resistance protein inhibitor ABCG2 cyclovirobuxin-d Preclinical calcium channel modulator CYC116 Phase 1 Aurora kinase inhibitor AURKA|AURKB|KDR cypermethrin Launched cyproheptadine Launched histamine receptor antagonist ADRA1A|ADRA1B|ADRA1D|CHRM1|CHRM2|CHRM3|HRH1|HTR2A|HTR2C|HTR6|HTR7 cyproterone Launched androgen receptor antagonist AR cyproterone-acetate Launched androgen receptor antagonist ADORA1|AR cyromazine Launched cysteamine Launched tissue transglutaminase inhibitor NPY2R|SST CYT-997 Phase 2 tubulin polymerization inhibitor TUBB cytarabine Launched ribonucleotide reductase inhibitor POLA1|POLB|POLD1|POLE cytisine Launched acetylcholine receptor agonist CHRNA2|CHRNA3|CHRNA4|CHRNA6|CHRNA7|CHRNB2|CHRNB4 cytochalasin-b Phase 2 microtubule inhibitor ACTB cytochlor Phase 1 cyt387 Phase 3 JAK1|JAK2|JAK3 CY208-243 Phase 2 dopamine receptor agonist CALY CZC24832 Preclinical PI3K inhibitor PIK3CG C106 Phase 3 C11-Acetate Phase 3 ABAT|ACE|AKR1C3|CA2|CELA1|ESR2|FFAR2|FFAR3|HPRT1|LTA4H|MMP12|NOS1|NOS3|PLA2G1B|PTPN1|SOD1|TXN C646 Preclinical histone acetyltransferase inhibitor EP300 D-(+)-maltose Preclinical AMY2B|MGAM D-alpha-tocopheryl-succinate Launched D-delta-Tocopherol Launched D-limonene Phase 1 D-Phenylalanine Preclinical enkephalinase inhibitor CCBL1|CRH|HCAR3 D-Serine Launched glutamate receptor agonist GLRA1|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|SERPINB3 D-4476 Preclinical TGF beta receptor inhibitor CSNK1A1|CSNK1D|TGFB1 D-64131 Preclinical microtubule inhibitor TUBB D-7193 Phase 2 DAA-1106 Preclinical benzodiazepine receptor agonist TSPO dabigatran Launched thrombin inhibitor F2 dabigatran-etexilate Launched thrombin inhibitor F2 dabrafenib Launched RAF inhibitor BRAF|LIMK1|NEK11|RAF1|SIK1 dacarbazine Launched DNA alkylating agent PGD|POLA2 dacinostat Phase 1 HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9 daclatasvir Launched HCV inhibitor dacomitinib Phase 3 EGFR inhibitor EGFR|ERBB2|ERBB4 dactinomycin Launched RNA polymerase inhibitor POLR2A daidzein Phase 2 estrogen receptor agonist ESRRA|ESRRB|ESRRG|TRPC5 dalargin Phase 2 opioid receptor agonist OPRM1 dalbavancin Launched bacterial cell wall synthesis inhibitor PNLIP dalcetrapib Phase 3 cholesteryl ester transfer protein inhibitor CETP dalfampridine Launched potassium channel blocker KCNA1|KCNA10|KCNA2|KCNA3|KCNA4|KCNA5|KCNA6|KCNA7|KCNB1|KCNB2|KCNC1|KCNC2|KCNC3|KCNC4|KCND1|KCND2|KCND3|KCNF1|KCNG1|KCNG2|KCNG3|KCNG4|KCNH1|KCNH2|KCNH3|KCNH4|KCNH5|KCNH6|KCNH7|KCNH8|KCNJ13|KCNJ5|KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5|KCNS1|KCNS2|KCNS3|KCNV1|KCNV2 daltroban Phase 3 thromboxane receptor antagonist TBXA2R danazol Launched estrogen receptor antagonist|progesterone receptor agonist AR|CCL2|ESR1|GNRHR|GNRHR2|PGR danegaptide Phase 2 gap junction modulator danirixin Phase 2 CC chemokine receptor antagonist CXCR2 danofloxacin Launched bacterial DNA gyrase inhibitor danoprevir Phase 2 HCV inhibitor dantrolene Launched calcium channel blocker RYR1|RYR3 dantron Withdrawn laxative danusertib Phase 2 Aurora kinase inhibitor|growth factor receptor inhibitor AURKA|AURKB|AURKC|FGFR1|NTRK1|RET|SLK dapagliflozin Launched sodium/glucose cotransporter inhibitor SLC5A1|SLC5A2 daphnetin Preclinical protein kinase inhibitor dapiprazole Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D dapivirine Phase 3 non-nucleoside reverse transcriptase inhibitor CYP3A4|CYP3A5 dapoxetine Launched selective serotonin reuptake inhibitor (SSRI) HTR1A|HTR1B|HTR2C|SLC6A4 daprodustat Phase 3 hypoxia inducible factor inhibitor EGLN1 dapsone Launched bacterial antifolate DHFR DAPT Preclinical gamma secretase inhibitor daptomycin Launched bacterial cell wall synthesis inhibitor darapladib Phase 3 phospholipase inhibitor PLA2G7 darglitazone Phase 2 PPAR receptor antagonist PPARG darifenacin Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 darunavir Launched HIV protease inhibitor CYP3A4 darusentan Phase 3 endothelin receptor antagonist EDNRA dasabuvir Launched HCV inhibitor dasatinib Launched Bcr-Abl kinase inhibitor|ephrin inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|src inhibitor|tyrosine kinase inhibitor ABL1|ABL2|BLK|EPHA2|FGR|FRK|FYN|HCK|KIT|LCK|LYN|PDGFRB|SRC|SRMS|STAT5B|YES1 DAU-5884 Preclinical acetylcholine receptor antagonist CHRM3 daucosterol Phase 2 apoptosis stimulant daunorubicin Launched RNA synthesis inhibitor|topoisomerase inhibitor TOP2A|TOP2B dazmegrel Phase 2 thromboxane synthase inhibitor TBXAS1 dazoxiben Phase 2 thromboxane synthase inhibitor TBXAS1 DBeQ Preclinical ATPase inhibitor CASP3 DBPR108 Phase 1 dipeptidyl peptidase inhibitor DPP4 DCC-2618 Phase 1 PDGFR tyrosine kinase receptor inhibitor|KIT inhibitor KIT|PDGFRA DCEBIO Preclinical potassium channel activator KCNN2|KCNN3|KCNN4 DCPIB Preclinical chloride channel blocker|gap junction modulator|glutamate inhibitor SLC1A2 debrisoquin Launched adrenergic neuron blocker SLC6A2 decamethonium Launched acetylcholine receptor agonist ACHE|CHRNA2 decamethoxine Phase 2 antiseptic decernotinib Phase 2/Phase 3 JAK inhibitor JAK3 decitabine Launched DNA methyltransferase inhibitor DNMT1|DNMT3A decoquinate Launched antiprotozoal agent defactinib Phase 2 focal adhesion kinase inhibitor PTK2 deferasirox Launched chelating agent CYP3A4 deferiprone Launched chelating agent UGT1A6 deferoxamine-mesylate Launched chelating agent deflazacort Launched glucocorticoid receptor agonist NR3C1 deforolimus Phase 3 mTOR inhibitor MTOR degarelix Launched gonadotropin releasing factor hormone receptor antagonist GNRHR dehydroacetic-acid Preclinical dehydrocholate Preclinical dehydrocholate-acid Preclinical dehydrocorydaline Phase 3 acetylcholinesterase inhibitor ACHE dehydroepiandrosterone Launched protein synthesis stimulant ESR1|ESR2|G6PD|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B|HSD17B1|NR1I2|NR1I3|PPARA|SIGMAR1|SULT2A1|SULT2B1 dehydroepiandrosterone-sulfate Launched androgen receptor agonist|estrogen receptor agonist AR|ESR1|ESR2 delamanid Launched bacterial cell wall synthesis inhibitor delanzomib Phase 1/Phase 2 proteasome inhibitor CMA1|CTSG|CYP3A4|ELANE delapril Launched angiotensin converting enzyme inhibitor ACE delavirdine Launched non-nucleoside reverse transcriptase inhibitor CYP3A4 delivert Launched angiotensin receptor agonist AGTR1|AGTR2 delphinidin Phase 2 membrane permeability inhibitor GLO1 delta-Tocotrienol Phase 1 HMGCR inhibitor HMGCR demecarium Launched acetylcholinesterase inhibitor ACHE|BCHE demeclocycline Launched bacterial 30S ribosomal subunit inhibitor denatonium-benzoate Preclinical denotivir Launched antiviral deoxyarbutin Preclinical tyrosinase inhibitor deoxycholic-acid Launched biliverdin reductase A activator|G protein-coupled receptor agonist EFTUD1|FPR1|GPBAR1 deoxycorticosterone-acetate Preclinical progestogen hormone NR3C2 deoxyepinephrine Preclinical adrenergic receptor agonist|dopamine receptor agonist ADRA1A|DRD1|DRD2 deptropine Preclinical histamine receptor antagonist HRH1 dequalinium Launched PKC inhibitor KCNN1|KCNN3 deracoxib Launched cyclooxygenase inhibitor PTGS2 deserpidine Launched angiotensin converting enzyme inhibitor ACE|SLC18A2 desipramine Launched tricyclic antidepressant ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD2|HRH1|HTR1A|HTR2A|HTR2C|SLC6A2|SLC6A4|SMPD1 deslanoside Launched Na/K-ATPase inhibitor ATP1A1|ATP1A2|ATP1A3|ATP1A4|ATP1B1|ATP1B2|ATP1B3|FXYD2 desloratadine Launched histamine receptor antagonist HRH1 desmethylclozapine Phase 2 acetylcholine receptor agonist HTR2C desmopressin-acetate Launched vasopressin receptor agonist AVPR1A|AVPR1B|AVPR2|OXTR desogestrel Launched progesterone receptor agonist ESR1|PGR desonide Launched glucocorticoid receptor agonist NR3C1|PLA2G1B desoximetasone Launched glucocorticoid receptor agonist NR3C1|PLA2G1B desoxycorticosterone-pivalate Launched corticosteroid agonist NR3C2 desoxycortone Preclinical mineralocorticoid receptor agonist NR3C1|NR3C2 desoxypeganine Phase 1 acetylcholinesterase inhibitor|monoamine oxidase inhibitor ACHE desvenlafaxine Launched serotonin–norepinephrine reuptake inhibitor (SNRI) SLC6A2|SLC6A3|SLC6A4 detomidine Launched adrenergic receptor agonist ADRA2A dexamethasone Launched glucocorticoid receptor agonist ANXA1|NOS2|NR0B1|NR3C1|NR3C2 dexamethasone-acetate Launched glucocorticoid receptor agonist dexamethasone-sodium-phosphate Launched glucocorticoid receptor agonist NR3C1 dexchlorpheniramine Launched histamine receptor antagonist dexfenfluramine Withdrawn serotonin receptor agonist HTR2C|SLC6A4 dexfosfoserine Preclinical membrane integrity inhibitor CFTR|GRM4|GRM6|GRM7|GRM8|KCNC4|PDPK1|PIM1|PRKACA|PRKCQ|PYGL|PYGM|REG1A|RHO|SERPINB3|SMAD2|TAOK2 dexlansoprazole Launched ATPase inhibitor ATP4A|ATP4B dexloxiglumide Phase 3 CCK receptor antagonist CCKAR dexniguldipine Phase 2 calmodulin antagonist ADORA3 dexpanthenol Launched dexrazoxane Launched chelating agent|topoisomerase inhibitor TOP2A|TOP2B dextran Launched dextroamphetamine Launched monoamine oxidase inhibitor ADRA1A|ADRA1B|SLC18A2|SLC6A2|SLC6A3|TAAR1 dextromethorphan Launched glutamate receptor antagonist|sigma receptor agonist CHRNA2|CHRNA3|CHRNA4|CHRNA7|CHRNB2|CHRNB4|CYBA|CYBB|GRIN3A|NCF1|NCF2|NCF4|OPRD1|OPRK1|OPRM1|PGRMC1|RAC1|RAC2|SIGMAR1|SLC6A2|SLC6A4 dextrose Launched DFB Preclinical glutamate receptor agonist GRM5 DH-97 Preclinical melatonin receptor antagonist MTNR1B DHBP Preclinical ryanodine receptor blocker diacerein Launched interleukin inhibitor IL1B diacetamate Preclinical diadenosine-tetraphosphate Phase 1 adenosine kinase inhibitor P2RY13|P2RY2 dianhydrogalactitol Phase 1 DNA alkylating agent diarylpropionitrile Preclinical estrogen receptor agonist ESR2 diatrizoic-acid Launched diaveridine Launched dihydrofolate reductase inhibitor diazepam Launched benzodiazepine receptor agonist ADRA1A|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GABRR1|GABRR2|GABRR3|TSPO diazooxonorleucine Phase 2 glutamate receptor antagonist diazoxide Launched potassium channel activator ATP1A1|CA1|CA2|KCNJ11|KCNJ8|KCNMA1|SLC12A3 dibekacin Launched bacterial 30S ribosomal subunit inhibitor dibenzepine Preclinical norepinephrine reputake inhibitor dibenzothiophene Preclinical dibutyl-phthalate Preclinical TRPA1 dichlorisone-acetate Phase 2 dichloroacetate Phase 3 pyruvate dehydrogenase kinase inhibitor PDK1 dichlorophen Launched anticestodal agent dichlorvos Launched acetylcholinesterase inhibitor diclazuril Launched antiprotozoal agent diclofenac Launched cyclooxygenase inhibitor AKR1C3|ALOX5|ASIC1|ASIC3|KCNQ2|KCNQ3|PLA2G2A|PPARG|PTGS1|PTGS2|SCN4A diclofenamide Launched carbonic anhydrase inhibitor CA1|CA12|CA2|CA4|CA7 diclofensine Phase 3 dopamine reuptake inhibitor DRD1|MAOA|MAOB dicloralurea Preclinical dicloxacillin Launched bacterial cell wall synthesis inhibitor dicoumarol Launched NADPH inhibitor CRYZ|NQO1|VKORC1 dicyclohexylamine Preclinical dicycloverine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3 didanosine Launched nucleoside reverse transcriptase inhibitor PNP dideoxyadenosine Phase 1 nucleoside reverse transcriptase inhibitor didox Launched ribonucleotide reductase inhibitor RRM1 dienestrol Launched estrogen receptor agonist ESR1 dienogest Launched progesterone receptor agonist PGR diethylcarbamazine Launched lipoxygenase inhibitor ALOX5|PTGS1 diethylstilbestrol Withdrawn estrogen receptor agonist ESR1|ESR2|ESRRB|ESRRG diethyltoluamide Launched ionotropic receptor IR40a activator difenpiramide Launched cyclooxygenase inhibitor|prostaglandin inhibitor diflorasone-diacetate Launched glucocorticoid receptor agonist NR3C1 difloxacin Launched bacterial DNA gyrase inhibitor diflunisal Launched prostanoid receptor antagonist PTGS1|PTGS2 difluprednate Launched glucocorticoid receptor agonist NR3C1 diftalone Launched cyclooxygenase inhibitor digitoxigenin Preclinical ATPase inhibitor ATP1A1 digitoxin Launched ATPase inhibitor ATP1A1 digoxigenin Preclinical steroid digoxin Launched ATPase inhibitor ATP1A1 dihomo-gamma-linolenic-acid Phase 2 prostanoid receptor agonist PTGS1|PTGS2 dihydrexidine Phase 2 dopamine receptor agonist DRD1|DRD2|DRD3|DRD4|DRD5 dihydroartemisinin Launched antimalarial agent dihydroergocristine Launched adrenergic receptor antagonist|prolactin inhibitor ADRA1A|ADRB1|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR2A|HTR3A|HTR4|HTR5A|HTR6|HTR7 dihydroergotamine Launched serotonin receptor agonist ADRA2A|DRD2|HTR1B|HTR1D|HTR1E|HTR1F|HTR2B|HTR7 dihydromyricetin Preclinical dihydrostreptomycin Withdrawn bacterial 30S ribosomal subunit inhibitor dihydrotachysterol Launched vitamin analog VDR dihydrotestosterone Launched androgen receptor agonist AR|HSD17B1 dihydroxyacetone Launched dihydroxyphenylglycine Preclinical glutamate receptor agonist GRM1|GRM5 diiodothyropropionic-acid Phase 2 thyroid hormone stimulant dilazep Launched adenosine reuptake inhibitor SLC29A1 diloxanide Launched protein synthesis inhibitor diltiazem Launched calcium channel blocker CACNA1C|CACNA1S|CACNA2D1|CACNG1|HTR3A|KCNA5 dimaprit Preclinical histamine receptor agonist HRH2|HRH3|HRH4 dimemorfan Launched sigma receptor agonist SIGMAR1 dimenhydrinate Launched histamine receptor antagonist HRH1 dimercaprol Launched chelating agent dimercaptosuccinic-acid Launched chelating agent DNMT1 dimesna Phase 3 tubulin polymerization inhibitor dimethadione Preclinical oxazolidine antiepileptic dimethicone Launched dimethindene-(S)-(+) Preclinical acetylcholine receptor antagonist HRH1 dimethisoquin Launched local anesthetic dimethyl-fumarate Launched nuclear factor erythroid derived|like (NRF2) activator KEAP1 dimethyl-isosorbide Preclinical cosmetic moisturizer dimetindene Launched histamine receptor antagonist|cholinergic receptor antagonist CHRM2|HRH1 dimetridazole Launched bacterial DNA inhibitor diminazene-aceturate Phase 3 angiotensin converting enzyme activator AOC1|PRDX5|PRSS1 dimpylate Launched acetylcholinesterase inhibitor ACHE dinaciclib Phase 3 CDK inhibitor CDK1|CDK2|CDK5|CDK9 dinitolmide Launched dinoprost Launched prostacyclin analog PTGDR|PTGDR2|PTGER1|PTGER2|PTGER3|PTGER4|PTGFR|PTGIR|TBXA2R dinoprostone Withdrawn prostanoid receptor agonist CATSPER1|CATSPER2|CATSPER3|CATSPER4|PTGDR|PTGDR2|PTGER1|PTGER2|PTGER3|PTGER4|PTGFR|TBXA2R dioscin Preclinical apoptosis stimulant CXCR3 diosgenin Preclinical steroid diosmetin Launched aryl hydrocarbon receptor agonist CYP1B1 diosmin Launched aryl hydrocarbon receptor agonist|capillary stabilizing agent AHR dioxybenzone Preclinical topical sunscreen agent dipeptamin Launched diperodon Preclinical local anesthetic diphemanil Launched acetylcholine receptor antagonist CHRM3 diphencyprone Phase 2 immunostimulant diphenhydramine Launched histamine receptor antagonist HRH1 diphenidol Launched acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4 diphenyleneiodonium Preclinical nitric oxide synthase inhibitor NOS2|NOS3 diphenylguanidine Preclinical diphenylpyraline Launched dopamine uptake inhibitor HRH1|SLC6A3 dipivefrine Launched adrenergic receptor agonist ACHE|ADRA1A|ADRA2A|ADRB2|BCHE dipraglurant Phase 2 glutamate receptor negative allosteric modulator GRM5 DIPT Launched dopamine reuptake inhibitor|serotonin reuptake inhibitor HTR1A|HTR2A|HTR2C dipyridamole Launched phosphodiesterase inhibitor ADA|PDE10A|PDE1A|PDE1B|PDE1C|PDE2A|PDE3A|PDE3B|PDE4A|PDE4B|PDE4C|PDE4D|PDE5A|PDE6A|PDE6B|PDE6C|PDE6D|PDE6G|PDE6H|PDE7A|PDE7B|PDE8A|PDE8B|PDE9A|SLC29A1 dipyrocetyl Launched chelating agent dirithromycin Launched bacterial 50S ribosomal subunit inhibitor diroximel-fumarate Phase 3 anti-inflammatory agent disodium sebacate Phase 1 HBA1|HBB disopyramide Launched sodium channel blocker CHRM1|CHRM2|CHRM3|KCND2|KCND3|KCNH2|SCN5A disulfiram Launched aldehyde dehydrogenase inhibitor|DNA methyltransferase inhibitor|TRPV agonist ALDH2|DBH dithranol Launched DNA synthesis inhibitor ditiocarb-sodium-trihydrate Phase 3 immunostimulant CA1|CA2|CA4 ditolylguanidine Preclinical sigma receptor agonist GRIN1|GRIN2A|GRIN2B|SIGMAR1 divalproex-sodium Launched benzodiazepine receptor agonist ALDH5A1 dixanthogen Preclinical dizocilpine-(+) Preclinical glutamate receptor antagonist GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D dizocilpine-(-) Phase 1 glutamate receptor antagonist DMAB-anabaseine Preclinical adrenergic receptor agonist CHRNA7 DMeOB Preclinical GRM5 DMH1 Preclinical ALK tyrosine kinase receptor inhibitor ACVR1 DMNB Preclinical DNA dependent protein kinase inhibitor DMP-543 Phase 2 acetylcholine release enhancer DMP-777 Phase 2 elastase inhibitor MPO DMPS Phase 1 chelating agent DMSO Preclinical control vehicle DNQX Preclinical glutamate receptor antagonist GRIA1|GRIA2|GRIK1|GRIN1|GRIN2A|GRIN2B dobutamine Launched adrenergic receptor agonist ADRB1|ADRB2 docebenone Phase 2 lipoxygenase inhibitor ALOX5 docetaxel Launched tubulin polymerization inhibitor BCL2|MAP2|MAP4|MAPT|NR1I2|TUBB|TUBB1 doconexent Launched PPAR receptor agonist FFAR1|PTGS1|PTGS2 doconexent-ethyl-ester Launched omega 3 fatty acid stimulant docosanol Launched lipase clearing factor inhibitor TLR7 docusate Launched laxative dodecyl-sulfate Preclinical LYZ dofequidar Phase 3 MRP inhibitor|P glycoprotein inhibitor ABCB1 dofetilide Withdrawn potassium channel blocker KCNH1|KCNH2|KCNJ12|KCNK2 dolasetron Launched serotonin receptor antagonist HTR3A dolastatin-10 Phase 2 tubulin polymerization inhibitor TUBB dolutegravir Launched HIV integrase inhibitor CYP3A4|CYP3A5|CYP3A7|POU2F2|UGT1A1 domiphen Preclinical domperidone Launched dopamine receptor antagonist DRD2|DRD3 donepezil Launched acetylcholinesterase inhibitor ACHE|HTR2A donitriptan Phase 2 serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR5A|HTR6 dopamine Launched dopamine receptor agonist DBH|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR7|SLC6A2|SLC6A3|SLC6A4 doramapimod Phase 2 p38 MAPK inhibitor MAPK11|MAPK12|MAPK13|MAPK14 doramectin Launched doripenem Launched bacterial cell wall synthesis inhibitor DPEP1 dorzolamide Launched carbonic anhydrase inhibitor CA1|CA12|CA14|CA2|CA4|CA7 dosulepin Launched norepinephrine reuptake inhibitor|serotonin–norepinephrine reuptake inhibitor (SNRI)|tricyclic antidepressant CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HRH1|SLC6A2|SLC6A4 dovitinib Phase 3 EGFR inhibitor|FGFR inhibitor|FLT3 inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor CSF1R|EGFR|FGFR1|FGFR2|FGFR3|FLT1|FLT3|FLT4|INSR|KDR|KIT|PDGFRA|PDGFRB doxapram Launched potassium channel blocker KCNK3|KCNK9 doxazosin Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|KCNH2|KCNH6|KCNH7 doxepin Launched histamine receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD2|HRH1|HRH2|HRH4|HTR1A|HTR2A|HTR2B|HTR2C|HTR6|KCNH2|SLC6A2|SLC6A4 doxercalciferol Launched vitamin D receptor agonist VDR doxifluridine Launched thymidylate synthase inhibitor TYMS doxofylline Launched adenosine receptor antagonist ADORA1|PDE4A|PDE4B|PDE4C|PDE4D doxorubicin Launched topoisomerase inhibitor TOP2A doxycycline Launched metalloproteinase inhibitor MMP8 doxycycline-hyclate Launched bacterial 30S ribosomal subunit inhibitor doxylamine Launched histamine receptor antagonist CHRM1|HRH1 DPC-681 Phase 1 HIV protease inhibitor DPCPX Phase 1 adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 DPI-201106 Phase 2 sodium channel activator ADRB2 DPO-1 Preclinical potassium channel blocker KCNA5 DPPE Phase 3 histamine receptor antagonist ABCB1|HRH1 DR-2313 Preclinical PARP inhibitor PARP1|PARP3 DRF053-(R) Preclinical CDK inhibitor CSNK1A1 drofenine Launched droloxifene Phase 3 selective estrogen receptor modulator (SERM) ESR1 dromostanolone-propionate Launched androgen receptor modulator AR dronedarone Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|CACNA1C|CACNA1D|CACNA1F|CACNA1S|CACNB1|CACNB2|CACNB3|CACNB4|KCNA5|KCNH2|KCNK2|SCN1A droperidol Launched dopamine receptor antagonist ADRA1A|DRD2|DRD3|DRD4|HTR2A dropropizine Launched antitussive drospirenone Launched mineralocorticoid receptor antagonist AR|NR3C2|PGR drotaverine Launched phosphodiesterase inhibitor CACNA1C|PDE4A droxicam Launched cyclooxygenase inhibitor PTGS1 droxidopa Launched norepinephrine precursor ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|PAH droxinostat Preclinical HDAC inhibitor HDAC6|HDAC8 DS2-(806622) Preclinical DU-728 Phase 1 structural glycoprotein antagonist ITGA2B|ITGB3 duloxetine Launched norepinephrine reuptake inhibitor|serotonin–norepinephrine reuptake inhibitor (SNRI) HTR2A|HTR2C|HTR6|SLC6A2|SLC6A3|SLC6A4 DUP-697 Phase 1 cyclooxygenase inhibitor PTGS2 dutasteride Launched 5 alpha reductase inhibitor SRD5A1|SRD5A2 DVD-111 Phase 2 dyclonine Launched sodium channel blocker SCN10A|SCN5A dydrogesterone Launched progesterone receptor agonist PGR dynasore Preclinical dynamin inhibitor DNM1|DNM1L|DNM2 dyphylline Launched adenosine receptor antagonist|phosphodiesterase inhibitor ADORA1|ADORA2A|PDE3A|PDE4A|PDE4B|PDE4C|PDE4D|PDE7A|PDE7B DY131 Preclinical estrogen-related receptor agonist ESRRB|ESRRG D609 Preclinical phospholipase inhibitor E-2012 Phase 1 gamma secretase modulator APH1B E-4031 Phase 1 potassium channel blocker KCNH1|KCNH2 ebastine Launched histamine receptor antagonist CYP3A4|HRH1 EBPC Preclinical aldose reductase inhibitor AKR1B1 ebrotidine Withdrawn histamine receptor antagonist HRH2 ebselen Phase 2/Phase 3 cyclooxygenase inhibitor|glutathione peroxidase agonist|H+/K+-ATPase inhibitor|nitric oxide synthase inhibitor ALB EC-23 Preclinical retinoid receptor agonist RARA|RARB|RARG ecabapide Phase 3 ecabet Launched gastrin inhibitor|urease inhibitor NOXO1 ecamsule-triethanolamine Launched echinomycin Phase 2 DNA intercalating agent econazole Launched lanosterol demethylase inhibitor|sterol demethylase inhibitor CYP51A1|NPY1R|NPY2R|TRPM2|TRPV5 ectoine-zwitterion Preclinical edaravone Launched nootropic agent BCL2 edelfosine Phase 2 phospholipase inhibitor editol Preclinical edoxaban Launched coagulation factor inhibitor F10 edoxudine Launched DNA directed DNA polymerase inhibitor edrophonium Launched acetylcholinesterase inhibitor ACHE|BCHE EDTMP Preclinical chelating agent efaproxiral Phase 3 haemoglobin oxygen release stimulant HBA1|HBB efaroxan Phase 2 adrenergic receptor antagonist ADORA2A efatutazone Phase 2 PPAR receptor agonist PPARG efavirenz Launched HIV protease inhibitor CYP1A2|CYP2B6|CYP2C19|CYP2C9|CYP2D6|CYP3A4 efinaconazole Launched lanosterol demethylase inhibitor CYP51A1 eflornithine Launched ornithine decarboxylase inhibitor ARG2|ODC1 efloxate Preclinical vasodilator efonidipine-monoethanolate Launched L-type calcium channel blocker|T-type calcium channel blocker CACNA1C|CACNA1G EGF816 Phase 2 EGFR inhibitor EGFR eglumetad Phase 2 glutamate receptor agonist GRM2|GRM3|GRM6|GRM8 EG00229 Preclinical neuropilin receptor antagonist NRP1 EHop-016 Preclinical Ras GTPase inhibitor RAC1|RAC3 EIT-hydrobromide Preclinical nitric oxide synthase inhibitor NOS2|NOS3 EI1 Preclinical histone lysine methyltransferase inhibitor EZH2 elacridar Phase 1 P glycoprotein inhibitor ABCB1 elactocin Phase 1 exportin antagonist XPO1 elafibranor Phase 3 PPAR receptor agonist PPARA|PPARD elagolix Phase 3 gonadotropin releasing factor hormone receptor antagonist GNRHR elbasvir Launched HCV inhibitor elemene Phase 2 VEGFR inhibitor elesclomol Phase 3 oxidative stress inducer HSPA1A eletriptan Launched serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2B|HTR7 eliglustat Launched Glycosyl transferase inhibitor UGCG elinogrel Phase 2 purinergic receptor antagonist P2RY12 eliprodil Phase 3 glutamate receptor antagonist GRIN1|GRIN2B ellagic-acid Phase 2 glutathione transferase inhibitor|non-nucleoside reverse transcriptase inhibitor CA1|CA12|CA14|CA2|CA3|CA4|CA5A|CA5B|CA6|CA7|CA9|CSNK2A1|GSK3B|PRKACA|PRKCA|PRKCB|SQLE|SYK ELN-441958 Preclinical bradykinin receptor antagonist BDKRB1 eltanolone Phase 3 membrane integrity inhibitor GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB2|GABRG2 eltoprazine Phase 2 serotonin receptor agonist HTR1A|HTR1B eltrombopag Launched thrombopoietin receptor agonist MPL eluxadoline Launched opioid receptor modulator OPRD1|OPRK1|OPRM1 elvitegravir Launched HIV integrase inhibitor embelin Preclinical HCV inhibitor|XIAP inhibitor XIAP EMD-1214063 Phase 1 hepatocyte growth factor receptor inhibitor MET EMD-386088 Preclinical serotonin receptor agonist HTR6 EMD-53998 Phase 1 phosphodiesterase inhibitor TNNC1 EMD-66684 Preclinical angiotensin receptor antagonist AGTR1 emedastine Launched histamine receptor antagonist HRH1 emetine Phase 2 protein synthesis inhibitor RPS2 emodin Preclinical 11-beta hydroxysteroid dehydrogenase inhibitor CSNK2A1 emorfazone Launched antiinflammatory agent|cyclooxygenase inhibitor emoxipin Phase 2 empagliflozin Launched sodium/glucose cotransporter inhibitor SLC5A1|SLC5A2 emtricitabine Launched nucleoside reverse transcriptase inhibitor enalapril Launched angiotensin converting enzyme inhibitor ACE enalaprilat Launched angiotensin converting enzyme inhibitor ACE enasidenib Phase 3 isocitrate dehydrogenase inhibitor IDH1 enbucrilate Launched enciprazine Phase 3 GABA receptor modulator GABRA1 endo-IWR-1 Preclinical PARP inhibitor TNKS|TNKS2 endoxifen Phase 2 estrogen receptor antagonist ESR1 enflurane Launched membrane permeability inhibitor ATP2C1|ATP5D|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GLRA1|GLRB|GRIA1|KCNA1|KCNK10|KCNK18|KCNK2|KCNK3|KCNK9|KCNN4 enilconazole Launched sterol demethylase inhibitor CYP19A1|CYP1A2|CYP2B6|CYP2C9|CYP2J2|CYP3A4|CYP3A5|NR1I2|PPARA|PTGER2 eniluracil Phase 3 dihydropyrimidine dehydrogenase inhibitor AOX1|DPYD|XDH enisamium-iodide Launched ENMD-2076 Phase 2 Aurora kinase inhibitor|FLT3 inhibitor|VEGFR inhibitor AURKA|FLT3|KDR|PDGFRA|PTK2|SRC enocitabine Launched DNA synthesis inhibitor CMPK1|RRM1|TYMS enoxacin Launched topoisomerase inhibitor TOP2A enoximone Launched phosphodiesterase inhibitor PDE3A enoxolone Launched gap junction modulator HSD11B1 enprofylline Phase 3 phosphodiesterase inhibitor ADORA1|ADORA2A|ADORA2B|ADORA3|PDE4A|PDE4B enrofloxacin Launched bacterial DNA gyrase inhibitor entacapone Launched catechol O methyltransferase inhibitor COMT entecavir Launched DNA replication inhibitor|nucleoside reverse transcriptase inhibitor entinostat Phase 3 HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC9 entrectinib Phase 2 ALK tyrosine kinase receptor inhibitor|proto-oncogene tyrosine protein kinase inhibitor ALK|NTRK1|NTRK2|NTRK3|ROS1 enzalutamide Launched androgen receptor antagonist AR enzastaurin Phase 3 PKC inhibitor AKT1|GSK3B|PRKCA|PRKCB|PRKCD|PRKCG EN460 Preclinical endoplasmic reticulum oxidation inhibitor ERO1A EO-1428 Preclinical p38 MAPK inhibitor MAPK11|MAPK14 epacadostat Phase 3 "indoleamine 2,3-dioxygenase inhibitor" IDO1 epalrestat Launched aldose reductase inhibitor AKR1B1 eperezolid Phase 1 bacterial 30S ribosomal subunit inhibitor eperisone Launched acetylcholine receptor antagonist CYP2J2 ephedrine Launched adrenergic receptor agonist ACHE|ADRA1A|ADRB2|SLC18A2|SLC6A2 ephedrine-(racemic) Launched adrenergic receptor agonist ADRA1A|ADRA2A epiandrosterone Preclinical steroid G6PD epicatechin-gallate-(-) Phase 2 bacterial DNA gyrase inhibitor BACE1|FASN epigallocatechin-gallate-(-) Phase 2/Phase 3 bacterial DNA gyrase inhibitor ELANE|EP300|FASN|KAT2B|MMP14|MMP2 epinastine Launched histamine receptor antagonist ADRA1A|ADRA2A|HRH1|HRH2|HTR2A|HTR7 epinephrine Launched adrenergic receptor agonist|neurotransmitter ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|PAH|TNF epinephrine-(racemic) Launched carbonic anhydrase activator epirizole Launched cyclooxygenase inhibitor PTGS1|PTGS2 epirubicin Launched topoisomerase inhibitor CHD1|TOP2A epitiostanol Launched androgen receptor agonist AR eplerenone Launched cytochrome P450 inhibitor NR3C2 epomediol Launched cholesterol inhibitor CYP7A1 epoprostenol Launched prostacyclin analog P2RY12|PTGER1|PTGER4|PTGIR|PTGIS epothilone-a Preclinical microtubule stabilizing agent epothilone-b Phase 3 microtubule stabilizing agent|tubulin polymerization inhibitor TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA4A|TUBA8|TUBB|TUBB1|TUBB3|TUBB4A|TUBB4B epothilone-d Phase 2 microtubule stabilizing agent|tubulin polymerization inhibitor TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA4A|TUBA8|TUBB|TUBB1|TUBB3|TUBB4A|TUBB4B eprazinone Launched mucolytic agent eprinomectin Launched benzodiazepine receptor agonist eprobemide Launched monoamine oxidase inhibitor MAOA eprodisate Phase 3 antiamyloidogenic agent|amyloid protein inhibitor SAA1 eprosartan Launched angiotensin receptor antagonist AGTR1 eptifibatide Launched platelet aggregation inhibitor ITGA2B|ITGB3 EPZ-5676 Phase 1 histone lysine methyltransferase inhibitor DOT1L EPZ004777 Preclinical histone lysine methyltransferase inhibitor DOT1L EPZ005687 Preclinical histone lysine methyltransferase inhibitor EZH2 EPZ011989 Preclinical histone lysine methyltransferase inhibitor EZH2 EPZ015666 Preclinical protein arginine N-methyltransferase inhibitor PRMT5 EPZ020411 Preclinical protein arginine N-methyltransferase inhibitor PRMT6 equilin Preclinical estrogen receptor agonist HSD17B1 equol Launched estrogen receptor agonist ESR1|ESR2 ER-27319 Preclinical mediator release inhibitor|SYK inhibitor SYK erastin Preclinical ion channel antagonist VDAC2 erbstatin-analog Preclinical EGFR inhibitor|tyrosine kinase inhibitor EGFR ercalcitriol Phase 1 vitamin D receptor agonist VDR erdafitinib Phase 2 FGFR inhibitor FGFR1|FGFR2|FGFR3|FGFR4 erdosteine Launched mucolytic agent ergocalciferol Launched vitamin analog VDR ergonovine Launched adrenergic receptor agonist|serotonin receptor agonist ADRA1A|HTR1E ergosterol Preclinical vitamin D precursor ergotamine Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|DRD1|DRD2|DRD5|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|SLC6A2 ERK5-IN-1 Preclinical MAP kinase inhibitor MAPK7 erlotinib Launched EGFR inhibitor EGFR|NR1I2 ertapenem Launched bacterial cell wall synthesis inhibitor erteberel Phase 2 estrogen receptor agonist ESR1|ESR2 ertugliflozin Phase 3 sodium/glucose cotransporter inhibitor SLC5A2 erythritol Launched erythromycin Launched NFkB pathway inhibitor MLNR erythromycin-estolate Launched bacterial 50S ribosomal subunit inhibitor ABCB1|ALB|CYP3A4|CYP51A1|KCNH2|MLNR|SLC47A1 erythromycin-ethylsuccinate Launched cytochrome P450 inhibitor|protein synthesis inhibitor ABCB1|ALB|CYP3A4|CYP51A1|KCNH2|MLNR|SLC47A1 erythrosine Preclinical coloring agent esaprazole Phase 2 escin Launched nitric oxide synthase stimulant escitalopram Launched selective serotonin reuptake inhibitor (SSRI) ADRA1A|CHRM1|HRH1|SLC6A2|SLC6A3|SLC6A4 esculin Phase 1 antioxidant eseroline-(-) Preclinical acetylcholinesterase inhibitor OPRD1|OPRM1 ESI-09 Preclinical EPAC inhibitor RAPGEF3|RAPGEF4 eslicarbazepine-acetate Launched sodium channel blocker SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A esmolol Launched adrenergic receptor antagonist ADRB1 esomeprazole Launched ATPase inhibitor ATP4A estetrol Phase 3 selective estrogen receptor modulator (SERM) ESR1 estradiol Launched estrogen receptor agonist ESR1|ESR2|GPER1|KCNMA1|NR1I2 estradiol-acetate Launched estrogen receptor agonist ESR1 estradiol-benzoate Preclinical contraceptive agent ESR1 estradiol-cypionate Launched estrogen receptor agonist ESR1 estradiol-valerate Launched estrogen receptor agonist ESR1 estramustine Launched DNA alkylating agent ESR1|ESR2|MAP1A|MAP2 estramustine-phosphate Launched DNA synthesis inhibitor|microtubule inhibitor ESR1|ESR2|MAP1A|MAP2 estriol Launched estrogen receptor agonist ESR1|ESR2 estrone Launched estrogen receptor agonist|estrogenic hormone ESR1|ESR2 estropipate Launched estrogen receptor agonist ESR1|ESR2 eszopiclone Launched benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|TSPO etacrynic-acid Launched sodium/potassium/chloride transporter inhibitor ATP1A1|SLC12A1 etafenone Launched calcium channel blocker etamsylate Launched haemostatic agent etanidazole Phase 3 bacterial cell wall synthesis inhibitor etazolate Phase 2 phosphodiesterase inhibitor GABRB3|PDE4A ETC-1002 Phase 3 AMPK inhibitor ACLY ETC-159 Phase 1 porcupine inhibitor|beta catenin inhibitor PORCN etebenecid Preclinical uricosuric blocker eterobarb Phase 2 anticonvulsant ethacizin Launched anticonvulsant ethacridine-lactate-monohydrate Preclinical DNA intercalating agent ethambutol Launched bacterial cell wall synthesis inhibitor ethamivan Preclinical respiratory stimulant ethanolamine-oleate Launched immunostimulant F12|FABP4|FFAR1|FFAR4|PLD2 ethaverine Launched calcium channel blocker ethenzamide Launched analgesic agent ethimizol Phase 1 ethinyl-estradiol Launched estrogen receptor agonist|estrogenic hormone ESR1|ESR2|NR1I2 ethionamide Launched mycolic synthesis inhibitor ethisterone Launched progestogen hormone TYR ethopabate Launched antiprotozoal agent ethosuximide Launched succinimide antiepileptic CACNA1G|CACNA1H|CACNA1I ethotoin Launched hydantoin antiepileptic SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A ethoxyquin Preclinical antioxidant ethoxzolamide Launched carbonic anhydrase inhibitor CA1|CA12|CA13|CA14|CA2|CA3|CA4|CA5A|CA5B|CA6|CA7|CA9 ethyl-paraben Preclinical ethyl-pyruvate Phase 2 tumor necrosis factor production inhibitor HMGB1|TNF ethyl-vanillin Preclinical ethyl-2-(carbamoyloxy)benzoate Phase 1 ethylenediaminetetraacetic-acid Launched PKC inhibitor ethylnorepinephrine Preclinical bronchodilator ethynodiol-diacetate Launched ESR1|PGR eticlopride Preclinical dopamine receptor antagonist DRD2|DRD3|DRD4 etidronic-acid Launched bone resorption inhibitor ATP6V1A|PTPRS etifenin Preclinical renal function diagnostic agent etifoxine Launched GABA receptor modulator GABRA1|GABRA2|GABRA3|GABRA5 etilefrine Launched adrenergic receptor agonist ADRA1A|ADRB1 etilevodopa Phase 3 dopamine receptor agonist DRD3 etizolam Launched benzodiazepine receptor agonist GABRA1 etodolac Launched cyclooxygenase inhibitor PTGS1|PTGS2|RXRA etofenamate Launched cyclooxygenase inhibitor PTGS1|PTGS2 etofibrate Launched PPAR receptor agonist PPARA etofylline Launched adenosine receptor antagonist ADORA1 etofylline-clofibrate Launched platelet aggregation inhibitor PPARA etomidate Launched GABA receptor modulator ADRA2B|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ etomoxir Phase 2 carnitine palmitoyltransferase inhibitor CPT1A etonogestrel Launched progesterone receptor agonist ESR1|PGR etoposide Launched topoisomerase inhibitor TOP2A|TOP2B etoposide-phosphate Launched topoisomerase inhibitor TOP2A etoricoxib Launched cyclooxygenase inhibitor PTGS2 etosalamide Preclinical anti-inflammatory agent etoxybamide Phase 2 ETP-46464 Preclinical ATR kinase inhibitor etravirine Launched non-nucleoside reverse transcriptase inhibitor CYP2C19|CYP2C9|CYP3A4 etretinate Withdrawn protein synthesis inhibitor RARA|RARB|RARG|RXRA|RXRB|RXRG eucalyptol Launched acetylcholinesterase inhibitor ACHE eucatropine Preclinical acetylcholine receptor antagonist eugenol Launched androgen receptor antagonist AR EUK-134 Preclinical catalase stimulant APP|SOD2 eupatilin Launched mucus protecting agent evacetrapib Phase 3 cholesteryl ester transfer protein inhibitor CETP evans-blue Launched glutamate receptor negative allosteric modulator GRIA1|PTPN1 evatanepag Phase 2 prostaglandin inhibitor PTGER2|PTGER4 everolimus Launched mTOR inhibitor MTOR evodiamine Preclinical ATPase inhibitor|TRPV agonist TRPV1 EVP-6124 Phase 3 acetylcholine receptor agonist CHRNA7 EVP4593 Preclinical NFkB pathway inhibitor EW-7197 Phase 1 TGF beta receptor inhibitor ACVR1B|TGFBR1 EX-527 Phase 2 SIRT inhibitor SIRT1 exalamide Launched membrane permeability inhibitor examorelin Phase 2 growth hormone releasing factor agonist GHRHR|GHSR exatecan-mesylate Phase 3 topoisomerase inhibitor TOP1 exemestane Launched aromatase inhibitor CYP19A1 exenatide Launched GLP receptor agonist GLP1R exherin Phase 2 cadherin antagonist CDH2 exifone Withdrawn nootropic agent TYR exisulind Phase 3 phosphodiesterase inhibitor PDE5A EXO-1 Preclinical ARF inhibitor ezatiostat Phase 2 glutathione transferase inhibitor GSTP1 ezetimibe Launched cholesterol inhibitor|Niemann-Pick C1-like 1 protein antagonist ANPEP|NPC1L1|SOAT1 ezutromid Phase 2 utrophin enhancer UTRN E7449 Phase 1/Phase 2 PARP inhibitor PARP1|PARP2|TNKS|TNKS2 F-11440 Phase 2 serotonin receptor agonist HTR1A fadrozole Launched aromatase inhibitor CYP11B1|CYP19A1 fagomine Phase 2 glucosidase inhibitor GLB1 falecalcitriol Launched vitamin D receptor agonist VDR famciclovir Launched DNA polymerase inhibitor famotidine Launched histamine receptor antagonist HRH2 famprofazone Preclinical cyclooxygenase inhibitor fananserin Phase 2 dopamine receptor antagonist|serotonin receptor antagonist HTR2A fanetizole Phase 3 neutrophil superoxide production farnesyl-thiosalicylic-acid-amide Phase 1 Ras GTPase inhibitor HRAS faropenem Launched lactamase inhibitor faropenem-medoxomil Launched lactamase inhibitor fasudil Launched rho associated kinase inhibitor PKIA|PRKACA|ROCK1|ROCK2 favipiravir Phase 3 RNA polymerase inhibitor FCE-22250 Phase 1 DNA directed DNA polymerase inhibitor fdcyd Phase 2 DNA methyltransferase inhibitor febuxostat Launched xanthine oxidase inhibitor XDH felbamate Launched glutamate receptor antagonist GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B felbinac Launched cyclooxygenase inhibitor CTSL felbinac-ethyl Launched cyclooxygenase inhibitor PTGS1|PTGS2 felodipine Launched calcium channel blocker CACNA1C|CACNA1D|CACNA1F|CACNA1H|CACNA1S|CACNA2D1|CACNA2D2|CACNB2|CALM1|CFTR|NR3C2|PDE1A|PDE1B|TNNC1|TNNC2 fenaclon Preclinical fenbendazole Launched tubulin polymerization inhibitor TUBB fenbufen Launched cyclooxygenase inhibitor PTGS1|PTGS2 fenclonine-(+/-) Preclinical tryptophan hydroxylase inhibitor PAH|TPH1|TPH2 fendiline Preclinical calcium channel blocker HTR2B fenigam Launched benzodiazepine receptor agonist GABBR1|GABBR2 fenipentol Launched choleretic agent fenobam Phase 2 glutamate receptor antagonist GRM5 fenofibrate Launched PPAR receptor agonist MMP25|PPARA fenofibric-acid Launched cytochrome P450 inhibitor CLCN1|PPARA fenoldopam Launched dopamine receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD4|DRD5 fenoprofen Launched prostaglandin inhibitor PTGS1|PTGS2|SLC5A8 fenoterol Withdrawn adrenergic receptor agonist ADRB1|ADRB2|ADRB3 fenoverine Launched acetylcholine receptor antagonist fenoxaprop-p-ethyl Preclinical NOS2|NOS3 fenretinide Phase 3 apoptosis stimulant|retinoid receptor agonist RARA fenspiride Launched bronchodilator fenthion Launched cholinesterase inhibitor fentiazac Launched cyclooxygenase inhibitor PTGS1|PTGS2 fenticonazole Launched bacterial cell wall synthesis inhibitor FERb-033 Preclinical EGFR inhibitor ERBB2 ferrostatin-1 Preclinical ferroptosis inhibitor ferulic-acid Phase 2 antioxidant CA1|CA12|CA14|CA2|CA4|CA6|CA9 fesoterodine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 fexaramine Preclinical FXR agonist NR1H4 fexinidazole Phase 2/Phase 3 fexofenadine Launched histamine receptor antagonist HRH1 FG-2216 Phase 2 hypoxia inducible factor prolyl hydroxylase inhibitor EGLN1|EGLN2|HIF1A FG-4592 Phase 3 hypoxia inducible factor prolyl hydroxylase inhibitor EGLN2 FG-7142 Preclinical GABA benzodiazepine site receptor inverse agonist FGIN-1-27 Preclinical inositol monophosphatase inhibitor TSPO FGIN-1-43 Preclinical benzodiazepine receptor agonist TSPO FH1 Preclinical hepatocyte function enhancer fiacitabine Phase 2 DNA synthesis inhibitor fidarestat Phase 3 aldose reductase inhibitor AKR1B1 fidaxomicin Launched RNA polymerase inhibitor filanesib Phase 3 kinesin inhibitor|kinesin-like spindle protein inhibitor KIF11 filgotinib Phase 2 JAK inhibitor JAK1|JAK2|JAK3|TYK2 fimasartan Launched angiotensin receptor antagonist AGTR1 finafloxacin Launched bacterial DNA gyrase inhibitor finasteride Launched 5 alpha reductase inhibitor AKR1D1|SRD5A1|SRD5A2 fingolimod Launched immunosuppressant|sphingosine phosphate receptor agonist S1PR1|S1PR5 fipexide Withdrawn psychoactive drug fipronil Launched chloride channel blocker|GABA gated chloride channel blocker firategrast Phase 2 integrin antagonist ITGA4 firocoxib Launched cyclooxygenase inhibitor PTGS2 fisetin Preclinical Aurora kinase inhibitor CDK6|FASN FIT Preclinical opioid receptor agonist OPRD1 FK-33-824 Phase 2 opioid receptor agonist OPRM1 FK-3311 Phase 2 cyclooxygenase inhibitor PTGS2 FK-866 Phase 2 niacinamide phosphoribosyltransferase inhibitor NAMPT FK-888 Phase 2 tachykinin antagonist TACR1|TACR2 FK-962 Phase 2 somatostatin receptor agonist flavin-adenine-dinucleotide Preclinical ACAD8|ACADM|ACADS|ACOX1|AIFM1|CYB5R1|CYB5R3|DAO|DLD|DPYD|ERO1LB|FDXR|GCDH|GFER|GSR|IL4I1|IVD|MAOA|MAOB|NOS1|NQO1|NQO2|POR|TXNRD1|XDH flavoxate Launched acetylcholine receptor antagonist CHRM1|CHRM2 flecainide Launched sodium channel blocker KCNA5|KCNA7|SCN4A|SCN5A fleroxacin Launched topoisomerase inhibitor FLI-06 Preclinical notch signaling inhibitor flibanserin Launched serotonin receptor agonist DRD4|HTR1A|HTR2A flindokalner Phase 3 potassium channel agonist KCNMA1|KCNN4|KCNQ2|KCNQ4|KCNQ5 floctafenine Launched cyclooxygenase inhibitor PTGS1|PTGS2 flopropione Launched serotonin receptor antagonist HTR1A florfenicol Launched protein synthesis inhibitor flosequinan Withdrawn phosphodiesterase inhibitor floxuridine Launched DNA synthesis inhibitor TYMS flubendazole Launched tubulin polymerization inhibitor TUBB flucloxacillin Launched bacterial cell wall synthesis inhibitor fluconazole Launched sterol demethylase inhibitor CYP51A1 flucytosine Launched other antifungal DNMT1 fludarabine Launched ribonucleotide reductase inhibitor ADA|RRM1|RRM2 fludarabine-phosphate Launched ribonucleotide reductase inhibitor DCK|POLA1|POLD1|POLE|RRM1|RRM2|RRM2B fludrocortisone-acetate Launched AR|NR3C1|NR3C2 fludroxycortide Launched glucocorticoid receptor agonist NR3C1|SERPINA6 flufenamic-acid Preclinical chloride channel blocker AKR1C3|ANO1|AR|GJA1|GJA10|GJA3|GJA4|GJA5|GJA8|GJA9|GJB1|GJB2|GJB3|GJB4|GJB5|GJB6|GJB7|GJC1|GJC2|GJC3|GJD2|GJD3|GJD4|GJE1|PANX1|PANX2|PANX3|PKD2L1|PTGS1|PTGS2|TRPC5|TRPM2|TRPM5 flumatinib Phase 3 Bcr-Abl kinase inhibitor ABL1|PDGFRB flumazenil Launched benzodiazepine receptor antagonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ flumecinol Launched flumequine Launched topoisomerase inhibitor flumetasone Launched glucocorticoid receptor agonist NR3C1 flumethasone Launched glucocorticoid receptor agonist NR3C1|PLA2G1B flumethazone-pivalate Preclinical glucocorticoid receptor agonist NR3C1|SERPINA6 flumexadol Preclinical flunarizine Launched calcium channel blocker CACNA1G|CACNA1H|CACNA1I|CALM1|HRH1 flunisolide Launched cytochrome P450 inhibitor NR3C1 flunixin-meglumin Launched prostanoid receptor antagonist fluocinolone-acetonide Launched glucocorticoid receptor agonist NR3C1|SERPINA6 fluocinonide Launched glucocorticoid receptor agonist NR3C1|SERPINA6|SMO fluorescein Launched SLC22A6 fluorometholone Launched glucocorticoid receptor agonist NR3C1 fluorometholone-acetate Launched NR3C1 fluoromethylcholine Launched fluoxetine Launched selective serotonin reuptake inhibitor (SSRI) ANO1|HTR2B|SLC6A4 fluoxymesterone Launched androgen receptor modulator AR|ESR1|NR3C1|PRLR flupentixol Launched dopamine receptor antagonist ADRA1A|CHRM1|DRD1|DRD2|DRD3|DRD5|HTR2A fluphenazine Launched dopamine receptor antagonist CALM1|DRD1|DRD2|DRD5|HRH1|HTR2A|HTR6|HTR7 fluphenazine-decanoate Launched dopamine receptor antagonist DRD2|HTR1B|HTR4 flupirtine Launched glutamate receptor antagonist ADRA2A|KCNQ1|KCNQ2 fluprazine Phase 1 serotonin receptor agonist HTR1A|HTR1B flurbiprofen-(+/-) Launched cyclooxygenase inhibitor PTGS1|PTGS2 flurbiprofen-(S)-(+) Launched cyclooxygenase inhibitor PTGS1|PTGS2 flurofamide Preclinical urease inhibitor flurothyl Preclinical fluroxene Preclinical local anesthetic fluspirilene Launched dopamine receptor antagonist CACNG1|DRD2|HRH1|HTR1A|HTR1D|HTR1E|HTR2A flutamide Launched androgen receptor antagonist AHR|AR fluticasone-propionate Launched glucocorticoid receptor agonist NR3C1|NR3C2|PGR|PLA2G4A flutrimazole Launched sterol demethylase inhibitor fluvastatin Launched HMGCR inhibitor HMGCR fluvoxamine Launched selective serotonin reuptake inhibitor (SSRI) SLC6A4 fmoc-l-leucine Phase 2 PPAR receptor agonist folic-acid Launched folate receptor ligand FOLR2|FOLR3|SLC19A1|SLC46A1 fomepizole Launched alcohol dehydrogenase inhibitor ADH1A|ADH1B|ADH1C|AKR1A1|CAT fomocaine Launched voltage-gated sodium channel modulator foretinib Phase 2 VEGFR inhibitor FLT1|FLT4|KDR|MET formestane Launched aromatase inhibitor CYP19A1 formononetin Preclinical alcohol dehydrogenase inhibitor ADH1C|SLC5A2 formoterol Launched adrenergic receptor agonist ADRB2 forodesine Phase 2 purinergic receptor antagonist PNP foropafant Phase 3 platelet activating factor receptor antagonist PTAFR forskolin Launched adenylyl cyclase activator ADCY2|ADCY5|GNAS fosamprenavir Launched HIV protease inhibitor fosaprepitant-dimeglumine Launched tachykinin antagonist TACR1 fosbretabulin Phase 3 tubulin polymerization inhibitor|VE-cadherin antagonist CDH5 foscarnet Launched DNA polymerase inhibitor fosfestrol Launched synthetic estrogen ESR1|ESR2 fosfomycin Launched bacterial cell wall synthesis inhibitor fosfosal Launched phosphodiesterase inhibitor PTGS1|PTGS2 fosfructose Phase 3 fructose diphosphate stimulant PKLR fosinopril Launched angiotensin converting enzyme inhibitor ACE fosinoprilat Launched angiotensin converting enzyme inhibitor ACE fosphenytoin Launched sodium channel blocker SCN5A fostamatinib Phase 3 SYK inhibitor RET|SYK fotemustine Launched thioredoxin inhibitor TXNRD1 foxy-5 Phase 1 WNT5a peptide mimetic WNT5A FPA-124 Preclinical AKT inhibitor FPH1-(BRD-6125) Preclinical hepatocyte function enhancer FPL-12495 Phase 1 glutamate receptor antagonist FPL-55712 Phase 1 leukotriene receptor antagonist FPL-62064 Phase 2 cyclooxygenase inhibitor|lipoxygenase inhibitor FPL-64176 Preclinical calcium channel activator CACNA1C|CACNA1S FPS-ZM1 Preclinical RAGE receptor antagonist AGER FR-122047 Preclinical cyclooxygenase inhibitor FR-139317 Phase 1 endothelin receptor antagonist EDNRA FR-180204 Preclinical MAP kinase inhibitor MAPK1|MAPK3 FRAX486 Preclinical serine/threonine kinase inhibitor PAK1|PAK2|PAK3|PAK4 frentizole Phase 1 immunosuppressant frovatriptan Launched serotonin receptor agonist HTR1A|HTR1B|HTR1D fruquintinib Phase 3 VEGFR inhibitor KDR ftaxilide Preclinical ftorafur Launched thymidylate synthase inhibitor TYMS fudosteine Launched mucolytic agent fulvestrant Launched estrogen receptor antagonist ESR1|ESR2|GPER1 fumagillin Launched methionine aminopeptidase inhibitor METAP2 furaltadone Launched bacterial DNA inhibitor furazolidone Launched bacterial DNA inhibitor furegrelate Phase 1 thromboxane synthase inhibitor TBXAS1 furosemide Launched diuretic CA2|GPR35|SLC12A1|SLC12A2 fursultiamine Launched vitamin B fusidic-acid Launched bacterial 30S ribosomal subunit inhibitor F351 Phase 2 TGF beta receptor inhibitor TGFB1 g-caryophyllene Preclinical acetylcholinesterase inhibitor ACHE G-1 Preclinical G protein-coupled receptor agonist GPER1 G-15 Preclinical estrogen receptor antagonist GPER1 GABA-linoleamide Phase 2 benzodiazepine receptor agonist gabapentin Launched calcium channel blocker ADORA1|CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1E|CACNA1F|CACNA1G|CACNA1H|CACNA1I|CACNA1S|CACNA2D1|CACNA2D2|CACNA2D3|CACNA2D4|CACNB1|CACNB2|CACNB3|CACNB4|CACNG1|CACNG2|CACNG3|CACNG4|CACNG5|CACNG6|CACNG7|CACNG8|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B gabapentin-enacarbil Launched adrenergic receptor agonist CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1E|CACNA1F|CACNA1G|CACNA1H|CACNA1I|CACNA1S|CACNA2D1|CACNA2D2|CACNA2D3|CACNA2D4|CACNB1|CACNB2|CACNB3|CACNB4|CACNG1|CACNG2|CACNG3|CACNG4|CACNG5|CACNG6|CACNG7|CACNG8 gabazine Preclinical GABA receptor antagonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRG2 gabexate Launched serine protease inhibitor PRSS1|TPSAB1 gaboxadol Phase 3 benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRD|GABRR1|GABRR2|GABRR3 gadobutrol Launched radiopaque medium gadodiamide Launched radiopaque medium gadopentetic-acid Launched contrast agent gadoterate-meglumine Launched radiopaque medium gadoteridol Launched radiopaque medium galantamine Launched acetylcholinesterase inhibitor ACHE|BCHE|CHRNA1|CHRNA10|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA6|CHRNA7|CHRNA9|CHRNB1|CHRNB2|CHRNB3|CHRNB4|CHRND|CHRNE|CHRNG galeterone Phase 3 androgen receptor modulator AR|CYP17A1 gallamine-triethiodide Launched acetylcholine receptor antagonist ACHE|CHRM2|CHRNA1|CHRNA2 gallic-acid Preclinical beta amyloid protein neurotoxicity inhibitor|PPAR receptor agonist CA1|CA12|CA14|CA2|CA4|CA6|CA9|SELP gallium-triquinolin-8-olate Phase 1 gallopamil Launched L-type calcium channel blocker ATP2A2 gambogic-acid Phase 2 caspase activator BCL2 gamma-aminobutyric-acid Preclinical benzodiazepine receptor agonist GABBR1|GABBR2|GABRA1|GABRA2|GABRA3|GABRA5|GABRB2|GABRG2|GATM|KCTD12|KCTD16|KCTD8|SLC6A1 gamma-linolenic-acid Phase 2 cyclooxygenase inhibitor|prostanoid receptor agonist PTGS1|PTGS2 ganaxolone Phase 3 GABA receptor modulator GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6 ganciclovir Launched DNA polymerase inhibitor ganetespib Phase 3 HSP inhibitor HSP90AA1 ganglioside-gm1 Phase 2 garenoxacin Launched topoisomerase inhibitor TOP2A gastrodin Phase 2 gatifloxacin Withdrawn bacterial DNA gyrase inhibitor gavestinel Phase 3 glutamate receptor antagonist GLRB GBR-12783 Preclinical dopamine uptake inhibitor GBR-12935 Preclinical dopamine uptake inhibitor AGTR1|SLC6A3 GBR-13069 Preclinical dopamine uptake inhibitor SLC6A3 GDC-0068 Phase 2 AKT inhibitor AKT1|AKT2|AKT3|PRKG1 GDC-0152 Phase 1 XIAP inhibitor BIRC2|BIRC3|BIRC7|XIAP GDC-0349 Phase 1 Pim kinase inhibitor PIK3CA GDC-0623 Phase 1 MEK inhibitor GDC-0810 Phase 2 selective estrogen receptor destabilizer ESR1 GDC-0834 Phase 1 Bruton's tyrosine kinase (BTK) inhibitor BTK GDC-0879 Preclinical RAF inhibitor BRAF GDC-0941 Phase 2 PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG GDC-0980 Phase 2 mTOR inhibitor|PI3K inhibitor FGR|MAP3K9|MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG|SYK GDC-0994 Phase 1 MAP kinase inhibitor MAPK1|MAPK3 gedunin Preclinical HSP inhibitor HSP90AA1 gefitinib Launched EGFR inhibitor EGFR geldanamycin Preclinical HSP inhibitor HSP90AA1|HSP90AB1 gemcadiol Phase 2 antilipemic gemcitabine Launched ribonucleotide reductase inhibitor CMPK1|RRM1|RRM2|TYMS gemcitabine-elaidate Phase 1 DNA synthesis inhibitor|apoptosis inhibitor CMPK1|RRM1|TYMS gemfibrozil Launched lipoprotein lipase activator LPL|PPARA|SLCO1B1|SLCO1B3|SLCO2B1 gemifloxacin Launched bacterial DNA gyrase inhibitor genipin Preclinical choleretic agent geniposide Preclinical GLP receptor agonist GLP1R geniposidic-acid Preclinical cyclooxygenase inhibitor genistein Phase 2/Phase 3 tyrosine kinase inhibitor CFTR|ESR1|ESR2|ESRRA|ESRRB|ESRRG|NCOA1|NCOA2|PPARG|PTK2B|TOP2A|TRPC5 gentamycin Launched bacterial 50S ribosomal subunit inhibitor HSPA8|LRP2 gentiopicrin Phase 3 glutamate receptor downregulator GRIN2B genz-123346 Preclinical glucosylceramidase inhibitor UGCG genz-644282 Phase 1 topoisomerase inhibitor TOP1 gepefrine Launched adrenergic receptor agonist gepon Phase 1 geranyl-farnesylacetate Phase 2 mucin production enhancer gestodene Launched contraceptive agent gestrinone Launched progesterone receptor antagonist AR|ESR1|PGR GF109203X Preclinical PKC inhibitor PDPK1|PIM1|PRKCI|PRKCZ GGTI-298 Preclinical GGTase inhibitor CDKN1A gidazepam Launched GABA benzodiazepine site receptor agonist gilteritinib Phase 3 FLT3 inhibitor FLT3 gimeracil Launched dihydropyrimidine dehydrogenase inhibitor DPYD ginkgolide-a Preclinical GABA receptor antagonist GLRA1|GLRB ginkgolide-b Phase 3 platelet activating factor receptor antagonist GLRA1|GLRA2|GLRA3|GLRB|HTR3A|HTR3B ginsenoside-c-k Preclinical NFkB pathway inhibitor|nitric oxide synthase inhibitor PTGS2 ginsenoside-rd Phase 3 calcium channel blocker ginsenoside-rg3 Launched angiogenesis inhibitor|apoptosis stimulant KCNH2 givinostat Phase 2 HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9 GKT137831 Phase 2 NADPH oxidase inhibitor NOX1|NOX4 GK921 Preclinical transglutaminase inhibitor TGM2 glafenine Withdrawn DeltaF508-CFTR Correctors CFTR glasdegib Phase 2 hedgehog pathway inhibitor SMO gliclazide Launched ATP channel blocker|insulin secretagogue ABCC8|VEGFA glimepiride Launched insulin secretagogue ABCC8|KCNJ1|KCNJ11 glipizide Launched sulfonylurea ABCC8|KCNJ10|KCNJ11|PPARG gliquidone Launched sulfonylurea ABCC8|KCNJ10|KCNJ8 GLPG0492 Phase 1 androgen receptor modulator AR GLPG0492-R-enantiomer Phase 1 androgen receptor modulator AR glucaric-acid Phase 1 gluconolactone Launched LCT glucosamine Launched glycosylated protein precursor IFNG|IL1B|MMP9|NFKB2|TNF glutamine-(l) Launched CTPS1|GLUL|GPRC6A|PPAT glutathione Phase 3 antioxidant ESD|GGT1|GLO1|GLRX|GLRX2|GPX1|GPX2|GPX3|GPX4|GPX5|GPX6|GPX7|GPX8|GSR|GSS|GSTA1|GSTA2|GSTA3|GSTA4|GSTA5|GSTK1|GSTM1|GSTM2|GSTM3|GSTM4|GSTM5|GSTO1|GSTO2|GSTP1|GSTT1|GSTZ1|HAGH|HPGDS|LTC4S|MGST1|MGST2|MGST3|TXNDC12 glutathione-monoisopropyl-ester Phase 2 lipid peroxidase inhibitor gly-gln Phase 2 glyburide Launched ATP channel blocker|insulin secretagogue|sulfonylurea ABCA1|ABCB11|ABCC8|ABCC9|CFTR|CPT1A|KCNJ1|KCNJ11|KCNJ5|KCNJ8|SLCO2B1 glycerol-monolaurate Launched beta lactamase inhibitor glycitein Phase 3 tumor necrosis factor release inhibitor TNF glycopyrrolate Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 GMX1778 Phase 1/Phase 2 NAMPT inhibitor NAMPT GNF-2 Preclinical Bcr-Abl kinase inhibitor ABL1|BCR GNTI Preclinical opioid receptor antagonist OPRK1|OPRM1 go-6983 Preclinical protein kinase inhibitor PRKCA|PRKCB|PRKCD|PRKCG|PRKCZ golgicide-a Preclinical ARF inhibitor GBF1 golvatinib Phase 2 VEGFR inhibitor KDR|MET gonadorelin Launched gonadotropin releasing factor hormone receptor agonist GNRHR|GNRHR2 goserelin-acetate Launched gonadotropin releasing factor hormone receptor agonist GNRHR|LHCGR gossypol Phase 2 BCL inhibitor|MCL1 inhibitor BCL2 GPI-1046 Preclinical FKBP inhibitor FKBP1A GPR120-modulator-1 Preclinical G protein-coupled receptor modulator FFAR4 GP1a Preclinical cannabinoid receptor agonist CNR2 GP2a Preclinical cannabinoid receptor agonist CNR2 GR-103691 Preclinical dopamine receptor antagonist DRD3 GR-113808 Preclinical serotonin receptor antagonist HTR4 GR-127935 Preclinical serotonin receptor antagonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR6 GR-135531 Preclinical melatonin receptor agonist GR-144053 Preclinical integrin antagonist ITGA2B|ITGB3 GR-159897 Preclinical tachykinin antagonist TAC1|TACR2 GR-235 Launched estrogen receptor agonist|FXR antagonist|progesterone receptor agonist NR1H4 GR-79236 Phase 1 adenosine receptor agonist ADORA1|ADORA2A gramicidin Launched bacterial permeability inducer gramine Preclinical norepinephrine reputake inhibitor granisetron Launched serotonin receptor antagonist HTR3A grapiprant Launched prostaglandin inhibitor PTGER4 grazoprevir Launched HCV inhibitor griseofulvin Launched tubulin polymerization inhibitor KRT12 GR125487 Preclinical serotonin receptor antagonist HTR4 GR46611 Preclinical serotonin receptor agonist HTR1D GS-39783 Preclinical GABA receptor modulator GABBR1 GS-6201 Phase 1 adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 GS-9620 Phase 2 toll-like receptor agonist TLR7 GS-9973 Phase 2 syk inhibitor SYK GSK-J1 Preclinical histone demethylase inhibitor KDM6B GSK-J2 Preclinical histone demethylase inhibitor GSK-J4 Preclinical histone lysine demethylase inhibitor KDM6A|KDM6B GSK-0660 Preclinical PPAR receptor antagonist PPARD GSK-3-inhibitor-IX Preclinical glycogen synthase kinase inhibitor|lipoxygenase inhibitor GSK3A|GSK3B GSK1059615 Phase 1 PI3K inhibitor PIK3CG GSK1070916 Phase 1 Aurora kinase inhibitor AURKA|AURKB|AURKC|CYP2D6|CYP3A4 GSK1292263 Phase 2 glucose dependent insulinotropic receptor agonist GRPR GSK163090 Phase 2 serotonin receptor antagonist HTR1A|HTR1B|HTR1D GSK1838705A Preclinical insulin growth factor receptor inhibitor ALK|IGF1R|INSR|RPS6KA1 GSK1904529A Preclinical IGF-1 inhibitor|insulin growth factor receptor inhibitor|insulin receptor ligand IGF1R|INSR GSK2110183 Phase 2 AKT inhibitor AKT1|AKT2|AKT3 GSK2126458 Phase 1 mTOR inhibitor|PI3K inhibitor MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG GSK2190915 Phase 2 lipoxygenase inhibitor ALOX5AP GSK2256294A Phase 1 epoxide hydolase inhibitor EPHX2 GSK2330672 Phase 2 bile acid transporter inhibitor SLC10A2 GSK256066 Phase 2 phosphodiesterase inhibitor PDE4A GSK2606414 Preclinical protein kinase inhibitor EIF2AK3|MYLK2 GSK2636771 Phase 2 PI3K inhibitor PIK3CB GSK2656157 Preclinical PERK inhibitor GSK2801 Preclinical bromodomain inhibitor BAZ2A|BAZ2B GSK2816126 Phase 1 histone lysine methyltransferase inhibitor EZH2 GSK2830371 Preclinical protein phosphatase inhibitor PPM1D GSK2838232 Phase 1 HIV gag inhibitor GSK2879552 Phase 1 histone lysine demethylase inhibitor KDM1A GSK3787 Preclinical PPAR receptor antagonist PPARD GSK429286A Preclinical rho associated kinase inhibitor ROCK1 GSK461364 Phase 1 PLK inhibitor PLK1 GSK503 Preclinical histone lysine methyltransferase inhibitor EZH2 GSK650394 Preclinical serum/glucocorticoid regulated kinase inhibitor SGK1|SGK2 GSK690693 Phase 1 AKT inhibitor AKT1|AKT2|AKT3|PAK4|PAK6|PAK7|PRKCQ|PRKG1|PRKX GSK923295 Phase 1 centromere associated protein inhibitor CENPE GTP-14564 Preclinical FLT3 inhibitor|tyrosine kinase inhibitor CSF1R|FLT3|KIT|PDGFRB GTS21 Phase 1/Phase 2 cholinergic receptor agonist CHRNA7 guacetisal Launched immunosuppressant guaiacol Launched local anesthetic CA2 guaifenesin Launched expectorant guanaben-acetate Launched adrenergic receptor agonist ADRA2A|ADRA2B|ADRA2C guanadrel Launched adrenergic inhibitor SLC6A2 guanethidine Launched adrenergic inhibitor SLC6A2 guanfacine Launched adrenergic receptor agonist ADRA2A|ADRA2B|ADRA2C guanidine Launched HSP inhibitor ALDH2|DLG4|GAMT|RNASE1 guanidinoethyldisulfide-bicarbonate Phase 2 nitric oxide synthase inhibitor NOS2 guanidinopropionic-acid Phase 2 creatine kinase inhibitor CKM guanosine Preclinical PNP guvacine Preclinical GABA uptake inhibitor SLC6A1|SLC6A11|SLC6A12|SLC6A13 GW-0742 Preclinical PPAR receptor agonist PPARD GW-1100 Preclinical G protein-coupled receptor agonist FFAR1 GW-1929 Preclinical PPAR receptor agonist PPARG GW-2580 Preclinical cFMS kinase inhibitor CSF1R GW-311616 Phase 1 leukocyte elastase inhibitor|elastase inhibitor ELANE GW-3965 Preclinical LXR agonist NR1H2|NR1H3 GW-405833 Preclinical cannabinoid receptor agonist CNR2 GW-4064 Preclinical FXR agonist NR1H4 GW-441756 Preclinical growth factor receptor inhibitor NTRK1 GW-501516 Phase 2 PPAR receptor agonist PPARA|PPARD GW-5074 Preclinical RAF inhibitor|leucine rich repeat kinase inhibitor NTRK1|RAF1 GW-583340 Preclinical EGFR inhibitor EGFR|ERBB2 GW-6471 Preclinical PPAR receptor antagonist PPARA GW-7647 Preclinical PPAR receptor agonist PPARA GW-788388 Preclinical ALK tyrosine kinase receptor inhibitor LCK|MAPK14|TGFBR1 GW-803430 Phase 1 melanin inhibitor KCNH2|MCHR1 GW-842166 Phase 2 cannabinoid receptor agonist CNR2 GW-843682X Preclinical PLK inhibitor PLK1|PLK3 GW-9508 Preclinical free fatty acid receptor agonist|G protein-coupled receptor agonist FFAR1|FFAR4 GW-9662 Preclinical PPAR receptor antagonist NCOA2|PPARG|RXRA GYKI-52466 Preclinical glutamate receptor antagonist GRIA1|GRIA2|GRIA3|GRIA4 gynostemma-extract Preclinical calcium channel modulator GZD824 Preclinical Bcr-Abl kinase inhibitor ABL1|BCR G007-LK Preclinical tankyrase inhibitor TNKS|TNKS2 H-89 Preclinical PKA inhibitor GSG2|PKIA|PRKACA HA-1004 Phase 2 calcium channel blocker HA-14-1 Preclinical BCL inhibitor BCL2 HA-966-(R)-(+) Preclinical glutamate receptor agonist GRIA1 HA-966-(S)-(-) Preclinical glutamate receptor antagonist GRIA1 halazone Launched halcinonide Launched glucocorticoid receptor agonist NR3C1 halobetasol-propionate Launched glucocorticoid receptor agonist NR3C1|PLA2G1B halofantrine Launched antimalarial agent KCNH2|KCNN4 halofuginone Launched collagenase inhibitor COL1A1|MMP2 halopemide Phase 2 phospholipase inhibitor PLD1|PLD2 haloperidol Launched dopamine receptor antagonist DRD1|DRD2|DRD3|DRD4|DRD5|GRIN2B|HRH1|HTR1A|HTR1D|HTR2A|HTR2B|HTR7|KCNH1 haloperidol-decanoate Launched psychoactive drug DRD2|DRD3|DRD4|HTR2A haloprogin Launched other antifungal halothane Launched glutamate receptor antagonist ATP2C1|ATP5D|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GLRA1|GLRB|GNG2|GRIN2A|GRIN3A|GRIN3B|KCNJ3|KCNJ6|KCNK10|KCNK12|KCNK13|KCNK15|KCNK18|KCNK2|KCNK3|KCNK9|KCNMA1|KCNN4|MT-ND1|NPSR1|RHO harmane Preclinical monoamine oxidase inhibitor MAOA|MAOB harringtonine Phase 3 protein synthesis inhibitor HA14-1 Preclinical BCL inhibitor BCL2 HC-030031 Phase 1 TRPA1 channel blocker TRPA1 HEMADO Preclinical ADORA1|ADORA2A|ADORA2B|ADORA3 hematoporphyrin Launched hematoxylin Preclinical hemin Launched enzyme inducer hemoglobin-modulators-1 Phase 3 hemoglobin modulator hemomex-s Launched PPARG heptaminol Launched vasoconstrictor HER2-Inhibitor-1 Preclinical EGFR inhibitor hesperadin Preclinical Aurora kinase inhibitor AURKB hesperetin Launched ACAT inhibitor DGAT1|MTTP|SOAT1|SOAT2 hesperidin Launched flavanone glycoside CACNA1B hetacillin Launched bacterial cell wall synthesis inhibitor hexachlorophene Launched potassium channel activator GLUD1|SDHD hexamethonium Preclinical cholinergic receptor antagonist CHRNA2|CHRNA3|CHRNA4|CHRNA6 hexamethylenebisacetamide Phase 2 AKT inhibitor|differentiation inducer|NFKB pathway inhibitor AKT1 hexaminolevulinate Launched hexasodium-phytate Phase 2 hexestrol Launched synthetic estrogen AKR1C1|ESR1|ESR2 hexetidine Launched local anesthetic hexonic-acid Preclinical hexoprenaline Launched adrenergic receptor agonist ADRB2 hexylcaine Launched sodium channel blocker SCN10A|SCN5A hexylene-glycol Preclinical AKR1C3|CTPS1|DLG4|HSP90AA1|NOS3|PGF|PLA2G1B|PTPN1|SELP hexylresorcinol Launched local anesthetic TYR higenamine Phase 1 adrenergic receptor agonist ADRB2 hippuric-acid Preclinical histamine Launched histamine receptor agonist HRH1|HRH2|HRH3|HRH4 HKI-357 Phase 1 EGFR inhibitor EGFR HLCL-61 Preclinical protein arginine N-methyltransferase inhibitor PRMT5 HMN-214 Phase 1 PLK inhibitor CSF1R|FGFR1|FLT1|FLT3|FLT4|KDR|KIT|PDGFRA|PDGFRB|RET homatropine Launched acetylcholine receptor antagonist CES1|CHRM1 homatropine-bromide Launched acetylcholine receptor antagonist homatropine-methylbromide Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 homidium Preclinical homochlorcyclizine Launched antihistamine HRH1 homoharringtonine Launched protein synthesis inhibitor RPL3 homoquinolinic-acid Preclinical glutamate receptor agonist GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D homosalate Preclinical HSP inducer homoveratrylamine Preclinical dopamine analog honokiol Phase 3 AKT inhibitor ALOX5|PTGS1|PTGS2 hordenine Preclinical HQK-1001 Phase 2 HTMT Preclinical histamine receptor agonist HRH4 huperzine-a Phase 2 acetylcholinesterase inhibitor ACHE hyaluronic-acid Launched C1QBP|CD44|HABP2|HAPLN1|HAPLN3|HAPLN4|HMMR|ICAM1|NCAN|VCAN hycanthone Launched RNA synthesis inhibitor hydralazine Launched vasodilator AOC3|P4HA1 hydrastinine Preclinical haemostatic agent hydrochlorothiazide Launched thiazide diuretic CA1|CA12|CA2|CA4|CA9|KCNMA1|SLC12A3 hydrocortisone Launched glucocorticoid receptor agonist hydrocortisone-acetate Launched glucocorticoid receptor agonist NR3C1|NR3C2 hydrocortisone-butyrate Launched glucocorticoid receptor agonist NR3C1 hydrocortisone-hemisuccinate Phase 2/Phase 3 hydrocortisone-phosphate Launched ANXA1|NOS2|NR3C1 hydrocortisone-valerate Launched glucocorticoid receptor agonist hydroflumethiazide Launched sodium/potassium/chloride transporter inhibitor ATP1A1|CA1|CA12|CA2|CA4|CA9|KCNMA1|SLC12A1|SLC12A3 hydroquinidine Launched antiarrhythmic hydroquinone Launched melanin inhibitor TYR hydroxyamphetamine Launched trace amine associated receptor agonist TAAR1 hydroxychloroquine Launched antimalarial agent TLR7|TLR9 hydroxyfasudil Preclinical rho associated kinase inhibitor PKIA|PRKACA|ROCK1 hydroxyprogesterone Launched progesterone receptor agonist PGR hydroxyprogesterone-acetate Launched progesterone receptor agonist PGR hydroxypropyl-beta-cyclodextrin Phase 2 hydroxystilbamidine Launched hydroxytoluic-acid Preclinical hydroxyurea Launched ribonucleotide reductase inhibitor RRM1|RRM2|RRM2B hydroxyzine Launched antihistamine HRH1 hygromycin-b Preclinical polypeptide synthesis inhibitor hymecromone Phase 2 monoamine oxidase inhibitor MAOA|MAOB hyodeoxycholic-acid Phase 1 atherosclerosis formation inhibitor hyoscyamine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4 hypericin Phase 2 tyrosine kinase inhibitor hyperin Preclinical aldose reductase inhibitor ACE|AKR1B1 hypoestoxide Phase 1 IKK inhibitor IKBKB|IL1B|TNF hypoxanthine Preclinical PARP inhibitor PNP I-BET-762 Phase 2 bromodomain inhibitor BRD2|BRD3|BRD4 I-BET151 Preclinical bromodomain inhibitor BRD2|BRD3|BRD4 I-BRD9 Preclinical bromodomain inhibitor BRD9 I-BZA Phase 2 I-BZA2 Phase 3 IB-MECA Phase 3 adenosine receptor agonist ADORA1|ADORA2A|ADORA2B|ADORA3 ibandronate Launched bone resorption inhibitor FDPS IBC-293 Preclinical hydroxycarboxylic acid receptor agonist HCAR3 ibotenic-acid Phase 1 glutamate receptor agonist GRIN1 ibrolipim Phase 2 lipoprotein lipase activator LPL ibrutinib Launched Bruton's tyrosine kinase (BTK) inhibitor BLK|BMX|BTK ibudilast Launched leukotriene receptor antagonist|phosphodiesterase inhibitor IL1B|IL6|PDE3A|PDE4A|PDE4B|PDE4C|PDE4D|PDE5A ibuprofen Launched cyclooxygenase inhibitor PTGS1|PTGS2 ibuprofen-(s) Preclinical cyclooxygenase inhibitor ASIC1|BCL2|CFTR|FABP2|PLAT|PPARG|PTGS1|PTGS2|SLC5A8|THBD ibuprofen-lysine Launched cyclooxygenase inhibitor PTGS1|PTGS2 ibuprofen-piconol Launched cyclooxygenase inhibitor PTGS1|PTGS2 ibutamoren Phase 2 growth hormone secretagogue receptor agonist GHR|GHSR ibutilide Launched potassium channel blocker CACNA1C|CACNA2D1|CACNB1|CACNG1|KCNH2|KCNH6|KCNH7|KCNJ11|KCNK1|KCNK6 icariin Phase 3 phosphodiesterase inhibitor PDE5A icaritin Phase 2 PPAR receptor antagonist PDE5A icatibant-acetate Launched bradykinin receptor antagonist ANPEP|BDKRB2 ICG-001 Preclinical beta-catenin inhibitor CTNNB1 ICI-162846 Phase 1 histamine receptor antagonist HRH2 ICI-192605 Phase 2 thromboxane receptor antagonist TBXA2R ICI-199441 Preclinical opioid receptor agonist CYP2D6|OPRD1|OPRK1|OPRM1|UTS2R ICI-63197 Preclinical phosphodiesterase inhibitor ICI-89406 Phase 1 adrenergic receptor antagonist ADRB1|ADRB2 icilin Phase 1 TRPV agonist TRPA1|TRPM8 icomucret Phase 3 mucin production enhancer LTB4R2 icosapent Launched platelet aggregation inhibitor ACSL3|ACSL4|FADS1|FFAR1|PPARD|PPARG|PTGS1|PTGS2|SLC8A1|TRPV1 icotinib Launched EGFR inhibitor EGFR IC261 Preclinical casein kinase inhibitor CSNK1A1|CSNK1D|CSNK1E|CSNK1G2 ID-1101 Phase 1 insulin sensitizer INS ID-8 Preclinical idalopirdine Phase 3 serotonin receptor antagonist HTR6 idarubicin Launched topoisomerase inhibitor TOP2A idasanutlin Phase 3 MDM inhibitor MDM2|TP53 idazoxan Phase 3 adrenergic receptor antagonist ADRA2A idebenone Launched calcium channel modulator idelalisib Launched PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG idoxuridin Launched DNA synthesis inhibitor idoxuridine Launched DNA directed DNA polymerase inhibitor IDRA-21 Preclinical glutamate receptor positive allosteric modulator GRIA1|GRIA2|GRIA3|GRIA4 idramantone Preclinical idronoxil Phase 3 XIAP inhibitor ENOX2|SPHK1 IEM1460 Preclinical glutamate receptor antagonist GRIA2 IEM1754 Preclinical glutamate receptor antagonist GRIA1 ifenprodil Launched adrenergic receptor antagonist|glutamate receptor antagonist GRIN1|GRIN2B ifosfamide Launched DNA alkylating agent CYP2A6|CYP2B6|CYP2C18|CYP2C19|CYP2C8|CYP2C9|CYP3A4|CYP3A5|CYP3A7|PTGS1 igmesine Phase 2 sigma receptor agonist SIGMAR1 iguratimod Launched cyclooxygenase inhibitor|NFkB pathway inhibitor PTGS2 IKK-16 Preclinical IKK inhibitor IKBKB IKK-2-inhibitor Preclinical IKK inhibitor|SYK inhibitor IKBKB IKK-2-inhibitor-V Phase 1 IKK inhibitor|NFkB pathway inhibitor IKBKB ilepcimide Phase 3 anticonvulsant ilomastat Phase 3 matrix metalloprotease inhibitor ACAN|ADAM28|MMP1|MMP12|MMP13|MMP14|MMP2|MMP3|MMP8|MMP9 iloperidone Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA2C|DRD1|DRD2|DRD3|DRD4|HRH1|HTR1A|HTR2A|HTR6|HTR7 iloprost Launched platelet aggregation inhibitor|prostanoid receptor agonist PDE4A|PDE4B|PDE4C|PDE4D|PLAT|PTGDR|PTGER1|PTGER2|PTGER3|PTGER4|PTGFR|PTGIR|TBXA2R imatinib Launched Bcr-Abl kinase inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor ABL1|CSF1R|DDR1|KIT|NTRK1|PDGFRA|PDGFRB|RET imeglimin Phase 2 gluconeogenesis inhibitor imetit Preclinical histamine receptor agonist HRH3|HRH4 imexon Phase 2 apoptosis stimulant|ribonucleotide reductase inhibitor RRM1|RRM2 imidacloprid Launched acetylcholine receptor antagonist CHRFAM7A imidafenacin Launched acetylcholine receptor antagonist CHRM1|CHRM3 imidapril Launched angiotensin converting enzyme inhibitor ACE imidurea Preclinical other antibiotic imiloxan Phase 1 adrenergic receptor antagonist ADRA2A|ADRA2B imipenem Launched bacterial cell wall synthesis inhibitor imipramine Launched norepinephrine reputake inhibitor|serotonin reuptake inhibitor ADRA1A|ADRA1B|ADRA1D|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD5|HRH1|HTR1A|HTR2A|HTR2C|HTR6|HTR7|KCND2|KCND3|KCNH1|KCNH2|SLC6A2|SLC6A3|SLC6A4 imiquimod Launched interferon inducer|toll-like receptor agonist TLR7|TLR8 immepip Preclinical histamine receptor agonist HRH3|HRH4 immethridine Phase 1 histamine receptor agonist HRH3 impentamine Preclinical histamine receptor antagonist HRH3 IMREG-1 Phase 3 INC-280 Phase 2 c-Met inhibitor MET INCA-6 Preclinical calcineurin inhibitor NFATC1 INCB-003284 Phase 2 CC chemokine receptor antagonist INCB-024360 Phase 2 "indoleamine 2,3-dioxygenase inhibitor" IDO1 INCB-3284 Phase 2 CC chemokine receptor antagonist CCR2 indacaterol Launched adrenergic receptor agonist ADRB1|ADRB2 indalpine Withdrawn selective serotonin reuptake inhibitor (SSRI) SLC6A4 indapamide Launched thiazide diuretic KCNE1|KCNQ1|SLC12A3 indatraline Preclinical norepinephrine transporter inhibitor MAOA|MAOB indeloxazine Withdrawn norepinephrine reuptake inhibitor|serotonin reuptake inhibitor indibulin Phase 1/Phase 2 tubulin polymerization inhibitor indinavir Launched HIV protease inhibitor CYP3A4|CYP3A5|CYP3A7 indiplon Phase 3 benzodiazepine receptor agonist GABRA1 indirubin Phase 2/Phase 3 CDK inhibitor|glycogen synthase kinase inhibitor CDK1|CDK5|GSK3A indirubin-3-monoxime Preclinical CDK inhibitor|glycogen synthase kinase inhibitor CDK1|CDK2|CDK5|CDK5R1|GSK3B indisulam Phase 2 CDK inhibitor CA1|CA12|CA14|CA2|CA6|CA7|CA9 indium(iii)-isopropoxide Preclinical indobufen Launched cyclooxygenase inhibitor|platelet aggregation inhibitor PTGS1|PTGS2 indocyanine-green Launched contrast agent SLCO1B1 indole-3-carbinol Phase 2/Phase 3 "aryl hydrocarbon receptor agonist|indoleamine 2,3-dioxygenase inhibitor" AHR indole-3-pyrubate Phase 2 melatonin receptor agonist indomethacin Launched cyclooxygenase inhibitor GLO1|PLA2G2A|PPARA|PPARG|PTGDR2|PTGR2|PTGS1|PTGS2|SLC46A1 indoprofen Withdrawn cyclooxygenase inhibitor|prostanoid receptor antagonist CXCR1|CXCR2|PTGS1|PTGS2 indoramin Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2B|ADRA2C indoximod Phase 2 "indoleamine 2,3-dioxygenase inhibitor" IDO1 ingenol-mebutate Launched PKC activator PRKCA|PRKCB|PRKCD|PRKCE|PRKCG INH1 Preclinical Hec1 inhibitor NDC80 inimur Launched other antifungal iniparib Phase 3 PARP inhibitor PARP1 inosine Launched neurotrophic agent PARP1|PNP inositol Launched insulin sensitizer CDIPT|GBA inositol-hexanicotinate Launched INS316 Phase 2 purinergic receptor antagonist INT-747 Phase 3 FXR agonist INT-767 Phase 1 FXR agonist GPBAR1 integrin-antagonist-1 Phase 1 integrin antagonist ITGAV|ITGB6 iobenguane Launched antineoplastic agent iocetamic-acid Launched radiopaque medium iodipamide Launched radiopaque medium ALB iodixanol Launched radiopaque medium iodoantipyrine Preclinical iododexetimide Phase 2 acetylcholine receptor antagonist iodophenpropit Preclinical histamine receptor antagonist HRH3|HRH4 iodoquinol Launched antiseptic iohexol Launched radiopaque medium iopamidol Launched radiopaque medium iopanic-acid Preclinical thyroid hormone inhibitor iopodic-acid Launched iopromide Launched radiopaque medium iothalamic-acid-d3 Preclinical radiopaque medium ioversol Launched radiopaque medium IOWH032 Phase 2 CFTR channel antagonist CFTR ioxaglic-acid Launched radiopaque medium ioxilan Launched radiopaque medium IOX1 Preclinical histone demethylase inhibitor EGLN1|KDM3A|KDM4C|KDM6B IOX2 Preclinical hypoxia inducible factor inhibitor EGLN1|KDM2A|KDM5C IPA-3 Preclinical p21 activated kinase inhibitor PAK1 IPAG Preclinical IPI-145 Phase 3 PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG ipidacrine Phase 3 acetylcholinesterase inhibitor ACHE ipragliflozin-l-proline Launched sodium/glucose cotransporter inhibitor SLC5A2 ipratropium Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 ipriflavone Launched bone resorption inhibitor iproniazid Withdrawn monoamine oxidase inhibitor MAOA|MAOB ipsapirone Phase 3 serotonin receptor agonist HTR1A irbesartan Launched angiotensin receptor antagonist AGTR1|JUN|SLC10A1 irinotecan Launched topoisomerase inhibitor TOP1|TOP1MT IRL-2500 Preclinical endothelin receptor antagonist EDNRB irosustat Phase 2 steroid sulfatase inhibitor CA2|STS irsogladine Launched phosphodiesterase inhibitor PDE4A isamoltane Phase 1 adrenergic receptor antagonist HTR1A|HTR1B isavuconazole Phase 3 cytochrome P450 inhibitor CYP3A4 isaxonine Withdrawn nerve growth factor agonist isbufylline Phase 2 phosphodiesterase inhibitor isepamicin Launched protein synthesis inhibitor isobutamben Preclinical local anesthetic isobutyramide Phase 2 gene expression stimulant HBE1|HBG1 isocarboxazid Launched monoamine oxidase inhibitor MAOA|MAOB isoconazole Launched fungal lanosterol demethylase inhibitor CYP17A1 isodibut Phase 2 aldehyde reductase inhibitor isoetharine Launched adrenergic receptor agonist ADRB1|ADRB2 isofloxythepin Phase 2 dopamine receptor antagonist isoflupredone-acetate Preclinical NR3C1 isoflurane Launched inhaled anaesthetic ATP2C1|ATP5D|CALM1|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GLRA1|GLRB|GRIA1|KCNA1|KCNK10|KCNK18|KCNK2|KCNK3|KCNK9 isoflurophate Launched cholinesterase inhibitor ACHE|BCHE isoguvacine Preclinical benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRR1|GABRR2|GABRR3 isoleucine Launched ACADSB|BCAT1|BCAT2|IARS|IARS2 isoliquiritigenin Preclinical guanylate cyclase activator GABBR1 isometheptene-mucate Launched ADRA1A|SLC18A2 isoniazid Launched FABI inhibitor CYP1A2|CYP2C19|CYP2C8|CYP2E1|CYP3A4 isopentyl-4-methoxycinnamate Launched isoprenaline Launched adrenergic receptor agonist ADRB1|ADRB2|ADRB3|MAPK1|PIK3R1|PIK3R2|PIK3R3 isopropamide-iodide Launched acetylcholine receptor antagonist CHRM3|CHRM4 isopropyl-myristate Launched isopropyl-palmitate Launched cosmetic moisturizer isosorbide Launched nitric oxide stimulant isosorbide-dinitrate Launched nitric oxide stimulant GUCY1A2|GUCY1A3|GUCY1B2|GUCY1B3|NPR1 isosorbide-mononitrate Launched nitric oxide stimulant GUCY1A2|GUCY1A3|GUCY1B2|GUCY1B3 isosteviol Phase 2 isotiquimide Phase 1 isotretinoin Launched retinoid receptor agonist RARA|RARB|RARG isovaleramide Phase 2 alcohol dehydrogenase inhibitor isoxepac Phase 2 anti-inflammatory agent isoxicam Withdrawn cyclooxygenase inhibitor PTGS1|PTGS2 isoxsuprine Launched adrenergic receptor agonist ADRB2 ispinesib Phase 2 kinesin inhibitor KIF11 isradipine Launched calcium channel blocker CACNA1C|CACNA1D|CACNA1F|CACNA1H|CACNA1S|CACNA2D1|CACNA2D2|CACNB2 ISRIB Preclinical eukaryotic translation initiation factor inhibitor|PERK inhibitor EIF2A|EIF2AK3 istaroxime Phase 2 ATPase inhibitor ATP1A1 istradefylline Launched adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 itacitinib Phase 2 JAK inhibitor JAK1 ITI214 Phase 1 phosphodiesterase inhibitor PDE1A itopride Launched dopamine receptor antagonist CHRM3|DRD2 itraconazole Launched cytochrome P450 inhibitor CYP51A1 ITX3 Preclinical GEF inhibitor TRIO IU1 Preclinical ubiquitin C-terminal hydrolase inhibitor USP14 ivabradine Launched HCN channel antagonist|potassium channel blocker|sodium channel blocker HCN1|HCN3|HCN4 ivacaftor Launched CFTR channel potentiator CFTR ivermectin Launched benzodiazepine receptor agonist CHRNA7|GABRB3|GLRA3|P2RX7 ivosidenib Phase 1/Phase 2 isocitrate dehydrogenase inhibitor IDH1 IWP-L6 Preclinical porcupine inhibitor PORCN ixabepilone Launched microtubule stabilizing agent TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA3D|TUBA3E|TUBA4A|TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8 ixazomib Launched proteasome inhibitor ixazomib-citrate Launched proteasome inhibitor JAK3-inhibitor-V Preclinical JAK inhibitor JAK3 JDTic Phase 1 opioid receptor antagonist OPRK1 JIB04 Preclinical histone lysine demethylase inhibitor KDM4E JK-184 Preclinical hedgehog pathway inhibitor JLK-6 Preclinical gamma secretase inhibitor PSEN1 JNJ-10191584 Preclinical histamine receptor antagonist HRH4 JNJ-16259685 Preclinical glutamate receptor antagonist GRM1 JNJ-1661010 Preclinical FAAH inhibitor FAAH JNJ-17203212 Preclinical TRPV antagonist TRPV1 JNJ-26481585 Phase 2 HDAC inhibitor HDAC1|HDAC10|HDAC11|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9|MDM2 JNJ-26990990 Phase 2 anticonvulsant JNJ-37822681 Phase 2 dopamine receptor antagonist DRD2 JNJ-38877605 Phase 1 tyrosine kinase inhibitor MET JNJ-40411813 Phase 2 glutamate receptor positive allosteric modulator GRM2 JNJ-42041935 Preclinical hypoxia inducible factor prolyl hydroxylase inhibitor PDK2 JNJ-42165279 Phase 2 FAAH inhibitor FAAH JNJ-63533054 Preclinical G protein-coupled receptor agonist GPR139 JNJ-7706621 Preclinical CDK inhibitor AURKA|AURKB|CDK1|CDK2 JNJ-7777120 Preclinical histamine receptor antagonist HRH4 josamycin Launched bacterial 50S ribosomal subunit inhibitor JQ1-(+) Preclinical bromodomain inhibitor BRD4|BRDT JTC-801 Phase 2 opioid receptor antagonist OPRL1 JTE-013 Preclinical lysophospholipid receptor antagonist P2RY10|S1PR2 JTE-607 Phase 2 cytokine production inhibitor IL10|IL1B|IL6|TNF JTE-907 Phase 1 cannabinoid receptor inverse agonist CNR2 JW-74 Preclinical WNT signaling inhibitor|tankyrase inhibitor TNKS|TNKS2 JX-401 Preclinical p38 MAPK inhibitor MAPK14 JZL-184 Preclinical monoacylglucerol lipase inhibitor MGLL K-MAP Phase 2 K-Ras(G12C)-inhibitor-12 Preclinical K-ras inhibitor KRAS K-Ras(G12C)-inhibitor-6 Preclinical K-ras inhibitor k-strophanthidin Phase 2 ATPase inhibitor ATP1A1 K-247 Phase 1 K-858 Preclinical kinesin-like spindle protein inhibitor KIF11 kaempferol Preclinical bone resorption inhibitor|estrogen-related receptor inverse agonist AKR1B1|ALOX15B|ALOX5|AR|CYP1B1|GLO1|HSD17B1|UGT3A1 kainic-acid Preclinical kainate receptor agonist GRIA1|GRIK1|GRIK2|GRIK3|GRIK4|GRIK5 kakonein Phase 2 GABA receptor antagonist|serotonin receptor antagonist kanamycin Launched bacterial 30S ribosomal subunit inhibitor KB-R7943 Preclinical sodium/calcium exchange inhibitor SLC8A1|TRPC3|TRPC5|TRPC6 KBG Phase 2 neprilysin inhibitor MME KD-023 Phase 2 ACAT inhibitor ACACA|ACACB KD025 Phase 2 rho associated kinase inhibitor ROCK2 kenpaullone Preclinical CDK inhibitor|glycogen synthase kinase inhibitor CCNB1|CDK1|CDK5|GSK3B ketanserin Launched serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|DRD1|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR5A|HTR7|SLC18A1|SLC18A2 ketoconazole Launched sterol demethylase inhibitor AR|CYP19A1|CYP21A2|KCNA10 ketoprofen Launched cyclooxygenase inhibitor CXCR1|PTGS1|PTGS2|SLC5A8 ketorolac Launched cyclooxygenase inhibitor PTGS1|PTGS2 ketotifen Launched histamine receptor agonist|leukotriene receptor antagonist|phosphodiesterase inhibitor HRH1|PDE4A|PDE4B|PDE4C|PDE4D|PDE7A|PDE7B|PDE8A|PDE8B|PGD kevetrin Phase 1 p53 activator KF-38789 Preclinical P selectin inhibitor SELP KH-CB19 Preclinical CDC inhibitor CLK1|CLK3|DYRK1A khellin Phase 2 vasodilator KHK-IN-1 Preclinical hexokinase inhibitor KHK KI-16425 Preclinical lysophosphatidic acid receptor antagonist LPAR1|LPAR3 KI-8751 Preclinical KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor KDR kifunensine Phase 1 mannosidase inhibitor MAN1B1|MAN2A1 kinetin Launched cell division inducer ki16198 Preclinical lipoprotein antagonist LPA KML29 Preclinical monoacylglucerol lipase inhibitor MGLL KN-62 Preclinical calcium/calmodulin dependent protein kinase inhibitor|purinergic receptor antagonist AKT1|CAMK2A|CHEK1|LCK|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|P2RX7|PRKCA|ROCK1|RPS6KB1|SGK1 KN-93 Preclinical calcium/calmodulin dependent protein kinase inhibitor CAMK2A Ko143 Preclinical BCRP inhibitor ABCB1|ABCC1 KP-1212 Phase 2 KPT-185 Preclinical exportin antagonist XPO1 KPT-276 Preclinical exportin antagonist XPO1 KRN-633 Preclinical VEGFR inhibitor FLT1|FLT4|KDR KT-433 Phase 2 uricosuric agent ku-0063794 Preclinical mTOR inhibitor MTOR KU-55933 Preclinical ATM kinase inhibitor ATM|PRKDC KU-60019 Preclinical ATM kinase inhibitor ATM kuromanin Preclinical ribosyl cyclase inhibitor CD38 KU14R Preclinical imidazoline receptor antagonist KW-2449 Phase 1 Abl kinase inhibitor|Aurora kinase inhibitor|FLT3 inhibitor ABL1|AURKA|AURKB|FLT3 KW-2478 Phase 1/Phase 2 HSP inhibitor KX2-391 Phase 2 src inhibitor|tubulin polymerization inhibitor SRC kynurenic-acid Preclinical glutamate receptor antagonist GPR35|GRIN1|GRIN2A|GRIN2B KY02111 Preclinical Wnt pathway inhibitor DKK1 K02288 Preclinical bone morphogenic protein inhibitor BMP1 K145 Preclinical sphingosine kinase inhibitor SPHK2 L-(+)-Rhamnose-Monohydrate Preclinical L-alanine Launched L-Arginine Launched nitric oxide precursor ARG2|ASL|ASS1|AZIN2|GPRC6A|NOS2|NOS3|SLC7A1|SLC7A3|SLC7A4 L-Ascorbyl-6-palmitate Preclinical L-asparagine Phase 3 ASNS|ASRGL1|NARS|NARS2|SLC1A5|SLC38A3 L-asparagine-n-hydroxy Preclinical L-Aspartic-Acid Launched metallic radical formation stimulant ACY1|ACY3|ADSS|ADSSL1|ASNS|ASPA|ASPH|ASRGL1|ASS1|CAD|DARS|DARS2|GOT1|GOT2|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|LYZ|PAICS|RNASE1|SLC1A1|SLC25A12|SLC25A13 L-Citrulline Launched nitric oxide stimulant ASS1|DDAH1|DDAH2|GPRC6A|NOS1|NOS2|NOS3|OTC|PADI1|PADI2|PADI3|PADI4|PADI6 L-cysteine Launched CARS|CARS2|CBS|CDO-1|CDO1|CSAD|CTH|GCLC|GCLM|GOT1|GSS|MGMT|NFS1|SLC19A3 L-Cysteinesulfinic-acid Preclinical glutamate receptor agonist GRM1|GRM5|GSR|HMGCS2|PAPOLA|PRDX2 L-Cystine Launched CTNS|SLC3A1|SLC7A11|SLC7A9 L-ergothioneine Phase 2 free radical scavenger L-glutamic-acid Launched glutamate receptor agonist AADAT|AASS|ABAT|ALDH18A1|ASNS|BCAT1|BCAT2|CCBL2|DNPEP|EARS2|ENPEP|EPRS|FOLH1|FPGS|FTCD|GAD1|GAD2|GATB|GCLC|GCLM|GGCX|GLS|GLS2|GLUD1|GLUD2|GLUL|GMPS|GOT1|GOT2|GPT|GPT2|GRIA1|GRIA2|GRIA3|GRIA4|GRID1|GRID2|GRIK1|GRIK2|GRIK3|GRIK4|GRIK5|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B|GRM1|GRM2|GRM3|GRM4|GRM6|GRM7|GRM8|LGSN|NADSYN1|NAGS|OPLAH|PFAS|PGCP|PSAT1|SLC1A1|SLC1A2|SLC1A3|SLC1A6|SLC1A7|SLC25A18|SLC25A22|SLC7A11|TAT L-Hydroxyproline Launched L-leucine Phase 3 BCAT1|BCAT2|LARS|LARS2|LCMT1|LCMT2 L-lysine Phase 2 serotonin receptor agonist GPRC6A|KARS|SLC7A1|SLC7A2|SLC7A3|SLC7A4 L-methionine Launched voltage-gated calcium channel ligand L-mimosine Preclinical dopamine beta hydroxylase inhibitor|eukaryotic translation initiation factor inhibitor DBH|EIF5A L-monomethylarginine Phase 3 nitric oxide synthase inhibitor NOS1|NOS2 L-NAME Phase 2/Phase 3 nitric oxide synthase inhibitor NOS3 L-NIL Preclinical nitric oxide synthase inhibitor NOS1|NOS2|NOS3 L-proline Launched glutamate receptor agonist EPRS|L3HYPDH|P3H1|P3H2|P3H3|P4HA1|P4HA2|PARS2|PPIA|PPIB|PPIC|PPIF|PPIG|PPIH|PRODH|PROSC|PYCR1|PYCR2|PYCRL|SLC6A14|SLC6A7 L-Quisqualic-acid Preclinical glutamate receptor agonist FOLH1|GRIA2|GRIK1|GRIK2|GRM1|GRM2|GRM3|GRM5|GRM7|GRM8 L-Theanine Launched glutamate receptor antagonist L-threonine Phase 2 TARS|TARS2|THNSL1 L-152804 Preclinical neuropeptide receptor antagonist NPY5R L-161982 Preclinical prostanoid receptor antagonist PTGER4 L-165041 Preclinical PPAR receptor agonist PPARD L-168049 Preclinical glucagon receptor antagonist GCGR L-365260 Phase 2 CCK receptor antagonist CCKAR|CCKBR|KCNQ1 L-368899 Phase 1 oxytocin receptor antagonist AVPR1A|AVPR2|OXTR L-655240 Phase 1 thromboxane receptor antagonist PTGES L-670596 Preclinical prostanoid receptor antagonist L-689560 Preclinical glutamate receptor antagonist GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D L-690330 Preclinical inositol monophosphatase inhibitor IMPA1 L-693403 Preclinical sigma receptor agonist|sigma receptor antagonist DRD2|SIGMAR1 L-694247 Preclinical serotonin receptor agonist HTR1A|HTR1B|HTR1D L-701252 Preclinical glutamate receptor antagonist GRIN1 L-701324 Preclinical glutamate receptor antagonist GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D L-733060 Preclinical tachykinin antagonist TACR1 L-741742 Preclinical dopamine receptor antagonist DRD3|DRD4|SCN1A|SCN3A L-745870 Preclinical dopamine receptor antagonist DRD1|DRD2|DRD3|DRD4|HTR1A|HTR2A|HTR6|HTR7 L-755507 Preclinical adrenergic receptor agonist ADRB1|ADRB2|ADRB3 L-778123 Phase 1 farnesyltransferase inhibitor FNTA|FNTB|PGGT1B labetalol Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRB1|ADRB2 lacidipine Launched calcium channel blocker CACNA1C lacitol Launched osmosis stimulant lacosamide Launched collapsin response mediator protein inhibitor|collapsin response mediator protein stimulant|sodium channel blocker SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A lactulose Launched laxative lafutidine Launched histamine receptor antagonist HRH2 lamivudine Launched nucleoside reverse transcriptase inhibitor lamotrigine Launched serotonin receptor antagonist|sodium channel blocker SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A lanatoside-c Preclinical cardiac glycoside landiolol Launched adrenergic receptor antagonist ADRB1 lanoconazole Launched sterol demethylase inhibitor lansoprazole Launched ATPase inhibitor ATP4A|ATP4B lapatinib Launched EGFR inhibitor EGFR|ERBB2 lappaconite Phase 2 sodium channel blocker laquinimod Phase 3 immunosuppressant CXCL2 laropiprant Launched prostanoid receptor antagonist PTGDR|PTGDR2|PTGER1|PTGER2|PTGER3|PTGFR|PTGIR|TBXA2R lasalocid Launched bacterial permeability inducer lasofoxifene Launched selective estrogen receptor modulator (SERM) ESR1|ESR2 latamoxef Launched bacterial cell wall synthesis inhibitor latanoprost Launched prostanoid receptor agonist PTGFR latrepirdine Phase 3 glutamate receptor antagonist HRH1|HTR6 latrunculin-b Phase 1 actin polymerization inhibitor ACTA1|MKL1|SPIRE2 lauric-acid Phase 3 bacterial permeability inducer GPR84|HNF4A|LTF|LY96|PLA2G2A|TLR4 lauric-diethanolamide Preclinical laurocapram Phase 3 lazabemide Phase 3 monoamine oxidase inhibitor MAOB LB-100 Phase 1 protein phosphatase inhibitor LB42708 Preclinical farnesyltransferase inhibitor LCL-161 Phase 2 XIAP inhibitor BIRC2|XIAP LCQ908 Phase 3 diacylglycerol O acyltransferase inhibitor DGAT1 LCZ696 Launched angiotensin receptor antagonist LDC1267 Preclinical protein tyrosine kinase inhibitor AXL|MERTK|TYRO3 LDN-212854 Preclinical bone morphogenic protein inhibitor ABL1|ACVR1|RIPK2 LDN-57444 Preclinical ubiquitin C-terminal hydrolase inhibitor LDN193189 Preclinical bone morphogenic protein inhibitor ACVR1|BMPR1A LE-135 Preclinical retinoid receptor agonist RARB ledipasvir Launched HCV inhibitor leflunomide Launched dihydroorotate dehydrogenase inhibitor|PDGFR tyrosine kinase receptor inhibitor AHR|DHODH|PTK2B lemborexant Phase 3 orexin receptor antagonist HCRTR1|HCRTR2 lenalidomide Launched anticancer agent CDH5|CRBN|PTGS2|TNF|TNFSF11 lenvatinib Launched FGFR inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor FLT4|KDR lercanidipine Launched calcium channel blocker CACNA2D1|CACNG1 lerisetron Phase 3 serotonin receptor antagonist HTR3A lersivirine Phase 2 non-nucleoside reverse transcriptase inhibitor lesinurad Launched uric acid diuretic SLC22A12 lestaurtinib Phase 3 FLT3 inhibitor|growth factor receptor inhibitor|JAK inhibitor FLT3|NTRK1 leteprinim Phase 2 nerve growth factor agonist letermovir Phase 3 CMV terminase inhibitor letosteine Launched mucolytic agent letrozole Launched aromatase inhibitor CYP19A1 leucomethylene-blue Phase 3 nitric oxide production inhibitor|tau aggregation inhibitor MAPT leucovorin Launched folate receptor ligand TYMS leucylleucine-methyl-ester Phase 2 leuprolide Launched gonadotropin releasing factor hormone receptor agonist GNRHR levalbuterol Launched adrenergic receptor agonist ADRB2 levallorphan Launched opioid antagonist CHRNA2|OPRM1 levamisole Withdrawn acetylcholine receptor agonist ALPL|ALPPL2|CHRNA3 levcromakalim Phase 3 potassium channel activator KCNJ5|KCNJ8 levetiracetam Launched calcium channel blocker CACNA1B|SCN1A|SV2A levo-phencynonate Launched acetylcholine receptor antagonist CHRM1 levobunolol Launched adrenergic receptor antagonist ADRB1|ADRB2|ADRB3 levobunolol-(+) Preclinical adrenergic receptor antagonist levobunolol-(+/-) Preclinical adrenergic receptor antagonist levocabastine Launched histamine receptor antagonist HRH1|NTSR2 levocarnitine Launched levocarnitine-propionate Launched carnitine palmitoyltransferase inhibitor CRAT levocetirizine Launched histamine receptor antagonist HRH1 levodopa Launched dopamine precursor DRD1|DRD2|DRD3|DRD4|DRD5|GPR143 levodropropizine Launched antitussive levofloxacin Launched bacterial DNA gyrase inhibitor TOP2A levomenol Launched levomenthol Launched OPRK1|TRPA1|TRPM8|TRPV3 levomepromazine Launched dopamine receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR2A|HTR2C levomequitazine Phase 2 histamine receptor antagonist HRH1 levonordefrin Launched vasodilator ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|SLC6A2 levonorgestrel Launched estrogen receptor agonist|glucocorticoid receptor antagonist|progesterone receptor agonist|progesterone receptor antagonist AR|ESR1|PGR|SRD5A1 levopropoxyphene Launched antitussive OPRD1|OPRK1|OPRM1 levosimendan Launched calcium sensitizer KCNJ11|KCNJ8|PDE3A|TNNC1 levosulpiride Launched dopamine receptor antagonist CA1|CA12|CA7|DRD2|DRD3 levothyroxine Launched thyroid hormone stimulant THRA|THRB LFM-A13 Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK LGK-974 Phase 2 porcupine inhibitor PORCN LGX818 Phase 3 RAF inhibitor BRAF LH846 Preclinical casein kinase inhibitor CSNK1D licarbazepine Phase 3 voltage-gated sodium channel blocker SCN5A licochalcone-a Phase 3 topoisomerase inhibitor PTPN1 licofelone Phase 3 cyclooxygenase inhibitor|lipoxygenase inhibitor ALOX5|PLA2G2E|PTGS2 lidamidine Launched adrenergic receptor agonist lidocaine Launched histamine receptor agonist EGFR|SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A lidoflazine Launched calcium channel blocker SCN1A|SCN3A|SLC29A1 ligustilide Preclinical tumor necrosis factor production inhibitor TNF limaprost-alfadex Launched prostanoid receptor agonist PTGER1 limonin Preclinical HIV protease inhibitor linaclotide Launched guanylate cyclase activator GUCY2C linagliptin Launched dipeptidyl peptidase inhibitor DPP4 linalool Phase 1 anticonvulsant lincomycin Launched bacterial 30S ribosomal subunit inhibitor lindane Launched GABRB1|GLRA1|GLRA2|GLRA3|GLRB linezolid Launched bacterial 50S ribosomal subunit inhibitor MAOA|MAOB linifanib Phase 3 PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor CSF1|CSF1R|FLT1|FLT3|FLT4|KDR|KIT|PDGFRB|RET|TEK linoleic-acid Phase 3 oxidative stress inducer FABP4|FFAR1|FFAR4|HNF4A|KCNB1|PPARG|TRPM8 linopirdine Phase 3 potassium channel blocker KCNQ2|KCNQ3|KCNQ4|KCNQ5 linsidomine Launched nitric oxide donor linsitinib Phase 3 IGF-1 inhibitor IGF1R|INSR|INSRR liothyronine Launched thyroid hormone stimulant THRA|THRB liothyronine-(isomer) Preclinical lipoamide Preclinical liraglutide Launched GLP receptor agonist GLP1R liranaftate Launched fungal squalene epoxidase inhibitor lirimilast Phase 2 phosphodiesterase inhibitor lisadimate Launched topical sunscreen agent lisinopril Launched angiotensin converting enzyme inhibitor ACE|ACE2 lisofylline Phase 2 interleukin receptor antagonist|STAT inhibitor lisuride Launched dopamine receptor agonist ADRA1A|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR6 lithium-acetoacetate Preclinical lithium-citrate Launched lithocholic-acid Preclinical FXR antagonist|vitamin D receptor agonist GPBAR1|NR1H4|NR1I2|VDR litronesib Phase 2 kinesin-like spindle protein inhibitor KIF11 lixivaptan Phase 3 vasopressin receptor antagonist AVPR2 LMI070 Phase 1/Phase 2 survival motor neuron protein modulator SMN1 LM11A-31 Phase 1 neurotrophic agent NGFR lobeline Launched acetylcholine receptor antagonist CHRNA10|CHRNA9|SLC18A2 lobendazole Preclinical anthelmintic agent lobenzarit Launched immunosuppressant lodoxamide Launched histamine receptor antagonist lofemizole Phase 3 cyclooxygenase inhibitor lofepramine Launched norepinephrine reuptake inhibitor|serotonin–norepinephrine reuptake inhibitor (SNRI) HTR1A|SLC6A2|SLC6A4 lofexidine Launched adrenergic receptor agonist ADRA2A lomefloxacin Launched bacterial DNA gyrase inhibitor TOP2A lomeguatrib Phase 2 O6-alkylguanine-DNA alkyltransferase inhibitor MGMT lomerizine Launched calcium channel blocker CACNA1B|SCN5A lometrexol Phase 2 glycinamide ribonucleotide formyltransferase inhibitor GART|MTHFD1 lomitapide Launched microsomal trigylceride transfer protein inhibitor MTTP lomustine Launched DNA synthesis inhibitor STMN4 lonafarnib Phase 3 farnesyltransferase inhibitor FNTA|HRAS|KRAS|NRAS lonidamine Launched glucokinase inhibitor GCK loperamide Launched opioid receptor agonist CACNA1A|CALM1|OPRD1|OPRK1|OPRM1|POMC lopinavir Launched HIV protease inhibitor loracarbef Launched bacterial cell wall synthesis inhibitor loratadine Launched histamine receptor antagonist HRH1 lorazepam Launched benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|TSPO lorcaserin Launched serotonin receptor agonist HTR2A|HTR2B|HTR2C loreclezole Phase 2 benzodiazepine receptor agonist GABRB2|GABRB3 lorediplon Phase 2 GABA receptor modulator GABRA1 lorglumide Phase 1 CCK receptor antagonist CCKAR|CCKBR lorlatinib Phase 2 ALK tyrosine kinase receptor inhibitor ALK lornoxicam Launched cyclooxygenase inhibitor PTGS1|PTGS2 losartan Launched angiotensin receptor antagonist AGTR1 losmapimod Phase 3 p38 MAPK inhibitor MAPK14 loteprednol Launched glucocorticoid receptor agonist|phospholipase inhibitor NR3C1 lovastatin Launched HMGCR inhibitor HDAC2|HMGCR|ITGAL|NR1I2 loxapine Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRA2C|ADRB1|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HRH2|HRH4|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2C|HTR3A|HTR5A|HTR6|HTR7|SLC6A2|SLC6A3|SLC6A4 loxistatin-acid Preclinical cysteine peptidase inhibitor CTSB LOXO-101 Phase 2 tropomyosin receptor kinase inhibitor NTRK1|NTRK2|NTRK3 loxoprofen Launched cyclooxygenase inhibitor|prostanoid receptor antagonist PTGS2 LPA2-antagonist-1 Preclinical lysophosphatidic acid receptor antagonist LPAR2 LRRK2-IN-1 Preclinical leucine rich repeat kinase inhibitor LRRK2 LTA Phase 2 LTB4 Phase 2 leukocyte activator LTB4R|LTB4R2 lubiprostone Launched chloride channel activator CLCN2 lucitanib Phase 2 FGFR inhibitor|VEGFR inhibitor FGFR1|FLT1|KDR|KIT|PDGFRA|PDGFRB|RET lufenuron Launched chitin inhibitor luliconazole Launched sterol demethylase inhibitor lumacaftor Launched CFTR channel agonist CFTR lumateperone Phase 3 serotonin receptor antagonist|dopamine receptor modulator DRD2|HTR2A lumefantrine Launched antimalarial agent ATP1A1 lumiracoxib Withdrawn cyclooxygenase inhibitor PTGS1|PTGS2 lupanine Phase 1 sodium channel blocker INS lurasidone Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA2A|ADRA2C|DRD2|HTR1A|HTR2A|HTR7 lutein Launched antioxidant luteolin Phase 2 glucosidase inhibitor TOP1 luzindole Preclinical melatonin receptor antagonist MTNR1A|MTNR1B LXR-623 Phase 1 LXR agonist AR|NR1H2|NR1H3|NR1I2|NR3C1 LX1031 Phase 2 tryptophan hydroxylase inhibitor TPH1 LX7101 Phase 1/Phase 2 LIM kinase inhibitor|rho associated kinase inhibitor LIMK2|ROCK1|ROCK2 lycopene Phase 3 free radical scavenger lylamine Preclinical cannabinoid receptor agonist CNR1 lymecycline Launched bacterial 50S ribosomal subunit inhibitor lynestrenol Launched progestogen hormone lypressin Launched vasopressin receptor agonist AVPR1A|AVPR1B|AVPR2 LY2090314 Phase 2 glycogen synthase kinase inhibitor GSK3B LY2109761 Preclinical TGF beta receptor inhibitor TGFBR1|TGFBR2 LY2140023 Phase 3 glutamate receptor agonist GRM3 LY215490 Phase 1 glutamate receptor antagonist GRIA1|GRIA2|GRIA3|GRIA4|GRIK1 LY2157299 Phase 2/Phase 3 TGF beta receptor inhibitor TGFBR1 LY2183240 Preclinical FAAH inhibitor|FAAH reuptake inhibitor FAAH LY2228820 Phase 2 p38 MAPK inhibitor MAPK14 LY223982 Phase 2 leukotriene receptor antagonist LTB4R LY225910 Preclinical CCK receptor antagonist CCKBR LY231617 Preclinical lipid peroxidase inhibitor LY2334737 Phase 1 antitumor agent|ribonucleotide reductase inhibitor LY2365109 Preclinical Glycine transporter 1 inhibitor SLC6A9 LY2452473 Phase 2 androgen receptor modulator AR LY255283 Preclinical leukotriene receptor antagonist LTB4R|LTB4R2 LY2584702 Phase 1 ribosomal protein inhibitor RPS6KB1 LY2603618 Phase 2 CHK inhibitor CHEK1 LY2606368 Phase 2 CHK inhibitor CHEK1 LY2608204 Phase 2 glucokinase activator GCK LY2784544 Phase 2 JAK inhibitor JAK2|JAK3 LY2801653 Phase 2 MET inhibitor MET LY2811376 Phase 1 beta-secretase inhibitor BACE1 LY2835219 Phase 3 CDK inhibitor CDK4|CDK6 LY2857785 Preclinical CDK inhibitor CDK9 LY2874455 Phase 1 FGFR antagonist FGFR1|FGFR2|FGFR3|FGFR4|KDR LY288513 Preclinical CCK receptor antagonist CCKBR LY2886721 Phase 1/Phase 2 beta-secretase inhibitor BACE1 LY294002 Preclinical mTOR inhibitor|PI3K inhibitor|DNA dependent protein kinase inhibitor|phosphodiesterase inhibitor|PLK inhibitor AKT1|CHEK1|GSK3B|LCK|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG|PLK1|PRKCA|PRKDC|ROCK1|RPS6KB1|SGK1 LY2979165 Phase 1 glutamate receptor agonist GRM2 LY3000328 Phase 1 cathepsin inhibitor CTSS LY3009120 Phase 1 RAF inhibitor BRAF|RAF1 LY3023414 Phase 2 PI3K inhibitor|mTOR inhibitor MTOR LY303511 Preclinical casein kinase inhibitor|mTOR inhibitor|PI3K inhibitor BRD2|BRD3|BRD4 LY310762 Preclinical serotonin receptor antagonist HTR1D LY320135 Preclinical cannabinoid receptor antagonist CNR1 LY344864 Preclinical serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR7 LY364947 Preclinical TGF beta receptor inhibitor|p38 MAPK inhibitor TGFBR1 LY393558 Preclinical serotonin receptor antagonist HTR1B|HTR1D|HTR2A|HTR2B LY411575 Preclinical gamma secretase inhibitor LY450108 Phase 1 glutamate receptor modulator LY456236 Preclinical glutamate receptor antagonist GRM1 m-Chlorophenylbiguanide Preclinical HTR3A|HTR3B m-THP Phase 1 M-14157 Phase 2 ATP-sensitive potassium channel antagonist KCNQ1 m-3M3FBS Preclinical PLCB2|PLCB3|PLCD1|PLCG1|PLCG2 M-344 Preclinical HDAC inhibitor mabuprofen Launched cyclooxygenase inhibitor mabuterol Launched adrenergic receptor agonist ADRB2 macelignan Preclinical antioxidant|antiinflammatory agent macitentan Launched endothelin receptor antagonist EDNRA|EDNRB madrasin Preclinical cell splicing inhibitor mafenide Launched carbonic anhydrase inhibitor CA12|CA14|CA2|CA4|CA6|CA9 magnolol Preclinical PPAR receptor agonist GABRA1|PPARG malathion Launched cholinesterase inhibitor ACHE|BCHE malic-acid Launched CS|ME2|PKD2L1 malotilate Launched protein synthesis stimulant maltobionic-acid Launched matrix metalloprotease inhibitor mandelic-acid Launched mangafodipir Launched contrast agent manidipine Launched calcium channel blocker CACNA1C|CACNA1D mannitol-D Launched diuretic maprotiline Launched norepinephrine reputake inhibitor|tricyclic antidepressant ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD2|HRH1|HTR2A|HTR2C|HTR7|SLC6A2 maraviroc Launched CC chemokine receptor antagonist CCR5 marbofloxacin Launched bacterial DNA gyrase inhibitor maribavir Phase 3 cytomegalovirus inhibitor|protein kinase inhibitor PYGM marimastat Phase 3 matrix metalloprotease inhibitor MMP1|MMP10|MMP11|MMP12|MMP13|MMP14|MMP15|MMP16|MMP17|MMP19|MMP2|MMP20|MMP21|MMP23A|MMP24|MMP25|MMP26|MMP27|MMP28|MMP3|MMP7|MMP8|MMP9 maropitant Launched neurokinin receptor antagonist TACR1 masitinib Launched KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|src inhibitor FGFR3|KIT|PDGFRA|PDGFRB masoprocol Launched lipoxygenase inhibitor ALOX5 matrine Phase 2 opioid receptor agonist OPRK1 mavoglurant Phase 2 glutamate receptor antagonist GRM5 maxacalcitol Launched vitamin D receptor agonist VDR maytansinol-isobutyrate Preclinical mazindol Launched dopamine reuptake inhibitor|selective serotonin reuptake inhibitor (SSRI) SLC6A2|SLC6A3|SLC6A4 MBX-2982 Phase 2 glucose dependent insulinotropic receptor agonist GPR119 MC-1 Phase 3 AADAT|ABAT|AGXT|AGXT2|ALAS1|AZIN2|BCAT1|BCAT2|CBS|CCBL1|CCBL2|CSAD|CTH|DDC|FTCD|GAD1|GAD2|GADL1|GCAT|GLDC|GOT1|GOT2|GPT|GPT2|HDC|IGSF10|KYNU|MOCOS|NFS1|OAT|ODC1|PDXDC1|PDXP|PHYKPL|PNPO|PROSC|PSAT1|PYGB|PYGL|PYGM|SCLY|SDS|SDSL|SEPSECS|SGPL1|SHMT1|SHMT2|SPTLC1|SPTLC2|SPTLC3|SRR|TAT|THNSL1 MCC950 Preclinical NOD like receptor inhibitor NLRP3 McN-5652-(+/-) Preclinical selective serotonin reuptake inhibitor (SSRI) mCPP Phase 2 serotonin receptor agonist HTR1A|HTR1D|HTR1E|HTR2A|HTR2B|HTR2C|HTR6 MC1568 Preclinical HDAC inhibitor HDAC2 MD-920 Phase 1 NFkB pathway inhibitor AADACL2 mdivi-1 Preclinical dynamin inhibitor DNM1 MDL-11939 Phase 2 serotonin receptor antagonist HTR2A|HTR2B|HTR2C MDL-27531 Preclinical glycine receptor agonist MDL-29951 Preclinical glutamate receptor antagonist FBP1 MDL-72832 Preclinical serotonin receptor agonist HTR1A MDL-73005EF Phase 1 serotonin receptor antagonist HTR1A MDMS Phase 2 DNA inhibitor mebendazole Launched tubulin polymerization inhibitor TUBA1A|TUBB|TUBB4B mebeverine Launched acetylcholine receptor antagonist CHRM1 mebhydrolin Launched antihistamine mebicar Launched anxiolytic mebrofenin Launched mecamylamine Launched acetylcholine receptor antagonist CHRNA1|CHRNA2|CHRNA3|CHRNA4|CHRNA6|CHRNA7 mecarbinate Preclinical mechlorethamine Launched DNA inhibitor meclinertant Phase 2/Phase 3 neurotensin receptor antagonist NTSR1|NTSR2 meclizine Launched constitutive androstane receptor (CAR) agonist HRH1|NR1I3 meclocycline-sulfosalicylate Launched bacterial 50S ribosomal subunit inhibitor meclofenamic-acid Launched cyclooxygenase inhibitor|prostanoid receptor antagonist ALOX5|CNR1|KCNQ2|KCNQ3|PTGS1|PTGS2 meclofenoxate Launched nootropic agent mecysteine Launched analgesic agent medetomidine Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C medica-16 Phase 2 ATP citrase lyase inhibitor FFAR1 medorinone Phase 1 medronic-acid Launched bone resorption inhibitor medroxyprogesterone Launched progesterone receptor agonist ESR1|PGR medroxyprogesterone-acetate Launched progesterone receptor agonist medrysone Launched glucocorticoid receptor agonist NR3C1 mefenamic-acid Launched cyclooxygenase inhibitor KCNQ1|PTGS1|PTGS2|TRPM3 mefexamide Preclinical psychoactive drug mefloquine Launched adenosine receptor antagonist|hemoglobin antagonist ADORA2A|HBA1 megestrol-acetate Launched progesterone receptor agonist NR3C1|PGR meglitinide Phase 2 potassium channel blocker CCR2 meglumine Launched excipient meglutol Launched HMGCR inhibitor HMGCR meisoindigo Phase 3 STAT inhibitor STAT3 MEK1-2-inhibitor Preclinical MEK inhibitor MAP2K2 MEK162 Phase 3 MEK inhibitor MAP2K1|MAP2K2 melatonin Launched melatonin receptor agonist|nitric oxide synthase inhibitor ASMT|CALM1|CALR|EPX|ESR1|HTR2B|MPO|MTNR1A|MTNR1B|NQO2|RORB meldonium Launched gamma butyrobetaine hydroxylase inhibitor BBOX1 melengestrol-acetate Preclinical progesterone receptor agonist melevodopa Launched dopamine precursor|dopamine receptor agonist DDC meloxicam Launched cyclooxygenase inhibitor PTGS1|PTGS2 melperone Launched dopamine receptor antagonist|serotonin receptor antagonist DRD2|HTR2A melphalan Launched DNA alkylating agent|DNA inhibitor melphalan-n-oxide Phase 1 hypoxia inducible factor inhibitor HIF1A meluadrine Preclinical memantine Launched glutamate receptor antagonist CHRFAM7A|DRD2|GRIN1|GRIN2A|GRIN2B|GRIN3A|HTR3A menadione Launched mitochondrial DNA polymerase inhibitor|phosphatase inhibitor AOX1|BGLAP|F10|F2|F7|F9|GGCX|NQO1|NQO2|PROC|PROS1|PROZ|VKORC1|VKORC1L1 menadione-bisulfite Phase 2 vitamin K GGCX|VKORC1|VKORC1L1 menatetrenone Launched bone resorption inhibitor menbutone Launched mepacrine Launched cytokine production inhibitor|NFkB pathway inhibitor|TP53 activator PLA2G1B|PLA2G4A|PLA2G6|PLCL1 meparfylon Preclinical mepazine Phase 2 MALT1 inhibitor (JH) MALT1 mepenzolate Launched acetylcholine receptor antagonist CHRM1|CHRM3 mephenesin Launched muscle relaxant mephentermine Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3 mephenytoin Launched hydantoin antiepileptic SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A mepiroxol Preclinical mepivacaine Launched potassium channel blocker|sodium channel blocker SCN10A meprednisone Launched NR3C1 meprobamate Launched GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ meprylcaine Preclinical local anesthetic meptazinol Launched opioid receptor agonist BCHE mepyramine Launched histamine receptor antagonist HRH1 mequinol Launched TYR merbarone Phase 2 topoisomerase inhibitor TOP2A merbromin Launched antiseptic mercaptopurine Launched immunosuppressant|protein synthesis inhibitor|purine antagonist HPRT1|IMPDH1|IMPDH2|PPAT mercaptosuccinic-acid Launched mericitabine Phase 2 HCV inhibitor merimepodib Phase 2 inosine monophosphate dehydrogenase inhibitor IMPDH1 meropenem Launched bacterial cell wall synthesis inhibitor mesalazine Launched cyclooxygenase inhibitor|lipoxygenase inhibitor|prostanoid receptor antagonist ALOX5|CHUK|IKBKB|MPO|PPARG|PTGS1|PTGS2 mesna Launched antioxidant mesoridazine Launched dopamine receptor antagonist DRD2|HTR2A mestinon Launched cholinesterase inhibitor ACHE|BCHE mestranol Launched estrogen receptor agonist ESR1 mesulergine Phase 2 dopamine receptor agonist HTR2A|HTR2B|HTR2C|HTR3A|HTR3B|HTR6|HTR7 meta-cresyl-acetate Preclinical metacetamol Preclinical analgesic agent metacresol Launched INS metafolin Launched AMT metamizole Withdrawn cyclooxygenase inhibitor|opioid receptor agonist PTGS1 metaphit Preclinical phencyclidine receptor acylator metaproterenol Launched adrenergic receptor agonist ADRB2 metaraminol Launched adrenergic receptor agonist ADRA1A metatinib Phase 1 Bcr-Abl kinase inhibitor ABL1|BCR metaxalone Launched muscle relaxant metazosin Phase 2 adrenergic receptor antagonist ADRA1A metenkephalin Phase 2 immunostimulant OPRD1 metergoline Launched dopamine receptor agonist|serotonin receptor antagonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|HTR7 metformin Launched insulin sensitizer ACACB|PRKAB1 methacholine Launched acetylcholine receptor agonist CHRM2|CHRM3|CHRM4 methacycline Launched protein synthesis inhibitor methanesulfonyl-fluoride Phase 2 acetylcholinesterase inhibitor ACHE methantheline Launched acetylcholine receptor antagonist CHRM1|HRH2 methapyrilene Withdrawn histamine receptor antagonist HRH1 metharbital Launched GABA receptor modulator CHRNA4|CHRNA7|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIA2|GRIK2 methazolamide Launched carbonic anhydrase inhibitor CA1|CA12|CA14|CA2|CA4|CA7 methenamine Launched bacterial DNA inhibitor methiazole Preclinical anthelmintic agent methicillin Launched bacterial cell wall synthesis inhibitor methimazole Launched antithyroid agent TPO methionine Launched BHMT|BHMT2|METAP2|MTR|MTRR methiopril Phase 2 angiotensin converting enzyme inhibitor ACE methocarbamol Launched muscle relaxant CA1 methoprene-(s) Preclinical methotrexate Launched dihydrofolate reductase inhibitor DHFR methoxamine Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D methoxsalen Launched DNA synthesis inhibitor CYP1A1|CYP1A2|CYP2A13|CYP2A6|CYP3A4 methoxyamine Phase 2 DNA repair enzyme inhibitor APEX1 methoxyflurane Launched membrane permeability inhibitor ATP2C1|ATP5D|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GLRA1|GLRB|GRIA1|KCNA1|MT-ND1 methoxyphenamine Launched adrenergic receptor agonist methscopolamine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3 methsuximide Launched T-type calcium channel binder CACNA1G|CACNA1H|CACNA1I methyclothiazide Launched chloride reabsorption inhibitor CA1|CA2|CA4|SLC12A1|SLC12A3 methyl-aminolevulinate Launched oxidizing agent FCGR1A|FECH methyl-nicotinate Phase 2 methyl-salicylate Launched methylatropine-nitrate Preclinical acetylcholine receptor antagonist CHRM1 methylbenzethonium-chloride Preclinical other antibiotic methyldopa Launched adrenergic receptor agonist ADRA2A|ADRA2B|ADRA2C|DDC methyldopate Launched methylene-blue Launched guanylyl cyclase inhibitor|nitric oxide production inhibitor ACHE methylergometrine Launched dopamine receptor antagonist|serotonin receptor antagonist DRD1|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C methyllycaconitine Preclinical acetylcholine receptor antagonist CHRNA7 methylnaltrexone Launched opioid receptor antagonist OPRD1|OPRK1|OPRM1 methylparaben Launched other antifungal methylphenidate Launched dopamine-norepinephrine reuptake inhibitor SLC6A2|SLC6A3|SLC6A4 methylprednisolone Launched glucocorticoid receptor agonist NR3C1 methylprednisolone-aceponate Launched anti-inflammatory agent|glucocorticoid receptor agonist NR3C1 methylprednisolone-sodium-succinate Launched glucocorticoid receptor agonist methylthiouracil Launched methysergide Launched serotonin receptor antagonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|HTR7 meticrane Launched diuretic metipranolol Withdrawn adrenergic receptor antagonist ADRB1|ADRB2 metirosine Launched tyrosine hydroxylase inhibitor TH metitepine Preclinical anti-HCVE2 HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|HTR7 metixene Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 metoclopramide Launched dopamine receptor antagonist|serotonin receptor antagonist CHRM1|DRD2|HTR3A|HTR3B|HTR4 metocurine Launched acetylcholine receptor antagonist CHRM2|CHRNA2 metolazone Launched carbonic anhydrase inhibitor SLC12A3 metoprolol Launched adrenergic receptor antagonist ADRB1|ADRB2 metoxibutropate Launched cyclooxygenase inhibitor PTGS1|PTGS2 metrifonate Phase 3 acetylcholinesterase inhibitor ACHE metrizamide Launched radiopaque medium metrizoic-acid Launched radiopaque medium metronidazole Launched DNA inhibitor CYP2C9|CYP3A4 metyrapone Launched cytochrome P450 inhibitor CYP11B1 mevastatin Preclinical HMGCR inhibitor HMGCR mexeneone Preclinical mexiletine Launched sodium channel blocker AHR|SCN4A|SCN5A mezlocillin Launched bacterial cell wall synthesis inhibitor ME0328 Preclinical PARP inhibitor PARP3 MF-101 Phase 3 estrogen receptor agonist CYP19A1|XDH MG-132 Preclinical proteasome inhibitor PSMB1 MG-624 Preclinical acetylcholine receptor antagonist CHRNA7 MGCD-265 Preclinical VEGFR inhibitor AXL|MET mianserin Launched serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD5|HRH1|HRH2|HRH4|HTR1A|HTR1F|HTR2A|HTR2B|HTR2C|HTR6|HTR7|OPRK1|SLC6A2|SLC6A3|SLC6A4 mibampator Phase 2 glutamate receptor modulator GRIA1 mibefradil Withdrawn T-type calcium channel blocker ANO1|CACNA1C|CACNA1D|CACNA1F|CACNA1G|CACNA1H|CACNA1I|CACNA1S|CACNB1|CACNB2|CACNB3|CACNB4|CATSPER1|CATSPER2|CATSPER3|CATSPER4 micafungin Launched "fungal 1,3-beta-D-glucan synthase inhibitor" miconazole Launched bacterial cell wall synthesis inhibitor KCNH2|KCNH6|KCNH7|KCNMA1|KCNMB1|KCNMB2|KCNMB3|KCNMB4|KCNN1|KCNN2|KCNN3|KCNN4|NOS2|NOS3|TRPM2|TRPV5 micronomicin Launched protein synthesis inhibitor midafotel Phase 3 glutamate receptor antagonist GRIN2A|GRIN2B|GRIN2C|GRIN2D midecamycin Launched protein synthesis inhibitor midodrine Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D midostaurin Phase 3 FLT3 inhibitor|KIT inhibitor|PKC inhibitor FLT3|PRKCG mifepristone Launched glucocorticoid receptor antagonist|progesterone receptor antagonist AR|NR1I2|NR3C1|PGR mifobate Phase 2 PPAR receptor antagonist PPARG miglitol Launched glucosidase inhibitor GAA|GANAB|GANC|MGAM miglustat Launched Glycosyl transferase inhibitor UGCG milacemide Phase 3 monoamine oxidase inhibitor MAOB milnacipran Launched serotonin–norepinephrine reuptake inhibitor (SNRI) GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B|SLC6A2|SLC6A4 milrinone Launched phosphodiesterase inhibitor PDE2A|PDE3A|PDE3B|PDE5A miltefosine Launched membrane integrity inhibitor PLA2G1B mimosine Preclinical DNA replication inhibitor CCL2|SHMT1|SHMT2|TYR minaprine Withdrawn serotonin reuptake inhibitor ACHE|CHRM1|DRD1|DRD2|HTR2A|HTR2B|HTR2C|MAOA|SLC6A4 minerval Phase 1/Phase 2 FAAH inhibitor minocycline Launched bacterial 30S ribosomal subunit inhibitor ALOX5|CASP1|CASP3|CYCS|IL1B|MMP9|VEGFA minodronic-acid Launched bone resorption inhibitor FDPS|GGPS1 minoxidil Launched KATP activator|Kir6 channel (KATP) activator|vasodilator ABCC9|KCNJ1|KCNJ10|KCNJ11|KCNJ8|PTGS1 miocamycin Launched other antibiotic MIRA-1 Preclinical apoptosis stimulant mirabegron Launched adrenergic receptor agonist ADRB1|ADRB2|ADRB3 miriplatin Launched DNA synthesis inhibitor mirodenafil Launched phosphodiesterase inhibitor PDE5A mirtazapine Launched adrenergic receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|DRD1|DRD2|DRD3|DRD5|HRH1|HRH3|HTR2A|HTR2B|HTR2C|HTR3A|HTR7|OPRK1|SLC6A2|SLC6A3|SLC6A4 misonidazole Phase 3 misoprostol Launched prostanoid receptor agonist PTGER2|PTGER3|PTGER4|PTGIR mitiglinide Launched insulin secretagogue ABCC8|KCNJ10|PPARG mitoflaxone Phase 2 antitumor agent VWF mitomycin-c Launched DNA alkylating agent|DNA synthesis inhibitor mitotane Launched antineoplastic agent CYP11A1|CYP11B1|ESR1|FDX1 mitoxantrone Launched topoisomerase inhibitor TOP2A mivacurium Launched acetylcholine receptor antagonist BCHE|CHRM2|CHRM3|CHRNA2 mivobulin Preclinical microtubule inhibitor mizolastine Launched histamine receptor antagonist HRH1 mizoribine Launched immunosuppressant|inosine monophosphate dehydrogenase inhibitor IMPDH1 MK-0354 Phase 2 niacin receptor agonist HCAR2|HCAR3 MK-0752 Phase 1/Phase 2 gamma secretase inhibitor MK-0773 Phase 2 androgen receptor modulator AR MK-0812 Phase 2 CC chemokine receptor antagonist CCR2 MK-0893 Phase 2 glucagon receptor antagonist GCGR MK-1775 Phase 2 WEE1 kinase inhibitor WEE1 MK-2048 Preclinical HIV integrase inhibitor MK-2206 Phase 2 AKT inhibitor AKT1|AKT2|AKT3 MK-2295 Phase 2 TRPV antagonist TRPV1 MK-2461 Phase 1/Phase 2 FGFR inhibitor|VEGFR inhibitor FGFR1|FGFR2|FGFR3|FLT1|FLT3|FLT4|KDR|MERTK|MET|MST1R|NTRK1|NTRK2|PDGFRB MK-2894 Preclinical prostaglandin inhibitor PTGER4 MK-3207 Phase 2 calcitonin antagonist CALCA MK-3697 Phase 2 orexin receptor antagonist HCRTR2 MK-5046 Preclinical bombesin receptor agonist BRS3|GRPR|NMBR MK-5108 Phase 1 Aurora kinase inhibitor AURKA|AURKB|AURKC MK-571 Phase 2 leukotriene receptor antagonist ABCC2|CYSLTR1 MK-6096 Phase 2 orexin receptor antagonist HCRTR1|HCRTR2 MK-8033 Phase 1 c-Met inhibitor MET MK-8245 Phase 2 stearoyl-CoA desaturase inhibitor SCD MK-8745 Preclinical Aurora kinase inhibitor AURKA MKT-077 Phase 1 HSP inhibitor MK2-IN-1 Preclinical MAP kinase inhibitor MAPKAPK2 ML-323 Preclinical ubiquitin specific protease inhibitor USP1 ML-9 Preclinical myosin light chain kinase inhibitor TRPC6 MLN-8054 Phase 1 Aurora kinase inhibitor AURKA MLN0128 Phase 2 mTOR inhibitor MTOR|PIK3CA|PIK3CD|PIK3CG MLN1117 Phase 1/Phase 2 PI3K inhibitor PIK3CA MLN2480 Phase 1 RAF inhibitor MLN9708 Phase 3 proteasome inhibitor ML130 Preclinical NOD1 inhibitor ML133 Preclinical potassium channel blocker ML161 Preclinical protease-activated receptor inhibitor ML167 Preclinical CLK inhibitor|DYRK inhibitor CLK4|DYRK1B ML204 Preclinical transient receptor potential channel antagonist TRPC4|TRPC5 ML314 Preclinical neurotensin agonist NTSR1 ML324 Preclinical histone lysine demethylase inhibitor KDM4A ML347 Preclinical ALK tyrosine kinase receptor inhibitor ACVR1|ACVRL1|BMPR1A MM-102 Preclinical WDR5/MLL interaction inhibitor MMPX Preclinical phosphodiesterase inhibitor MM77 Preclinical serotonin receptor antagonist HTR1A MN-64 Preclinical tankyrase inhibitor TNKS MNITMT Preclinical lymphocyte inhibitor mocetinostat Phase 2 HDAC inhibitor HDAC1|HDAC11|HDAC2|HDAC3 moclobemide Launched monoamine oxidase inhibitor MAOA|MAOB modafinil Launched adrenergic receptor agonist ADRA1B|SLC6A3 modaline Preclinical moexipril Launched angiotensin converting enzyme inhibitor ACE|ACE2 mofegiline Phase 1 monoamine oxidase inhibitor MAOA|MAOB mofezolac Launched cyclooxygenase inhibitor PTGS1 moguisteine Phase 2 ATP-sensitive potassium channel inhibitor molidustat Phase 2 hypoxia inducible factor inhibitor EGLN2 molindone Launched dopamine receptor antagonist CHRM1|DRD2|HRH1|HTR1A|HTR2A molsidomine Launched guanylate cyclase stimulant GUCY1A3 mometasone Launched glucocorticoid receptor agonist NR3C1 mometasone-furoate Launched glucocorticoid receptor agonist NR3C1 monastrol Preclinical kinesin inhibitor KIF11 monensin Launched bacterial permeability inducer monobenzone Launched melanin inhibitor TYR monoctanoin Launched monosodium-alpha-luminol Launched monostearin Preclinical montelukast Launched leukotriene receptor antagonist ALOX5|CYSLTR1 moprolol Launched adrenergic receptor antagonist moracizine Launched sodium channel blocker SCN5A morantel Launched acetylcholine receptor agonist morin Preclinical cytochrome P450 inhibitor ADORA2A|ESR2|FASN|MCL1|SLC22A12 morinidazole Launched other antibiotic CYP51A1 morniflumate Launched anti-inflammatory agent moroxydine Launched antiviral mosapride Launched serotonin receptor agonist HTR4 motesanib Phase 3 KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor FLT1|FLT4|KDR|KIT motolimod Phase 1/Phase 2 toll-like receptor agonist TLR8 moxalactam Launched bacterial cell wall synthesis inhibitor moxaverine Launched phosphodiesterase inhibitor moxidectin Launched chloride channel antagonist moxifloxacin Launched bacterial DNA gyrase inhibitor TOP2A moxisylyte Withdrawn adrenergic receptor antagonist moxonidine Launched imidazoline receptor agonist ADRA2A|ADRA2B|ADRA2C mozavaptan Launched vasopressin receptor antagonist AVPR1A|AVPR1B|AVPR2 MPEP Preclinical glutamate receptor antagonist GRM1|GRM4|GRM5 MPI-0479605 Preclinical mitotic kinase inhibitor TTK Mps1-IN-5 Preclinical protein kinase inhibitor MR-16728 Preclinical acetylcholine release enhancer MR-948 Phase 1 thromboxane synthase inhibitor TBXAS1 MRK-016 Phase 1 GABA receptor inverse agonist GABRA1|GABRA2|GABRA3|GABRA5 MRK-409 Phase 1 benzodiazepine receptor agonist MRS-1220 Preclinical adenosine receptor antagonist ADORA2B|ADORA3 MRS1334 Preclinical adenosine receptor antagonist ADORA3 MRS1845 Preclinical calcium channel blocker MRS2578 Preclinical purinergic receptor antagonist P2RY6 MRS3777 Preclinical adenosine receptor antagonist ADORA2A MSX-122 Phase 1 CC chemokine receptor antagonist CXCR4 MTPG Preclinical glutamate receptor antagonist GRM2|GRM3 mubritinib Phase 1 protein tyrosine kinase inhibitor EGFR|ERBB2 mupirocin Launched isoleucyl-tRNA synthetase inhibitor muscimol Phase 1 benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRR1|GABRR2|GABRR3 MUT056399 Phase 1 FABI inhibitor MY-5445 Preclinical phosphodiesterase inhibitor|platelet aggregation inhibitor PDE5A mycophenolate-mofetil Launched dehydrogenase inhibitor|inositol monophosphatase inhibitor IMPDH1|IMPDH2 mycophenolic-acid Launched dehydrogenase inhibitor|inositol monophosphatase inhibitor IMPDH1|IMPDH2 myricetin Preclinical androgen receptor agonist|cytochrome P450 inhibitor PIK3CG myricitrin Preclinical PKC inhibitor NOS1|PRKCA myristyl-nicotinate Phase 1 topical sunscreen agent N-(2-chlorophenyl)-2-({(2E)-2-[1-(2-pyridinyl)ethylidene]hydrazino}carbothioyl)hydrazinecarbothioamide Preclinical N-(3-methoxyphenyl)prop-2-enamide Preclinical N-(4-chlorophenyl)acrylamide Preclinical N-(4-Methoxyphenyl)acrylamide Preclinical N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide Preclinical sigma receptor ligand N-acetyl-D-glucosamine Phase 2/Phase 3 B4GALT1|B4GALT2|B4GALT3|B4GALT4|NAGK|NAGLU|NAGPA|RENBP N-acetyl-tyrosine Launched N-acetylcarnosine Phase 2 N-acetylglycyl-D-glutamic-acid Preclinical glutamate receptor agonist N-acetylmannosamine Phase 1 CHIT1 N-acetyltryptamine Preclinical melatonin receptor agonist N-alpha-Methylhistamine-dihydrochloride Phase 3 histamine receptor agonist HRH4 N-benzylacrylamide Preclinical N-benzylnaltrindole Preclinical opioid receptor antagonist N-cyanopyrrolidine Preclinical CTSK N-demethylantipyrine Preclinical N-hydroxynicotinamide Preclinical N-methylformamide Phase 2 N-methyllidocaine-iodide Preclinical antiarrhythmic medication N-methylpyrrolidone Phase 1 N-methylquipazine Preclinical serotonin receptor agonist HTR1A|HTR1D|HTR2A|HTR2B|HTR2C|HTR3A|HTR3B|HTR6|SLC6A4 N-MPPP Preclinical opioid receptor agonist N-oxydiethylenebenzothiazole-2-sulfenamide Preclinical N-phenylacrylamide Preclinical N-salicoylaminophenol Preclinical ribonucleotide reductase inhibitor nabumetone Launched cyclooxygenase inhibitor PTGS1|PTGS2 nadide Launched electron acceptor AHCY|AKR1A1|ALDH2|BLVRA|DHPS|DLD|GALE|HMGCR|HSD17B1|HSD17B4|IMPDH2|MGAM|P2RY11|SORD|TRPM2 nadifloxacin Launched bacterial DNA gyrase inhibitor nadolol Launched adrenergic receptor antagonist ADRB1|ADRB2|ADRB3 NADPH Preclinical AASS|DPYD|GHSR|TXNRD1 nafadotride Preclinical dopamine receptor antagonist DRD2|DRD3|HTR1A nafamostat Launched serine protease inhibitor ASIC1|ASIC2|ASIC3|C1R|PRSS1|TPSAB1|TRPM7 nafcillin Launched bacterial cell wall synthesis inhibitor CYP1A2|CYP3A4|SLC22A6 naftidrofuryl Launched adrenergic receptor antagonist naftifine Launched fungal squalene epoxidase inhibitor SQLE naftopidil Launched adrenergic receptor antagonist ADRA1A nalbuphine Launched opioid receptor agonist|opioid receptor antagonist OPRD1|OPRK1|OPRM1 nalfurafine Launched opioid receptor agonist OPRK1|OPRM1 nalidixic-acid Launched bacterial DNA gyrase inhibitor nalmefene Launched opioid receptor antagonist OPRD1|OPRK1|OPRM1 naloxegol Launched opioid receptor antagonist OPRM1 naloxone Launched opioid receptor antagonist CREB1|ESR1|OPRD1|OPRK1|OPRM1|TLR4 naloxone-benzoylhydrazone Preclinical opioid receptor antagonist OPRK1|OPRM1 naltrexone Launched opioid receptor antagonist OPRD1|OPRK1|OPRM1|SIGMAR1 naltriben Preclinical opioid receptor antagonist OPRD1|OPRK1|OPRM1 naltrindole Preclinical opioid receptor antagonist OPRD1|OPRK1|OPRM1 Nampt-IN-1 Preclinical NAN-190 Preclinical serotonin receptor agonist ADRA1A|ADRA1B|ADRA1D|HTR1A|HTR1F nanchangmycin Preclinical other antibiotic nandrolone Launched imidazoline receptor agonist AR|CYP19A1|MAOA|MAOB nandrolone-decanoate Phase 1 androgenic steroid AR napabucasin Phase 3 STAT inhibitor STAT3 naphazoline Launched adrenergic receptor agonist ADRA1A|ADRA2A naphthoquine-phosphate Launched antimalarial agent napirimus Phase 1 immunosuppressant naproxen Launched cyclooxygenase inhibitor PTGS1|PTGS2 narasin Launched antiprotozoal agent naratriptan Launched serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F naringenin Phase 1 aromatase inhibitor|TRPV antagonist CYP19A1|CYP1B1|ESR2|GLO1|HSD17B1 naringeninic-acid Phase 1 HCAR2|PTGR1 naringin Preclinical cytochrome P450 inhibitor SLCO1A2 naringin-dihydrochalcone Preclinical cytochrome P450 inhibitor narlaprevir Phase 2/Phase 3 HCV inhibitor nastorazepide Phase 2 CCK receptor antagonist CCKBR natamycin Launched fungal ergosterol inhibitor nateglinide Launched insulin secretagogue ABCC8|KCNJ10|KCNJ11|PPARG navarixin Phase 2 CC chemokine receptor antagonist CXCR1|CXCR2 navitoclax Phase 2 BCL inhibitor BCL2|BCL2L1|BCL2L2 NBI-27914 Preclinical corticosteroid releasing factor receptor antagonist CRHR1 NBQX Preclinical glutamate receptor antagonist GRIA1|GRIA2|GRIA3|GRIA4|GRIK1|GRIN1|GRIN2A|GRIN2B NCS-382 Preclinical GABA receptor antagonist GABBR1|GABBR2|SLC52A2 NE-100 Phase 2 sigma receptor antagonist SIGMAR1 nebivolol Launched adrenergic receptor antagonist ADRB1|ADRB2 nebracetam Phase 3 acetylcholine receptor agonist CHRM1 NECA Launched adenosine receptor agonist ADORA1|ADORA2A|ADORA2B|ADORA3|HSP90B1 necrostatin-1 Preclinical RIPK inhibitor RIPK1 necrostatin-2 Preclinical necroptosis inhibitor|RIPK inhibitor RIPK2 nedaplatin Launched DNA inhibitor nedocromil Launched histamine receptor antagonist CYSLTR1|CYSLTR2|FPR1|HSP90AA1|PTGDR nefazodone Withdrawn adrenergic inhibitor|norepinephrine reuptake inhibitor|serotonin receptor antagonist|serotonin reuptake inhibitor ADRA1A|ADRA1B|ADRA2A|CYP3A4|HTR1A|HTR2A|HTR2C|SLC6A2|SLC6A3|SLC6A4 nefiracetam Phase 3 acetylcholine receptor agonist|benzodiazepine receptor agonist CHRM1 nefopam Launched cyclooxygenase inhibitor nelarabine Launched DNA synthesis inhibitor|T cell inhibitor POLA1 nelfinavir Launched HIV protease inhibitor CYP1A2|CYP2B6|CYP2C19|CYP2C9|CYP2D6|CYP3A4|CYP3A7 nemonapride Launched dopamine receptor antagonist DRD2|DRD3|DRD4 nemorubicin Phase 2 topoisomerase inhibitor TOP1|TOP2A neo-gilurytmal Launched neohesperidin Preclinical neohesperidin-dihydrochalcone Preclinical neomycin Launched bacterial 30S ribosomal subunit inhibitor CXCR4 neomycin-sulfate Launched bacterial 30S ribosomal subunit inhibitor neostigmine Launched acetylcholinesterase inhibitor ACHE nepafenac Launched cyclooxygenase inhibitor PTGS1|PTGS2 nepicastat Phase 2 dopamine beta hydroxylase inhibitor DBH neratinib Phase 3 EGFR inhibitor EGFR|ERBB2|KDR nerbacadol Phase 3 cyclooxygenase inhibitor neridronic-acid Launched bone resorption inhibitor FDPS nesbuvir Phase 2 RNA polymerase inhibitor netilmicin Launched protein synthesis inhibitor netupitant Launched tachykinin antagonist TACR1 neurodazine Preclinical neurogenesis of non-pluripotent C2C12 myoblast inducer nevirapine Launched non-nucleoside reverse transcriptase inhibitor CYP1A2|CYP2A6|CYP2B6|CYP2C9|CYP2D6|CYP3A4|CYP3A5 nexturastat-a Preclinical HDAC inhibitor HDAC1|HDAC6 NFKB-activation-inhibitor-II Preclinical NFkB pathway inhibitor RELA NG-nitro-arginine Phase 1 nitric oxide synthase inhibitor NOS1|NOS2|NOS3 NGB-2904 Preclinical dopamine receptor antagonist DRD3 NGD-94-1 Phase 1 dopamine receptor antagonist DRD4 NH125 Preclinical eukaryotic translation elongation factor 2 inhibitor niacin Launched NAD precursor|vitamin B DGAT2|HCAR1|HCAR2|HCAR3|NNMT|QPRT nialamide Withdrawn monoamine oxidase inhibitor COMT|MAOA|MAOB nibentan Phase 2 potassium channel blocker nicaraven Phase 3 free radical scavenger nicardipine Launched calcium channel blocker ADORA3|ADRA1A|ADRA1B|ADRA1D|CACNA1C|CACNA1D|CACNA2D1|CACNB2|CALM1|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|PDE1A|PDE1B nicergoline Launched adrenergic receptor antagonist ADRA1A niceritrol Launched NAD precursor niclosamide Launched DNA replication inhibitor|STAT inhibitor STAT3 nicorandil Launched nitric oxide donor|potassium channel activator KCNJ11 nicotinamide Launched protein synthesis stimulant BST1|LDHA|PARP1|SIRT5 nicotine Launched acetylcholine receptor agonist CHAT|CHRNA10|CHRNA2|CHRNA3|CHRNA4|CHRNA5|CHRNA6|CHRNA7|CHRNA9|CHRNB2|CHRNB3|CHRNB4|CYP19A1|TBXAS1|TRPA1 nicotinyl-alcohol-tartrate Launched nifedipine Launched calcium channel blocker CACNA1C|CACNA1D|CACNA1F|CACNA1H|CACNA1S|CACNA2D1|CACNB2|CALM1|GLRA1|GLRA3|GLRB|KCNA1|KCNA5|NR1I2|TRPM3 nifekalant Launched potassium channel blocker nifenalol Launched adrenergic receptor antagonist ADRB1|ADRB2 nifenazone Launched analgesic agent niflumic-acid Launched cyclooxygenase inhibitor ANO1|CLCN1|CLCNKA|CLCNKB|KCNQ1|PLA2G1B|PLA2G4A|PTGS1|PTGS2|UGT1A9 nifuroxazide Launched bacterial DNA inhibitor nifursol Launched bacterial DNA inhibitor nifurtimox Launched DNA inhibitor niguldipine-(S)-(+) Preclinical adrenergic receptor antagonist ADRA1A nikethamide Withdrawn immunostimulant nilotinib Launched Abl kinase inhibitor|Bcr-Abl kinase inhibitor ABL1|KIT nilutamide Launched androgen receptor antagonist AR nilvadipine Launched calcium channel blocker CACNA1C|CACNA1D|CACNA1S|CACNA2D1|CACNA2D3|CACNB2 nimesulide Launched cyclooxygenase inhibitor LTF|PLA2G2E|PTGS1|PTGS2 nimodipine Launched calcium channel blocker AHR|CACNA1C|CACNA1D|CACNA1F|CACNA1S|CACNB1|CACNB2|CACNB3|CACNB4|CFTR|NR3C2 nimorazole Launched bacterial DNA inhibitor nimustine Launched DNA alkylating agent nintedanib Launched FGFR inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor FGFR1|FGFR2|FGFR3|FGFR4|FLT1|FLT4|KDR|PDGFRA|PDGFRB niraparib Phase 3 PARP inhibitor PARP1 niridazole Launched phosphofructokinase inhibitor nisin Phase 1 bacterial cell wall synthesis inhibitor nisoldipine Launched calcium channel blocker CACNA1C|CACNA1D|CACNA1F|CACNA1S|CACNA2D1|CACNB2 nisoxetine Phase 1 norepinephrine reuptake inhibitor SLC6A2|SLC6A3|SLC6A4 nitarsone Launched nitazoxanide Launched pyruvate ferredoxin oxidoreductase inhibitor nitecapone Phase 2 catechol O methyltransferase inhibitor COMT nitenpyram Launched nithiamide Preclinical bacterial DNA inhibitor nitisinone Launched hydroxyphenylpyruvate dioxygenase inhibitor HPD nitrendipine Launched calcium channel blocker CACNA1C|CACNA1D|CACNA1H|CACNA1S|CACNA2D1|CACNA2D2|CACNB2|CACNG1|KCNN4 nitrocaramiphen Preclinical cholinergic receptor antagonist CHRM1 nitrofurantoin Launched DNA inhibitor nitrofurazone Launched bacterial DNA inhibitor nitromide Launched nitrosodimethylurea Preclinical DNA synthesis inhibitor nitroxoline Launched cathepsin inhibitor METAP2 nizatidine Launched histamine receptor antagonist HRH2 nizofenone Launched ion channel antagonist NKP-1339 Phase 1 HSP inhibitor NLG919 Phase 1 "indoleamine 2,3-dioxygenase inhibitor" IDO1 NMDA Preclinical glutamate receptor agonist GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D NMS-E973 Preclinical HSP inhibitor NMS-P715 Preclinical protein kinase inhibitor NMS-1286937 Phase 1 PLK inhibitor FLT3|PLK1|PLK2|PLK3 NMS-873 Preclinical ATPase inhibitor VCP NM107 Phase 2 RNA polymerase inhibitor NNC-05-2090 Preclinical GABA uptake inhibitor|GAT inhibitor SLC6A12 NNC-55-0396 Preclinical T-type calcium channel blocker CATSPER1|CATSPER2|CATSPER3|CATSPER4 NNC-63-0532 Preclinical opioid receptor agonist OPRL1 NNC-711 Preclinical GABA uptake inhibitor SIGMAR1|SLC6A1 NO-ASA Phase 2 cyclooxygenase inhibitor PTGS2 nobiletin Preclinical MEK inhibitor MAP2K1 nocodazole Preclinical tubulin polymerization inhibitor HPGDS nolatrexed Phase 3 thymidylate synthase inhibitor TYMS nomegestrol-acetate Launched progesterone receptor agonist PGR nomifensine Withdrawn dopamine uptake inhibitor|noradrenaline uptake inhibitor DRD2|MAOA|MAOB|MPO|SLC6A2|SLC6A3 nonivamide Launched TRPV agonist TRPV1 nonoxynol-9 Launched membrane integrity inhibitor nor-Binaltorphimine-dihydrochloride Preclinical opioid receptor antagonist OPRD1|OPRK1|OPRM1 norcyclobenzaprine Preclinical adrenergic receptor agonist|serotonin receptor antagonist norelgestromin Launched PGR norepinephrine Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|PAH|SLC18A1|SLC18A2 norethindrone Launched progestogen hormone PGR norethindrone-acetate Launched progesterone receptor agonist norethisterone Launched progesterone receptor agonist PGR norethisterone-enanthate Launched contraceptive agent noretynodrel Launched progestogen hormone PGR norfloxacin Launched bacterial DNA gyrase inhibitor TOP2A norfluoxetine Phase 1 selective serotonin reuptake inhibitor (SSRI) HTR2B norgestimate Launched progesterone receptor agonist ESR1|PGR norgestrel Launched progesterone receptor agonist PGR nornicotine Preclinical acetylcholine receptor agonist nortriptyline Launched tricyclic antidepressant ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD2|HRH1|HTR1A|HTR2A|HTR2C|HTR6|KCNJ10|PGRMC1|SIGMAR1|SLC6A2|SLC6A4 norvancomycin Preclinical noscapine Launched bradykinin receptor antagonist|tubulin polymerization inhibitor SIGMAR1 NOV-002 Phase 3 GSR|GSTM2 novobiocin Launched bacterial DNA gyrase inhibitor NPC-01 Phase 3 steroid NPC-15199 Phase 2 ICAM1 antagonist PPARG NPPB Preclinical chloride channel blocker ANO1|CLCN2|CLCN7|TRPA1 NPS-2143 Preclinical calcium receptor antagonist CASR NPY-5RA972 Preclinical neuropeptide receptor antagonist NPY5R NQDI-1 Preclinical caspase inhibitor CASP3 NS-018 Phase 1/Phase 2 JAK inhibitor JAK1|JAK2|JAK3|TYK2 NS-8 Phase 2 potassium channel agonist KCNMA1 NSC-23766 Preclinical Ras GTPase inhibitor NSC-319726 Preclinical p53 activator NSC-3852 Preclinical HDAC inhibitor HDAC1 NSC-405020 Preclinical matrix metalloprotease inhibitor MMP1 NSC-4644 Phase 2 ACAT inhibitor|sterol regulatory element binding protein (SREBP) inhibitor PYGM NSC-625987 Preclinical CDK inhibitor CDK2|CDK4 NSC-632839 Preclinical ubiquitin specific protease inhibitor SENP2|USP1|USP2|USP7 NSC-663284 Preclinical CDC inhibitor CDC25A|CDC25B|CDC25C NSC-697923 Preclinical ubiquitin-conjugating enzyme inhibitor UBE2N NSC-95397 Preclinical CDC inhibitor CDC25A|CDC25B NSC-9965 Preclinical acetylcholine receptor antagonist CHRNA4|CHRNB2 NSC5844 Preclinical CC chemokine receptor agonist CCR1 NSI-189 Phase 2 neurotrophic agent NTNCB Preclinical neuropeptide receptor antagonist NPY5R nTZDpa Preclinical PPAR receptor agonist PPARG NT157 Preclinical IGF-1 inhibitor IGF1R NU-1025 Preclinical PARP inhibitor PARP1 NU-7026 Preclinical DNA dependent protein kinase inhibitor|mTOR inhibitor|PI3K inhibitor PRKDC NU-7441 Preclinical DNA dependent protein kinase inhibitor PRKDC nuclomedone Phase 3 immunosuppressant nutlin-3 Preclinical MDM inhibitor MDM2|TP53 NU6027 Preclinical CDK inhibitor CCNA2|CDK2 NVP-ADW742 Preclinical insulin growth factor receptor inhibitor IGF1R NVP-AEW541 Preclinical IGF-1 inhibitor IGF1R|INSR NVP-AUY922 Phase 2 HSP inhibitor HSP90AA1|HSP90AB1 NVP-BEZ235 Phase 2 mTOR inhibitor|PI3K inhibitor ATR|MTOR|PIK3CA|PIK3CD|PIK3CG NVP-BGJ398 Phase 2 FGFR inhibitor FGFR1|FGFR2|FGFR3|FGFR4|KDR NVP-BHG712 Preclinical ephrin inhibitor EPHB4 NVP-BSK805 Preclinical JAK inhibitor JAK2 NVP-BVU972 Preclinical MET inhibitor MET NVP-DPP728 Phase 2 dipeptidyl peptidase inhibitor DPP4 NVP-HSP990 Phase 1 HSP inhibitor HSP90AA1|HSP90AB1 NVP-TAE226 Preclinical protein tyrosine kinase inhibitor PTK2 NVP-TAE684 Preclinical ALK tyrosine kinase receptor inhibitor ALK|INSR NVP-TNKS656 Preclinical tankyrase inhibitor TNKS2 NVP-231 Preclinical ceramidase inhibitor CERK NXY-059 Phase 3 free radical scavenger nystatin Launched fungal ergosterol inhibitor N20C Preclinical glutamate receptor antagonist N6-cyclopentyladenosine Preclinical adenosine receptor agonist ADORA1|ADORA2A|ADORA2B|ADORA3|SLC29A1 N6-methyladenosine Preclinical N6022 Phase 1/Phase 2 alcohol dehydrogenase inhibitor ADH5 o-acetyl-L-serine Preclinical PTGS1 o-mercapto-benzoic-acid Preclinical O-1918 Preclinical cannabinoid receptor antagonist o-3M3FBS Preclinical phospholipase activator OAC1 Preclinical Oct activator OAC2 Preclinical Oct activator POU5F1 obatoclax Phase 3 BCL inhibitor BCL2 obeticholic-acid Phase 3 FXR agonist NR1H4 obidoxime Launched cholinesterase reactivator ACHE ochromycinone Phase 1 STAT inhibitor STAT3 ocinaplon Phase 3 GABA receptor modulator GABRA1|GABRA2|GABRA3|GABRA5 OCO-1112 Phase 2 cholesterol inhibitor octadecan-1-ol Preclinical octamethyltrisiloxane Preclinical octenidine Launched membrane integrity inhibitor octinoxate Launched octisalate Launched octocrylene Launched octodrine Preclinical antitumor agent octopamine Preclinical trace amine associated receptor agonist F10|TAAR1 octreotide Launched somatostatin receptor agonist SSTR1|SSTR2|SSTR3|SSTR5 OC000459 Phase 2 CRTH receptor antagonist PTGDR2 odanacatib Phase 3 cathepsin inhibitor CTSK ODM-201 Phase 3 androgen receptor antagonist AR ODQ Preclinical guanylyl cyclase inhibitor GUCY1A2|GUCY1A3|GUCY1B3 ofloxacin Launched bacterial DNA gyrase inhibitor TOP2A OG-L002 Preclinical histone lysine demethylase inhibitor KDM1A oglemilast Phase 2 phosphodiesterase inhibitor olanzapine Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRA2C|ADRB1|ADRB2|ADRB3|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|HRH1|HRH2|HRH4|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR3A|HTR5A|HTR6|HTR7 olaparib Launched PARP inhibitor PARP1|PARP2 OLDA Preclinical TRPV agonist GPR119 oleamide Preclinical cannabinoid receptor agonist HTR7|PLA2G2A oleandrin Phase 1 Na/K-ATPase inhibitor oleanolic-acid Preclinical G protein-coupled receptor agonist GPBAR1 oleoylethanolamide Preclinical cannabinoid receptor agonist|glucose dependent insulinotropic receptor agonist|potassium channel blocker|PPAR receptor agonist CNR1|GPR119|GPR55|PPARA olesoxime Phase 2/Phase 3 apoptosis stimulant oleuropein Phase 2 estrogen receptor agonist GPER1 oligomycin-a Preclinical ATP synthase inhibitor|ATPase inhibitor ATP5A1 olmesartan Launched angiotensin receptor antagonist AGTR1 olmesartan-medoxomil Launched angiotensin receptor antagonist AGTR1 olmutinib Launched EGFR inhibitor|Bruton's tyrosine kinase (BTK) inhibitor BTK|EGFR olomoucine Preclinical CDK inhibitor CDK1|CDK2|CDK5|MAPK1 olopatadine Launched histamine receptor antagonist HRH1|S100A1|S100A12|S100A13|S100A2|S100B olprinone Launched phosphodiesterase inhibitor PDE3A olsalazine Launched cyclooxygenase inhibitor IFNG|TPMT oltipraz Phase 3 nuclear factor erythroid derived|like (NRF2) activator ANG olvanil Preclinical TRPV agonist CNR1|GPR119|TRPV1 omadacycline Phase 3 bacterial 30S ribosomal subunit inhibitor omarigliptin Launched dipeptidyl peptidase inhibitor DPP4 ombitasvir Launched HCV inhibitor OMDM-2 Preclinical FAAH inhibitor GPR119 omecamtiv-mecarbil Phase 2 cardiac myosin activator MYBPC3 omega-(4-Iodophenyl)pentadecanoic acid Preclinical omega-3-acid-esters Launched cholesterol inhibitor omeprazole Launched ATPase inhibitor ATP4A|CLCN2 omeprazole-magnesium Launched proton pump inhibitor ATP4A|ATP4B omeprazole-sulfide Phase 1 ATPase inhibitor ON-01500 Preclinical apoptosis stimulant oncrasin-1 Preclinical apoptosis stimulant ONC201 Phase 2 AKT inhibitor|MAP kinase inhibitor TNFSF10 ondansetron Launched serotonin receptor antagonist HTR1A|HTR1B|HTR3A|HTR3B|HTR4|OPRM1 ONO-4059 Phase 1 Bruton's tyrosine kinase (BTK) inhibitor BTK ONO-4817 Phase 1 matrix metalloprotease inhibitor MMP8 ONX-0914 Preclinical proteasome inhibitor ON123300 Preclinical CDK inhibitor CDK4|NUAK1|PDGFRB OPC-21268 Phase 1 vasopressin receptor antagonist AVPR1A|AVPR2|OXTR opicapone Phase 3 catechol O methyltransferase inhibitor COMT opipramol Launched sigma receptor agonist oprozomib Phase 1/Phase 2 proteasome inhibitor OR-486 Preclinical catechol O methyltransferase inhibitor COMT orantinib Phase 3 FGFR inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor AURKA|AURKB|EGFR|FGFR1|FGFR2|KDR|PDGFRA|PDGFRB orbifloxacin Launched bacterial DNA gyrase inhibitor ORE1001 Phase 1/Phase 2 angiotensin converting enzyme inhibitor ACE2 Org-12962 Phase 2 serotonin receptor agonist HTR2A|HTR2B|HTR2C org-26576 Phase 2 glutamate receptor modulator org-27569 Preclinical cannabinoid receptor modulator CNR1 org-9768 Phase 1 adrenergic receptor antagonist ADRA2A oridonin Preclinical BCL inhibitor BCL2 oritavancin Launched bacterial cell wall synthesis inhibitor orlistat Launched lipase inhibitor CNR1|DAGLA|DAGLB|FASN|LIPF|PNLIP ornidazole Launched antiprotozoal agent ornithine Launched NFkB pathway modulator ARG1|ARG2|GATM|GPRC6A|OAT|OAZ1|OAZ2|OAZ3|OTC|SLC25A15|SLC25A2|SLC7A1|SLC7A2|SLC7A3|SLC7A4 orotic-acid Phase 2 DHODH orphanin-fq Phase 1 opioid receptor agonist OPRL1|OPRM1 orphenadrine Launched acetylcholine receptor antagonist GRIN1|GRIN2D|GRIN3A|GRIN3B|HRH1|SCN10A|SLC6A2 orteronel Phase 3 androgen biosynthesis inhibitor|androgen receptor antagonist|cytochrome P450 inhibitor CYP17A1 ORY-1001 Phase 1/Phase 2 histone lysine demethylase inhibitor KDM1A oseltamivir-carboxylate Launched neuraminidase inhibitor oseltamivir-phosphate Launched neuraminidase inhibitor CES1|NEU1|NEU2 osemozotan Phase 2/Phase 3 serotonin receptor agonist HTR1A OSI-027 Phase 1 mTOR inhibitor MTOR OSI-420 Preclinical EGFR inhibitor EGFR OSI-930 Phase 1 KIT inhibitor|VEGFR inhibitor KDR|KIT osimertinib Launched EGFR inhibitor EGFR ospemifene Launched selective estrogen receptor modulator (SERM) ESR1|ESR2 ostarine Phase 3 androgen receptor modulator AR osthol Preclinical calcium channel blocker OT-R-antagonist-1 Preclinical oxytocin receptor antagonist AVPR1A|OXTR otamixaban Phase 3 coagulation factor inhibitor F10 otenzepad Phase 3 acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 otilonium Launched acetylcholine receptor antagonist CACNA1C OTS167 Phase 1 maternal embryonic leucine zipper kinase inhibitor MELK OTS514 Preclinical TOPK inhibitor OTX015 Phase 1/Phase 2 bromodomain inhibitor BRD2|BRD3|BRD4 ouabain Launched ATPase inhibitor ATP1A1 oxacillin Launched bacterial cell wall synthesis inhibitor oxacyclohexadecan-2-one Preclinical protein kinase inhibitor oxaliplatin Launched DNA inhibitor oxaloacetate Phase 2/Phase 3 glutamate release inhibitor CS|SPR oxandrolone Launched androgen receptor agonist AR oxantel Phase 3 anthelmintic agent oxaprozin Launched cyclooxygenase inhibitor PTGS1|PTGS2 oxatomide Launched histamine receptor antagonist HRH1 oxazepam Launched GABA benzodiazepine site receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GABRR1|GABRR2|GABRR3 oxcarbazepine Launched sodium channel blocker SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A oxelaidin Launched antitussive oxethazaine Launched local anesthetic oxfendazole Launched anthelmintic agent oxfenicine Phase 1 carnitine palmitoyltransferase inhibitor CPT1A|CPT1B oxibendazole Launched tubulin polymerization inhibitor TUBB|TUBB4B oxiconazole Launched bacterial cell wall synthesis inhibitor oxidopamine Preclinical neurotoxin oxiniacic-acid Preclinical oxiperomide Phase 2 dopamine receptor antagonist oxiracetam Launched acetylcholine receptor agonist oxolamine Launched antitussive oxolinic-acid Preclinical bacterial DNA gyrase inhibitor oxonic-acid Preclinical uricase inhibitor oxotremorine-m Preclinical acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4 oxotremorine-sesquifumarate Preclinical cholinergic receptor agonist CHRM1|CHRM2|CHRM3|CHRM4 oxprenolol Launched adrenergic receptor antagonist ADRB1|ADRB2 oxtriphylline Launched adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3|HDAC2|PDE3A|PDE4A|PDE4B|PDE5A oxybenzone Launched lipase inhibitor LIPE oxybuprocaine Launched local anesthetic SCN10A oxybutynin Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3 oxyclozanide Launched oxyfedrine Launched adrenergic receptor agonist oxymatrine Launched oxymetazoline Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|HTR1B|HTR1D|HTR2C oxymetholone Launched androgen receptor agonist AR oxyphenbutazone Withdrawn cyclooxygenase inhibitor PLA2G2E|PTGS1|PTGS2 oxyphencyclimine Launched cholinergic receptor antagonist CHRM1|CHRM2|CHRM3 oxyphenonium Launched cholinergic receptor antagonist CHRM1 oxypurinol Phase 2/Phase 3 xanthine oxidase inhibitor XDH oxyquinoline Launched chelating agent METAP2 oxytetracycline Launched bacterial 30S ribosomal subunit inhibitor oxytocin Launched oxytocin receptor agonist AVPR1A|AVPR1B|AVPR2|OXTR ozagrel Launched thromboxane synthase inhibitor TBXAS1 ozanimod Phase 3 sphingosine 1 phosphate receptor agonist S1PR1 ozolinone Phase 3 diuretic O6-Benzylguanine Phase 3 O6-alkylguanine-DNA alkyltransferase inhibitor MGMT p-dimethylinamyl-benzoate Preclinical PA-824 Phase 3 nitric oxide donor FASN PAC-1 Phase 1 caspase activator CASP3 paclitaxel Launched tubulin polymerization inhibitor BCL2|MAP2|MAP4|MAPT|NR1I2|TLR4|TUBB|TUBB1 PACOCF3 Preclinical phospholipase inhibitor PLA2G4A pacritinib Phase 3 FLT3 inhibitor|JAK inhibitor FLT3|JAK1|JAK2|JAK3 paeoniflorin Preclinical anticonvulsant paeonol Preclinical anti-inflammatory agent pafuramidine Phase 3 DNA synthesis inhibitor palbociclib Launched CDK inhibitor CDK4|CDK6 palifosfamide Phase 3 DNA alkylating agent paliperidone Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRA2C|CYP2D6|CYP3A4|CYP3A5|DRD1|DRD2|DRD3|DRD4|HRH1|HTR1A|HTR1D|HTR2A|HTR2C palmatine-chloride Preclinical dopamine synthesis inhibitor CYP3A4 palmitoleic-acid Preclinical palmitoylcarnitine Preclinical protein kinase inhibitor palmitoylethanolamide Launched cannabinoid receptor agonist CNR2|GPR119|GPR55 palomid-529 Phase 1 AKT inhibitor|mTOR inhibitor MTOR palonosetron Launched serotonin receptor antagonist HTR3A palosuran Phase 2 urotensin receptor antagonist UTS2R palovarotene Phase 2 retinoid receptor agonist RARG pamabrom Launched diuretic pamidronate Launched bone resorption inhibitor FDPS pancuronium Launched acetylcholine receptor antagonist CHRM2|CHRM3|CHRNA1|CHRNA2 panobinostat Launched HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC4|HDAC6|HDAC7|HDAC8|HDAC9 pantethine Launched coenzyme A precursor pantoprazole Launched ATPase inhibitor ATP4A pantothenic-acid Launched coenzyme A precursor papaverine Launched phosphodiesterase inhibitor PDE10A|PDE4B|PDE5A para-toluenesulfonamide Phase 3 CA12|CA2|CA6|CA9 paracetamol Launched cyclooxygenase inhibitor FAAH|PTGS1|PTGS2|TRPV1 parachlorophenol Launched antiinfective drug paramethadione Launched anticonvulsant CACNA1G|CACNA1H|CACNA1I paraxanthine Phase 1 adenosine receptor antagonist parbendazole Preclinical tubulin polymerization inhibitor TUBB pardoprunox Phase 3 serotonin receptor agonist|dopamine receptor agonist DRD2|DRD3|DRD4|HTR1A|HTR7 parecoxib Launched cyclooxygenase inhibitor LTF parethoxycaine Preclinical local anesthetic pargyline Launched monoamine oxidase inhibitor MAOA|MAOB paricalcitol Launched vitamin D receptor agonist VDR paritaprevir Launched HCV inhibitor paromomycin Launched bacterial 30S ribosomal subunit inhibitor paroxetine Launched selective serotonin reuptake inhibitor (SSRI) CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HTR2A|SLC6A2|SLC6A4 paroxypropione Launched gonadotropin inhibitor parthenolide Phase 1 NFkB pathway inhibitor parthenolide-(-) Preclinical NFkB pathway inhibitor HDAC1 parthenolide-(alternate-stereo) Preclinical NFkB pathway inhibitor IKBKB|RELA pasiniazid Launched cyclooxygenase inhibitor pasireotide Launched somatostatin receptor agonist SSTR1|SSTR2|SSTR3|SSTR5 pazopanib Launched KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor CSF1R|FGF1|FGFR1|FGFR3|FLT1|FLT4|ITK|KDR|KIT|PDGFRA|PDGFRB|SH2B3 pazufloxacin Launched topoisomerase inhibitor PCA-4248 Phase 1 platelet activating factor receptor antagonist PTAFR PCI-24781 Phase 1/Phase 2 HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC6 PCI-34051 Preclinical HDAC inhibitor HDAC1|HDAC10|HDAC6|HDAC8 PCO-400 Phase 1 potassium channel activator KCNJ8 PD-0325901 Phase 2 MEK inhibitor MAP2K1 PD-102807 Preclinical acetylcholine receptor antagonist CHRM4 PD-118057 Preclinical potassium channel activator KCNH2 PD-123319 Phase 1 angiotensin antagonist AGTR2 PD-128907 Preclinical dopamine receptor agonist DRD2|DRD3 PD-153035 Phase 1 EGFR inhibitor EGFR|KDR PD-156707 Preclinical endothelin receptor antagonist EDNRA|EDNRB PD-158780 Preclinical EGFR inhibitor EGFR PD-160170 Preclinical neuropeptide receptor antagonist NPY1R PD-161570 Preclinical FGFR inhibitor FGFR1 PD-166793 Preclinical collagenase inhibitor|metalloproteinase inhibitor MMP13|MMP2|MMP3 PD-168077 Preclinical dopamine receptor agonist DRD2 PD-168393 Preclinical EGFR inhibitor EGFR|ERBB2|SRC PD-173074 Preclinical FGFR inhibitor|VEGFR inhibitor FGFR1|FGFR2|FGFR3|FGFR4|FLT1|FLT4|KDR|PDGFRA|PDGFRB PD-184352 Phase 2 MEK inhibitor MAP2K1|MAP3K1|MAP3K2 PD-198306 Preclinical MAP kinase inhibitor|MEK inhibitor MAP2K1|MAP2K2 PD-318088 Preclinical MEK inhibitor MAP2K1 PD-407824 Preclinical PKC inhibitor WEE1 PD-81723 Preclinical adenosine receptor agonist ADORA1 PD-98059 Preclinical MEK inhibitor AKT1|CHEK1|GSK3B|LCK|MAP2K1|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|PRKCA|RAF1|ROCK1|RPS6KB1|SGK1 PDE10-IN-1 Preclinical phosphodiesterase inhibitor PDE10A PD1-PDL-inhibitor-1 Preclinical programmed death ligand inhibitor CD274 peficitinib Phase 3 JAK inhibitor JAK1|JAK2|JAK3 pefloxacin Launched bacterial DNA gyrase inhibitor TOP2A pelanserin Phase 2 serotonin receptor antagonist HTR2A pelitinib Phase 2 EGFR inhibitor EGFR pemetrexed Launched dihydrofolate reductase inhibitor|thymidylate synthase inhibitor ATIC|DHFR|GART|TYMS pemirolast Launched mediator release inhibitor HRH1 pempidine Launched ganglionic blocker penbutolol Launched adrenergic receptor antagonist ADRB1|ADRB2|HTR1A|HTR1B penciclovir Launched DNA directed DNA polymerase inhibitor penfluridol Launched T-type calcium channel blocker CACNA1G penicillamine-(D) Launched chelating agent penicillamine-(racemic) Preclinical penicillin-v-potassium Launched bacterial cell wall synthesis inhibitor pentacosanoic-acid Preclinical pentagastrin Launched CCK receptor agonist CCKBR pentamidine Launched anti-pneumocystis agent TRDMT1 pentetic-acid Phase 2 chelating agent PGD pentobarbital Withdrawn barbiturate antiepileptic|GABA receptor modulator CHRNA4|CHRNA7|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIA2|GRIK2|GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D|GRIN3A|GRIN3B pentolinium Launched cholinergic receptor antagonist CHRNA10|CHRNA3|CHRNA4|CHRNB4 pentostatin Launched adenosine deaminase inhibitor|ribonucleotide reductase inhibitor ADA pentoxifylline Launched phosphodiesterase inhibitor ADORA1|ADORA2A|ADORA2B|ADRA2B|NT5E|PDE10A|PDE1A|PDE1B|PDE1C|PDE2A|PDE3A|PDE3B|PDE4A|PDE4B|PDE4C|PDE4D|PDE5A|PDE6A|PDE6B|PDE6C|PDE6D|PDE6G|PDE6H|PDE7A|PDE7B|PDE8A|PDE8B|PDE9A|TNF pentylenetetrazol Withdrawn GABA receptor antagonist pepstatin Preclinical aspartic protease inhibitor CTSB|CTSD|CTSL|REN peramivir Launched neuraminidase inhibitor perampanel Launched glutamate receptor antagonist GRIA1|GRIA2|GRIA3|GRIA4 perchlozone Launched peretinoin Phase 3 retinoid receptor agonist RXRA perfluamine Launched perflubron Launched contrast agent perfluorodecalin Launched pergolide Withdrawn dopamine receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C perhexiline Launched carnitine palmitoyltransferase inhibitor CPT1A|CPT2 perifosine Phase 3 AKT inhibitor AKT1 perillyl-alcohol Phase 2 apoptosis stimulant|farnesyltransferase inhibitor FNTA perindopril Launched angiotensin converting enzyme inhibitor ACE perindoprilat Phase 2 angiotensin converting enzyme inhibitor ACE permethrin Launched SCN1A perospirone Launched dopamine receptor antagonist|serotonin receptor antagonist DRD2|DRD3|DRD4 perphenazine Launched dopamine receptor antagonist CALM1|DRD1|DRD2|HRH1|HTR2A|HTR2C|HTR6|HTR7 peruvoside Phase 1 cardiac glycoside perzinfotel Phase 2 glutamate receptor antagonist GRIN1|GRIN2A|GRIN2B PETCM Preclinical caspase activator CASP3 pevonedistat Phase 2 nedd activating enzyme inhibitor NAE1|UBA3 pexidartinib Phase 3 tyrosine kinase inhibitor CSF1R|FLT3|KIT pexmetinib Phase 1 TIE tyrosine kinase inhibitor|MAP kinase inhibitor MAPK14|TEK PF-02545920 Phase 2 phosphodiesterase inhibitor PDE10A PF-03049423 Phase 2 phosphodiesterase inhibitor PDE5A PF-03084014 Phase 2 gamma secretase inhibitor PF-03758309 Phase 1 p21 activated kinase inhibitor PAK4 PF-03814735 Phase 1 Aurora kinase inhibitor AURKA|AURKB PF-03882845 Phase 1 PF-04136309 Phase 2 CC chemokine receptor antagonist PF-04217903 Phase 1 c-Met inhibitor MET PF-04418948 Phase 1 prostaglandin inhibitor PTGER2 PF-04447943 Phase 2 phosphodiesterase inhibitor PDE9A PF-04457845 Phase 2 FAAH inhibitor FAAH PF-04620110 Phase 1 diacylglycerol O acyltransferase inhibitor DGAT1 PF-04691502 Phase 2 mTOR inhibitor|PI3K inhibitor MTOR|PIK3CA PF-04937319 Phase 2 glucokinase activator GCK PF-05190457 Phase 2 growth hormone secretagogue receptor inverse agonist GHSR PF-05212384 Phase 2 mTOR inhibitor|PI3K inhibitor MTOR|PIK3CA PF-06447475 Preclinical serine/threonine kinase inhibitor LRRK2 PF-06463922 Phase 2 ALK tyrosine kinase receptor inhibitor ALK|FES|ROS1 PF-3274167 Phase 2 oxytocin receptor antagonist AVPR1A|OXTR PF-3845 Preclinical FAAH inhibitor FAAH PF-4708671 Preclinical ribosomal protein inhibitor RPS6KB1 PF-477736 Phase 1 CHK inhibitor CHEK1|CHEK2 PF-4981517 Preclinical cytochrome P450 inhibitor CYP3A4 PF-5274857 Preclinical smoothened receptor antagonist SMO PF-562271 Phase 1 focal adhesion kinase inhibitor PTK2|PTK2B PF-573228 Preclinical focal adhesion kinase inhibitor CDK1|CDK2|CDK7|GSK3B|IKBKB PF-670462 Preclinical casein kinase inhibitor CSNK1D|CSNK1E PF-8380 Preclinical autotaxin inhibitor ENPP2 PF-915275 Phase 1 11-beta hydroxysteroid dehydrogenase inhibitor HSD11B1 PFI-1 Preclinical bromodomain inhibitor BRD4 PFK-015 Phase 1 phosphofructokinase inhibitor PFKFB3 PFK-158 Phase 1 phosphofructokinase inhibitor PFKFB3 PG-9 Preclinical acetylcholine receptor agonist PGL5001 Phase 2 JNK inhibitor MAPK10|MAPK8|MAPK9 PH-797804 Phase 2 p38 MAPK inhibitor MAPK11|MAPK14 PHA-665752 Preclinical c-Met inhibitor MET PHA-680632 Preclinical Aurora kinase inhibitor AURKA|AURKB|AURKC PHA-767491 Preclinical CDC inhibitor CDK1|RPS6KB1 PHA-793887 Phase 1 CDK inhibitor CDK1|CDK2|CDK4|CDK5|CDK7|CDK9 PHA-848125 Phase 2 CDK inhibitor|growth factor receptor inhibitor CDK2|CDK4|CDK7|NTRK1 PHCCC Preclinical glutamate receptor agonist GRM1|GRM4 phenacaine Launched local anesthetic phenacemide Launched sodium channel blocker SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A phenacetin Withdrawn cyclooxygenase inhibitor PTGS1 phenazone Launched cyclooxygenase inhibitor PTGS1|PTGS2 phenazopyridine Launched local anesthetic SCN1A phenelzine Launched monoamine oxidase inhibitor ABAT|AOC3|GAD2|GPT|GPT2|MAOA|MAOB|SLC6A2|SLC6A3|SLC6A4 phenethicillin Launched bacterial cell wall synthesis inhibitor phenethyl-isothiocyanate Phase 2 anticancer agent CYP2E1 phenformin Withdrawn AMPK activator KCNJ8|PRKAA1 phenindamine Launched histamine receptor antagonist HRH1 phenindione Launched vitamin K antagonist VKORC1 pheniramine Launched histamine receptor antagonist HRH1 phenol Preclinical CA1|CA12|CA14|CA2|CA4|CA9 phenolphthalein Withdrawn indicator dye UGT1A9 phenolsulfonphthalein Launched phenothiazine Preclinical dopamine receptor antagonist phenothrin Launched phenoxybenzamine Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|ADRB2|CALM1 phenprobamate Launched muscle relaxant phenprocoumon Launched vitamin K antagonist VKORC1 phenserine Phase 3 acetylcholinesterase inhibitor|beta amyloid synthesis inhibitor ACHE|BCHE phensuximide Launched succinimide antiepileptic CACNA1G|CACNA1H|CACNA1I phentermine Launched dopamine uptake inhibitor|serotonin reuptake inhibitor MAOA|MAOB|SLC6A2|SLC6A3|SLC6A4 phentolamine Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C phenyl-aminosalicylate Launched phenyl-salicylate Launched antiseptic phenylacetylglutamine Phase 2 DNA methylase inhibitor|protein synthesis inhibitor phenylbenzimidazole-sulfonic-acid Launched phenylbutazone Withdrawn cyclooxygenase inhibitor|prostanoid receptor antagonist PTGIS|PTGS1|PTGS2 phenylbutyrate Launched HDAC inhibitor HDAC1 phenylephrine Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D phenylethyl-alcohol Preclinical phenylmercuric-acetate Preclinical other antifungal phenylmethylsulfonyl-fluoride Preclinical serine protease inhibitor phenylpiracetam Launched noradrenaline uptake inhibitor phenytoin Launched hydantoin antiepileptic SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A phloretin Launched sodium/glucose cotransporter inhibitor AQP9|CLCN3|SLC23A1 phlorizin Preclinical sodium/glucose cotransporter inhibitor SLC5A1|SLC5A11|SLC5A2|SLC5A3 phloroglucin Launched phortress Phase 1 aryl hydrocarbon receptor ligand AHR phosphatidylcholine Launched PCTP PHT-427 Preclinical AKT inhibitor|pyruvate dehydrogenase inhibitor AKT2|PDPK1 phthalylsulfacetamide Preclinical phthalylsulfathiazole Launched dihydropteroate synthetase inhibitor PHTPP Preclinical estrogen receptor antagonist ESR2 physostigmine Launched cholinesterase inhibitor ACHE|BCHE physostigmine-salicylate Phase 3 acetylcholinesterase inhibitor phytonadione Launched BGLAP|GGCX phytosphingosine Phase 1 PI-103 Preclinical mTOR inhibitor|PI3K inhibitor MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG|PRKDC PI-828 Preclinical PI3K inhibitor pibenzimol Phase 2 DNA inhibitor piboserod Phase 2 serotonin receptor antagonist HTR2B|HTR4 picartamide Phase 2 H+/K+-ATPase inhibitor ATP4A piceatannol Preclinical SYK inhibitor ATP5A1|ATP5B|ATP5C1|IRF3 piclamilast Phase 2 phosphodiesterase inhibitor PDE4A|PDE4B|PDE4C|PDE4D picolamine Preclinical picolinic-acid Phase 2 chelating agent piconol Preclinical picotamide Launched thromboxane receptor antagonist|thromboxane synthase inhibitor TBXA2R picrotin Phase 2 GABA receptor antagonist GABRA1|GABRR1|GLRA1|GLRA2|GLRA3|GLRB picrotoxinin Preclinical GABA receptor antagonist GLRA1|GLRA2|GLRA3|GLRB|HTR3A|HTR3B pidolic-acid Launched ADAM28|AMY1A|AMY2A|AMY2B|ANG|CCL8|HCRT|IGLC1|KRTAP5-2|TFF2|VEGFA pidotimod Launched interferon receptor agonist|interleukin receptor agonist pifithrin-alpha Preclinical TP53 inhibitor TP53 pifithrin-mu Preclinical HSP inhibitor HSPA1A|TP53 PIK-293 Preclinical PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG PIK-294 Preclinical PI3K inhibitor PIK3CB|PIK3CD|PIK3CG PIK-75 Preclinical DNA protein kinase inhibitor|PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG|PRKDC PIK-93 Preclinical PI3K inhibitor PI4KB|PIK3C3|PIK3CG pikamilone Phase 1 piketoprofen Launched cyclooxygenase inhibitor pilaralisib Phase 2 PI3K inhibitor pilocarpine Launched acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 pilsicainide Launched sodium channel blocker SCN5A PIM-1-Inhibitor-2 Preclinical Pim kinase inhibitor PIM1 pimavanserin Launched serotonin receptor inverse agonist DRD2|HTR2A pimecrolimus Launched calcineurin inhibitor FKBP1A|MTOR pimethixene Launched antihistamine pimobendan Launched calcium sensitizer|phosphodiesterase inhibitor PDE3A pimonidazole Phase 3 pimozide Launched dopamine receptor antagonist CACNA1I|CALM1|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR2A|KCNA10|KCNH2 pinacidil Launched ATP channel activator|potassium channel activator ABCC8|ABCC9 pinanediol Preclinical pinaverium Launched T-type calcium channel blocker CACNA1C pincainide Phase 1 antiarrhythmic pindolol Launched adrenergic receptor antagonist ADRB1|ADRB2|HTR1A|HTR1B|HTR2A|HTR2B pindolol-(-) Preclinical adrenergic receptor antagonist|serotonin receptor antagonist HTR1A pinitol Phase 2 gamma secretase inhibitor pinocembrin Phase 2 cytochrome P450 inhibitor CYP1B1 pioglitazone Launched insulin sensitizer|PPAR receptor agonist PPARG|TRPM3 pipamperone Launched dopamine receptor antagonist DRD2|HRH1|HTR1A|HTR1B|HTR1D|HTR2A pipecuronium Launched neuromuscular blocker CHRM2|CHRM3|CHRNA2 pipemidic-acid Launched topoisomerase inhibitor pipenzolate Launched cholinergic receptor antagonist CHRM1 piperacetazine Launched dopamine receptor antagonist piperacillin Launched bacterial cell wall synthesis inhibitor piperaquine-phosphate Launched antimalarial agent piperazine Launched benzodiazepine receptor agonist GABRB3 piperazinedione Phase 2 DNA synthesis inhibitor piperidolate Launched acetylcholine receptor antagonist CHRM1 piperine Phase 1 monoamine oxidase inhibitor MAOA|MAOB|TRPV1 piperonyl-butoxide Launched cytochrome P450 inhibitor pipobroman Launched DNA alkylating agent pipotiazine-palmitate Launched dopamine receptor antagonist|serotonin receptor antagonist DRD1|DRD2|HTR1A|HTR2A piracetam Launched acetylcholine receptor agonist GRIA1|GRIA2|GRIA3|GRIA4 pirarubicin Launched topoisomerase inhibitor TOP2A pirenoxine Launched AGE inhibitor pirenperone Preclinical serotonin receptor antagonist HTR2A|HTR7 pirenzepine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 piretanide Launched glucocorticoid receptor agonist SLC12A1|SLC12A2 pirfenidone Launched TGF beta receptor inhibitor FURIN|TNF piribedil Launched dopamine receptor agonist ADRA1A|ADRA2A|ADRA2C|DRD2|DRD3|DRD4|HTR1A|HTR2B piricapiron Phase 2 dopamine receptor antagonist|serotonin receptor antagonist HTR2A pirinixic-acid Preclinical PPAR receptor agonist PPARA pirlindole Launched monoamine oxidase inhibitor MAOA piroctone-olamine Launched pirodavir Phase 2 piromidic-acid Phase 2 bacterial DNA gyrase inhibitor piroxicam Launched cyclooxygenase inhibitor PTGS1|PTGS2 piroximone Phase 2 phosphodiesterase inhibitor PDE3A pirquinozol Phase 1 histamine release inhibitor PIT Preclinical purinergic receptor antagonist P2RY1 pitavastatin Launched HMGCR inhibitor HMGCR pivagabine Launched corticosteroid releasing factor receptor antagonist CRHR1|CRHR2 pivampicillin Launched bacterial cell wall synthesis inhibitor pivanex Phase 2 HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC8 pivmecillinam Launched bacterial cell wall synthesis inhibitor pixantrone Launched topoisomerase inhibitor TOP2A pizotifen Launched serotonin receptor antagonist HTR1A|HTR2A|HTR2C PI3K-IN-2 Phase 2 PI3K inhibitor PI4KIII-beta-inhibitor-1 Preclinical PI4K inhibitor PI4K2B PJ-34 Preclinical PARP inhibitor EEF2|PARP1|PARP15|PARP3 PK-11195 Phase 1 benzodiazepine receptor antagonist TSPO PKI-166 Phase 1 EGFR inhibitor EGFR PKI-179 Phase 1 mTOR inhibitor|PI3K inhibitor MTOR pleconaril Phase 3 plerixafor Launched CC chemokine receptor antagonist ACKR3|CCR4|CXCR4 plicamycin Launched alcohol dehydrogenase inhibitor plinabulin Phase 3 tubulin polymerization inhibitor plovamer-acetate Phase 2 TAT|TH|YARS|YARS2 plurisin-#1 Preclinical stearoyl-CoA desaturase inhibitor SCD PLX-4720 Preclinical RAF inhibitor BRAF|KDR PLX8394 Phase 1/Phase 2 serine/threonine kinase inhibitor BRAF PMPA Preclinical glutamate receptor antagonist FOLH1 PNU-120596 Preclinical acetylcholine receptor agonist CHRNA7 PNU-142633 Phase 2 serotonin receptor agonist HTR1D PNU-22394 Phase 2 serotonin receptor agonist HTR2A|HTR2B|HTR2C|MAOA|MAOB PNU-282987 Preclinical cholinergic receptor agonist CHRNA7 PNU-37883 Preclinical ATP-sensitive potassium channel antagonist PNU-74654 Preclinical beta-catenin inhibitor CTNNB1|TCF4 PNU-89843 Preclinical benzodiazepine receptor agonist GABBR1 podophyllotoxin Launched microtubule inhibitor|tubulin polymerization inhibitor IGF1R|TOP2A|TUBA4A|TUBB polidocanol Launched local anesthetic polydatin Phase 2 ICAM1 expression inhibitor ICAM1 polyinosine Preclinical immunostimulant ADSSL1|HPRT1|IMPDH2|PYGM polymyxin-b-sulfate Launched bacterial permeability inducer polythiazide Launched sodium/chloride cotransporter inhibitor SLC12A3 pomalidomide Launched angiogenesis inhibitor|tumor necrosis factor production inhibitor CRBN|PTGS2|TNF ponatinib Launched Bcr-Abl kinase inhibitor|FLT3 inhibitor|PDGFR tyrosine kinase receptor inhibitor ABL1|BCR|FGFR1|FGFR2|FGFR3|FGFR4|FLT3|KDR|KIT|LCK|LYN|PDGFRA|RET|SRC|TEK ponesimod Phase 3 sphingosine 1 phosphate receptor agonist S1PR1 posaconazole Launched sterol demethylase inhibitor CYP3A4 potassium-canrenoate Launched mineralocorticoid receptor antagonist NR3C2 potassium-iodide Launched potassium-p-aminobenzoate Launched pozanicline Phase 2 acetylcholine receptor antagonist CHRNA4|CHRNB2 poziotinib Phase 2 EGFR inhibitor EGFR|ERBB2|ERBB4 PP-1 Preclinical src inhibitor HCK|RET PP-121 Preclinical protein tyrosine kinase inhibitor ABL1|EGFR|HCK|KDR|MTOR|PDGFRA|PIK3CA|PIK3CB|PIK3CD|PIK3CG|PRKDC|SRC PP-2 Preclinical src inhibitor ABL1|LCK|LYN|RIPK2|SRC PPT Preclinical estrogen receptor agonist ESR1 PP242 Preclinical mTOR inhibitor MTOR|PASK PQ-401 Preclinical IGF-1 inhibitor IGF1R PR-619 Preclinical DUB inhibitor practolol Withdrawn adrenergic receptor antagonist ADRB1 pralatrexate Launched dihydrofolate reductase inhibitor DHFR|TYMS pralidoxime Launched acetylcholinesterase inhibitor ACHE|BCHE pralidoxime-chloride Launched acetylcholinesterase inhibitor ACHE|BCHE pramipexole Launched dopamine receptor agonist ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C pramiracetam Launched acetylcholine receptor agonist pramoxine Launched topical anesthetic pranidipine Phase 2 calcium channel blocker CACNA1C pranlukast Launched leukotriene receptor antagonist CYSLTR1|CYSLTR2|IL5|MUC2|NFKB1|RNASE3|TNF pranoprofen Launched cyclooxygenase inhibitor prasterone-acetate Preclinical prasugrel Launched purinergic receptor antagonist P2RY12 pravadoline Preclinical cyclooxygenase inhibitor CNR1|CNR2 pravastatin Launched HMGCR inhibitor HMGCR|SLCO1B1 praziquantel Launched anthelmintic agent prazosin Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|KCNH2|KCNH6|KCNH7 PRE-084 Preclinical sigma receptor agonist SIGMAR1 preclamol Phase 2 dopamine receptor agonist DRD2 prednicarbate Launched phospholipase activator NR3C1|PLA2G1B prednisolone Launched glucocorticoid receptor agonist NR3C1|NR3C2|SERPINA6 prednisolone-acetate Launched glucocorticoid receptor agonist NR3C1 prednisolone-hemisuccinate Preclinical glucocorticoid receptor agonist NR3C1 prednisolone-sodium-phosphate Launched glucocorticoid receptor agonist NR3C1 prednisolone-tebutate Launched anti-inflammatory agent prednisone Launched glucocorticoid receptor agonist HSD11B1|NR3C1 pregabalin Launched voltage-gated calcium channel ligand CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1E|CACNA1F|CACNA1G|CACNA1H|CACNA1I|CACNA1S|CACNA2D1|CACNA2D2|CACNA2D3|CACNA2D4|CACNB1|CACNB2|CACNB3|CACNB4|CACNG1|CACNG2|CACNG3|CACNG4|CACNG5|CACNG6|CACNG7|CACNG8 pregnenolone Launched glutamate receptor modulator CYP17A1|SULT2B1 pregnenolone-succinate Preclinical GABA receptor negative allosteric modulator preladenant Phase 3 adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 prenylamine Withdrawn calcium channel blocker CALM1|MYLK2 presatovir Phase 2 RSV fusion inhibitor pridinol Launched muscle relaxant prilocaine Launched local anesthetic SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A primaquine Launched antimalarial agent|DNA inhibitor KRT7|NQO2 PRIMA1 Preclinical TP53 inhibitor ACHE primidone Launched GABA receptor antagonist CHRNA4|CHRNA7|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIA2|GRIK2|SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A prinaberel Phase 2 estrogen receptor agonist ESR2|NCOA1 priralfinamide Phase 3 sodium channel blocker CACNA1B pritelivir Phase 2 helicase primase inhibitor proacipimox Phase 1 cholesterol inhibitor proadifen Preclinical nitric oxide synthase inhibitor NOS1 probenecid Launched uricosuric blocker PANX1|SLC22A11|SLC22A6|SLC22A8|SLCO1C1 probucol Launched atherogenesis inhibitor ABCA1|ABCB11|CES1 procainamide Launched sodium channel blocker DNMT1|SCN5A procaine Launched HMGCR inhibitor CHRNA2|GRIN3A|HTR3A|KCNMA1|KCNMB1|KCNMB2|KCNMB3|KCNMB4|KCNN1|KCNN2|KCNN3|KCNN4|MAOA|MAOB|RYR1|RYR2|SCN10A|SLC6A3 procarbazine Launched monoamine oxidase inhibitor procaterol Launched adrenergic receptor agonist ADRB2 prochlorperazine Launched dopamine receptor antagonist DRD1|DRD2|DRD3|DRD4 procodazole Preclinical immunostimulant procyanidin-b-2 Phase 2 procyclidine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4 procysteine Phase 3 glutathione synthase stimulant profenamine Launched butyrylcholinesterase inhibitor|cholinergic receptor antagonist CHRM1|CHRM2|GRIN3A proflavine-hemisulfate Phase 2 topical anesthetic F2 progesterone Launched progesterone receptor agonist CATSPER1|CATSPER2|CATSPER3|CATSPER4|CYP17A1|ESR1|NR3C2|OPRK1|PGR|TRPC5 proglumetacin Launched cyclooxygenase inhibitor PTGS1|PTGS2 proglumide Withdrawn CCK receptor antagonist CCKAR|CCKBR proguanil Launched dihydrofolate reductase inhibitor DHFR prolylleucylglycinamide Phase 2 melanocyte-stimulating hormone release inhibitor promazine Launched dopamine receptor antagonist ADRA1A|ADRA1B|ADRA1D|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|HRH1|HTR2A|HTR2C promestriene Launched estrogen receptor agonist ESR1 promethazine Launched histamine receptor antagonist ADRA1A|CALM1|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD2|HRH1|HTR2A pronethalol Withdrawn adrenergic receptor antagonist propacetamol Launched cyclooxygenase inhibitor PTGS2 propafenone Launched antiarrhythmic ADRB1|ADRB2|KCNA5|KCNH2|SCN5A propagermanium Launched interferon receptor agonist|CCR agonist CCR2 propantheline Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4 propatylnitrate Launched propentofylline Launched adenosine reuptake inhibitor|phosphodiesterase inhibitor PDE1A propidium-iodide Preclinical ACHE propiolactone Launched propiverine Launched acetylcholine receptor antagonist CHRM1 propofol Launched benzodiazepine receptor agonist FAAH|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|SCN2A|SCN4A propoxur Launched propoxycaine Launched local anesthetic propranolol Launched adrenergic receptor antagonist propranolol-(R) Preclinical adrenergic receptor antagonist ADRB2|ADRB3 propranolol-(S) Preclinical adrenergic receptor antagonist ADRB1|ADRB2|ADRB3|HTR1A|HTR1B|HTR5A|SLC10A1 propyl-benzoate Launched propylene-glycol Launched F13A1 propylhexedrine Launched adrenergic receptor agonist SLC18A2|TAAR1 propylparaben Launched propylthiouracil Launched thyroid peroxidase inhibitor DIO1|TPO proquazone Launched cyclooxygenase inhibitor PTGS1|PTGS2 proscillaridin-a Launched protionamide Launched protirelin Launched thyrotropin releasing hormone receptor agonist TRHR protoporphyrin-ix Preclinical heme oxygenase inhibitor HMOX1 protriptyline Launched tricyclic antidepressant SLC6A2|SLC6A4 proxodolol Launched adrenergic receptor antagonist proxyfan Preclinical histamine receptor modulator HRH3 proxymetacaine Launched sodium channel blocker SCN10A|SCN5A proxyphylline Launched PRT062070 Phase 1 JAK inhibitor|syk inhibitor SYK PRT062607 Phase 2 syk inhibitor FGR|MAP3K9|SYK PRT4165 Preclinical polycomb repressive complex inhibitor PRC1 prucalopride Launched serotonin receptor agonist HTR4 prulifloxacin Launched bacterial DNA gyrase inhibitor pruvanserin Phase 2 serotonin receptor antagonist HTR2A|HTR2C PRX-08066 Phase 2 serotonin receptor antagonist HTR2B PSB-06126 Preclinical NTPDase inhibitor ENTPD3 PSB-11 Preclinical adenosine receptor antagonist ADORA1|ADORA2A|ADORA3 PSB-1115 Preclinical adenosine receptor antagonist ADORA1|ADORA2B|ADORA3 PSB-36 Preclinical adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 PSI-6130 Phase 1 RNA polymerase inhibitor PSI-7976 Preclinical HCV inhibitor PSN-375963 Preclinical glucose dependent insulinotropic receptor agonist GPR119 psoralen Launched MAOA|MAOB PS178990 Phase 1 androgen receptor modulator AR PT-2385 Phase 1 hypoxia inducible factor inhibitor EPAS1 PTC-209 Preclinical BMI-1 inhibitor pterostilbene Phase 2/Phase 3 cyclooxygenase inhibitor|PPAR receptor agonist PTGS2 PU-H71 Phase 1 HSP inhibitor HSP90AA1 puerarin Phase 2 serotonin receptor antagonist pumosetrag Phase 2 serotonin receptor agonist HTR3A|HTR4 purmorphamine Preclinical smoothened receptor agonist SMO puromycin Preclinical protein synthesis inhibitor NHP2L1|RPL10L|RPL11|RPL13A|RPL15|RPL19|RPL23|RPL23A|RPL26L1|RPL3|RPL37|RPL8|RSL24D1 purvalanol-a Preclinical CDK inhibitor CDK1|CDK2|CDK4|CDK5|CSNK1G3|RPS6KA1|SRC purvalanol-b Preclinical tyrosine kinase inhibitor CDK2|CDK4|CDK5|MAPK1|MAPK3|SRPK2 putrescine Phase 2 tissue transglutaminase inhibitor AMD1|KCNJ4|ODC1 PX-12 Phase 2 thioredoxin inhibitor TXN|TXNRD1 PX-478 Phase 1 hypoxia inducible factor inhibitor PYM50028 Phase 2 neurotrophic agent PYR-41 Preclinical ubiquitin activating enzyme inhibitor pyrantel Launched nicotinic receptor agonist pyrantel-pamoate Launched neuromuscular blocker pyrantel-tartrate Preclinical acetylcholine receptor agonist CHRNA1 pyrazinamide Launched fatty acid synthase inhibitor FASN pyrazinoylguanidine Phase 1 diuretic pyrazolanthrone Preclinical JNK inhibitor MAPK10|MAPK8|MAPK8IP1|MAPK9|TTK pyrazoloacridine Phase 2 topoisomerase inhibitor TOP1|TOP2A pyrethrins Launched pyridoxal Launched PDXK pyridoxal-isonicotinoyl-hydrazone Phase 2 apoptosis stimulant pyridoxamine Phase 3 AGE inhibitor pyridoxine Launched vitamin B DDC|PDXK pyrimethamine Launched dihydrofolate reductase inhibitor DHFR|SLC47A1 pyrithione-zinc Launched ATP synthase inhibitor KCNQ1|KCNQ2|KCNQ4|KCNQ5 pyrithyldione Withdrawn psychoactive drug pyritinol Launched pyronaridine Phase 3 antimalarial agent pyroxamide Phase 1 HDAC inhibitor HDAC1 pyrrolidine-dithiocarbamate Preclinical NFkB pathway inhibitor HSD11B1|RELA pyrvinium Launched androgen receptor antagonist pyrvinium-pamoate Launched androgen receptor antagonist AR P22077 Preclinical ubiquitin specific protease inhibitor USP7 P276-00 Phase 2 CDK inhibitor CDK1|CDK4|CDK9 P5091 Preclinical ubiquitin specific protease inhibitor USP7 Q-203 Phase 1 ATP synthase inhibitor quazinone Phase 2 phosphodiesterase inhibitor PDE3A|PDE3B quercetin Launched polar auxin transport inhibitor ATP5A1|ATP5B|ATP5C1|HCK|HIBCH|PIK3CG|PIM1|STK17B|UGT3A1 quetiapine Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2C|HTR3A|HTR6|HTR7|SLC6A2 quiflapon Phase 2 leukotriene synthesis inhibitor ALOX5|ALOX5AP quinagolide Launched dopamine receptor agonist DRD2 quinapril Launched angiotensin converting enzyme inhibitor ACE quinaprilat Launched angiotensin converting enzyme inhibitor ACE quinelorane Phase 3 dopamine receptor agonist DRD2|DRD3 quinestrol Launched estrogen receptor agonist ESR1 quinethazone Launched thiazide diuretic CA1|CA2|SLC12A1|SLC12A2|SLC12A3 quinidine Launched sodium channel blocker KCNA5|KCNA7|KCNH1|KCNH2|KCNH5|KCNK1|KCNK6|SCN5A|SLC29A4 quinine Launched hemozoin biocrystallization inhibitor GP9|KCNB2|KCNN4|SLC29A4 quinine-ethyl-carbonate Launched quinolinic-acid Preclinical glutamate receptor agonist quinpirol-(-) Phase 2 dopamine receptor agonist DRD1|DRD2|DRD3|DRD4|HTR1A|HTR2A|HTR2B|HTR2C quipazine Preclinical serotonin receptor agonist quizartinib Phase 3 FLT3 inhibitor CSF1R|FLT3|KIT|PDGFRA|PDGFRB|RET QX-222 Preclinical sodium channel blocker QX-314 Preclinical sodium channel blocker MAPK14|TGFBR1 r(-)-apomorphine Launched dopamine receptor agonist DRD2|HTR5A R-1479 Phase 1 HCV inhibitor R-428 Phase 1 AXL kinase inhibitor AXL R-59022 Preclinical diacylglycerol kinase inhibitor|protein kinase inhibitor DGKA R-96544 Preclinical serotonin receptor antagonist HTR2A rabeprazole Launched ATPase inhibitor|gastrin inhibitor ATP4A racecadotril Launched enkephalinase inhibitor MME raclopride Launched dopamine receptor antagonist DRD2|DRD3|HTR1A ractopamine Launched adrenergic receptor agonist radafaxine Phase 2 dopamine-norepinephrine reuptake inhibitor SLC6A3 radezolid Phase 2 bacterial 30S ribosomal subunit inhibitor|bacterial 50S ribosomal subunit inhibitor RAF265 Phase 2 RAF inhibitor|VEGFR inhibitor BRAF raloxifene Launched estrogen receptor antagonist|selective estrogen receptor modulator (SERM) ESR1|ESR2 raltegravir Launched HIV integrase inhibitor raltitrexed Launched thymidylate synthase inhibitor FPGS|TYMS ramatroban Launched prostanoid receptor antagonist PTGDR2|TBXA2R ramelteon Launched melatonin receptor agonist MTNR1A|MTNR1B ramifenazone Launched cyclooxygenase inhibitor ramipril Launched angiotensin converting enzyme inhibitor ACE ramosetron Launched serotonin receptor antagonist HTR3A ranirestat Phase 3 aldose reductase inhibitor AKR1B1 ranitidine Launched histamine receptor antagonist HRH2 ranolazine Launched sodium channel blocker SCN10A|SCN4A|SCN5A|SCN9A rapastinel Phase 2 glutamate receptor agonist rasagiline Launched monoamine oxidase inhibitor BCL2|MAOB ravoxertinib Phase 1 ERK1 and ERK2 phosphorylation inhibitor MAPK1|MAPK3 ravuconazole Phase 2 sterol demethylase inhibitor RBC8 Preclinical Ral GTPase inhibitor RALA|RALB rebamipide Launched free radical scavenger FPR1 rebastinib Phase 1 Bcr-Abl kinase inhibitor|TIE tyrosine kinase inhibitor|VEGFR inhibitor ABL1|BCR|FGR|FLT3|HCK|LYN|SRC reboxetine Launched adrenergic receptor antagonist SLC6A2 refametinib Phase 2 MEK inhibitor MAP2K1|MAP2K2 regadenoson Launched adenosine receptor agonist ADORA1|ADORA2A|ADORA2B|ADORA3 regorafenib Launched FGFR inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|RAF inhibitor|RET tyrosine kinase inhibitor|VEGFR inhibitor ABL1|BRAF|DDR2|EPHA2|FGFR1|FGFR2|FLT1|FLT4|FRK|KDR|KIT|MAPK11|NTRK1|PDGFRA|PDGFRB|RAF1|RET|TEK relcovaptan Phase 2 vasopressin receptor antagonist AVPR1A|AVPR1B|AVPR2|OXTR relebactam Phase 3 beta lactamase inhibitor remacemide Phase 3 glutamate receptor antagonist GRIN1 remimazolam Phase 3 benzodiazepine receptor agonist GABBR1 remoxipride Withdrawn dopamine receptor antagonist DRD2|DRD3|DRD4|HTR2A|SIGMAR1 repaglinide Launched insulin secretagogue ABCC8|KCNJ11|PPARG reparixin Phase 3 CC chemokine receptor antagonist CXCR1|CXCR2 repsox Preclinical TGF beta receptor inhibitor TGFBR1 resatorvid Phase 3 toll-like receptor antagonist TLR4 reserpine Launched vesicular monoamine transporter inhibitor SLC18A1|SLC18A2 resibufogenin Phase 2 Na/K-ATPase inhibitor resiquimod Phase 3 toll-like receptor agonist TLR7|TLR8 resminostat Phase 2 HDAC inhibitor HDAC1|HDAC3|HDAC6|HDAC8 resorcinol Launched phosphodiesterase inhibitor CA12|CA14|CA2|PTGS1 resveratrol Launched cytochrome P450 inhibitor|SIRT activator CSNK2A1|NQO2|PTGS1|PTGS2 retapamulin Launched protein synthesis inhibitor retaspimycin Phase 3 HSP inhibitor HSP90AA1 retigabine Launched potassium channel activator KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5 retinaldehyde Launched retinol Launched retinoid receptor ligand ALDH1A1|ALDH1A2|ALDH1A3|DHRS3|DHRS4|LRAT|NR2C2|RBP1|RBP3|RDH11|RDH12|RDH13|RDH14|RDH5|RDH8|RETSAT|RHO|RLBP1|RXRA|RXRB|RXRG retinyl-acetate Launched retinyl-palmitate Launched REV-5901 Phase 2 leukotriene receptor antagonist|lipoxygenase inhibitor ALOX5 revaprazan Launched potassium-competitive acid antagonist ATP4A reversine Preclinical Aurora kinase inhibitor AURKB|INCENP|MAP2K1 RGB-286638 Phase 1 CDK inhibitor CDK1|CDK2|CDK3|CDK4|CDK5|CDK6|CDK7|CDK9|FLT3|GSK3B|JAK2|MAP3K7|MAPK9 RGFP966 Preclinical HDAC inhibitor HDAC3 RG108 Preclinical DNA methyltransferase inhibitor DNMT1|DNMT3B RG1530 Phase 1 FGFR inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor FGFR1|FGFR2 RG2833 Phase 1 HDAC inhibitor HDAC1|HDAC3 RG4733 Phase 2 gamma secretase inhibitor PSEN1 RG7112 Phase 1 MDM inhibitor MDM2 RHC-80267 Preclinical triacylglycerol lipase inhibitor DAGLA|DAGLB rhein Phase 1 HSP90AA1 rheochrysidin Preclinical protein tyrosine kinase inhibitor PTPN1 rhodamine-123 Phase 1 RI-1 Preclinical RAD51 ribavirin Launched antiviral ADK|ENPP1|IMPDH1|IMPDH2|NT5C2 ribitol Preclinical ribociclib Phase 3 CDK inhibitor CDK4|CDK6 riboflavin Launched vitamin B2 BLVRB|RFK riboflavin-5-phosphate-sodium Launched BLVRB|DHODH|DPYD|HAO1|HAO2|MT-ND1|NOS1|PNPO|POR|PPCDC|RFK|RPS6KA4|SGK1 ribostamycin Launched bacterial 30S ribosomal subunit inhibitor ribostamycin-sulfate Launched bacterial 30S ribosomal subunit inhibitor P4HB ricinoleic-acid Launched prostanoid receptor agonist PTGER3 rifabutin Launched protein synthesis inhibitor HSP90AA1|HSP90B1 rifampin Launched RNA polymerase inhibitor NR1I2|SLCO1A2|SLCO1B1|SLCO1B3 rifamycin Launched DNA directed RNA polymerase inhibitor SLCO1A2|SLCO1B1|SLCO1B3|SLCO2B1 rifamycin-sv Phase 3 RNA synthesis inhibitor rifapentine Launched RNA polymerase inhibitor CYP2C8|CYP2C9|CYP3A4 rifaximin Launched RNA synthesis inhibitor NR1I2 rigosertib Phase 3 cell cycle inhibitor|PLK inhibitor PLK1 rilmenidine Launched adrenergic receptor agonist|imidazoline receptor agonist ADRA2A rilpivirine Launched non-nucleoside reverse transcriptase inhibitor NR1I2|SCN10A riluzole Launched glutamate inhibitor KCNK10|KCNK2|KCNK4|KCNN4|SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A|SLC7A11 rimantadine Launched antiviral|RNA synthesis inhibitor rimcazole Phase 1 sigma receptor antagonist SIGMAR1 rimexolone Launched glucocorticoid receptor agonist NR3C1|SERPINA6 rimonabant Withdrawn cannabinoid receptor antagonist CNR1|GPR55 riociguat Launched guanylate cyclase stimulant GUCY1A2|GUCY1A3|GUCY1B2|GUCY1B3 riodipine Phase 2 calcium channel blocker riodoxol Launched other antibiotic ripasudil Launched rho associated kinase inhibitor ROCK1|ROCK2 ripazepam Phase 2 benzodiazepine receptor agonist GABRA1 risedronate Launched osteoclast inhibitor FDPS risperidone Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD4|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2C|HTR6|HTR7 RITA Preclinical MDM inhibitor MDM2 ritanserin Phase 3 serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|HTR7 ritodrine Launched adrenergic receptor agonist ADRB2 ritonavir Launched HIV protease inhibitor CYP1A2|CYP2B6|CYP2C19|CYP2C8|CYP2C9|CYP2D6|CYP2E1|CYP3A4|CYP3A5|CYP3A7 rivanicline Phase 2 acetylcholine receptor agonist CHRNA4|CHRNB2|CXCL8 rivaroxaban Launched coagulation factor inhibitor F10 rivastigmine Launched acetylcholinesterase inhibitor ACHE|BCHE rizatriptan Launched serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F RKI-1447 Preclinical rho associated kinase inhibitor CDC42BPA|DMPK|LIMK1|MYLK|PAK1|PKN1|ROCK1|ROCK2 RLX Preclinical RN-1734 Preclinical TRPV antagonist TRPV4 RN-1747 Preclinical TRPV agonist TRPV4 Ro-04-5595 Preclinical GRIN2B Ro-08-2750 Preclinical NGF Ro-10-5824 Preclinical dopamine receptor agonist DRD4 Ro-106-9920 Preclinical NFkB pathway inhibitor Ro-15-4513 Preclinical GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB2|GABRG2 Ro-19-4605 Preclinical GABRA1|GABRA2|GABRA3|GABRA5 Ro-20-1724 Preclinical phosphodiesterase inhibitor PDE3A|PDE4A|PDE4B|PDE4C|PDE4D Ro-25-6981 Preclinical GRIN2B Ro-28-1675 Preclinical glucokinase activator GCK Ro-48-8071 Preclinical oxidosqualene cyclase inhibitor LSS Ro-4987655 Phase 1 MEK inhibitor MAP2K1 Ro-5126766 Phase 1 RAF inhibitor|MEK inhibitor BRAF|MAP2K1|MAP2K2|RAF1 Ro-60-0175 Preclinical HTR2A|HTR2B|HTR2C Ro-61-8048 Preclinical kynurenine 3-monooxygenase inhibitor KMO Ro-90-7501 Preclinical APP Ro-9187 Preclinical HCV inhibitor rociletinib Phase 3 EGFR inhibitor EGFR rocuronium Launched acetylcholine receptor antagonist CHRM2|CHRNA2|HTR3A rofecoxib Withdrawn cyclooxygenase inhibitor ELN|PTGS2 roflumilast Launched phosphodiesterase inhibitor PDE4A|PDE4B|PDE4C|PDE4D rolipram Phase 3 phosphodiesterase inhibitor rolipram-R(-) Preclinical phosphodiesterase inhibitor PDE4A|PDE4B|PDE4C|PDE4D|PDE5A rolipram-S(+) Preclinical phosphodiesterase inhibitor rolitetracycline Launched bacterial 30S ribosomal subunit inhibitor rolziracetam Phase 2 romidepsin Launched HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9 ronidazole Launched antiprotozoal agent ropinirole Launched dopamine receptor agonist ADRA2A|ADRA2B|ADRA2C|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C ropivacaine Launched sodium channel blocker SCN10A roquinimex Phase 3 angiogenesis inhibitor|tumor necrosis factor production inhibitor rosamicin Phase 2 protein synthesis inhibitor roscovitine Phase 2 CDK inhibitor CDK2|CDK9 rose-bengal Launched contrast agent rose-bengal-disodium Phase 2 immunostimulant rose-bengal-lactone Launched coloring agent rosiglitazone Withdrawn insulin sensitizer|PPAR receptor agonist ACSL4|FFAR1|PPARG|TRPC5|TRPM3 rosmarinic-acid Launched GABA transaminase inhibitor MCL1|TYR rosoxacin Launched topoisomerase inhibitor rostafuroxine Phase 2 ATPase inhibitor ATP1A1 rosuvastatin Launched HMGCR inhibitor HMGCR rotigotine Launched dopamine receptor agonist ADRA2B|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A rotundine Launched serotonin receptor agonist DRD1|DRD2|DRD3|HTR1A roxarsone Launched antiprotozoal agent roxatidine-acetate Launched histamine receptor antagonist HRH2 roxithromycin Launched bacterial 50S ribosomal subunit inhibitor ABCB1|MLNR RP67580 Preclinical RRx-001 Phase 2 glucose 6-phosphate dehydrogenase inhibitor G6PD RS-0481 Phase 2 immunostimulant RS-100329 Preclinical adrenergic receptor antagonist ADRA1A|ADRA1D RS-102221 Preclinical serotonin receptor antagonist HTR2A|HTR2B|HTR2C RS-102895 Preclinical CCR antagonist CCR2 RS-127445 Phase 1 serotonin receptor antagonist HTR2A|HTR2B|HTR2C RS-16566 Preclinical serotonin receptor antagonist RS-17053 Preclinical adrenergic receptor antagonist ADRA1A|ADRA1D RS-23597-190 Preclinical serotonin receptor antagonist HTR4 RS-39604 Preclinical serotonin receptor antagonist HTR4 RS-45041-190 Preclinical imidazoline receptor agonist RS-504393 Preclinical CC chemokine receptor antagonist CCL2|CCR2 RS-56812 Preclinical serotonin receptor partial agonist HTR3A RS-67333 Preclinical serotonin receptor partial agonist HTR4 RS-67506 Preclinical serotonin receptor partial agonist HTR4 RS-79948 Preclinical adrenergic receptor antagonist ADRA2A RSV604 Phase 2 RSV replication inhibitor RTA-408 Phase 2 nitric oxide production inhibitor NFE2L2 RU-24969 Phase 1 serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C|HTR5A|HTR6 RU-28318 Phase 2 cytochrome P450 inhibitor NR3C2 RU-42173 Phase 2 adrenergic receptor agonist ADRB2 RU-58841 Phase 2 androgen receptor antagonist AR rubitecan Phase 3 topoisomerase inhibitor TOP1 rucaparib Phase 3 PARP inhibitor PARP1|PARP2 rucinol Phase 1 tyrosinase inhibitor TYR rufinamide Launched voltage-gated sodium channel blocker GRM5|SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A rufloxacin Launched bacterial DNA gyrase inhibitor rupatadine Launched histamine receptor antagonist|platelet activating factor receptor antagonist HRH1|PTAFR rutaecarpine Preclinical cyclooxygenase inhibitor PTGS2 rutin Launched antioxidant|capillary stabilizing agent|nitric oxide scavenger AKR1C3 ruxolitinib Launched JAK inhibitor JAK1|JAK2|JAK3|TYK2 ruxolitinib-(S) Preclinical JAK inhibitor JAK1|JAK2 RWJ-21757 Phase 1 toll-like receptor agonist TLR7 RWJ-67657 Phase 1 MAP kinase inhibitor MAPK14|PTGS2 RX-3117 Phase 1/Phase 2 DNA synthesis inhibitor|CDK inhibitor CDK2|DNMT1 RX-821002 Preclinical adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C ryuvidine Preclinical histone lysine methyltransferase inhibitor CDK2|CDK4 R112 Preclinical syk inhibitor SYK R306465 Phase 1 HDAC inhibitor R547 Phase 1 CDK inhibitor CDK1|CDK2|CDK4|CDK7 S-Isopropylisothiourea Preclinical nitric oxide synthase inhibitor NOS3 S-methylcysteine Phase 1 CTSD|MGMT S-Nitrosoglutathione Phase 1 nitric oxide stimulant PTPN1 S-Sulfo-L-cysteine-sodium-salt Preclinical glutamate receptor agonist S-Trityl-L-cysteine Preclinical mitotic kinesin inhibitor S-111 Phase 2 PARP inhibitor PARP1 S-14506 Preclinical serotonin receptor agonist HTR1A saccharin Launched DNA polymerase inhibitor CA1|CA12|CA2|CA9 saclofen Preclinical GABA receptor antagonist GABBR1|GABBR2|KCTD12|KCTD16|KCTD8 sacubitril Launched neprilysin inhibitor MME safflower-yellow Preclinical anti-inflammatory agent safinamide Launched dopamine uptake inhibitor|glutamate inhibitor|monoamine oxidase inhibitor MAOB safingol Phase 1 PKC inhibitor TRPM3 safranal Phase 2 benzodiazepine receptor agonist GABBR1 salazodine Phase 2 salicin Phase 1 anti-inflammatory agent salicyl-alcohol Preclinical salicylamide Launched analgesic agent salicylanilide Preclinical other antibiotic salicylic-acid Launched cyclooxygenase inhibitor AKR1C1|PTGS1|PTGS2 salidroside Preclinical beta amyloid protein neurotoxicity inhibitor APP salinomycin Launched salirasib Phase 2 mTOR inhibitor TRPA1 salmeterol Launched adrenergic receptor agonist ADRB2 salsolinol-1-carboxylic-acid Preclinical salubrinal Preclinical eukaryotic translation initiation factor inhibitor EIF2S1 salvianolic-acid-B Phase 2 metalloproteinase inhibitor|EGFR inhibitor MMP9 salvinorin-a Phase 1 opioid receptor agonist OPRD1|OPRK1|OPRM1 sal003 Preclinical eukaryotic translation initiation factor inhibitor EIF2A sanazole Phase 1 sangivamycin Phase 1 DNA inhibitor sanguinarium-chloride Phase 1 apoptosis stimulant CASP3 SANT-1 Preclinical smoothened receptor antagonist SHH|SMO SANT-2 Preclinical smoothened receptor antagonist SHH|SMO sapropterin Launched phenylalanine 4-hydroxylase stimulant NOS3|PAH|TH|TPH1 saquinavir Launched HIV protease inhibitor CYP3A4 SAR-245409 Phase 1/Phase 2 PI3K inhibitor MTOR|PIK3CG saracatinib Phase 2/Phase 3 src inhibitor ABL1|LCK|SRC|YES1 sarafloxacin Launched bacterial DNA gyrase inhibitor sarcosine Phase 2 Glycine transporter 1 inhibitor SLC6A9 sari-59-801 Phase 1 saroglitazar Phase 3 PPAR receptor agonist PPARA|PPARG sarpogrelate Launched serotonin receptor antagonist HTR2A|HTR2B|HTR2C SAR131675 Preclinical VEGFR inhibitor FLT4 SAR405838 Phase 1 MDM inhibitor MDM2 SAR407899 Phase 2 rho associated kinase inhibitor ROCK1 sasapyrine Launched NFkB pathway inhibitor PTGS1|PTGS2 satraplatin Phase 3 DNA alkylating agent savolitinib Phase 2 c-Met inhibitor MET saxagliptin Launched dipeptidyl peptidase inhibitor DPP4 SB-200646 Preclinical serotonin receptor antagonist HTR2B|HTR2C SB-202190 Preclinical p38 MAPK inhibitor AKT1|ALOX5|CHEK1|GSK3B|LCK|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|PRKCA|ROCK1|RPS6KB1|SGK1 SB-203186 Preclinical serotonin receptor antagonist HTR4 SB-203580 Preclinical p38 MAPK inhibitor AKT1|ALOX5|CHEK1|CYP2D6|CYP3A4|GAK|GSK3B|LCK|MAPK1|MAPK10|MAPK11|MAPK12|MAPK14|MAPK8|MAPK9|PRKCA|RAF1|RIPK2|ROCK1|RPS6KB1|SGK1|SRC|TNF SB-205384 Preclinical GABA receptor modulator GABRA3|GABRA5|GABRA6 SB-206553 Preclinical serotonin receptor antagonist HTR2A|HTR2B|HTR2C SB-216641 Preclinical serotonin receptor antagonist HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C SB-216763 Preclinical glycogen synthase kinase inhibitor CCNA2|CDK2|GSK3A|GSK3B SB-218078 Preclinical CHK inhibitor CHEK1 SB-218795 Preclinical tachykinin antagonist TACR3 SB-221284 Preclinical serotonin receptor antagonist HTR2A|HTR2B|HTR2C SB-222200 Preclinical tachykinin antagonist TACR3 SB-225002 Preclinical CC chemokine receptor antagonist CXCR2 SB-228357 Preclinical serotonin receptor antagonist HTR2A|HTR2B|HTR2C SB-2343 Phase 1 mTOR inhibitor|PI3K inhibitor MTOR|PIK3CA|PIK3CB|PIK3CD|PIK3CG SB-239063 Preclinical p38 MAPK inhibitor MAPK11|MAPK14|PTGS2 SB-242235 Phase 1 p38 MAPK inhibitor HSPB1|MAPK14 SB-258585 Preclinical serotonin receptor antagonist HTR6 SB-269970 Preclinical serotonin receptor antagonist HTR7 SB-271046 Phase 1 serotonin receptor antagonist HTR6 SB-328437 Preclinical CCR antagonist SB-334867 Preclinical orexin receptor antagonist HCRTR1|HCRTR2 SB-366791 Preclinical TRPV antagonist TRPV1 SB-408124 Preclinical orexin receptor antagonist HCRTR1|HCRTR2 SB-415286 Preclinical glycogen synthase kinase inhibitor GSK3A|GSK3B|RPS6KB1 SB-431542 Preclinical TGF beta receptor inhibitor ACVR1C|TGFBR1 SB-505124 Preclinical ALK tyrosine kinase receptor inhibitor TGFBR1 SB-525334 Preclinical TGF beta receptor inhibitor TGFBR1 SB-590885 Preclinical RAF inhibitor BRAF SB-657510 Preclinical urotensin receptor antagonist UTS2R SB-683698 Phase 1 integrin antagonist ITGA4|ITGAV|ITGB1|ITGB7 SB-705498 Phase 2 TRPV antagonist TRPV1 SB-742457 Phase 3 serotonin receptor antagonist HTR6 SB-743921 Phase 1/Phase 2 kinesin-like spindle protein inhibitor KIF11 SB-756050 Phase 1 G protein-coupled receptor agonist GPBAR1 SB-939 Phase 2 HDAC inhibitor HDAC1|HDAC10|HDAC3|HDAC4|HDAC5|HDAC9 SC-10 Preclinical protein kinase activator PRKCA SC-12267 Phase 2 dihydroorotate dehydrogenase inhibitor IL17A SC-144 Preclinical P glycoprotein inhibitor SC-19220 Preclinical prostanoid receptor antagonist PTGER1 SC-560 Preclinical cyclooxygenase inhibitor PTGS1 SC-9 Preclinical protein tyrosine kinase activator PRKCA SCH-202676 Preclinical G protein-coupled receptor modulator CHRM1|CHRM2|DRD1|DRD2 SCH-23390 Preclinical dopamine receptor antagonist DRD1|DRD5|HTR2C|KCNJ4|KCNJ6 SCH-28080 Phase 1 ATPase inhibitor ATP4A SCH-58261 Preclinical adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 SCH-900776 Phase 2 CHK inhibitor CDK2|CHEK1 schisandrin-b Preclinical antioxidant ATR schisandrol-b Phase 3 lipid peroxidase inhibitor sclareol Preclinical sclareolide Launched other antifungal SCMC-Lys Launched mucolytic agent GSTP1 scopine Launched scopolamine Launched acetylcholine receptor antagonist scopolamine-n-oxide Preclinical acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|SI SCP-1 Phase 1 analgesic agent scriptaid Preclinical HDAC inhibitor HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9 SCS Preclinical SD-169 Preclinical p38 MAPK inhibitor MAPK14 SD-208 Preclinical TGF beta receptor inhibitor TGFBR1 SDM25N Preclinical opioid receptor antagonist OPRD1 SDZ-NKT-343 Phase 1 tachykinin antagonist TACR1 SDZ-SER-082 Preclinical serotonin receptor antagonist HTR2A|HTR2B|HTR2C SDZ-WAG-994 Phase 2 adenosine receptor agonist ADORA1 SDZ-205-557 Preclinical serotonin receptor antagonist HTR3A|HTR3B SDZ-21009 Preclinical adrenergic receptor antagonist|serotonin receptor antagonist HTR1A|HTR1B SDZ-220-040 Preclinical glutamate receptor antagonist GRIN1 SDZ-220-581 Preclinical glutamate receptor antagonist GRIN1 se-methylselenocysteine Phase 2 secalciferol Launched vitamin D receptor agonist VDR seclazone Phase 1 anti-inflammatory agent secnidazole Launched acetylcholinesterase inhibitor|microtubule inhibitor secoisolariciresinol-(-) Preclinical secoisolariciresinol-diglucoside Phase 2 antioxidant securinine Preclinical GABA receptor antagonist|TP53 activator GABRA1 selamectin Launched nematocide selegiline Launched monoamine oxidase inhibitor MAOA|MAOB selenomethionine Launched selexipag Phase 3 platelet aggregation inhibitor|IP1 prostacyclin receptor agonist PTGIR selfotel Phase 3 glutamate receptor antagonist GRIN2A|GRIN2B|GRIN2C|GRIN2D selinexor Phase 2/Phase 3 exportin antagonist XPO1 selumetinib Phase 3 MEK inhibitor MAP2K1 semagacestat Phase 3 gamma secretase inhibitor PSEN1 semapimod Phase 2 cytokine production inhibitor|p38 MAPK inhibitor MAPK14 semaxanib Phase 3 VEGFR inhibitor FGFR1|FLT1|KDR|KIT|PDGFRA|PDGFRB|RET semustine Phase 3 DNA alkylating agent senicapoc Phase 3 intermediate conductance potassium channel blocker KCNN4 sennoside-a Launched glycoside agonist sennoside-protonated Preclinical seocalcitol Phase 3 vitamin D receptor agonist VDR SEP-227900 Phase 1 D-Amino Acid Oxidase Inhibitor DAO seratrodast Launched prostanoid receptor antagonist TBXA2R serdemetan Phase 1 MDM inhibitor MDM2 serotonin Launched growth factor receptor activator DRD1|DRD5|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR3A|HTR3B|HTR4|HTR5A|HTR6|HTR7|SLC36A1 sertaconazole Launched sterol demethylase inhibitor sertindole Withdrawn dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|DRD2|DRD3|DRD4|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2C|HTR6|KCNH2 sertraline Launched selective serotonin reuptake inhibitor (SSRI) SLC6A3|SLC6A4 sesamin Preclinical NFkB pathway inhibitor setipiprant Phase 3 prostaglandin inhibitor PTGDR2 setiptiline Launched adrenergic receptor antagonist HRH1|HTR2A|HTR2C sevelamer Launched phosphate antagonist sevoflurane Launched membrane integrity inhibitor ATP2C1|ATP5D|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GLRA1|GLRB|GRIA1|KCNA1|KCNK10|KCNK18|KCNK2|KCNK3|KCNK9|MT-ND1 SEW-2871 Preclinical lysophospholipid receptor agonist S1PR1 SGC-CBP30 Preclinical bromodomain inhibitor CREBBP|EP300 SGC-0946 Preclinical histone lysine methyltransferase inhibitor SGI-1027 Preclinical DNA methyltransferase inhibitor DNMT1|DNMT3A|DNMT3B SGI-1776 Phase 1 Pim kinase inhibitor FLT3|PIM1|PIM2|PIM3 SGX523 Phase 1 hepatocyte growth factor receptor inhibitor MET shikimic-acid Preclinical SIB-1553A Phase 2 acetylcholine receptor agonist CHRNB4 SIB-1757 Preclinical glutamate receptor antagonist GRM5 SIB-1893 Preclinical glutamate receptor antagonist GRM4|GRM5 sibutramine Withdrawn serotonin–norepinephrine reuptake inhibitor (SNRI) SLC6A2|SLC6A3|SLC6A4 SID-7969543 Preclinical steroidogenic factor antagonist NR5A1 siguazodan Phase 1 phosphodiesterase inhibitor PDE3A sildenafil Launched phosphodiesterase inhibitor PDE5A|PDE6G|PDE6H|SLCO1B1|SLCO1B3 silibinin Launched cytochrome P450 inhibitor ALOX5 silodosin Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D silver-sulfadiazine Launched PABA antagonist silymarin Launched simeprevir Launched HCV inhibitor CYP1A2|CYP3A4 simvastatin Launched HMGCR inhibitor HMGCR|ITGB2 sinefungin Preclinical DNA methyltransferase inhibitor|RNA synthesis inhibitor CARM1 sinomenine Preclinical angiogenesis inhibitor sipatrigine Phase 2 voltage-gated sodium channel blocker CACNA1D|SCN10A|SCN1A|SCN3A|SCN4A|SCN5A|SCN9A siponimod Phase 3 sphingosine phosphate receptor modulator S1PR1 siramesine Phase 2 sigma receptor antagonist ADRA1A|ADRA1B|ADRA1D sirolimus Launched mTOR inhibitor FGF2|FKBP1A|MTOR sirtinol Preclinical SIRT inhibitor SIRT1|SIRT2 sisomicin Launched protein synthesis inhibitor sisomicin-sulfate Launched bacterial 30S ribosomal subunit inhibitor sitafloxacin Launched bacterial DNA gyrase inhibitor sitagliptin Launched dipeptidyl peptidase inhibitor DPP4 sitaxentan Withdrawn endothelin receptor antagonist EDNRA sitosterol Preclinical sivelestat Launched elastase inhibitor CELA1|ELANE SJ-172550 Preclinical MDM inhibitor MDM4 SK&F-10047-(+) Phase 1 sigma receptor agonist SIGMAR1 SKA-31 Preclinical potassium channel activator KCNN4 skepinone-l Preclinical p38 MAPK inhibitor MAPK14 SKF-38393 Preclinical dopamine receptor agonist CALY|DRD1|DRD5 SKF-77434 Preclinical dopamine receptor agonist DRD1 SKF-81297 Preclinical dopamine receptor agonist DRD1|DRD5 SKF-83566 Preclinical dopamine receptor antagonist DRD1|DRD5 SKF-86002 Preclinical p38 MAPK inhibitor ALOX5|MAPK14 SKF-89976A Preclinical GABA uptake inhibitor SLC6A1 SKF-91488 Preclinical histamine N-methyltransferase inhibitor HNMT SKF-96365 Preclinical calcium channel blocker CYP3A4|PKD2|TRPC1|TRPC3|TRPC4|TRPC5|TRPV2 SKI-II Preclinical sphingosine kinase inhibitor SPHK1 SKLB1002 Preclinical VEGFR inhibitor KDR SLV-320 Phase 2 adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 SM-108 Phase 2 SM-164 Preclinical XIAP inhibitor BIRC2|BIRC3|XIAP SM-21 Preclinical sigma receptor antagonist PGRMC1 SMI-4a Preclinical Pim kinase inhibitor PIM1 SN-38 Launched topoisomerase inhibitor TOP1 SN-6 Preclinical sodium/calcium exchange inhibitor SNAP Phase 2 nitric oxide donor PTPN1 SNAP-5089 Preclinical adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|CACNA1C|CACNA1D SNAP-94847 Preclinical ADRA1A|DRD2 SNC-80 Preclinical OPRD1 SNG-1153 Preclinical selective estrogen receptor modulator (SERM) ESR1 SNS-314 Phase 1 Aurora kinase inhibitor AURKA|AURKB|AURKC SNX-2112 Phase 1 HSP inhibitor SNX-5422 Phase 1/Phase 2 HSP inhibitor HSP90AA1 sobetirome Phase 1 thyroid hormone receptor agonist THRA|THRB sobrepin Launched mucolytic agent sodium-ascorbate Launched sodium-butyrate Phase 2 HDAC inhibitor BCHE|FFAR2|FFAR3|HDAC1|HDAC2|HDAC3|HDAC8 sodium-danshensu Preclinical sodium-dodecyl-sulfate Preclinical ALB|LYZ sodium-glucoheptonate Launched sodium-gluconate Launched sodium-gualenate Launched antacid sodium-monofluorophosphate Launched PYGM sodium-nitrite Launched nitric oxide donor sodium-nitroprusside Launched nitric oxide donor sodium-orthovanadate Preclinical sodium-oxybate Launched benzodiazepine receptor agonist GABRB1|HCAR1|SLC52A2 sodium-picosulfate Launched sodium-salicylate Launched prostanoid receptor antagonist ASIC3|PTGS1|PTGS2 sodium-stibogluconate Launched tyrosine phosphatase inhibitor PTPN6|TOP1 sodium-tanshinone-ii-a-sulfonate Phase 2 potassium channel activator sodium-tetradecyl-sulfate Launched PROC|PROS1 sofalcone Launched mucus protecting agent CBR1 sofosbuvir Launched RNA polymerase inhibitor solamargine Phase 3 apoptosis inhibitor solcitinib Phase 1 JAK inhibitor JAK1 solifenacin-succinate Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 solithromycin Phase 3 protein synthesis inhibitor somantadine Phase 1 antiviral somatostatin Launched somatostatin receptor agonist OPRD1|OPRM1|SSTR1|SSTR2|SSTR3|SSTR4|SSTR5 sonidegib Launched smoothened receptor antagonist SMO sophocarpine Phase 3 sorafenib Launched FLT3 inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|RAF inhibitor|RET tyrosine kinase inhibitor|VEGFR inhibitor BRAF|DDR2|FGFR1|FLT1|FLT3|FLT4|KDR|KIT|PDGFRB|RAF1|RET sorbic-acid Preclinical sorbinil Phase 3 aldose reductase inhibitor AKR1B1 sorbitan-monostearate Preclinical sorbitol Launched mucolytic agent sotagliflozin Phase 3 sodium/glucose cotransporter inhibitor SLC5A1|SLC5A2 sotalol Launched adrenergic receptor antagonist ADRB1|ADRB2|KCNH2 sotrastaurin Phase 2 PKC inhibitor PRKCA|PRKCB|PRKCD|PRKCE|PRKCH|PRKCQ SP-420 Phase 1 spaglumic-acid Launched glutamate receptor antagonist GRM3 sparfloxacin Withdrawn bacterial DNA gyrase inhibitor TOP2A sparfosate Phase 3 aspartate carbamoyltransferase inhibitor CA2|CA4|CAD sparteine-sulfate Launched spectinomycin Launched bacterial 30S ribosomal subunit inhibitor spermidine Preclinical glutamate receptor modulator KCNJ4|TXNRD1 spermine Preclinical CA14|CA4|CA6|CA9|CASR|GRIN1|GRIN2A|KCNJ4|ODC1|SMOX|SMS|TRPM4|TRPM5 sphingosylphosphorylcholine Preclinical gene expression stimulant GPR12 spiperone Launched dopamine receptor antagonist ADRA1A|ADRA1B|ADRA1D|DRD1|DRD2|DRD3|DRD4|DRD5|HTR1A|HTR1D|HTR2A|HTR2B|HTR2C|HTR6|HTR7 spiradoline Phase 2 opioid receptor agonist OPRK1 spiramycin Launched bacterial 50S ribosomal subunit inhibitor spirobromin Phase 1 spironolactone Launched mineralocorticoid receptor antagonist AR|CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1F|CACNA1G|CACNA1H|CACNA1I|CACNA1S|CACNA2D1|CACNA2D2|CACNA2D3|CACNB1|CACNB2|CACNB3|CACNB4|CACNG1|CYP11B2|NR3C1|NR3C2|PGR|SHBG spiroxatrine Preclinical serotonin receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|HTR1A|HTR2B spizofurone Withdrawn splitomycin Preclinical SIRT inhibitor SIRT1 SPP301 Phase 3 endothelin receptor antagonist EDNRA SQ-109 Phase 3 bacterial cell wall synthesis inhibitor FDFT1 SQ-22536 Preclinical adenylyl cyclase inhibitor ADCY1 SR-11302 Preclinical SR-2640 Phase 2 leukotriene receptor antagonist CYSLTR1 SR-27897 Phase 2 CCK receptor antagonist CCKAR SR-3306 Preclinical JNK inhibitor MAPK10|MAPK8|MAPK9 SR-33805 Phase 1 calcium channel blocker SR-57227A Phase 2 serotonin receptor agonist HTR3A SR-59230A Preclinical adrenergic receptor antagonist ADRB1|ADRB2|ADRB3 SR-95639A Preclinical acetylcholine receptor agonist CHRM1 SRC-kinase-inhibitor-I Preclinical src inhibitor CSK|LCK|RIPK2 SRPIN340 Preclinical serine arginine protein kinase inhibitor SRPK1|SRPK2 SRT1720 Preclinical SIRT activator SIRT1 SRT2104 Phase 2 SIRT activator SIRT1 SSR128129E Preclinical ST-1859 Phase 1 antiamyloidogenic agent ST-2825 Preclinical myeloid differentiation primary response inhibitor MYD88 ST-91 Preclinical adrenergic receptor agonist STA-5326 Phase 2 interleukin synthesis inhibitor IL12A stanozolol Launched androgen receptor agonist AR stattic Preclinical STAT3-inhibitor-VI Preclinical STAT inhibitor STAT3 stavudine Launched DNA directed DNA polymerase inhibitor|nucleoside reverse transcriptase inhibitor stemregenin-1 Preclinical aryl hydrocarbon receptor antagonist AHR stepronin Launched mucolytic agent stetaderm Launched STF-083010 Preclinical serine/threonine kinase inhibitor ERN1 STF-118804 Preclinical NAMPT inhibitor NAMPT STF-62247 Preclinical autophagy inducer stigmasterol Preclinical stiripentol Launched GABA uptake inhibitor GABRA3 stobadine Phase 2 adrenergic receptor antagonist ADRA1A streptomycin Launched bacterial 30S ribosomal subunit inhibitor streptozotocin Launched DNA alkylating agent SLC2A2 strontium-ranelate Launched bone formation stimulant|bone resorption inhibitor CASR strychnine Preclinical acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|CHRNA10|CHRNA9|GLRA1|GLRA2|GLRA3|GLRB SU-11274 Preclinical hepatocyte growth factor receptor inhibitor|tyrosine kinase inhibitor MET SU-4312 Preclinical PDGFR tyrosine kinase receptor inhibitor|tyrosine kinase inhibitor|VEGFR inhibitor KDR|PDGFRB substance-p Phase 1 neurokinin receptor antagonist TACR1|TACR2|TACR3 succinic-acid Launched ALDH5A1|ASPH|BBOX1|HSD17B6|OXCT1|OXCT2|P3H1|P3H2|P3H3|P4HA1|P4HA2|PLOD1|PLOD3|SDHA|SDHB|SDHC|SDHD|SLC13A1|SLC13A2|SLC13A3|SLC25A10|SUCLA2|SUCLG1|SUCLG2|SUCNR1|TMLHE succinylcholine-chloride Launched CHRFAM7A|CHRM1|CHRM2|CHRM3|CHRNA1|CHRNA10 succinylsulfathiazole Phase 2 dihydrofolate reductase inhibitor DHFR sucralfate Launched antacid EGF|FGA|FGB|FGF2|FGG sucralose Launched sucrose Launched ACTA1|ATOX1|C22orf28|LYZ sucrose-octaacetate Preclinical sudan-iv Preclinical sufentanil Launched opioid receptor modulator OPRD1|OPRK1|OPRM1 sulbactam Launched beta lactamase inhibitor sulbactam-pivoxil Launched beta lactamase inhibitor sulbentine Preclinical other antifungal sulbutiamine Launched acetylcholine receptor antagonist sulconazole Launched sterol demethylase inhibitor sulfabenzamide Launched bacterial antifolate sulfacarbamide Withdrawn sulfacetamide Launched PABA antagonist sulfachlorpyridazine Launched bacterial antifolate sulfadiazine Launched bacterial antifolate sulfadoxine Launched dihydropteroate synthase inhibitor sulfafurazole Launched bacterial antifolate sulfaguanidine Launched bacterial antifolate sulfamerazine Launched bacterial antifolate sulfameter Launched dihydrofolate reductase inhibitor DHFR sulfamethazine Launched PABA antagonist sulfamethizole Launched bacterial antifolate sulfamethoxazole Launched PABA antagonist sulfamethoxypyridazine Withdrawn bacterial antifolate sulfametopyrazine Launched PABA antagonist sulfamonomethoxine Launched bacterial antifolate sulfamoxole Launched PABA antagonist sulfanilamide Launched carbonic anhydrase inhibitor CYP2C19|CYP2C9|CYP2D6|CYP2E1|CYP3A4 sulfanilate-zinc Preclinical sulfanitran Launched sulfaphenazole Launched dihydropteroate synthetase inhibitor DHPS sulfapyridine Launched PABA antagonist sulfaquinoxaline Launched vitamin K antagonist sulfasalazine Launched cyclooxygenase inhibitor ACAT1|ALOX5|CHUK|IKBKB|PLA2G1B|PPARG|PTGS1|PTGS2|SLC46A1|SLC7A11|TBXAS1 sulfathiazole Launched dihydropteroate synthase inhibitor sulfinpyrazone Launched uricosuric blocker ABCC1|ABCC2|FPR1|SLC22A12 sulfisoxazole-acetyl Launched folic acid antagonist sulforaphane Phase 2 anticancer agent|aryl hydrocarbon receptor antagonist NFE2L2 sulindac Launched cyclooxygenase inhibitor AKR1B1|MAPK3|PPARD|PTGDR2|PTGS1|PTGS2 sulisobenzone Launched sulmazole Phase 1 adenosine receptor antagonist sulmetozine Launched gastrin inhibitor GAST suloctidil Withdrawn adrenergic receptor antagonist sulphadimethoxine Launched dihydropteroate synthetase inhibitor sulpiride Launched dopamine receptor antagonist sumanirole Phase 3 dopamine receptor agonist DRD2 sumatriptan Launched serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR5A|HTR6|HTR7 SUN-B-8155 Preclinical calcitonin agonist CALCR sunitinib Launched FLT3 inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|RET tyrosine kinase inhibitor|VEGFR inhibitor suplatast Launched histamine release inhibitor|immunoglobulin inhibitor suprofen Withdrawn cyclooxygenase inhibitor PTGS1|PTGS2 suramin Launched DNA synthesis inhibitor F2|FSHR|P2RY1|P2RY11|P2RY13|P2RY2|PLA2G2A|RYR1|RYR2|SIRT5 suritozole Phase 2 GABA receptor inverse agonist GABBR1 sutezolid Phase 2 protein synthesis inhibitor suvorexant Launched orexin receptor antagonist HCRTR1|HCRTR2 suxibuzone Launched cyclooxygenase inhibitor SU014813 Phase 2 PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor KDR SU3327 Preclinical JNK inhibitor MAPK8 SU9516 Preclinical CDK inhibitor CDK1|CDK2|CDK4|CDK5 swainsonine Phase 2 alpha mannosidase inhibitor MAN2A1 SX-011 Preclinical MAP kinase inhibitor MAPK14 SYM-2081 Preclinical kainate receptor antagonist GRIK1|GRIK2|GRIK3|GRIK4|GRIK5|SLC1A2 SYM-2206 Preclinical glutamate receptor antagonist GRIA1|GRIA2|GRIA3|GRIA4 symclosene Preclinical synephrine Launched adrenergic receptor agonist ADRA1A S1P1-agonist-III Preclinical sphingosine kinase inhibitor S1PR1 S18986 Phase 2 glutamate receptor modulator GRIA1|GRIA2|GRIA3|GRIA4 S26948 Preclinical PPAR receptor agonist PPARG T-0070907 Preclinical PPAR receptor antagonist PPARG T-0156 Preclinical phosphodiesterase inhibitor PDE5A T-0901317 Preclinical LXR agonist NCOA1|NCOA2|NR1H2|NR1H3|NR1I2|RXRB T-5224 Phase 2 AP inhibitor JUN T-62 Phase 2 adenosine receptor modulator ADORA2A TA-01 Preclinical casein kinase inhibitor|MAP kinase inhibitor CSNK1D|CSNK1E|MAPK14 tabimorelin Phase 2 growth hormone secretagogue receptor agonist GHSR tacalcitol Launched vitamin D receptor agonist VDR tacedinaline Phase 3 HDAC inhibitor HDAC1 tacrine Launched acetylcholinesterase inhibitor ACHE|BCHE tacrolimus Launched calcineurin inhibitor FKBP1A tadalafil Launched phosphodiesterase inhibitor PDE11A|PDE5A tafamidis-meglumine Launched transthyretin amyloid inhibitor TTR tafenoquine Phase 3 antimalarial agent tagatose Phase 3 phosphorylase inhibitor PYGL TAK-063 Phase 2 phosphodiesterase inhibitor PDE10A TAK-220 Phase 1 CC chemokine receptor antagonist CCR5 TAK-285 Phase 1 EGFR inhibitor ERBB2 TAK-593 Phase 1 VEGFR inhibitor PDGFRA TAK-632 Preclinical RAF inhibitor BRAF TAK-715 Phase 2 p38 MAPK inhibitor MAPK14 TAK-733 Phase 1 MEK inhibitor MAP2K1 TAK-875 Phase 3 insulin secretagogue FFAR1 TAK-901 Phase 1 Aurora kinase inhibitor AURKB TAK-960 Phase 1 PLK inhibitor PLK1 talabostat Phase 3 dipeptidyl peptidase inhibitor|fibroblast activation protein inhibitor DPP4 taladegib Phase 2 smoothened receptor antagonist DHH|IHH|SMO talampanel Phase 2 glutamate receptor antagonist GRIA1|GRIA2|GRIA3|GRIA4 talarozole Phase 2 cytochrome P450 inhibitor CYP26A1 talazoparib Phase 3 PARP inhibitor PARP2 talc Launched talinolol Launched adrenergic receptor antagonist ADRB1 talipexole Launched adrenergic receptor agonist|dopamine receptor agonist ADRA2A|DRD2|HTR3A talmapimod Phase 2 p38 MAPK inhibitor MAPK11|MAPK14 talnetant Phase 2 tachykinin antagonist TACR2|TACR3 talniflumate Launched cyclooxygenase inhibitor CLCA1 taltirelin Launched thyrotropin releasing hormone receptor agonist TRHR taltobulin Phase 1 tubulin polymerization inhibitor TAME Preclinical tamibarotene Launched retinoid receptor agonist RARA|RARB tamoxifen Launched estrogen receptor antagonist|selective estrogen receptor modulator (SERM) EBP|ESR1|ESR2|GPER1|PRKCA|PRKCB|PRKCD|PRKCE|PRKCG|PRKCI|PRKCQ|PRKCZ tamsulosin Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D tanaproget Phase 2 progesterone receptor agonist PGR tandospirone Launched serotonin receptor agonist HTR1A tandutinib Phase 2 FLT3 inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor CSF1R|FLT3|KIT|PDGFD|PDGFRB tanespimycin Phase 3 HSP inhibitor HSP90AA1 tangeritin Preclinical cell cycle inhibitor tannic-acid Launched PARG inhibitor ANO1 tanshinone-i Phase 2 AP inhibitor IFNG tanshinone-iia Phase 2/Phase 3 anti-inflammatory agent|interleukin inhibitor IL1B|NR1I2|TNF tapentadol Launched opioid receptor agonist HTR3A|OPRD1|OPRK1|OPRM1|SLC6A2|SLC6A4 taprenepag Phase 2 prostaglandin receptor agonist PTGER2 tarafenacin Phase 2 acetylcholine receptor antagonist CHRM3 taranabant Phase 3 cannabinoid receptor inverse agonist CNR1 targinine Phase 3 nitric oxide synthase inhibitor NOS3 tariquidar Phase 3 P glycoprotein inhibitor ABCB1 tartaric-acid Launched antioxidant ATP6V1C1|B3GAT1|DDX6|HIF1AN|TREM1 TAS-103 Phase 1 topoisomerase inhibitor TOP1 taselisib Phase 3 PI3K inhibitor PIK3CA tasimelteon Launched melatonin receptor agonist MTNR1A|MTNR1B tasisulam Phase 3 apoptosis stimulant tasquinimod Phase 3 angiogenesis inhibitor|S100A9 inhibitor HDAC4 tasuldine Phase 3 mucolytic agent taurine Launched antioxidant taurocholate Phase 1 G protein-coupled receptor agonist CEL|FABP6|SLCO1C1 taurolidine Launched apoptosis stimulant tavaborole Launched leucyl-tRNA synthetase inhibitor taxifolin Phase 2 opioid receptor antagonist ADIPOR2 tazarotene Launched retinoid receptor agonist RARA|RARB|RARG|RXRB tazemetostat Phase 2 histone lysine methyltransferase inhibitor EZH2 tazobactam Launched beta lactamase inhibitor TBA-354 Phase 1 TBOA-(DL) Preclinical excitatory amino acid transporter inhibitor SLC1A1|SLC1A2|SLC1A3|SLC1A6|SLC1A7 TCID Preclinical TCN201 Preclinical glutamate receptor antagonist GRIN2A TCS-359 Preclinical FLT3 inhibitor FLT3 TCS2002 Preclinical glycogen synthase kinase inhibitor GSK3B TC1 Preclinical beta-secretase inhibitor BACE1 TC2559 Preclinical acetylcholine receptor agonist CHRNA4 tebipenem Launched bacterial cell wall synthesis inhibitor CNR1 tecalcet Phase 2 calcium-sensing receptor agonist CASR tecastemizole Phase 3 histamine receptor antagonist KCNH2 tecovirimat Phase 3 orthopoxvirus egress inhibitor tedizolid Launched bacterial 50S ribosomal subunit inhibitor tedizolid-phosphate Launched protein synthesis inhibitor tegaserod Withdrawn serotonin receptor partial agonist HTR2A|HTR2B|HTR2C|HTR4 tegobuvir Phase 3 HCV inhibitor|protease inhibitor teicoplanin Launched bacterial cell wall synthesis inhibitor teicoplanin-A2-1 Launched bacterial cell wall synthesis inhibitor teicoplanin-a2-3 Launched bacterial cell wall synthesis inhibitor telaprevir Launched HCV inhibitor CTSA|PGR telatinib Phase 2 KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor KDR telbivudine Launched DNA polymerase inhibitor TK2 telcagepant Phase 3 calcitonin antagonist CALCRL|RAMP1 telenzepine Phase 3 acetylcholine receptor antagonist CHRM1 telithromycin Launched bacterial 30S ribosomal subunit inhibitor|bacterial 50S ribosomal subunit inhibitor CYP1A2|CYP2D6|CYP3A4|CYP3A5|CYP3A7 telmesteine Launched mucolytic agent telmisartan Launched angiotensin receptor antagonist AGTR1|PPARG telotristat Phase 3 serotonin receptor antagonist|serotonin release inhibitor TPH1 temazepam Withdrawn benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GABRR1|GABRR2|GABRR3|TSPO temefos Launched cholinesterase inhibitor temocapril Launched angiotensin converting enzyme inhibitor ACE temoporfin Launched radical formation stimulant temozolomide Launched DNA alkylating agent MGMT tempol Phase 2 free radical scavenger temsirolimus Launched mTOR inhibitor MTOR tenatoprazole Phase 2 ATPase inhibitor IDO1 teneligliptin Launched dipeptidyl peptidase inhibitor DPP4 tenidap Phase 3 cyclooxygenase inhibitor KCNJ4|PTGS1 tenilsetam Phase 3 AGE inhibitor teniposide Launched topoisomerase inhibitor TOP2A|TOP2B tenofovir Launched HIV integrase inhibitor|nucleoside reverse transcriptase inhibitor tenofovir-alafenamide Preclinical nucleoside reverse transcriptase inhibitor tenofovir-disoproxil Launched nucleoside reverse transcriptase inhibitor CYP1A2 tenovin-1 Preclinical SIRT inhibitor|TP53 activator SIRT1 tenovin-6 Preclinical SIRT inhibitor SIRT1|SIRT2|SIRT3 tenoxicam Launched cyclooxygenase inhibitor PTGS1|PTGS2 tenylidone Preclinical tepoxalin Launched cyclooxygenase inhibitor|lipoxygenase inhibitor ALOX5 TEPP-46 Preclinical pyruvate kinase isozyme activator PKM teprenone Launched mucus protecting agent terameprocol Phase 1/Phase 2 lipoxygenase inhibitor BIRC5|CDK1 terazosin Launched adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|KCNH2|KCNH6|KCNH7 terbinafine Launched fungal squalene epoxidase inhibitor SQLE terbutaline Launched adrenergic receptor agonist ADRB2 terciprazine Phase 1 terconazole Launched sterol demethylase inhibitor terfenadine Withdrawn histamine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HRH1|KCNH1|KCNH2 terguride Launched dopamine receptor agonist|serotonin receptor antagonist ADRA1A|ADRA2A|ADRA2B|ADRA2C|DRD2|DRD3|DRD4|HTR1A|HTR1B|HTR1D|HTR2A|HTR2B|HTR2C teriflunomide Launched dihydroorotate dehydrogenase inhibitor DHODH terlipressin Launched vasopressin receptor agonist AVPR1A|AVPR1B|AVPR2 terodiline Phase 3 cholinergic receptor antagonist teroxirone Phase 1 DNA inhibitor terpene Preclinical terreic-acid-(-) Preclinical Bruton's tyrosine kinase (BTK) inhibitor BTK terutroban Phase 3 prostanoid receptor antagonist TBXA2R tesaglitazar Phase 3 insulin sensitizer|PPAR receptor agonist PPARA|PPARG testolactone Launched aromatase inhibitor CYP19A1 testosterone Launched androgen receptor agonist AR testosterone-enanthate Launched androgen receptor agonist AR testosterone-propionate Launched androgen receptor agonist AR testosterone-undecanoate Launched androgen receptor agonist AR tetrabenazine Launched vesicular monoamine transporter inhibitor DRD2|SLC18A1|SLC18A2 tetracaine Launched membrane integrity inhibitor SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A tetracycline Launched bacterial 30S ribosomal subunit inhibitor PRNP tetradecylthioacetic-acid Phase 2 lipid peroxidase inhibitor tetraethylenepentamine Phase 2/Phase 3 superoxide dismutase inhibitor SOD1|SOD2 tetrahydrofolic-acid Launched ALDH1L1|AMT|ATIC|FOLR2|FTCD|MTFMT|MTHFD1|MTHFD2|MTHFR|MTR|SHMT1|SHMT2 tetrahydropapaverine Preclinical tetrahydrouridine Phase 2 cytidine deaminase inhibitor CDA tetrahydrozoline Launched adrenergic receptor agonist tetramethylthiuram-monosulfide Preclinical tetramisole Launched immunostimulant tetrandrine Preclinical calcium channel blocker SLC6A3 tetrazol-5-yl-glycine-(RS) Preclinical glutamate receptor agonist GRIN1|GRIN2A|GRIN2B|GRIN2C|GRIN2D tetrindole Phase 3 monoamine oxidase inhibitor MAOA tetroquinone Preclinical TG-003 Preclinical CLK inhibitor CLK1|CLK4|DYRK1A|DYRK1B TG-02 Phase 1 CDK inhibitor|FLT3 inhibitor|JAK inhibitor CDK1|CDK2|CDK7|CDK9|FLT3|JAK2 TG-100572 Preclinical src inhibitor|VEGFR inhibitor KDR|SRC TG-100713 Preclinical PI3K inhibitor TG-100801 Phase 2 src inhibitor|VEGFR inhibitor FGFR1|FLT1|KDR|SRC TG-101209 Preclinical JAK inhibitor JAK2|JAK3 TG-101348 Phase 3 FLT3 inhibitor|JAK inhibitor BRD4|JAK1|JAK2|JAK3|TYK2 TGR-1202 Phase 3 PI3K inhibitor TGX-221 Preclinical PI3K inhibitor PIK3CB|PIK3CD TG100-115 Phase 1/Phase 2 PI3K inhibitor PIK3CA|PIK3CB|PIK3CD|PIK3CG TH-302 Phase 3 DNA alkylating agent thaliblastine Phase 2 DNA inhibitor thalidomide Launched tumor necrosis factor production inhibitor CRBN|FGFR2|NFKB1|ORM1|ORM2|PTGS2|TNF theobromine Launched phosphodiesterase inhibitor ADORA1|ADORA2A|PDE4B theophylline Launched adenosine receptor antagonist thiamet-g Preclinical GLCNAC phosphotransferase inhibitor MGEA5 thiamine Launched vitamin B SLC19A2|SLC19A3|TPK1 thiamine-pyrophosphate Launched thiamphenicol Launched bacterial 50S ribosomal subunit inhibitor thiamylal Launched glutamate receptor antagonist GABRA1|KCNJ11|KCNJ8 thiazovivin Preclinical rho associated kinase inhibitor thiethylperazine Launched dopamine receptor antagonist DRD1|DRD2|DRD4 thiocolchicoside Launched GABA receptor antagonist GABRA1|GABRB2|GABRG2|GLRA1|GLRB thioctic-acid Launched reducing agent ACHE|LIAS|LIPT1|PTGS2|SLC5A6 thiodiglycol Preclinical thioguanine Launched purine antagonist IMPDH1|IMPDH2 thiomersal Launched other antibiotic OXCT1 thiopental Launched GABA receptor antagonist CHRNA4|CHRNA7|FAAH|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GRIA2|GRIK2 thioperamide Preclinical histamine receptor antagonist HRH3|HRH4 thiophanate Preclinical thioproperazine Launched dopamine receptor antagonist ADRA1A|ADRA1B|DRD1|DRD2|HTR1A|HTR2A thioridazine Withdrawn dopamine receptor antagonist ADRA1A|ADRA1B|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR2A|HTR2C|HTR6|HTR7|KCNH2 thiorphan Phase 1 membrane metalloendopeptidase inhibitor MME thiostrepton Launched FOXM1 inhibitor|protein synthesis inhibitor FOXM1 thiotepa Launched cytochrome P450 inhibitor CYP2B6|CYP3A4 thiothixene Launched dopamine receptor antagonist DRD1|DRD2|HRH1|HTR2A thiram Launched JAK2 thonzonium Launched ATPase inhibitor thonzylamine Launched antihistamine threo-2-methylisocitrate-(DL) Preclinical isocitrate lyase substrate thymol Launched GABA receptor positive allosteric modulator TRPA1 thymol-iodide Preclinical THZ1 Preclinical CDK inhibitor CDK7 THZ1-R Preclinical CDK inhibitor CDK7 THZ2 Preclinical CDK inhibitor CDK7 TH588 Preclinical MTH1 inhibitor NUDT1 tiabendazole Launched angiogenesis inhibitor tiagabine Launched GABA uptake inhibitor SLC6A1 tianeptine Launched selective serotonin reuptake enhancer (SSRE) OPRD1|OPRK1|OPRM1 tiapride Launched dopamine receptor antagonist DRD2|DRD3 tiaprofenic-acid Launched cyclooxygenase inhibitor PTGS1|PTGS2 tiaramide Launched anti-inflammatory agent tibolone Launched androgen receptor agonist|estrogen receptor agonist|progesterone receptor agonist ESR1 ticagrelor Launched purinergic receptor antagonist P2RY12 ticarcillin Launched lactamase inhibitor ticlopidine Launched purinergic receptor antagonist P2RY12 TIC10 Phase 2 AKT inhibitor|TRAIL modulator AKT1|MAPK1 tideglusib Phase 2 glycogen synthase kinase inhibitor GSK3B tienilic-acid Withdrawn sodium/potassium/chloride transporter inhibitor|cytochrome P450 inhibitor CYP2C9|SLC12A1 tie2-kinase-inhibitor Preclinical TIE tyrosine kinase inhibitor KDR|MAPK14 tifenazoxide Phase 1 ATP-sensitive potassium channel agonist ABCC8|KCNJ11 tigecycline Launched bacterial 30S ribosomal subunit inhibitor tiletamine Launched glutamate receptor antagonist tilmicosin Launched bacterial 50S ribosomal subunit inhibitor tilorone Launched interferon inducer tiludronate Launched bone resorption inhibitor|osteoclast inhibitor ATP6V1A|MMP2|PTPN1 timofibrate Phase 2 cholesterol inhibitor|lipase clearing factor inhibitor LPL timolol Launched adrenergic receptor antagonist ADRB1|ADRB2 timonacic Launched antioxidant ANXA5 tinidazole Launched antiprotozoal agent tioconazole Launched sterol demethylase inhibitor CYP51A1 tioguanine Phase 2 purine antagonist tiopronin Launched chelating agent|reducing agent tiotidine Phase 2 histamine receptor antagonist HRH2 tiotropium Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3 tioxolone Preclinical carbonic anhydrase inhibitor CA2 tipifarnib Phase 3 farnesyltransferase inhibitor FNTA|FNTB tipiracil Launched thymidine phosphorylase inhibitor TYMP tiplaxtinin Phase 1 plasminogen activator inhibitor SERPINE1 tipranavir Launched HIV protease inhibitor tiprenolol Phase 2 adrenergic receptor antagonist ADRB1|ADRB2|ADRB3 tiquizium Launched acetylcholine receptor antagonist tiracizine Withdrawn sodium channel blocker SCN5A tirapazamine Phase 3 DNA inhibitor tirasemtiv Phase 2 troponin activator tiratricol Launched thyroid hormone stimulant THRA|THRB tirofiban Launched platelet aggregation inhibitor|structural glycoprotein antagonist ITGA2B|ITGB3 titanocene-dichloride Phase 2 apoptosis stimulant tivantinib Phase 3 tyrosine kinase inhibitor MET tivozanib Phase 3 VEGFR inhibitor FLT1|FLT4|KDR|KIT|PDGFRA|PDGFRB tizanidine Launched adrenergic receptor agonist ADRA2A|ADRA2B|ADRA2C|NISCH TMC-353121 Phase 2 RSV fusion inhibitor TMC647055 Phase 2 RNA polymerase inhibitor TMPH Preclinical TMS Preclinical TNP-470 Phase 2 methionine aminopeptidase inhibitor tobramycin Launched bacterial 30S ribosomal subunit inhibitor tocainide Launched sodium channel blocker SCN5A toceranib Launched protein tyrosine kinase inhibitor FLT1|FLT3|KDR|PDGFRA|PDGFRB tocofersolan Launched antioxidant todralazine Launched antihypertensive agent tofacitinib Launched JAK inhibitor JAK1|JAK2|JAK3|TYK2 tofisopam Launched phosphodiesterase inhibitor|cytochrome P450 inhibitor CYP3A4|PDE10A|PDE2A|PDE3A|PDE4A tofogliflozin Launched sodium/glucose cotransporter inhibitor GCK tolamolol Phase 3 adrenergic receptor antagonist ADRB1|ADRB2|ADRB3 tolazamide Launched ATP channel blocker ABCC8|KCNJ1|KCNJ10|KCNJ11 tolazoline Launched adrenergic receptor antagonist ADRA1A|ADRA2A|ADRA2B|ADRA2C|HRH1|HRH2 tolbutamide Launched ATP channel blocker ABCC8|KCNJ1|KCNJ11|KCNJ8 tolcapone Withdrawn catechol O methyltransferase inhibitor COMT tolfenamic-acid Launched cyclooxygenase inhibitor|prostanoid receptor antagonist tolimidone Phase 2 src activator LYN|SRC tolmetin Launched cyclooxygenase inhibitor PTGS1|PTGS2 tolnaftate Launched fungal squalene epoxidase inhibitor tolonidine Launched adrenergic receptor antagonist ADRA2A tolonium Launched toloxatone Launched monoamine oxidase inhibitor MAOA|MAOB tolperisone Launched voltage-gated sodium channel blocker CYP2C19|CYP2D6 tolrestat Withdrawn aldose reductase inhibitor AKR1A1|AKR1B1|AKR1B10 tolterodine Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 toltrazuril Launched antiprotozoal agent tolvaptan Launched vasopressin receptor antagonist AVPR1A|AVPR2 tomelukast Phase 3 leukotriene receptor antagonist CYSLTR1 tonabersat Phase 2 gap junction modulator|nitric oxide production inhibitor topiramate Launched carbonic anhydrase inhibitor|glutamate receptor antagonist|kainate receptor antagonist CA1|CA12|CA2|CA4|CA7|GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GRIA1|GRIA2|GRIA3|GRIA4|GRIK1|GRIK2|GRIK3|GRIK4|GRIK5|SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A topiroxostat Launched xanthine oxidase inhibitor XDH topotecan Launched topoisomerase inhibitor TOP1|TOP1MT torasemide Launched electrolyte reabsorption inhibitor|thromboxane receptor antagonist SLC12A1 torcetrapib Phase 3 cholesteryl ester transfer protein inhibitor CETP torcitabine Phase 2 DNA polymerase inhibitor DCK|TK2 toremifene Launched estrogen receptor antagonist|selective estrogen receptor modulator (SERM) ESR1 torin-1 Preclinical mTOR inhibitor MTOR torin-2 Preclinical mTOR inhibitor MTOR tosedostat Phase 2 peptidase inhibitor ANPEP|LAP3|NPEPPS tosufloxacin Launched bacterial DNA gyrase inhibitor toyocamycin Phase 1 serine/threonine kinase inhibitor ERN1 tozadenant Phase 3 adenosine receptor antagonist ADORA2A tozasertib Phase 2 Aurora kinase inhibitor|Bcr-Abl kinase inhibitor|FLT3 inhibitor|JAK inhibitor AURKA|AURKB|AURKC|LCK TP-0903 Preclinical AXL kinase inhibitor AXL TPCA-1 Preclinical IKK inhibitor IKBKB TPPS4 Phase 1 tracazolate Phase 2 GABA receptor modulator GABRA1 TRAM-34 Preclinical potassium channel antagonist KCNN4 tramadol Launched norepinephrine reputake inhibitor|opioid receptor agonist|serotonin reuptake inhibitor CHRFAM7A|CHRM3|GRIN3A|HTR2C|OPRD1|OPRK1|OPRM1|SLC6A2|SLC6A4 trametinib Launched MEK inhibitor MAP2K1|MAP2K2 tramiprosate Phase 3 beta amyloid protein neurotoxicity inhibitor APP trandolapril Launched angiotensin converting enzyme inhibitor ACE tranexamic-acid Launched antifibrinolytic|plasminogen activator inhibitor PLG tranilast Launched angiogenesis inhibitor HPGDS|HRH1 trans-2-Undecenoic-acid Preclinical trans-4-Hydroxycrotonic-acid Preclinical gamma hydroxybutyric acid ligand trans-4-Methoxycinnamic-acid Preclinical tranylcypromine Launched monoamine oxidase inhibitor KDM1A|MAOA|MAOB trap-101 Preclinical nociceptin/orphanin FQ receptor antagonist|opioid receptor antagonist OPRL1 trapidil Launched PDGFR tyrosine kinase receptor inhibitor PDGFRA travoprost Launched prostanoid receptor agonist PTGFR traxoprodil Phase 2 glutamate receptor antagonist GRIN2B trazodone Launched adrenergic receptor antagonist|serotonin receptor antagonist|serotonin reuptake inhibitor ADRA1A|ADRA2A|HRH1|HTR1A|HTR2A|HTR2B|HTR2C|SLC6A4 trebenzomine Phase 2 trelagliptin Launched dipeptidyl peptidase inhibitor DPP4 tremorine Preclinical acetylcholine receptor agonist treosulfan Launched DNA synthesis inhibitor trepibutone Launched cholinergic receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4 trequinsin Phase 1 phosphodiesterase inhibitor PDE5A tretazicar Phase 2 DNA replication inhibitor NQO2 tretinoin Launched retinoid receptor agonist|retinoid receptor ligand ALDH1A1|ALDH1A2|GPRC5A|NR0B1|NR2C2|PPARD|RARA|RARB|RARG|RARRES1|RORB|RORC|RXRB|RXRG triacetin Launched triamcinolone Launched glucocorticoid receptor agonist NR3C1|SERPINA6 triamcinolone-acetonide Launched glucocorticoid receptor agonist|immunosuppressant NR3C1 triamterene Launched sodium channel blocker SCNN1A|SCNN1B|SCNN1D|SCNN1G triapine Phase 2 ribonucleotide reductase inhibitor RRM1|RRM2 triazolam Withdrawn GABA benzodiazepine site receptor agonist GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6|GABRB1|GABRB2|GABRB3|GABRD|GABRE|GABRG1|GABRG2|GABRG3|GABRP|GABRQ|GABRR1|GABRR2|GABRR3|TSPO tribenoside Launched anti-inflammatory agent|capillary stabilizing agent tribomsalan Preclinical tribromoethanol Preclinical analgesic agent tributyrin Phase 1 HDAC inhibitor tricaprylin Launched trichlormethiazide Launched chloride channel blocker ATP1A1|CA1|CA2|CA4|SLC12A1|SLC12A3 trichlormethine Preclinical DNA alkylating agent trichloroacetic-acid Launched trichloroethylene Preclinical trichostatin-a Preclinical HDAC inhibitor HDAC1|HDAC10|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9 triciribine Phase 1/Phase 2 AKT inhibitor AKT1|AKT2|AKT3 triclabendazole Launched microtubule inhibitor DNMT1 triclocarban Launched other antibiotic triclosan Launched antibacterial agent DNMT1 tridihexethyl Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3 trientine Launched chelating agent CA14 trifluoperazine Launched dopamine receptor antagonist ADRA1A|CALM1|CALY|DRD2|DRD4|HRH1|HTR2A|HTR2C|S100A4|TNNC1 triflupromazine Launched dopamine receptor antagonist CHRM1|CHRM2|DRD1|DRD2|HTR2B trifluridine Launched DNA directed DNA polymerase inhibitor|thymidylate synthase inhibitor TYMS triflusal Launched cyclooxygenase inhibitor|platelet aggregation inhibitor|thromboxane synthase inhibitor NFKB1|NOS2|PDE10A|PTGS1 trigonelline Phase 1 trihexyphenidyl Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 trilostane Launched 3beta-hydroxy-delta5-steroid dehydrogenase inhibitor ESR1|ESR2|HSD3B1|HSD3B2 TRIM Preclinical trimebutine Launched opioid receptor agonist OPRD1|OPRK1|OPRM1 trimeprazine Launched histamine receptor ligand|histamine receptor antagonist HRH1 trimetazidine Launched 3-ketoacyl CoA thiolase inhibitor ACAA2 trimethadione Launched oxazolidine antiepileptic CACNA1G|CACNA1H|CACNA1I trimethobenzamide Launched histamine receptor antagonist DRD2 trimethoprim Launched dihydrofolate reductase inhibitor DHFR|TYMS trimethoquinol Launched adrenergic receptor antagonist ADRB2|ADRB3 trimethylolpropane-triacrylate Preclinical trimetozine Launched sedative trimipramine Launched norepinephrine reputake inhibitor|tricyclic antidepressant ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRB1|ADRB2|ADRB3|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD5|HRH1|HTR1A|HTR1D|HTR2A|HTR2C|HTR3A|SLC6A2|SLC6A3|SLC6A4 trioxsalen Launched DNA synthesis inhibitor tripelennamine Launched histamine receptor antagonist HRH1 triprolidine Launched histamine receptor antagonist HRH1 triptan Phase 1 serotonin receptor agonist HTR1B|HTR1D triptolide Phase 3 RNA polymerase inhibitor RELA triptorelin Launched gonadotropin releasing factor hormone receptor agonist GNRHR troclosene Launched trofinetide Phase 2 cytokine production inhibitor IFNG|IL6|TNF troglitazone Withdrawn insulin sensitizer|PPAR receptor agonist ACSL4|ESRRA|ESRRG|PPARG|SERPINE1|SLC29A1|TRPM3 troleandomycin Launched protein synthesis inhibitor trolox Launched antioxidant tromaril Launched prostanoid receptor antagonist trometamol Launched AMD1|CANT1|DCN|NEIL1|VEGFA tropesin Launched cyclooxygenase inhibitor PTGS1|PTGS2 tropicamide Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4 tropisetron Launched serotonin receptor antagonist GLRA1|GLRA2|GLRB|HTR3A|HTR4 trospium Launched acetylcholine receptor antagonist CHRM1 trovafloxacin Withdrawn bacterial DNA gyrase inhibitor TOP2A troventol Phase 1 trovirdine Phase 1 non-nucleoside reverse transcriptase inhibitor troxerutin Launched antioxidant troxipide Launched glucosamine synthetase stimulant TRO19622 Phase 2/Phase 3 apoptosis inhibitor TRV130 Phase 3 opioid receptor agonist OPRM1 tryptanthrin Preclinical cyclooxygenase inhibitor IDO1 tryptophan Launched serotonin receptor partial agonist CASR|IDO1|SLC36A1|WARS|WARS2 TTNPB Phase 1 retinoid receptor agonist RARA|RARB|RARG TU-2100 Phase 2 tuaminoheptane Launched tubastatin-a Preclinical HDAC inhibitor HDAC6 tubocurarine Launched acetylcholine receptor antagonist ACHE|CHRNA2|HTR3A|HTR3B|KCNN1|KCNN2|KCNN3|ZACN tucatinib Phase 2 EGFR inhibitor ERBB2 TUG-770 Preclinical free fatty acid receptor agonist FFAR1 tulobuterol Launched adrenergic receptor agonist ADRB2 TW-37 Preclinical BCL inhibitor BCL2|BCL2L1|MCL1 TWS-119 Preclinical glycogen synthase kinase inhibitor GSK3B|JUN|MYC TXA127 Phase 2 angiotensin receptor agonist TY-52156 Preclinical sphingosine 1-phosphate receptor antagonist S1PR3 tylosin Launched protein synthesis inhibitor tyloxapol Launched NFkB pathway inhibitor LPL|NFKB2 tymazoline Launched tyrphostin-AG-1296 Preclinical FLT3 inhibitor FLT3 tyrphostin-AG-1478 Preclinical EGFR inhibitor EGFR|MAPK14 tyrphostin-AG-18 Preclinical EGFR inhibitor|tyrosine kinase inhibitor EGFR tyrphostin-AG-494 Preclinical EGFR inhibitor EGFR tyrphostin-AG-825 Preclinical protein tyrosine kinase inhibitor ERBB2 tyrphostin-AG-835 Preclinical protein tyrosine kinase inhibitor EGFR tyrphostin-AG-879 Preclinical tyrosine kinase inhibitor ERBB2|KDR|NTRK1 tyrphostin-AG-99 Preclinical tyrosine kinase inhibitor EGFR tyrphostin-A9 Preclinical protein tyrosine kinase inhibitor|tyrosine kinase inhibitor U-0124 Preclinical MEK inhibitor U-0126 Preclinical MEK inhibitor AKT1|CHEK1|GSK3B|LCK|MAP2K1|MAP2K2|MAP2K7|MAPK1|MAPK11|MAPK12|MAPK14|MAPK8|PRKCA|RAF1|ROCK1|RPS6KB1|SGK1 U-0521 Preclinical catechol O methyltransferase inhibitor COMT U-104 Preclinical carbonic anhydrase inhibitor CA1|CA12|CA2|CA9 U-18666A Preclinical oxidosqualene cyclase inhibitor U-50488-(+/-) Preclinical opioid receptor agonist OPRK1 U-50488-(-) Preclinical opioid receptor agonist OPRK1 U-54494A Preclinical opioid receptor agonist OPRK1 U-75799E Phase 1 growth hormone releasing factor agonist GHSR U-99194 Preclinical dopamine receptor antagonist DRD3 UB-165 Preclinical acetylcholine receptor agonist CHRNA3|CHRNA4|CHRNB2 ubenimex Launched leukotriene synthesis inhibitor LTA4H|RNPEP UBP-302 Preclinical glutamate receptor antagonist GRIK1 UCL-2077 Preclinical slow afterhyperpolarization channel blocker ufenamate Launched cyclooxygenase inhibitor PTGS1|PTGS2 UH-232-(+) Preclinical dopamine receptor antagonist DRD2|DRD3|DRD4|HTR1A UK-383367 Phase 1 Procollagen C-Endopeptidase Inhibitors BMP1 ulifloxacin Launched ulipristal Launched progesterone receptor antagonist PGR umeclidinium Launched acetylcholine receptor antagonist CHRM1|CHRM2|CHRM3 UNBS-5162 Phase 1 CC chemokine receptor antagonist UNC0224 Preclinical histone lysine methyltransferase inhibitor EHMT1|EHMT2 UNC0321 Preclinical histone lysine methyltransferase inhibitor EHMT2 UNC0631 Preclinical histone lysine methyltransferase inhibitor EHMT2 UNC0638 Preclinical histone lysine methyltransferase inhibitor EHMT1|EHMT2 UNC0642 Preclinical histone lysine methyltransferase inhibitor EHMT1|EHMT2 UNC0646 Preclinical histone lysine methyltransferase inhibitor EHMT2 UNC0737 Preclinical histone lysine methyltransferase inhibitor EHMT1|EHMT2 UNC1215 Preclinical L3MBTL antagonist L3MBTL3 UNC1999 Preclinical histone lysine methyltransferase inhibitor EZH2 UNC2025 Preclinical MER tyrosine kinase inhibitor|FLT3 inhibitor FLT3|MERTK UNC2250 Preclinical MER tyrosine kinase inhibitor MERTK UNC669 Preclinical L3MBTL antagonist L3MBTL1 undecylenic-acid Launched other antifungal UPF-1069 Preclinical PARP inhibitor PARP2 uprosertib Phase 2 AKT inhibitor AKT1|AKT2|AKT3 uracil Launched DPYD|UCKL1 uracil-mustard Launched DNA synthesis inhibitor urapidil Launched adrenergic receptor antagonist HTR1A URB597 Phase 1 FAAH inhibitor FAAH|FAAH2|TRPA1 urea Launched hydroxy radical formation stimulant ARG1|CA2|CTNNB1 urethane Preclinical local anesthetic uric-acid Phase 3 PYGL uridine Phase 2 dopamine receptor agonist LSM6|TYMP uridine-triacetate Launched uridine-5'-triphosphate Launched purinergic receptor activator P2RY11|P2RY2|P2RY4|P2RY6|UCK2 URMC-099 Preclinical mixed lineage kinase inhibitor CDKL2|DAPK3|FLT3|LRRK2|MAP3K10|MAP3K11|MAP3K2|MAP3K9|SRPK2 ursodeoxycholyltaurine Phase 2 cholesterol inhibitor ursodiol Launched nuclear factor erythroid derived|like (NRF2) activator NR1H4 ursolic-acid Phase 1 ATPase inhibitor|NFkB pathway inhibitor|STAT inhibitor HSD11B1|PLA2G1B|PTPN1|PYGM usniacin-(+) Preclinical MAP kinase activator PTPN1 V-51 Phase 1 adrenergic receptor antagonist val Phase 2 BCAT1|PCCB|VARS valaciclovir Launched DNA polymerase inhibitor valdecoxib Withdrawn cyclooxygenase inhibitor CA12|PTGS2 valethamate Launched acetylcholine receptor antagonist CHRM1|CHRM4|CHRM5 valganciclovir Launched DNA synthesis inhibitor valnemulin Launched bacterial 50S ribosomal subunit inhibitor valnoctamide Phase 3 arachidonic acid acylation inhibitor|benzodiazepine receptor agonist valproic-acid Launched HDAC inhibitor ABAT|ACADSB|ALDH5A1|HDAC1|HDAC2|HDAC9|OGDH|SCN10A|SCN11A|SCN1A|SCN1B|SCN2A|SCN2B|SCN3A|SCN3B|SCN4A|SCN4B|SCN5A|SCN7A|SCN8A|SCN9A valpromide Launched epoxide hydolase inhibitor valrocemide Phase 2 valrubicin Launched DNA inhibitor|topoisomerase inhibitor TOP2A valsartan Launched angiotensin receptor antagonist AGTR1 valsartan-sacubitril-combination Launched angiotensin receptor antagonist|neprilysin inhibitor AGTR1 valspodar Phase 3 P glycoprotein inhibitor ABCB1 vancomycin Launched bacterial cell wall synthesis inhibitor vandetanib Launched EGFR inhibitor|RET tyrosine kinase inhibitor|VEGFR inhibitor EGFR|EPHA1|EPHA10|EPHA2|EPHA3|EPHA4|EPHA5|EPHA6|EPHA7|EPHA8|EPHB1|EPHB2|EPHB3|EPHB4|EPHB6|ERBB2|ERBB3|ERBB4|FLT1|FLT4|KDR|PTK6|RET|SRC|TEK|VEGFA vanillin Preclinical ABAT|ALDH5A1 vanillylacetone Preclinical vanitiolide Preclinical vanoxerine Phase 3 dopamine uptake inhibitor SLC6A3 vardenafil Launched phosphodiesterase inhibitor PDE5A|PDE6G|PDE6H varenicline Launched acetylcholine receptor agonist CHRNA3|CHRNA4|CHRNA6|CHRNA7 varespladib Phase 3 secretory phospholipase inhibitor PLA2G2A vasopressin Launched vasopressin receptor agonist AVPR1A|AVPR1B|AVPR2|OXTR vatalanib Phase 3 KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor|VEGFR inhibitor EGFR|FLT1|FLT4|KDR|PDGFRB VBY-825 Preclinical cathepsin inhibitor CTSB|CTSL|CTSS VCH-916 Phase 1 HCV inhibitor VE-821 Preclinical ATR kinase inhibitor ATR VE-822 Phase 2 ATR kinase inhibitor ATM|ATR|MTOR|PIK3CG vecuronium Launched acetylcholine receptor antagonist CHRNA2 veliflapon Phase 3 leukotriene synthesis inhibitor ALOX5AP veliparib Phase 3 PARP inhibitor PARP1|PARP2 velneperit Phase 2 neuropeptide receptor antagonist NPY5R vemurafenib Launched RAF inhibitor BRAF|RAF1 venetoclax Launched BCL inhibitor BCL2 venlafaxine Launched adrenergic inhibitor|norepinephrine reuptake inhibitor|serotonin–norepinephrine reuptake inhibitor (SNRI) SLC6A2|SLC6A3|SLC6A4 VER-49009 Preclinical HSP inhibitor HSP90AA1 verapamil Launched calcium channel blocker CACNA1A|CACNA1B|CACNA1C|CACNA1D|CACNA1F|CACNA1G|CACNA1I|CACNA1S|CACNB1|CACNB2|CACNB3|CACNB4|CYP3A4|KCNA10|KCNA7|KCNH2|KCNJ11|NALCN|SCN5A|SLC29A4|SLC6A4 verbascoside Phase 2/Phase 3 PKC inhibitor|NFkB pathway inhibitor vercirnon Phase 3 CC chemokine receptor antagonist CCR9 verinurad Phase 2 urate transporter inhibitor SLC22A12 vernakalant Launched potassium channel blocker KCNA5 verteporfin Launched photosensitizing agent verubulin Phase 2 tubulin polymerization inhibitor TUBB vesamicol Preclinical acetylcholinesterase inhibitor SLC18A3 vesnarinone Launched phosphodiesterase inhibitor KCNH2|PDE3A VGX-1027 Phase 1 tumor necrosis factor receptor antagonist TLR4 vicriviroc Phase 3 CC chemokine receptor antagonist CCR5 vidarabine Launched antiviral ADA vigabatrin Launched GABA aminotransferase inhibitor ABAT|GABBR1|SLC32A1 vilanterol Launched adrenergic receptor agonist ADRB2 vilazodone Launched serotonin reuptake inhibitor DRD2|DRD3|HRH1|HTR1A|HTR4|SLC6A4 vildagliptin Launched dipeptidyl peptidase inhibitor DPP4 viloxazine Launched norepinephrine reuptake inhibitor SLC6A2 vinblastine Launched microtubule inhibitor|tubulin polymerization inhibitor JUN|TUBA1A|TUBB|TUBD1|TUBE1|TUBG1 vinburnine Launched adrenergic receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4 vincamine Withdrawn adrenergic receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4 vincristine Launched tubulin polymerization inhibitor TUBA4A|TUBB vindesine Launched tubulin polymerization inhibitor TUBB|TUBB1 vinflunine Launched microtubule inhibitor vinorelbine Launched tubulin polymerization inhibitor TUBA1A|TUBA1B|TUBA1C|TUBA3C|TUBA3D|TUBA3E|TUBA4A|TUBB|TUBB1|TUBB2A|TUBB2B|TUBB3|TUBB4A|TUBB4B|TUBB6|TUBB8 vinpocetine Launched phosphodiesterase inhibitor|sodium channel blocker PDE1A|PDE1C viomycin Launched protein synthesis inhibitor vipadenant Phase 1 adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 vismodegib Launched hedgehog pathway inhibitor|smoothened receptor antagonist SMO vitamin-b12 Launched vitamin-E Phase 2/Phase 3 PKC inhibitor|LDL oxidation inhibitor ALOX5|DGKA|NR1I2|PPP2CA|PPP2CB|PRKCA|PRKCB|SEC14L2|SEC14L3|SEC14L4 VLX600 Phase 1 ubiquitin C-terminal hydrolase inhibitor USP14 voglibose Launched glucosidase inhibitor MGAM volasertib Phase 3 PLK inhibitor PLK1 volinanserin Phase 3 serotonin receptor antagonist HTR2A|HTR2B|HTR2C|KCNH2 vonoprazan Launched potassium-competitive acid antagonist ATP4A vorapaxar Launched thrombin receptor antagonist F2R voreloxin Phase 3 topoisomerase inhibitor TOP2A voriconazole Launched cytochrome P450 inhibitor CYP2C19|CYP2C9|CYP3A4|CYP3A5|PTGS1 vorinostat Launched HDAC inhibitor HDAC1|HDAC10|HDAC11|HDAC2|HDAC3|HDAC5|HDAC6|HDAC8|HDAC9 vortioxetine Launched serotonin receptor agonist|serotonin receptor antagonist HTR1A|HTR1B|HTR2A|HTR2C|HTR3A|HTR5A|HTR6|HTR7|SLC6A4 voxtalisib Phase 2 mTOR inhibitor|PI3K inhibitor MTOR|PIK3CA VP-20629 Phase 1 beta amyloid antagonist PLA2G2E|SLC36A1 VS-4718 Phase 1 focal adhesion kinase inhibitor VT-464 Phase 2 cytochrome P450 inhibitor CYP17A1 VTP-27999 Phase 1 renin inhibitor REN VU-0240551 Preclinical potassium/chloride cotransporter inhibitor SLC12A5 VUF10166 Preclinical serotonin receptor antagonist HTR3A|HTR3B VU0155069 Preclinical phospholipase inhibitor PLD1 VU0238429 Preclinical acetylcholine receptor allosteric modulator CHRM5 VU0357121 Preclinical glutamate receptor positive allosteric modulator GRM5 VU0361737 Preclinical glutamate receptor positive allosteric modulator GRM4 VU0364439 Preclinical glutamate receptor positive allosteric modulator GRM4 VU0364770 Preclinical glutamate receptor positive allosteric modulator GRM4 VX-11e Preclinical MAP kinase inhibitor MAPK1 VX-222 Phase 2 HCV inhibitor VX-661 Phase 3 CFTR channel agonist CFTR VX-702 Phase 2 p38 MAPK inhibitor MAPK11|MAPK12|MAPK14 VX-745 Phase 2 p38 MAPK inhibitor MAPK11|MAPK12|MAPK14 VX-765 Phase 2 caspase inhibitor CASP1 W-54011 Preclinical anaphylatoxin chemotactic receptor antagonist C5AR1 walrycin-b Preclinical transcriptional regulatory protein WalR warfarin Launched vitamin K antagonist VKORC1 WAY-100635 Phase 1 serotonin receptor antagonist HTR1A WAY-161503 Preclinical serotonin receptor agonist HTR2C WAY-170523 Preclinical metalloproteinase inhibitor MMP13 WAY-200070 Preclinical estrogen receptor agonist ERBB2|ERBB3|ERBB4|ESR2 WAY-213613 Preclinical glutamate inhibitor SLC1A2 WAY-316606 Preclinical secreted frizzled related protein inhibitor SFRP1 WAY-362450 Phase 1 FXR agonist NR1H4 WAY-600 Preclinical mTOR inhibitor MTOR WAY-629 Preclinical serotonin receptor agonist HTR2C WB-4101 Preclinical adrenergic receptor antagonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C|HTR1A WEHI-345-analog Preclinical src inhibitor WHI-P154 Preclinical JAK inhibitor EGFR|JAK1|JAK2|JAK3 WIKI4 Preclinical Wnt pathway inhibitor|tankyrase inhibitor TNKS2 WIN-18446 Preclinical aldehyde dehydrogenase inhibitor ALDH1A2 WIN-64338 Preclinical bradykinin receptor antagonist BDKRB2 wnt-c59 Preclinical porcupine inhibitor PORCN wortmannin Preclinical PI3K inhibitor PI4KA|PI4KB|PIK3CA|PIK3CD|PIK3CG|PIK3R1|PLK1|PRKDC WP1066 Phase 1 STAT inhibitor STAT3 WP1130 Preclinical deubiquitinase inhibitor JAK2|UCHL5|USP14|USP9X WR99210 Preclinical dihydrofolate reductase inhibitor TYMS Wy-16922 Phase 1 histamine release inhibitor WYE-125132 Preclinical mTOR inhibitor MTOR WYE-354 Preclinical mTOR inhibitor MTOR WZ-3146 Preclinical EGFR inhibitor EGFR WZ-4002 Preclinical EGFR inhibitor EGFR|ERBB2 WZ4003 Preclinical AMPK inhibitor NUAK1|NUAK2 WZ8040 Preclinical EGFR inhibitor EGFR WZ811 Preclinical CC chemokine receptor antagonist CXCR4 xaliproden Phase 3 serotonin receptor agonist HTR1A xamoterol Phase 3 adrenergic receptor agonist ADRB1 xanomeline Phase 3 acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR6|HTR7 xanthone Preclinical antimalarial agent XAV-939 Preclinical tankyrase inhibitor TNKS|TNKS2 XBD173 Phase 2 benzodiazepine receptor ligand TSPO XE-991 Preclinical potassium channel blocker KCNQ1|KCNQ2|KCNQ3|KCNQ4|KCNQ5 xenalipin Phase 2 xibenolol Phase 3 adrenergic receptor antagonist xilobam Phase 1 xipamide Launched carbonic anhydrase inhibitor SLC12A3 XL-147 Phase 2 PI3K inhibitor PIK3CA|PIK3CD|PIK3CG XL-647 Phase 3 EGFR inhibitor|VEGFR inhibitor EGFR|EPHB4|ERBB2|FLT4|KDR XL019 Phase 1 JAK inhibitor JAK1|JAK2|JAK3 XL228 Phase 1 Abl kinase inhibitor|insulin growth factor receptor inhibitor|src inhibitor IGF1R|SRC XL388 Preclinical mTOR inhibitor MTOR XL888 Phase 1 HSP inhibitor XMD17-109 Preclinical MAP kinase inhibitor MAPK7 XMD8-92 Preclinical MAP kinase inhibitor DCLK2|MAPK7|PLK4|TNK1 xylazine Launched adrenergic receptor agonist ADRA2A|ADRA2B|ADRA2C xylometazoline Launched adrenergic receptor agonist ADRA1A|ADRA1B|ADRA1D|ADRA2A|ADRA2B|ADRA2C xylose Launched Y-134 Preclinical estrogen receptor antagonist ESR1|ESR2 Y-26763 Phase 1 potassium channel activator KCNJ8 Y-27152 Phase 1 potassium channel activator KCNJ8 Y-27632 Preclinical rho associated kinase inhibitor PKIA|PKN2|PRKACA|PRKCE|ROCK1|ROCK2 Y-29794 Preclinical prolyl endopeptidase inhibitor PREP Y-320 Preclinical interleukin inhibitor IL17A Y-39983 Phase 2 rho associated kinase inhibitor ROCK1|ROCK2 YK-4-279 Preclinical apoptosis inhibitor EWSR1|FLI1 YM-155 Phase 2 survivin inhibitor BIRC5 YM-201636 Preclinical PI3K inhibitor YM-298198 Preclinical glutamate receptor antagonist GRM1 YM-511 Phase 2 aromatase inhibitor CYP19A1 YM-58483 Preclinical calcium channel blocker TRPC3|TRPC5|TRPM4 YM-750 Phase 1 ACAT inhibitor SOAT1 YM-90709 Preclinical IL5 inhibitor CSF2RB|IL5RA YM-976 Phase 1 phosphodiesterase inhibitor PDE4A YM022 Phase 2 CCK receptor antagonist CCKBR YO-01027 Preclinical gamma secretase inhibitor yohimbine Launched adrenergic receptor antagonist ADRA2A|ADRA2B|ADRA2C|DRD2|DRD3|HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR7|KCNJ1|KCNJ10|KCNJ11|KCNJ12|KCNJ14|KCNJ15|KCNJ8 YS-035 Preclinical calcium channel blocker Y16 Preclinical rho associated kinase inhibitor RHOA zacopride Phase 2 serotonin receptor antagonist HTR3A|HTR3B|HTR4|HTR5A zafirlukast Launched leukotriene receptor antagonist CYSLTR1|CYSLTR2 zalcitabine Launched nucleoside reverse transcriptase inhibitor zaldaride Phase 3 calmodulin antagonist CALM1 zaleplon Launched benzodiazepine receptor agonist GABRA1|GABRB1|GABRG2|TSPO zaltidine Phase 3 histamine receptor antagonist HRH2 zaltoprofen Launched cyclooxygenase inhibitor ZAMI-633 Phase 3 urease inhibitor zamifenacin Phase 3 acetylcholine receptor antagonist CHRM3 zanamivir Launched neuraminidase inhibitor NEU2 ZAPA Preclinical zaprinast Phase 2 phosphodiesterase inhibitor GPR35|PDE1A|PDE4D|PDE5A|PDE9A zardaverine Phase 2 phosphodiesterase inhibitor PDE4D zatebradine Phase 3 HCN channel blocker HCN1|HCN2|HCN3|HCN4 ZCL-278 Preclinical CDC inhibitor CDC42 ZD-2079 Phase 2 adrenergic receptor agonist ADRB3 ZD-7114 Phase 1 adrenergic receptor agonist ADRB3 ZD-7155 Preclinical angiotensin receptor antagonist AGTR1 ZD-7288 Phase 2 HCN channel blocker HCN1|HCN2|HCN3|HCN4 zeatin Phase 1 zebularine Preclinical DNA methyltransferase inhibitor CDA|DNMT1 zibotentan Phase 3 endothelin receptor antagonist EDNRA zidovudine Launched nucleoside reverse transcriptase inhibitor TERT zileuton Launched leukotriene synthesis inhibitor|lipoxygenase inhibitor ALOX5 zilpaterol Launched adrenergic receptor agonist ADRB2 zimelidine Withdrawn selective serotonin reuptake inhibitor (SSRI) MAOA|MAOB|SLC6A4 zinc-undecylenate Launched other antifungal zindotrine Phase 2 phosphodiesterase inhibitor ziprasidone Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA1A|ADRA1B|ADRA2A|ADRA2B|ADRA2C|CHRM1|CHRM2|CHRM3|CHRM4|CHRM5|DRD1|DRD2|DRD3|DRD4|DRD5|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2C|HTR3A|HTR6|HTR7|SLC6A4 ZK-164015 Preclinical estrogen receptor antagonist ESR1|ESR2 ZK-200775 Phase 2 kainate receptor antagonist ZK-93423 Phase 3 benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3|GABRA5|GABRB2|GABRG2 ZK-93426 Phase 1 benzodiazepine receptor antagonist GABRA1|GABRA2|GABRA3|GABRA5 ZK811752 Phase 2 CC chemokine receptor antagonist CCR1 ZLN005 Preclinical ZM-226600 Preclinical Kir6 channel (KATP) activator ZM-241385 Preclinical adenosine receptor antagonist ADORA1|ADORA2A|ADORA2B|ADORA3 ZM-306416 Preclinical Abl kinase inhibitor|src inhibitor|VEGFR inhibitor EGFR|FLT1|FLT4|KDR ZM-323881 Preclinical VEGFR inhibitor KDR ZM-336372 Preclinical RAF inhibitor BRAF|LCK|MAPK14|RAF1 ZM-39923 Preclinical JAK inhibitor JAK1|JAK3 ZM-447439 Preclinical Aurora kinase inhibitor AURKA|AURKB zofenopril-calcium Launched angiotensin converting enzyme inhibitor ACE zolantidine Preclinical histamine receptor antagonist zoledronic-acid Launched bone resorption inhibitor FDPS|GGPS1 zolimidine Launched mucus protecting agent zolmitriptan Launched serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F zolpidem Launched benzodiazepine receptor agonist GABRA1|GABRA2|GABRA3 zomepirac Withdrawn prostaglandin synthesis inhibitor PTGDR2 zometapine Phase 2 zonisamide Launched sodium channel blocker|T-type calcium channel blocker CA1|CA10|CA11|CA12|CA13|CA14|CA2|CA3|CA4|CA5A|CA5B|CA6|CA7|CA8|CA9|CACNA1G|CACNA1H|CACNA1I|MAOA|MAOB|SCN10A|SCN11A|SCN1A|SCN1B|SCN2A|SCN2B|SCN3A|SCN3B|SCN4A|SCN4B|SCN5A|SCN7A|SCN8A|SCN9A zopolrestat Phase 2 zosuquidar Phase 3 P glycoprotein inhibitor ABCB1|ABCB4 zotarolimus Launched mTOR inhibitor FKBP1A zotepine Launched dopamine receptor antagonist|serotonin receptor antagonist ADRA2B|DRD2|DRD3|DRD4|HRH1|HTR1A|HTR1B|HTR1D|HTR1E|HTR2A|HTR2C|HTR6|HTR7|SLC6A2|SLC6A4 zoxazolamine Phase 2 myorelaxant ZSTK-474 Phase 1/Phase 2 PI3K inhibitor PIK3CB|PIK3CD|PIK3CG zuclopenthixol Launched dopamine receptor antagonist ADRA1A|ADRA2A|DRD1|DRD2|DRD5|HRH1|HTR2A Z160 Phase 2 N-type calcium channel blocker CACNA2D1 1-(piperidin-1-yl)prop-2-en-1-one Preclinical 1-(2-chloro-5-methylphenoxy)-3-(isopropylamino)-2-propanol Preclinical 1-acetyl-4-methylpiperazine Preclinical acetylcholine receptor agonist 1-azakenpaullone Preclinical glycogen synthase kinase inhibitor CCNB1|CDK1|CDK5|GSK3B 1-deoxymannojirimycin Preclinical alpha mannosidase inhibitor MAN2A1 1-EBIO Preclinical potassium channel activator KCNN1|KCNN2|KCNN3|KCNN4 1-ethyl-2-pyrrolidone Preclinical transdermal absorption-enhancing compound 1-hexadecanal Preclinical sphingosine 1 phosphate receptor substrate DBI|RHO 1-hexadecanol Launched 1-naphthyl-PP1 Preclinical src inhibitor SRC 1-octacosanol Phase 2 1-octanol Phase 2 GJA1|GJA10|GJA3|GJA4|GJA5|GJA8|GJA9|GJB1|GJB2|GJB3|GJB4|GJB5|GJB6|GJB7|GJC1|GJC2|GJC3|GJD2|GJD3|GJD4|GJE1 1-phenylbiguanide Preclinical serotonin receptor agonist HTR3A|HTR3B 10-deacetylbaccatin Preclinical antitumor agent 10-DEBC Preclinical AKT inhibitor PIM1 10-hydroxycamptothecin Preclinical topoisomerase inhibitor TOP1 10058-F4 Preclinical c-Myc inhibitor 12-O-tetradecanoylphorbol-13-acetate Phase 2 PKC activator KCNT2|TRPV4 1400W Preclinical nitric oxide synthase inhibitor NOS1|NOS2|NOS3 17-alpha-methyltestosterone Launched aromatase inhibitor AR 17-hydroxyprogesterone-caproate Launched progesterone receptor agonist AR|ESR1|ESR2|NR1H4|NR1I2|NR3C1|PGR 17-PA Preclinical glucocorticoid receptor agonist 2'-c-methylguanosine Preclinical HCV inhibitor 2'-MeCCPA Preclinical adenosine receptor agonist ADORA1 2-(3-mercaptopropyl)pentanedioic acid Phase 1 glutamate carboxypeptidase inhibitor FOLH1 2-[1-(4-piperonyl)piperazinyl]benzothiazole Preclinical serotonin receptor agonist HTR4 2-aminobenzenesulfonamide Preclinical carbonic anhydrase inhibitor CA12|CA14|CA2|CA6|CA9 2-APB Preclinical "1,4,5-trisphosphate inhibitor" TRPC1|TRPC3|TRPC4|TRPC5|TRPC6|TRPC7|TRPM2|TRPM3|TRPM6|TRPV1|TRPV6 2-BFI Preclinical imidazoline receptor ligand ADRA2A|ADRA2B|ADRA2C|MAOA|MAOB 2-chloro-N6-cyclopentyladenosine Preclinical adenosine receptor agonist ADORA1|ADORA2A|ADORA2B|ADORA3 2-Chloropyrazine Preclinical 2-CMDO Preclinical dopamine receptor antagonist DRD2|DRD4 2-cyanopyrimidine Preclinical cathepsin inhibitor 2-Deoxy-2-{[methyl(nitroso)carbamoyl]amino}hexose Preclinical 2-deoxyglucose Phase 2 glycolysis inhibitor SLC2A1|SLC2A2|SLC2A3|SLC2A4 2-ethoxybenzoic-acid Phase 1 analgesic agent 2-fluoro-2-deoxy-D-galactose Phase 1 LCT 2-hydroxyethyl-salicylate Launched 2-hydroxyflutamide Phase 1/Phase 2 androgen receptor antagonist AR 2-hydroxysaclofen Preclinical GABA receptor antagonist GABBR1|GABBR2 2-iminobiotin Phase 2 nitric oxide synthase inhibitor NOS1|NOS2 2-iodohippuric-acid Preclinical 2-iodomelatonin Preclinical melatonin receptor agonist MTNR1A|MTNR1B|NQO2 2-methoxyestradiol Phase 2 hypoxia inducible factor inhibitor COMT|CYP19A1|CYP1A1|CYP1B1|HIF1A|TUBB 2-methyl-5-hydroxytryptamine Preclinical serotonin receptor agonist HTR1B|HTR1D|HTR1E|HTR1F|HTR3A|HTR3B|HTR6 2-methyl-5-nitrophenol Preclinical 2-methylimidazole Preclinical cholesterol inhibitor 2-octyldodecan-1-ol Preclinical 2-Oleoylglycerol Phase 1 glucose dependent insulinotropic receptor ligand GPR119 2-oxoglutaric-acid Preclinical OXGR1 2-oxopropanoate Preclinical pyruvate dehydrogenase kinase inhibitor ABAT|AGXT2|PC|PDHB|PKLR|PKM|SLC16A1|SLC16A2|SLC16A3|SLC16A4|SLC16A5|SLC16A6|SLC16A7|SLC16A8 2-phenylmelatonin Preclinical melatonin receptor agonist MTNR1A|MTNR1B 2-PMDQ Preclinical adrenergic receptor antagonist ADRA1A 2-pyridylethylamine Preclinical histamine receptor agonist HRH1 2-TEDC Preclinical lipoxygenase inhibitor ALOX12 2-thiouracil Preclinical 20-hydroxyecdysone Preclinical ecdysone receptor modulator 3'-fluorobenzylspiperone Preclinical dopamine receptor ligand DRD2 3-(4-methylbenzylidene)camphor Launched endocrine disruptor 3-alpha-bis-(4-fluorophenyl)-methoxytropane Preclinical dopamine uptake inhibitor CHRM1|SLC6A2|SLC6A3|SLC6A4 3-alpha-Hydroxy-5-beta-androstan-17-one Preclinical 3-amino-benzamide Phase 2 PARP inhibitor PARP1 3-anilinopropan-1-ol Preclinical 3-AQC Preclinical serotonin receptor agonist HTR3A 3-bromo-7-nitroindazole Preclinical nitric oxide synthase inhibitor NOS1|NOS2|NOS3 3-bromocamphor Launched 3-bromopyruvate Preclinical hexokinase inhibitor HK2 3-carboxy-4-hydroxyphenylglycine-(R) Preclinical glutamate receptor antagonist GRIN1|GRIN2A|GRIN2B|GRIN2C 3-carboxy-4-hydroxyphenylglycine-(S) Preclinical glutamate receptor antagonist GRM1|GRM5 3-CPMT Preclinical dopamine reuptake inhibitor 3-deazaadenosine Phase 2 adenosylhomocysteinase inhibitor AHCY 3-deazaneplanocin-A Preclinical histone lysine methyltransferase inhibitor EZH2 3-deazauridine Preclinical cytidine deaminase inhibitor 3-hydroxy-3-phenylpentanamide Phase 1 GABA receptor modulator 3-indolebutyric-acid Preclinical B2M|HLA-A|TRAC|TRBC1 3-MATIDA Preclinical GRM1 3-methyl-GABA Preclinical GABA aminotransferase activator ABAT 3-methyladenine Preclinical PI3K inhibitor PI3 3-MPPI Preclinical adrenergic receptor ligand ADRA1A 3PO Preclinical phosphofructokinase inhibitor PFKFB3 4-(4-fluorobenzoyl)-1-(4-phenylbutyl)-piperidine Preclinical serotonin receptor antagonist HTR2A 4-aminohippuric-acid Preclinical SLC22A6 4-carboxy-3-hydroxyphenylglycine-(RS) Preclinical glutamate receptor agonist|glutamate receptor antagonist GRM1 4-carboxy-3-hydroxyphenylglycine-(S) Preclinical glutamate receptor agonist|glutamate receptor antagonist GRM1|GRM2 4-chlorophenylguanidine Preclinical urokinase inhibitor PLAUR 4-DAMP Preclinical cholinergic receptor antagonist CHRM1|CHRM2|CHRM3|CHRM4|CHRM5 4-galactosyllactose Preclinical AMY2B 4-HQN Preclinical PARP inhibitor PARP1 4-hydroxy-phenazone Preclinical 4-IBP Preclinical sigma receptor agonist SIGMAR1 4-iodo-L-phenylalanine DPP4 4-iodo-6-phenylpyrimidine Preclinical macrophage migration inhibiting factor inhibitor MIF 4-methylgenistein Preclinical protein tyrosine kinase inhibitor CYP19A1|ESRRA|ESRRB|ESRRG|FASN 4-methylhistamine Preclinical histamine receptor agonist HRH4 4-mu-8C Preclinical IRE1 inhibitor ERN1 4-P-PDOT Preclinical melatonin receptor antagonist MTNR1A|MTNR1B 4-phenolsulfonic-acid Preclinical 4-PPBP Preclinical sigma receptor ligand SIGMAR1 4-propylbenzoic-acid Preclinical 4-pyrimidinecarbonitrile Preclinical 4-tert-butylphenol Preclinical 4EGI-1 Preclinical protein synthesis inhibitor EIF4E 4E1RCat Preclinical protein synthesis inhibitor EIF4E|EIF4G1 4SC-202 Phase 1 HDAC inhibitor HDAC1 5'-Chloro-5'-deoxy-ENBA-(+/-) Preclinical adenosine receptor agonist ADORA1 5-aminolevulinic-acid Launched oxidizing agent ALAD 5-BDBD Preclinical purinergic receptor antagonist P2RX4 5-carboxamidotryptamine Preclinical serotonin receptor agonist HTR1A|HTR1B|HTR1D|HTR1E|HTR1F|HTR2A|HTR2B|HTR2C|HTR5A|HTR6|HTR7 5-fluoro-3-pyridyl-methanol Preclinical 5-fluorouracil Launched thymidylate synthase inhibitor DPYD|TYMS 5-FP Phase 1 thymidylate synthase inhibitor TYMS 5-HMF Phase 2 5-hydroxyectoine Preclinical 5-hydroxymethyl-tolterodine Phase 1 acetylcholine receptor antagonist CHRM3 5-hydroxytryptophan Launched neurotransmitter SLC36A1|SLC36A2 5-iodo-A-85380 Phase 2 acetylcholine receptor agonist 5-methylfurmethiodide Preclinical acetylcholine receptor agonist CHRM1|CHRM2|CHRM3|CHRM4 5-methylhydantoin-(D) Preclinical 5-methylhydantoin-(L) Preclinical 6-aminochrysene Phase 2 transferase inhibitor 6-aminopenicillanic-acid Preclinical 6-benzylaminopurine Preclinical purinergic receptor activator 6-chloromelatonin Preclinical melatonin receptor agonist MTNR1A|MTNR1B 6-iodo-nordihydrocapsaicin Preclinical TRPV antagonist TRPV1 7-aminocephalosporanic-acid Preclinical beta lactamase inhibitor 7-chlorokynurenic-acid Preclinical glutamate receptor antagonist GRIN1|GRIN2A|GRIN2B|GRIN2C 7-hydroxy-DPAT Preclinical dopamine receptor agonist DRD2|DRD3 7-hydroxy-PIPAT Preclinical dopamine receptor ligand DRD3 7-hydroxystaurosporine Phase 2 CDK inhibitor|CHK inhibitor|PKC inhibitor CHEK1|MARK3|PDPK1 7-keto-DHEA Launched steroid 7-methoxytacrine Phase 2 acetylcholinesterase inhibitor ACHE 7-methylxanthine Phase 2 adenosine receptor antagonist 7-nitroindazole Preclinical nitric oxide synthase inhibitor NOS1|NOS2|NOS3 8-bromo-cAMP Preclinical PKA activator 8-bromo-cGMP Preclinical PKA activator PRKG1 8-hydroxy-DPAT Preclinical serotonin receptor agonist CDK1|CHEK1|CHEK2|GSK3B|HTR5A|HTR7|LCK|MAPK14|MARK1|PDPK1|PRKCA|PRKCB|PRKCD|PRKCE|PRKCG 8-hydroxy-PIPAT Preclinical dopamine receptor ligand DRD2|DRD3 8-M-PDOT Preclinical melatonin receptor agonist MTNR1A|MTNR1B 80841-78-7 Preclinical 9-aminoacridine Preclinical 9-aminocamptothecin Phase 2 topoisomerase inhibitor TOP1 9-anthracenecarboxylic-acid Preclinical ANO1|CLCN1