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IntestinalВ Permeability or Leaky Gut Syndrome (LGS)В may be a major contributor of disease and dysfunction and may account for a very large component of many chronic complaints.
Leaky Gut Syndrome is a very common problem of modern society in part because of antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs), like Motrin, Advil, Aleve, Vioxx, etc.В While this discussion is not going to focus on the pros and cons of antibiotics or NSAIDs, both damage the natural balance the bowel requires to operate optimally. A second stress on the immune system with a leaky gut is when the liver and lymphatic system become overwhelmed and as a result, the immune system serves as an overflow. The most important organ in resistance to infection is the adrenal gland.В Leaky Gut Syndrome slowlyВ diminishes adrenal function.
While lactobacillus supplementation is often recommended to help with leaky gut and Candida overgrowth, most of the lactobacillus sold today does not survive in the intestine, either due to poor terrain or due to being a strain that does not implant in the human intestines.. Confirming the Diagnosis:В Laboratory tests can help confirm and gauge various aspects of Leaky Gut including Candida levels, digestive function, food allergies, etc.
The digestive tract is a dark, moist environment that provides a steady stream of fluid and nutrition and is therefore an optimal breeding ground for microbes of all different types.В  There are approximately 500 different species of microrganisms within the gut (1). Bottle fed children are at the highest risk for poor gut function due to the toxic ingredients in typical bottle based formulas.В  Breast feeding, whole-food based diet and natural toxin free lifestyle offer a significant defense against leaky gut syndrome (7).
When the gut flora is damaged from environmental toxins such as anti-biotic usage, chlorinated water, industrial meat, processed food & drinks, etc. The second arm is responsible for immune activation and inflammatory based reactions.В  When the first arm is damaged the second arm begins to become hyperactive which leads to autoimmune reactions. Once the gut membrane is damaged, we need to help support the healing of the damaged intestinal tract. Many individuals fail to ever effectively repair their gut membrane and replenish the gut membrane. Yes, Mary – Splenda destroys the gut as well as it is basically a number of chlorine molecules. Researchers believe a combination of physical and mental health problems can lead to dysfunction and breakdown of the gastrointestinal lining that leads to the development of IBS and various Gastrointestinal disorders.

A leaky gut is almost always associated with autoimmune disease (including Rheumatoid Arthritis), hence reversing an autoimmune disease also depends on the healing of the lining of the gastrointestinal tract. This gut-joint axis is likely the same mechanism as the gut-brain axis or the gut-skin axis that produce the myriad of symptoms and diseases we are now seeing. With my RA diagnosis, I gradually came to understand how gastrointestinal health in general, and Leaky Gut Syndrome in particular, contributes to many seemingly unrelated symptoms. When damage occurs to the mucosal barrier of the gut lining, we are increasingly losing a huge part of our immune system that works hard to fight off new invading molecules or proteins. In RA, it is commonplace that the drugs used to relieve pain and inflammation can further damage the gut lining, even as quick as two weeks of consumption of those rheumatoid drugs. At the moment, the precise role of Leaky Gut Syndrome in RA remains unclear, but it appears to be part of a vicious cycle that makes the condition worse from time to time.
Unless specifically investigated, the role of altered intestinal permeability in patients with Leaky Gut often goes unnoticed. Intestinal Barrier Function Test that can be ordered from BioHealth Diagnostics – This test analyzes saliva or blood serum sample for an assessment of the integrity of the gut’s mucosal barrier, antigen penetration, dysbiosis, leaky gut, mal-absorption, dietary protein sensitivity, intestinal permeability, etc. Therefore, if you wish to reverse RA, you must also learn to address the causes of your Leaky Gut Syndrome at its sources and target treatments which usually require several components including avoidance of enterotoxic drugs, allergic foods, elimination of infections and bacteria overgrowth, nutritional dietary supplements and so forth.
It also contributes to PMS, uterine fibroid, breast fibroids, chronic fatigue syndrome and pediatric immune deficiencies. Patients need to understand that allergenic foods keep the intestines inflamed, allowing toxins to continuously enter the body and perpetuate the process that leads to a leaky gut.
Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. To begin with, it is a pathological condition that occurs as part of many different diseases and syndromes. The Leaky Gut Syndrome, through increased permeability of the intestinal lining, triggers inflammation of gut lining when our immune system begins invading altered molecules that pass through this gut lining to get access to our immune system.

With an over-active immune system, the microvilli of the gut lining becomes damaged, our ability to properly digest food is hence lost, and harmful pathogens can flourish on these undigested food proteins and crowd out beneficial bacteria, resulting in an imbalance in our gut flora. The relationship between food allergies or intolerance and leaky gut is complex and circular. The metabolic demand of a normally rapid cell turnover (usually 3 to 6 days) must be met if healing of damaged gut lining is to occur; but when these are not met due to mal-absorption of nutrients, hyperpermeability will exacerbate. If the signs and symptoms of Leaky Gut are ignored or unrecognized, it promotes continual damage to happen further and eventually, the overwhelmed immune system will start attacking other tissues and organs resulting in other forms of autoimmune diseases. While it is not necessary for clinical tests of proving the presence of Leaky Gut Syndrome in patients with RA (since predominantly, RA patients are almost always likely to suffer from Leaky Gut), there are safe, non-invasive and affordable lab tests for measuring the small intestinal permeability available in the market. As leaky gut syndrome connects apparently unrelated disorders, it is one of the most misunderstood concepts today.
The level of measured antibodies will be able to determine the stage of Leaky Gut Syndrome in the body. The researchers at the University of Oslo, Norway, looked at food-related antibodies that show up in the gut rather than blood of people with RA. This abnormally large spaces present between the cells of the gut wall allow passage of toxic materials, bacteria, fungi, parasites, undigested protein, fat and other waste not normally absorbed into the bloodstream in the healthy state. High-throughput sequencing reveals the incomplete, short-term recovery of infant gut microbiota following parenteral antibiotic treatment with ampicillin and gentamicin.

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