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Vitamin B11 is actually an 'old' name for the vitamin; nowadays it is usually called Folic acid. The term folate is used to denote the group of compounds processing the same vitamin activity, which includes natural folates and folic acid.
Folate is the quite instable form in which Vitamin B11 occurs naturally in food and the human body.
Folic acid is the synthesized form of the natural compound called Folate (naturally occurring in the human body).
Folic acid itself is not biologically active; its biological importance is due to tetrahydrofolate and other derivatives after its conversion to Dihydrofolic acid in the liver.
5-methyltetrahydrofolate (or levomefolic acid) is the natural, activated coenzyme form of Folic acid. It is used at the cellular level for deoxyribonucleic acid reproduction (DNA; the molecular basis for heredity), the cysteine cycle, and the regulation of homocysteine.
Folinic acid (Calcium folinate, Calcium salt pentahydrate, calcium levofolinate) is an intermediate product of the metabolism of Folic acid.
Folic acid and Folate function primarily as a methyl-group donor and are essential in numerous bodily functions. Folic acid is particularly important in aiding rapid cell division and growth, for example during childhood and pregnancy. Certain foods are very high in Folate, these include: leafy vegetables (such as asparagus, spinach, and turnip greens), legumes (such as dried or fresh beans, peas, and lentils), baker's yeast, fortified grain products (pasta, cereal, and bread), sunflower seeds, egg yolks, liver and liver products, and kidneys.
Other foods contain moderate amounts of Folate: beer, certain fruits (orange juice, cantaloupe, canned pineapple juice, honeydew melon, banana, grapefruit, raspberry, and strawberry), and vegetables (beets, tomato juice, corn, broccoli, vegetable juice, Brussels sprouts, and romaine lettuce).
After oral administration of RDA amounts, only a small part of Folic acid is eliminated from the body; only a trace amount of the drug appears in the urine. Next to oral administration, it is also possible to administrate Folic acid in a parenteral way, with the use of an aqueous solution (for instance, a Folate sodium injection).
The third way of applying Folic acid is topically through personal care products and cosmetics as an anti-photo-aging cosmetic ingredient.
Folic acid is more effective when taken with the B group vitamins, (especially vitamin B12 and vitamin B6). The use of Folic acid is, obviously, most effective for treating or preventing Folic acid deficiency.
Some studies conclude that Folic acid might also help to prevent other birth defects and it may assist to reduce the risk of toxemia in pregnancy, premature labor and hemorrhaging. Folic acid deficiency is considered to be one of the most common nutritional deficiencies, although it is uncommon in modern, Western diets.
When deficient of Folic acid, people might suffer from fatigue, irritability, nerve damage with weakness and limb numbness (peripheral neuropathy), tendon hyper-reflexivity, restless legs syndrome, insomnia, depression, dementia, cognitive disturbances, weight loss, psychiatric disorders, acne, a sore tongue, and cracking at the corners of the mouth. Alcoholics, individuals with liver disease, pregnant women, nursing mothers, cancer patients, and individuals suffering from HIV have a higher risk of having a Folic acid deficiency. There is no known industrial application of Folic acid other than as a beneficial ingredient and as a component in some skin care products. A panel of scientific experts in the USA has determined that Folic acid is GRAS (Generally Recognized as Safe).


Because of the difference in bioavailability between supplemented Folic acid and the different forms of Folate found in food, the dietary Folate equivalent (DFE) system was established in the USA. Folate intake exceeding this RDA may be needed by for lactating mothers nursing more than one infant.
Higher maintenance dosages may be required in alcoholics, patients with hemolytic anemia, patients with chronic infections, or patients receiving anticonvulsants.
The therapeutic dose of Folic acid that is used is usually adapted to the clinical condition of the patient. There is also a concern that high levels of Folate in the blood can mask a vitamin B12 deficiency, which can lead to nerve damage. It should be noted that Folic acid is given with caution to patients with abnormal renal function. The vitamin is also known as Folacin, Folate, Folic acid, Vitamin M, Vitamin Bc and Vitamin Be. Leafy vegetables are a principal source of Folate, although in modern, Western diets a larger dietary source may be found in cereals and bread. Folic acid is absorbed more easily then Folate; however, after absorption both Folate and Folic acid have the same function. After ingestion, the process of conversion of Folic acid to the metabolically active coenzyme forms is relatively complex. Levomefolic acid is generated by methylenetetrahydrofolate reductase from 5,10-methylenetetrahydrofolate, and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferase, also known as methionine synthase. Children and adults both require Folic acid to produce healthy red blood cells and prevent anemia. The human body needs Folate to produce and maintain new cells: it helps to synthesize, repair, and methylate DNA, as well as to act as a cofactor in biological reactions involving Folate.
Folic acid in cosmetics also seems to have skin regeneration properties, improvement of skin elasticity, decrease of skin roughness and it can modulate DNA repair in UV-damaged skin. Folate is required to make red blood cells and white blood cells and Folate deficiency may lead to (megaloblastic) anemia. In addition, a deficiency of dietary Folate takes months to develop, as normal individuals have about 500-20,000 Вµg (microgram) of Folate stored in the body. Furthermore, shortage of Folic acid may be indicated with heartburn, diarrhea or constipation, and an elevated plasma homocysteine. Synthesis of the active forms of Folic acid requires adequate liver and intestinal function, several enzymes, and sufficient supplies of riboflavin (vitamin B2), niacin (vitamin B3), pyridoxine (vitamin B6), vitamin C, zinc, and serine. It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary Folate. Folate is also essential for the metabolism of homocysteine, and helps maintain normal levels of this amino acid. Wills in 1931 led to the identification of Folate as the nutrient needed to prevent the anemia of pregnancy.
Folic acid tablets can be found as a mono-component or in combination with other vitamins and minerals.
Furthermore, women using birth control pills or busy with hormone replacement therapy may benefit from Folic acid.


Sodium Folate is a clear, water-soluble, mobile liquid with a yellow to orange-yellow colour.
Despite the biochemical complexity of this process, evidence suggests that oral supplementation with Folic acid increases the body's pool of the active reduced Folate metabolites (such as Methyltetrahydrofolate) in individuals that are in good physical shape.
Also, children drinking goat's milk instead of cow's milk could benefit from folic acid supplements. It is intended for use in dry crystalline or microencapsulated form as an alternative to Folic acid in foods, including dietary supplements. Folate was identified as the corrective substance in yeast extract in the late 1930s, and was extracted from spinach leaves in 1941. It acts as a coenzyme carrier in certain Folate-mediated reactions, although it does not require Dihydrofolate reductase activity. Regular Folic acid is not effective in reversing the effects of Folic acid reductase inhibitors such as methotrexate. When a woman has enough folic acid in her body before and during pregnancy, it can prevent major birth defects, including:Spina bifida (SPEYE-nuh BIF-ih-duh), which occurs when an unborn baby’s spinal column does not close to protect the spinal cord. Talk with your doctor about how much folic acid you need if:You are pregnant or are planning to become pregnant.
Pregnant women need 400 to 800 mcg of folic acid in theВ veryВ early stages of pregnancyВ often before they know that they are pregnant. Some doctors prescribe prenatal vitamins that contain higher amounts of folic acid.You are breastfeeding.
Some doctors suggest that breastfeeding women keep taking their prenatal vitamins to be sure they are getting plenty of folic acid while they are breastfeeding and should they become pregnant again.You had a baby with a birth defect of the brain or spine and want to get pregnant again.
Taking this high dose of folic acid can lower the risk of having another baby with these birth defects.You have a family member with spina bifida. If you have a hard time swallowing pills, you might try a chewable or liquid product that has folic acid.
Please note, if you already are taking a daily prenatal vitamin, you probably are getting all the folic acid you need. We cannot be sure that eating foods that contain folate would have the same benefits as consuming folic acid. In the United States, most women who eat foods enriched with folic acid are still not getting all that they need.
But unless your doctor tells you otherwise, do not consume more than 1,000 mcg of folic acid a day.
Consuming too much folic acid can hide signs that a person is lacking vitamin B12, which can cause nerve damage.



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