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Some have embraced the diet as healthy and reasonable, while others think it is downright harmful. Fortunately… science can give us some answers here, because 5 human studies have been done on the paleo diet so far.
The paleo diet emulates the diet of our hunter-gatherer ancestors, based on the premise that they did not suffer from the same diseases as modern humans. This diet advocates consumption of unprocessed animals and plants, including meat, fish, eggs, vegetables, fruits, nuts and seeds.
Details: 29 men with heart disease and elevated blood sugars or type 2 diabetes, were randomized to either a paleolithic diet (n=14) or a Mediterranean-like diet (n=15). The main outcomes measured were glucose tolerance, insulin levels, weight and waist circumference. As you can clearly see from the graphs, only the paleo diet group saw a significant improvement in glucose tolerance. The 2-hour Area Under the Curve (AUC) for blood glucose went down by 36% in the paleo group, compared to 7% in the control group.
Every patient in the paleo group ended up having normal blood sugars, compared to 7 of 15 patients in the control group. The paleo group ended up eating 451 fewer calories per day (1344 compared to 1795) without intentionally restricting calories or portions. Conclusion: A paleolithic diet lead to greater improvements in waist circumference and glycemic control, compared to a Mediterranean-like diet. Details: 14 healthy medical students (5 male, 9 female) were instructed to eat a paleolithic diet for 3 weeks.

Conclusion: The individuals lost weight and had a mild reduction in waist circumference and systolic blood pressure. Details: 13 individuals with type 2 diabetes were placed on either a paleolithic diet or a typical Diabetes diet in a cross-over study.
Conclusion: The paleo diet caused more weight loss and several improvements in cardiovascular risk factors, compared to a Diabetes diet. Details: 10 healthy women with a BMI over 27 consumed a modified paleolithic diet for 5 weeks.
Conclusion: During the 5 week trial, the women lost weight and had major reductions in liver fat. So, only human studies that isolate diet as the sole variable are included in the analysis. I did not include Frassetto, et al (4) because they controlled for calories to make sure that the participants didn’t lose weight. It is worth mentioning again that Ryberg, et al (5) had an average reduction in liver fat of 47% after 5 weeks on the paleo diet, which is very impressive. It is clear from looking at the studies that the paleo diet does lead to improvements in insulin sensitivity and glycemic control (1, 3, 5), although the results were not always statistically significant (2, 4).
Overall, the paleo diet was very well tolerated and there were no reports of adverse effects.
Additionally, the paleo diet used in the studies is not typical for the way paleo is often practiced today.
In this study, the women had an average reduction in liver fat of 49%, but no significant effect on the fat content of muscle cells.

A Palaeolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischaemic heart disease. Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. A Palaeolithic-type diet causes strong tissue-specific effects on ectopic fat deposition in obese postmenopausal women. Very interesting study, but there are too many confounders to conclude anything about the diet itself.
The Blue Team The 5-foot-10-inch former athlete lost 23 pounds and 10 inches between mid-July but she wants to continue to work toward weighing less than 200 and being comfortable in her body.
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