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LAWRENCE — Two prominent senior scientists at the University of Kansas are the 2013 recipients of the KU Research Achievement Award. Craig Freeman, curator-in-charge and senior scientist in the Division of Botany at the Biodiversity Institute’s R.L.
Todd Williams, director of KU’s Analytical Proteomics Laboratory and a senior scientist and director of KU’s Mass Spectrometry Laboratory. This is the first year we’ve presented two awards,” said Steve Warren, vice chancellor for research and graduate studies, “but it’s entirely fitting. Freeman came to KU in 1986 as coordinator of the Kansas Natural Heritage Inventory under the auspices of the Kansas Biological Survey and The Nature Conservancy. Leonard Krishtalka, director of the Biodiversity Institute, nominated Freeman for the award. Freeman’s academic background includes a Bachelor of Arts degree from Wartburg College and master's and doctoral degrees from Kansas State University.
Williams came to KU in 1989 as an assistant scientist, with duties as director and high-performance instrument operator in the Mass Spectrometry Laboratory.
Williams’ academic background includes a Bachelor of Arts degree from Middlebury College, master's and doctoral degrees from the University of Maine, and a postdoctoral experience at the University of California, Berkeley.

The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression, and genetic information in the university’s programs and activities. Current address: Department of Internal Medicine, University of South Florida School of Medicine, 12901 Bruce B. Abstract Hsp90 has become the target of intensive investigation, as inhibition of its function has the ability to simultaneously incapacitate proteins that function in pathways that represent the six hallmarks of cancer. This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
The award is the highest honor given annually to a full-time academic staff researcher working in a department or research center on KU’s Lawrence campus.
Williams will be recognized at a ceremony Wednesday, June 26, and Freeman will be recognized July 8. Craig and Todd are outstanding examples of academic staff research engagement, with excellent professional reputations that impact their work with colleagues at KU and around the world.
He has been affiliated with the survey ever since, including three years as acting co-director.
While a number of Hsp90 inhibitors have made it into clinical trials, a number of short-comings have been noted, such that the search continues for novel Hsp90 inhibitors with superior pharmacological properties.

The award was established in 2006 and is administered by the Office of Research and Graduate Studies.
In 1990 he joined the herbarium — part of the Biodiversity Institute since 1995 — serving in progressively more responsible roles until becoming curator-in-charge in 1999 and senior scientist. To identify new potential Hsp90 inhibitors, we have utilized a high-throughput assay based on measuring Hsp90-dependent refolding of thermally denatured luciferase to screen natural compound libraries. He was made a courtesy associate professor of chemistry in 1999 and a courtesy professor of medicinal chemistry in 2000. Four compounds, anthothecol, garcinol, piplartine, and rottlerin, were further characterized, and the ability of these compounds to inhibit the refolding of luciferase, and reduce the rate of growth of MCF7 breast cancer cells, correlated with their ability to suppress the Hsp90-dependent maturation of the heme-regulated eIF2? kinase, and deplete cultured cells of Hsp90-dependent client proteins. Thus, this screen has identified an additional 44 compounds with known beneficial pharmacological properties, but with unknown mechanisms of action as possible new inhibitors of the Hsp90 chaperone machine.

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