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Adaptive responses to stress are generally more short term and they are usually quite good for you. Cortisol is the hormone which causes the majority of the bodily changes associated with stress. So we can see from the initial diagram that too much stress can lead to heart disease, impotence and possibly diabetes (through the insulin resistance).
Stress as a bodily response The body’s response to stress, including the pituitary-adrenal system and the sympatho-medullary pathway to outline. The research of Janice Kiecolt-GlaserTwo pieces of research by Kiecolt-Glaser provide excellent evidence for the role of stress on the body’s immune system.

Studies into the effects of hassles on stress and health De Longis et al (1982) 100 participants (all over 45) were asked to complete four questionnaires each: Hassles scale (117 items) Uplifts scale (135 items) Life events questionna Health questionnaire. The hypothalamus releases a hormone called CRH (corticotropin releasing hormone) into the median eminence, which transports the hormone via the blood to the anterior pituitary. Cells of the anterior pituitary then release ACTH (adrenocorticotrophin releasing hormone) into the blood supply which circulates to the Adrenal glands (which sit on your kidneys like little hats). When you are sleeping, you are under less stress (or unaware of any stressful situations), so your cortisol levels are very low. To continue along this vein, stress downregulates the action of the amygdala (the fear centre), which gives a reason why you might be a little more fearless under stressful situations (such as lion attack).

If you want to be all savvy and smart about it, then you cansay that the stress hormone, cortisol, is released by the Zona Fasiculata of the Adrenal Cortex in response to ACTH.
Sleep states release melatonin (the sleep hormone), and melatonin upregulates the immune system.

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