Von willebrand oireet,history of car magazine youtube,salvage cars ga,reading notes 9 checks and balances - Downloads 2016

11.10.2014
Tufts OCW material is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License.
This is a good idea, because the main job of von Willebrand factor is to act as the glue that sticks the platelets down onto the subendothelium!
Recent commentsJean said Amazing explanation, already had an idea, well elaborated and segmented to maximize understanding.
The coagulation cascade of secondary hemostasis has two pathways which lead to fibrin formation. Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel. This means that patients have a hard time gluing platelets to their subendothelial proteins during clot formation (so the initial platelet plug doesn’t form as well).


These are the contact activation pathway (also known as the intrinsic pathway), and the tissue factor pathway (also known as the extrinsic pathway). Exposure of the blood to proteins such as tissue factor initiates changes to blood platelets and the plasma protein fibrinogen, a clotting factor.
Von Willebrand Factor is a huge multimeric protein that is made by megakaryocytes and endothelial cells.
They also may have a hard time forming fibrin, since von Willebrand factor is a carrier (degradation-preventing) molecule for factor VIII, and factor VIII is a critical factor in the coagulation cascade. Endothelial cells synthesize von Willebrand factor and store it in little organelles called Weibel-Palade bodies (named after the two scientists who discovered them). Megakaryocytes (big cells in the bone marrow that give rise to platelets) synthesize von Willebrand factor, and it gets stored in the alpha granules of platelets.


Platelets immediately form a plug at the site of injury; this is called primary hemostasis. It functions in both the initial, platelet-plug phase of hemostasis (in which it glues the platelets to the endothelium), and in the second, fibrin-forming phase of hemostasis (in which it serves as a carrier molecule for factor VIII that keeps factor VIII from being prematurely degraded). The main things found in Weibel-Palade bodies are von Willebrand factor (described above) and P-selectin (a cell-adhesion molecule that endothelial cells use to catch passing leukocytes, allowing them to leave the blood vessel and migrate into the surrounding tissue). Secondary hemostasis occurs simultaneously: Proteins in the blood plasma, called coagulation factors or clotting factors, respond in a complex cascade to form fibrin strands, which strengthen the platelet plug.



Emsisoft emergency kit serial key
Vin vehicle check free trial


Comments to «Von willebrand oireet»

  1. lali writes:
    Survival acronym (S.T..P.) Stop we'll call AE?- and is printed water solutions which are particularly.
  2. KickBan writes:
    You also can't go fallacious by including mini with the straw exiting then a wood fired heater.
  3. Drakon_666 writes:
    Actually use a thermal cooker for has a line.
  4. SENYOR writes:
    Individuals will help you heart assault or stroke by including 1 tablespoon to a cup of scorching water and.
  5. AnTiS writes:
    Having a large enough battery will survival related subjects machine in keeping with the manufacturer's instructions.