Figure 2. Classification criteria for systemic lupus erythematosus (SLE).

§ = additional criteria within the same domain will not be counted; * = in an assay with 90% specificity against relevant disease controls. Anti‐β₂ GPI = anti‐β₂ -glycoprotein I; anti-dsDNA = anti‐double‐stranded DNA.

Additive criteria
Do not count a criterion if there is a more likely explanation than SLE.
Occurrence of a criterion on at least one occasion is sufficient.
SLE classification requires at least one clinical criterion and ≥10 points.
Criteria need not occur simultaneously.
Within each domain, only the highest weighted criterion is counted toward the total score§.

Antinuclear antibodies (ANA) at a titer of ≥1:80 on HEp-2 cells or an equivalent positive test (ever)	No		Yes
See "Additive criteria" information in the "Abbreviation(s) and Footnotes(s)" section below

A. Clinical domains and criteria
1. Constitutional
Fever	No	Yes
2. Hematologic
Leukopenia	No	Yes
Thrombocytopenia	No	Yes
Autoimmune hemolysis	No	Yes
3. Neuropsychiatric
Delirium	No	Yes
Psychosis	No	Yes
Seizure	No	Yes
4. Mucocutaneous
Non-scarring alopecia	No	Yes
Oral ulcers	No	Yes
Subacute cutaneous OR discoid lupus	No	Yes
Acute cutaneous lupus	No	Yes
5. Serosal
Pleural or pericardial effusion	No	Yes
Acute pericarditis	No	Yes
6. Musculoskeletal
Joint involvement	No	Yes
7. Renal
Proteinuria >0.5g/24h	No	Yes
Renal biopsy Class II or V lupus nephritis	No	Yes
Renal biopsy Class III or IV lupus nephritis	No	Yes

B. Immunology domains and criteria
1. Antiphospholipid antibodies
Anti-cardiolipin antibodies OR Anti-β2GP1 antibodies OR Lupus anticoagulant	No	Yes
2. Complement proteins
Low C3 OR low C4	No	Yes
Low C3 AND low C4	No	Yes
3. SLE-specific antibodies
Anti-dsDNA antibody* OR Anti-Smith antibody	No	Yes

Score
Result :