Working with VM replication sets (Windows) : VMware vSphere snapshot replication sets : Limitations for VMware vSphere snapshot replication
 
Limitations for VMware vSphere snapshot replication
The following information applies to the VM replication function for vSphere snapshots.
• Avoid scheduling or performing VMware VADP backup and VMware vSphere snapshot replication activities at the same time on the same vSphere virtual machine. Doing so can adversely affect the backup or replication process.