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02.11.2014

I am thrilled to announce that the NCIC Clinical Trials Group (NCIC CTG) has developed and will lead an international clinical trial of a new class of cancer drug aimed at curing lung cancer in patients who have had surgery and chemotherapy for disease confined to the lung. The trial is being conducted internationally, with collaboration from the Intergroupe Francophone de Cancerologie Thoracique (France), the National Cancer Institute (US), Naples (Italy), the Australasian Lung Cancer Trials Group & National Health and Medical Research Council Clinical Trials Centre (Australia), , the Spanish Lung Cancer Group, the Dutch Society for Pulmonology and Tuberculosis (NVALT), the Central and East European Oncology Group, the Korean Cancer Study Group and the National Cancer Centre Singapore.
The Faculty of Health Sciences’ vision is to Ask Questions, Seek Answers, Advance Care and Inspire Change.
The following is a guest blog from Angela Luedke, PhD student, Centre for Neuroscience Studies. One of the best things about being a Dean at Queen’s is the close and special relationship I have with our three academic hospitals in Kingston. Physicians (Oncologists) and Surgeons will work with recognized treatment guidelines, but all patients will be given information and treatment options by their clinicians. Another important role for Multi-Disciplinary Teams (MDT’s) is in the development of local and national guidelines and protocols to optimize the use of available services and to standardize diagnostic and treatment approaches.
The diagnosis of Non-Small Cell Lung Cancer (NSCLC) will have been made by histology or cytology following detection of a lung tumor on imaging. The treatment options for lung cancer differ for non small cell lung cancer (NSCLC), and for small cell lung cancer (SCLC).
There are three main treatment options for lung cancer: surgical resection, chemotherapy, and radiation therapy. In addition to established treatments for NSCLC and small cell lung cancer, there are treatments that are more experimental. Adjuvant means treatment given after the main treatment and neo-adjuvant means treatment given before the primary treatment.
Surgical removal of the lung tumor is performed for stages 1, 2, and 3 of Non-Small Cell Lung Cancer (NSCLC) and is performed ‘palliatively’ (to relieve symptoms) in stage 4 disease.
Surgery is the definitive first-line treatment for stage 1 and 2 NSCLC, where there is no tumor involvement of the mediastinum.
Some small lesions are not amenable to segmentectomy due to their location: lobectomies are usually favored in such a scenario, although extended segmentectomies and bi-segmentectomies have been reported.
In patients with early-stage NSCLC, video-assisted thoracoscopic surgery (VATS) may be an alternative to an ‘open’ thoracotomy for patients undergoing lobectomy. Local tumor ‘recurrence’ after surgery: for stage 1 and stage 2 tumors, is reported to be 23 % at five years (Kelsey et al, 2009).
In 2004, the American Society of Clinical Oncology (ASCO) updated its recommendations for post-treatment surveillance in patients with NSCLC  (Pfister et al., 2004). If you have had, or are facing surgery for lung cancer remember, scars are just tattoos with better stories. In patients with stage 1 or stage 2 NSCLC, who have limited lung capacity, radiation therapy alone may be used. Patients who have a small primary tumor (< 5 cm) and impaired lung function or medical co-morbidity that prevents surgical resection or for those who refuse surgery, stereotactic body radiation therapy (SBRT) may be given. Post-operative (or ‘adjuvant’) radiation therapy is used to prevent local recurrence following resection of NSCLC. Radiation therapy, nothing to worry about – a day without radiation is a day without sunshine.
Because NSCLC is not very sensitive to most chemotherapy drugs, chemotherapy alone is not considered to be a curative treatment (unlike the case for small cell lung cancer). In 2004, the American Society of Clinical Oncology (ASCO) updated their guidelines on the treatment of non-resectable NSCLC (Pfister et al., 2004). In late-stage NSCLC, radiation therapy and surgery are used to relieve symptoms, such as pain, cough or hemoptysis; these treatments are not intended to be a cure nor may they improve patient survival. Short courses of radiation therapy may also be given for patients who are not candidates for more aggressive therapy or who have very advanced-stage lung cancer, or for those who relapse following their initial treatment. Treatment for stage 4 NSCLC may include a platinum-based chemotherapy agent and a non-platinum chemotherapy drug. A targeted therapy may be a drug (such as a tyrosine kinase inhibitor or TKI), an antibody (a monoclonal antibody) or a protein that targets a particular cancer cell in order to inhibit the cancer cell’s growth. The use of targeted therapy in stage 4 NSCLC, usually with a combination of two or more agents, may improve overall survival (OS) in some patients.
Graviola lives in areas of high humidity where the winters are relatively warm because this plant does not tolerate temperatures below 5 degrees when experiencing damage to the leaves and smaller branches.
Graviola has a pleasant and sweet taste that compares with a combination of strawberries and pineapple. According to expert estimates, Graviola selectively kills cancer cells by up to 10,000 stronger than chemotherapy or medications.


Compounds Graviola tree and up to 10,000 are stronger than Adriamycin, which is commonly used in chemotherapy. Besides the effect on cancer, also is very effective against fungi and parasites, bacteria, regulates blood pressure and helps with depression, nervous disorders and stress. After the discovery of medicinal properties, the pharmaceutical industry is faced with the following problem: the law is that a natural ingredient or plant cannot be patented.
But the pharmaceutical industry did not want to give up from Graviola – laboratory pharmacists are trying to synthesize the most powerful ingredient of Graviola that kills cancer cells. Full range later conducted research confirmed the effectiveness of Graviola, but the results often remained hidden from the public eye. The only listed possible side effects of consuming Graviola are associated with a high concentration anonacina, a chemical that is associated with certain atypical forms of Parkinson’s disease.
It’s a shame that thousands of people a day, die from the effects of various forms of cancer as a natural remedy at hand.
This picture gives you a pretty good idea of what Cushing’s does to the human body on a superficial level. It might seem that the last thing you should be thinking about when living through a serious illness is your appearance. I feel like our society forgets about those who once were healthy, but our now sick and have changed physically.
I hope that together the community can remind you that your outer appearance is changing but so is your inner person.
Enter your email address to subscribe to this blog and receive notifications of new posts by email. Welcome to Running for Rare DiseasesMarathon runners dedicated to making a positive impact on the lives of people with serious diseases have teamed up with NORD to make a difference.
This research contract with AstraZeneca is the largest in the history of the Faculty of Health Sciences.
Lung cancer is the second most common cancer in North America and is the leading cancer killer in both men and women. Its primary mission is to assess the effectiveness of interventions to prevent the development of cancer or improve the care of those patients who do develop cancer What started as a small operation has now grown into a sophisticated organization with 100 staff, a dozen senior investigators, partnerships with centres across the globe and ongoing support from the Canadian Cancer Society.
The choice of lung cancer treatment is based on the type of cancer (NSCLC versus SCLC) and the stage of the cancer (see Section 7). Stage 1 and stage 2 NSCLC accounts for 30 % of cases; this proportion increases in screened populations. A wedge lung resection: will preserve the most lung tissue and is recommended for small primary lung tumors, usually stage 0 or stage 1. A lobectomy: completely removes one of the five lobes of the lung and is recommended for larger or more central tumors. VATS is a minimally-invasive approach to the treatment of early-stage NSCLC and is useful for those patients with significant medical comorbidity. Post-operative ‘surveillance:’ there have been no randomized clinical trials to compare different surveillance strategies for patients with NSCLC. History and physical examination is recommended for lung cancer patients who have been treated (with ‘curative intent’) and in the absence of symptoms, every 3 months during the first 2 years; the every 6 months through to year 5, and then annually. Studies have shown that while post-operative radiation therapy can reduce the frequency of local tumor recurrence, it effects on overall survival (OS) is unclear. The role of adjuvant’ chemotherapy is to destroy any cancer cells that may have been missed by surgery, or that may have metastasized. The most common combination is cisplatin along with either an older (etoposide) or a newer chemotherapy agent, such as pemetrexed (Alimta), docetaxel, gemcitabine or vinorelbine.
As part of ASCO’s review of previous studies and clinical data, the 2004 investigators found that the long-term survival for patients with non-resectable NSCLC was rare. Unlike conventional medicines, Graviola does not harm healthy cells, and effectively kills cancer cells.
In this way pharmaceutical industry has lost the chance that from this natural remedy earn huge profits. You can get Cushing’s by taking glucocorticoid medications (like Prednisone) for an extended period of time. Our ongoing efforts in the NCIC CTG serve to reinforce our FHS industry engagement strategy, which strives to fortify existing relationships with industry and to promote and develop new ones. The new drug, MEDI4736 (AstraZeneca), is one of a new class of pharmaceuticals that helps the body’s immune system recognize and attack cancer. The trial exists because we asked questions: how can we think about different ways of treating lung cancer?


Each treatment option will have a way of removing or destroying lung cancer, but will also have side effects and possible complications.
For this reason, lung function tests are performed before considering surgery, to assess how adequate lung function will be following tumor removal. The presence of N1 involvement will result in a lobectomy in patients with adequate cardiopulmonary function. Recent studies support the safety and efficacy of VATS lobectomy for patients with stage I NSCLC.
These patients have a poorer prognosis than those with negative resection margins (R0), but post-operative radiation therapy may be required for this group of patients. There are some other ‘ablative’ techniques such as radiofrequency ablation and cryoablation that are still experimental, but these may be offered in some cases.
But for patients who do achieve long-term survival, these patients have a high risk of a second primary lung cancer (estimated at 1% to 2% per year). Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients. American Society of Clinical Oncology treatment of unresectable non–small-cell lung cancer guideline: Update. After the loss of millions of dollars invested in testing, pharmaceutical company withdrew the project, while maintaining the confidentiality of all the benefits that Graviola has.
They contain nimbinen, nimbin, nimbinene, nimandial and such compounds that treat fungus, bacteria and inflammations.You could use neem in a number of ways to get relief from various issues, diseases and infections. Not all patients experience all of these changes in their bodies but most people experience at least some of them. As you start to get sick, the body you have been living in since birth begins to transform before your very eyes.
Drugs in this class have already been approved for use in patients with malignant melanoma, but this will be the first trial in the world to test the drug in the setting of early lung cancer treatment.
Should this evaluation show that surgery will result in inadequate post-operative lung function, limited surgery or no surgery will be performed and, alternative treatment approaches will be considered.
However, in most centers, following initial treatment, history, physical examination, and periodic chest CT imaging will be performed at clinic follow-up.
It is good for your immune system, improves metabolism and biological processes and is a great relieving agent. At some point, you look in the mirror and you know longer recognize the person staring back at you. It was two years of hard work to pull together this trial with our industry partner, Astra Zeneca and to solidify relationships with collaborators across the world. The frequency of chest CT surveillance examinations will depend upon the risk of recurrence.
As a result, together we are inspiring change with a resolve to turn the way that we think about cancer on its head: from a disease that always wins, to a disease that we can consistently defeat.
Drinking the extract of neem leaves purifies blood, removes all toxins that cause infections, and fights free radicals.
Neem dilates the blood vessel leading to better blood circulation, and controls blood pressure.
Fungus can be a cause for lung infections, bronchi infection and could affect the mucous membranes.
The symptoms of fungal infections are reduced and oral thrush is controlled by neem leaves. Fungal infections that affect your hair, nails and skin, and ringworms on your feet and hands are also treated using neem leaves.
When mosquitoes are exposed to the smell of crushed neem leaves, they are not able to lay eggs. Neem is great at healing herpes by absorbing the virus and preventing it from affecting entering the areas that are affected. Making a tea with neem leaves and applying neem ointment on cold sores gives your relief from the symptoms of herpes.Boiling neem leaves and taking the water to have a bath is good for treating skin problems. This is good for treating frizzy hair and making your hair manageable. Consuming neem leaves regularly treats infection, cold, herpes, chicken pox, influenza and other viral infections. Viral fever is reduced by eating neem leaves. The extract of neem seeds and leaves relieves pain, reduces fecer and controls inflammation.



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