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Read on to learn about the most common forms of injectable testosterone, therapeutic dosages, pros and cons of testosterone injections, and injection demonstration resources. The most common forms of injectable testosterone for testosterone replacement therapy (TRT) include testosterone enanthate (TE) and testosterone cypionate (TC). The recommended dosing regimen of testosterone enanthate or testosterone cypionate for testosterone therapy is 75 to 100 mg every week or 150 to 200 mg every other week.1-5 Weekly injections are preferred because more frequent injections lower fluctuations in serum testosterone. Testosterone enanthate and testosterone cypionate only need to be injected every week or every other week.
Following an injection of testosterone enanthate or testosterone cypionate, T levels exceed normal physiological levels for the first two to three days.
Testosterone injections are more likely to cause an increased red blood cell count than other forms. In addition to not mimicking physiologic dosing, injectable testosterone also show a stronger impact on raising red blood cell levels than transdermal options.10-13 Testosterone stimulates the production of red blood cells. Men using injectable testosterone should be vigilant in monitoring for this particular problem. Injection site pain is relatively common although injection site pain rarely indicates a problem. Need to visit a physician for testosterone injections if unable to self-administer at home. In its Phase 3 Study, treatment with AVEED 750 mg maintained T levels in the normal range over 10 week dosing interval.6,14 The figure below illustrates T levels after the third injection. Both testosterone enanthate and testosterone cypionate are widely available in generic forms from compounding pharmacies. For injection information, the University of Michigan provides a detailed PDF primer on How to give a Testosterone Intramuscular (IM) Injection. Similar to testosterone cypionate, testosterone enanthate is a slow-acting injectable form of the androgen testosterone.
In comparison to testosterone enanthate and testosterone cypionate, testosterone propionate is a faster-acting form of the androgen testosterone.
Due to the very slow-acting nature, Aveed will offer men with low testosterone a more convenient treatment option than currently available preparations. Testosterone Lozenges Testosterone Lozenges Transbuccal (oral absorbable) forms of testosterone work by absorption through the mucous membranes of the mouth. The two most common forms (testosterone enanthate and testosterone cypionate) are both generic medications in the United States. Dosages can be changed with each injection, if necessary, to achieve optimal concentrations. A simple measure of your red blood cell count can alert your physician of this problem, which can then be treated. While testosterone undecanoate does not raise levels above normal, testosterone injections of TU still do not mimic physiologic dosing.
Also, most of the major low testosterone clinics use testosterone injections as the preferred testosterone replacement therapy administration method (See EMG’s Testosterone Resource Center for more information on the major low testosterone clinics). The primary difference between esters is the rate at which testosterone enters the bloodstream following an injection.

Following deep intramuscular injection, the drug provides a sustained release of testosterone into the bloodstream for 2 to 3 weeks.14 Testosterone cypionate possesses a half-life of 10-12 days. Following deep intramuscular injection, the drug provides a sustained release of testosterone into the bloodstream for 2 to 3 weeks.14 Testosterone enanthate possesses a half-life of 8-10 days.
Following deep intramuscular injection, the drug provides a sustained release of testosterone into the bloodstream for up to 10 weeks. It is intended for general informational purposes only and does not address individual circumstances.
However, for a considerable number of TRT users, testosterone injections produce red blood cell levels above safe levels over 50%.
Lowering the injectable dosage and shortening the time between injections may potentially reduce the possibility of this side effect. Testosterone undecanoate has actually been available under the brand name Nebido for over 10 years outside the US. The most commonly recommended dosing regimen for TRT is is 75 to 100 mg every week or 150 to 200 mg every other week. Testosterone undecanoate has been available under the brand name Nebido for over 10 years in more than 80 countries.
TRT in adult men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline.
The decline of androgen levels in elderly men and its clinical and therapeutic implications. Pharmacokinetics, efficacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate and testosterone cypionate for the treatment of hypogonadal men. Onset of effects of testosterone treatment and time span until maximum effects are achieved.
Androgen and erythropoiesis: evidence for an androgen receptor in erythroblasts from human bone marrow cultures. Multicenter contraceptive efficacy trial of injectable testosterone undecanoate in Chinese men. Comparison of T, DHT, LH, and FSH in serum after injection of testosterone enanthate of testosterone cypionate.
In fact, testosterone does fuel sex drive and muscle mass, but it also regulates mood and bone strength. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health.
These fluctuations can affect mood, emotional stability, and sexual activity.2 Shortening the interval between injections and lowering the dosage proportionally can minimize this cyclical nature of highs and lows.
Shortening the interval between testosterone injections and lowering the dose can minimize this cyclical nature of highs and lows, which is why weekly injections of 75 to 100 mg are preferred to every other week injections of 150 to 200 mg. In comparison, testosterone gels require daily dosing and testosterone enanthate and testosterone cypionate require injections every other week (26 injections per year). When a man's level falls below normal, a doctor may prescribe shots, gels, or patches.  But there is some debate over who needs treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site.

As a result, they have longer half-lives and are absorbed more slowly from the injection area. The longer lasting version of injectable testosterone, testosterone undecanoate, maintains T levels in normal ranges.
The drug provides a sustained release of testosterone into the bloodstream for up to 10 weeks. Following baseline administration of 750 mg, a second 750 mg dose is given at 4 weeks followed by 750 mg every 10 weeks thereafter. Aging and Testosterone LevelsA slow drop in testosterone is a normal part of aging, sometimes called "andropause" or "male menopause." For many men, this doesn't cause any significant problems or symptoms.
Due to their long half-lives, both TE and TC provide a sustained release of testosterone into the bloodstream for one to two weeks.
As a result, testosterone injections of TE or TC need only be administered every week or every other week.
Low Testosterone and SexA drop in testosterone doesn't always interfere with sex, but it can make it more difficult for your brain and body to get aroused. Testosterone, Mood, and ThinkingSome men have subtle problems like irritability or other mood changes, poor concentration, and less energy. These symptoms can easily be caused by other health problems though, like anemia, depression, sleep troubles, or a chronic illness.
What Causes Low Testosterone?Getting older is the most common reason testosterone levels dip. Testing for Low TestosteroneTestosterone is usually measured with a blood test done early in the morning, when levels are highest. Treating Low TestosteroneIf you have low blood levels of testosterone AND symptoms that affect your daily life, your doctor may suggest taking supplemental testosterone.  Not everyone with low testosterone will need treatment. Testosterone Replacement TherapyIf you need treatment, your doctor may prescribe testosterone to boost your levels. Some studies suggest this can strengthen a man's muscles, protect his bones, and improve his sex drive.
Testosterone InjectionsTestosterone comes in several forms, including shots, gels, patches, and tablets you place on your gums. Testosterone Use and CancerThere's some concern that long-term use of testosterone may cause prostate cancer in older men.
Men taking testosterone will need regular checkups to look for early signs of prostate cancer. This covers: All men over 50, men over 40 with a family history of prostate cancer, and all African American men.

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