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admin | Multivitamin Benefits | 01.01.2015
This CellML model runs in OpenCell and can reproduce one oscillation (which is true to the published results) but is unable to produce further oscillations. Schematic diagram of the mathematical model representing the luteinizing hormone releasing hormone (LHRH), luteinizing hormone (LH), and testosterone system.
This is probably because there are time delays in the origianl model which as yet can not be described in CellML.
In this model the hypothalamic secretion of the hormone LHRH (luteinizing hormone releasing hormone) is controlled by a combination of local testosterone concentration and of the local concentration of the pituitary hormone LH (luteinizing hormone).

Since LHRH stimulates the release of LH, and LH in turn stimulates the release of testosterone, the three hormones constitute a three-component "feedback" network.
We show how this model is able to account for the pulsatility of the release of these three hormones.
Furthermore, the model is consistent with results obtained from a wide range of experimental manipulations of the system.
For example, it accounts for the changes observed in hormone release patterns after castration.

In particular, it follows that no "neural clock", or "neural pulse-generator", is required to force the system into pulsatile behaviour.

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