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admin | Natural Testosterone Replacement | 17.08.2014
How can you press and pull your way to greatness when moving a heavy, loaded bar leads to muscle catabolism, inflammation, and atrophy?
Muscle growth is definitely the result of hard training, precise nutrition, consistency, and adequate rest, but it's also the result of much deeper interactions at the cellular level. Let's take an intimate look at what happens inside the body to instigate muscle growth, and how you can maximize your own gains! Within hours of muscle injury, neutrophils and macrophagesa€”white blood cells critical to decreasing inflammationa€”infiltrate your injured muscle. Signaling pathways ultimately control the activation and expansion of satellite cells, and enable them to produce larger, stronger muscles.
Satellite cells possess a single nucleus that acts as a control center, which regulates gene expression. Over the two-week period in which satellite cells are called upon to heal damaged muscles, our injured fibers are flooded with a residual pool of normally dormant satellite cells. Needless to say, sufficient levels of cardio and resistance training don't hurt either.
This is because the degree to which we place mechanical stress on our muscles is in direct relation to the disruption of muscle cell organelles, the proliferation of satellite cells, and, ultimately, muscle hypertrophya€”an increase in a muscle fiber's size.
The importance of blisteringly intensive weight-training sessions on satellite cell recruitment cannot be debated. Train Briefly And Intensely Short bouts of high-intensity weight training have been proven to boost IGF-1 levels to a far greater extent than longer, slower sessions.
Up The Fat Eat 0.5 g of fat per pound of body weight daily to increase IGF-1 bioavaliability.
Consume Whey Protein In one study, subjects who took 40 g of whey before and after workouts for 10 weeks experienced double the IGF-1 output and a threefold increase in the amount of IGF-1.
Eat Your Meat Meat-eaters tend to have higher circulating IGF-1 levels, and, as a result, more muscle mass. Milk It Milk has been shown to increase IGF-1 irrespective of its whey and casein composition.
Increase The D Researchers found that, by treating subjects with either 5,000 or 7,000 IU of vitamin D three times per week, they were able to significantly raise these circulating IGF-1 levels. While it's better known for increasing intramuscular energy, glucose uptake, and protein synthesis, insulin has also been shown to enhance satellite cell fusion.
Insulin levels can also be boosted by consuming 20-40 g of fast-digesting carbs, such as fruits, early in the morning.
In addition to engaging muscle protein synthesis and encouraging our blood vessels to relax and dilatea€”increasing blood and nutrient flow to heal training-induced muscle damagea€”insulin also increases how much muscle glycogen is stored in muscle tissue. Carb Up Eating 30-80 g of fast-digesting carbs along with 30 g of whey protein within 30 minutes of completing a lifting session helps insulin efficiently perform its muscle-building role and start the healing process. Be An Alpha Supplementing with alpha lipoic acid (ALA), an antioxidant that mimics the effect insulin has on muscle cells, may enhance insulin sensitivity. Include The Forgotten Vitamin K Vitamin K has been shown to improve insulin sensitivity by converting a substance called carboxylated osteocalcin, which plays a positive role in glucose metabolism.
The most coveted bodybuilding hormone of all, testosterone is also a key player in satellite cell activation. Ditch The Drugs By reducing or eliminating alcohol, caffeine, cigarettes, and other such drugs from your system, you offset the risk of excessive cortisol release, a stress hormone which may counteract testosterone production. Time Your Carb Intake While the proper timing of high-sugar carbs is a necessary anabolic measure to ensure optimal glycogen uptake, overconsumption of this energy macronutrient is no good. Get Sufficient Shut-eye Sleeping soundly has been suggested to increase testosterone levels.
Stay Lean Keep your body fat at respectable levelsa€”under 12 percent for males and 20 percent for femalesa€”to optimally balance your hormonal system and offset the possibility of lower testosterone levels. Eat Fat By consuming sufficient healthy fatsa€”including those found in avocados, olive oil, fatty fish, nuts, and lean animal meatsa€”you can maintain the structural integrity of your bodily cells while providing the raw materials needed for testosterone production.
Train Hard And Fast Intensive training sessions under 45 minutes that emphasize the basic compound movements are best for maximizing testosterone production. A key component in the muscle-growth process, growth hormone (GH), among many other functions, stimulates the production of IGF-1. In controlling how large our muscle fibers grow, GH dictates the extent to which we may progress in our training. Intensify Training The GH released in response to resistance training is proportional to the intensity generated. Quick-Burst It Periodic high-intensity burst-type training, in which the heart rate exceeds the anaerobic threshold for 30 seconds at a time, may enhance GH production.
Supplement With Arginine And Lysine Taking both of these supplements immediately before training and sleeping (3-5 g of each per serving) may elevate GH. Supplement With Glutamine By taking 2-10 g of glutamine immediately after workouts and before bed, you may not only improve your immune system integrity and muscle recovery, but also elevate GH levels. Heart Disease Prevention: 10 Ways To Improve Your Heart Health Your cardiovascular health goes beyond spending 30 minutes on the treadmill! As an active martial artist, bodybuilder and accredited personal trainer, David employs the latest cutting edge research to enhance his own progress. Xenical helps you to achieve weight loss without suppressing your appetite.It is one of the most successful treatment for weight loss.
After you've wired us the payment, it normally about 24 (48 weekend) hours till we withdraw your money and ship out your order and email you a tracking number. We don't work with express deliveries via DHL, Fedex or UPS because they refuse to ship any kind of medicine.
Packaging is excellent and discreet, in order to save space and make the package smaller, we sometimes take the ampoules and tablets out of their bulky boxes. Very important thing is that we do not sell needles & syrgines for injectable steroids. Sadly, as most lifters and athletes will tell you, these gains don't last, and your eternal quest for more eventually hits a non-scalable walla€”unless you adapt. You want to pack on more muscle or improve performance, and the reason you can get your gains at the gym is because your body is the most adaptable thing on the planeta€”even more so than your iPhone. A well-established study in the "British Medical Journal" calculated the exact speed and amount of adaptation your body is capable ofa€”it's a formula called General Adaptive Syndrome (GAS), and it explains why you need variety to undergo continued adaptation. The GAS graph shows that your body grows and performs in peaks, troughs, and plateaus that have a start and end point. During the first week of this new training cycle, your body will adapt and might actually make gains.


If you're training for sport, this is the time when you'll become fitter and improve upon your overall performance. This is when you reach a point where your rate of adaptation slows down and you hit a muscle-building or performance plateau. You need to take at least two weeks rest or do a totally new type of training that is the antithesis of what you were doing. Bear in mind that athletes usually adopt new techniques every 4 weeks while novices can keep making gains for up to 8-12 weeks using the same technique. The results can seem instant and almost seem effortless, but they are actually the reward of months of consistent and persistent effort.
Rest is never a bad thing, and it's recommended that you take a break whenever you hit a plateau or switch routines. Should you choose to do this, make sure the new technique is vastly different from the last one you did or builds directly on your previous routines.
This will keep you in a perpetual state of exhaustion which can lead to overtraining and burnout. Once you have all that information, then you can put it together in a long-term training plan that corrects failures and builds on success.
Always remember to mix things up to challenge your body and mind, because variety is the spice of a muscular life.
The following is a progressive plan to help a beginner progress to an intermediate lifter in less than a year. The high reps of endurance training will gradually accustom your muscles to being resistance training without any risk of injury. By this stage your muscles and nervous system will be attuned to getting put through its paces. You will have now mastered the form of the basic exercises and can dramatically add weight to build strength and power with lower repetitions. The difference between exercise and training is that exercise is movement without purpose, while training has vision and a clear goal. Even if you're a total beginner, you don't need a personal trainer to tell you how to schedule your long-term training strategy. Pay attention to your progress and, when your performance starts to decline, take a week off and start training for growth using the hypertrophy training guidelines.
When the scale tells you that you aren't adding muscle, start a power or strength training program. Now that you know the rules of the game, you can tailor your plan to your goals and play smarter than your competitor.
Summer Shredded: Get A Beach-Ready Body Don't get caught with your shirt on when the weather warms up. Captain America's Training Plan To look like a superhero on screen, you need to train like a superhero in the gym. Authoritative exercise and eating plans direct from the worlda€™s top trainers, professional athletes, and movie stars. Put simply, your body's reaction to stressors is what kicks off the swolification process. Small, cell-signaling proteins called cytokines are then released, attracting more white blood cells along with satellite cells.
When signaled, these relatively dormant cells wake up, engage, and rise to the occasion by proliferating at the site of muscle injury.
When prompted by tissue damage, satellite cells replicate and differentiate into mature muscle cells by fusing to existing fibers. To work their muscle-building magic, these satellite cells must become part of the cell cycle and replicate the molecular pathways that were responsible for laying down our very first muscle fibers during initial cell formation. First, your health has to be in good standing, which includes optimal hydration, sound sleep, a diet low in simple sugars and trans fats, and a good balance of quality proteins, carbs, and fats. After all, lifting does more than build boulder shoulders and barnyard backa€”it induces tissue vascularity, which aids in the circulation of nutrients and oxygen as well as the removal of waste products. In order to optimize satellite cell activation and myogenesisa€”better known as the formation of muscular tissuea€”you have to maximize the microtrauma that signals muscle injury.
Training intensity should be your number one priority to enlist the greatest number of satellite cells and kick off the muscle-growing process. But an often-overlooked part of the muscle-growth process is the combined effect of growth factors and anabolic hormones in the process. In fact, it's been suggested that it contributes to muscle hypertrophy by stimulating the proliferation of satellite cells. An eight-week study of creatine versus placebo found that subjects taking creatine recorded an IGF-1 increase of 78 percent compared with the control group, who were assessed at 54 percent.
To optimize IGF-1 levels, consume 20-30 g of whey protein 30 minutes before training and 20-30 g immediately after. Vegans typically have 15 percent lower IGF-1 levels compared to their carnivorous counterparts.
By consuming 2-3 glasses of milk each day, we may significantly elevate our circulating IGF-1 levels while boosting IGFB-3, a binding protein that assists IGF-1's role as a muscle builder. It does this by increasing satellite cell density and promoting extensive myotube formation and enhanced differentiation. Testosterone increases neurotransmitter levels at the muscle fiber site, stimulates GH responses in the anterior pituitary, interacts with nuclear receptors in DNA, and modulates satellite cell activity through increased IGF-1 production and androgen receptor density.
In fact, an immediate drop in testosterone levels may be experienced following a high-carb feeding, and 3-4 such meals per day may lead to lower overall T-levels. Sufficient uninterrupted sleepa€”at least eight hours each nighta€”is also one of the most effective ways to boost GH production. Secreted from the anterior pituitary gland following intensive weight sessions, GH is crucial for the uptake and final-stage integration of amino acids into new muscle proteins.
GH is thought to promote the second phase of myogenesis, or the formation of muscular tissue.
Completing such bursts five times within the same workout has been shown to activate super-fast-twitch muscle fibers which, in turn, maximizes GH levels. 10: Breaking Insights In Training, Nutrition, And Supplementation Every month, academic journals publish dozens of new studies about training, nutrition, and athletic performance. We are your personal trainer, your nutritionist, your supplement expert, your lifting partner, your support group. Go to [ order ] and fill in the form your personal data, which we will use to send you the selected items.


We send using ordinary Post Service, in most cases, package travels about 4 - 6 days for customers from Europe, and 7 - 10 days to USA citizens (7 days to New York, 10 days to West costs). From the moment you fill your lungs for the very first time as a newborn, being "more" is all you think about. It's the same with your love lifea€”dating the same partner, eating at the same restaurants, and always doing the same things can't fulfill your emotional needsa€”unless you do these things with the one whose finger you end up putting a ring on, of course. Seduce them with a new workout every 4-8 weeks and their progress will keep you satisfied for as long as you're willing to make them sweat. Let's say you've just begun a new training cycle that you plan to stick with for as long as possible. It'll be a refreshing change so you'll be motivated to see how far this new technique can take your physique and performance.
You might not be able to push the same size weights you did the previous week or squeeze out as many reps. You'll think about quitting, but may get a glimmer of hope in the final workouts of this week that will seem slightly easier and yield some strength increases. Each week sees an improvement and you'll soon sport arms so powerful you could throw a lamb chop past a starving wolf.
As soon as your gains taper off and begin to plateau (usually somewhere after week 5 or 6), you should take a break, then switch programs. The stimulus isn't different enough to cause your muscles to develop and they become stale. Let your muscles play the field of training techniques to keep growing and improving their performance.
But the moment you feel the relationship with a training technique going sour because of a lack of gains, you have a few options: use a new training technique (way of exercising), take one or two weeks to rest from all training, or dramatically reduce your workout load by at least 60 percent. But if you're motivated and keen on getting fast results, then feel free to jump straight into a new technique. Starting a new routine that's not different enough from the previous one means there won't be enough variation to trigger growth and progress. For constant progress, decide on your goals and take your muscles out on the town by gathering information on several different types of training that are specific to your end goal. You can now start gunning for size by decreasing the repetitions, increasing the size of the weights you use, and setting personal bests.
There's no point thrashing it out for two months, stacking on muscle, shedding fat, and bolstering your performance only to quit and watch it waste away. Lay the foundations by doing strength endurance training (or any other technique suited to beginners) for 2-3 months. You'll notice that, after this, you'll revert back to endurance training to shock your muscles into growing further.
It has been shown that the strongest wave of GH occurs within the first hour of sleep; GH is then released in episodic waves once every 90 minutes.
Take some of the strategies you've learned above, and implement them in your own quest for more mass!
Effect of protein supplementation during a 6-mo strength and conditioning program on insulin-like growth factor I and markers of bone turnover in young adults. Effect of creatine supplementation and resistance-exercise training on muscle insulin-like growth factor in young adults. Single-Cell Analysis of Regulatory Gene Expression in Quiescent and Activated Mouse Skeletal Muscle Satellite Cells. Androgen Receptor in Human Skeletal Muscle and Cultured Muscle Satellite Cells: Up-Regulation by Androgen Treatment. Acute effect of brief low- and high-intensity exercise on circulating insulin-like growth factor (IGF) I, II, and IGF-binding protein-3 and its proteolysis in young healthy men. Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men.
Synthesis and Secretion of Insulin-Like Growth Factor and Its Binding Protein by the Perfused Rat Liver: Dependence on Growth Hormone Status. Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies. Release of Hepatocyte Growth Factor from Mechanically Stretched Skeletal Muscle Satellite Cells and Role of pH and Nitric Oxide. Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation. Kinetics of Myoblast Proliferation Show That Resident Satellite Cells Are Competent to Fully Regenerate Skeletal Muscle Fibers.
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You get damn good at it, too, because there's an unquenchable worldwide thirst for more horsepower, more information, more sex, more calories, more money, more strength, and more size. The new stimulus would be to do 3 sets of 15 reps on a totally new set of exercises or even on all the same group of exercises. You might train hard for weeks with no results then, all of a sudden, progress slaps you in the face and your best lifts jump up by 44 pounds or you stack on 4 pounds of muscle.
This seems counterintuitive, but your muscles won't be used to doing such high repetitions, which will shock and spark the growth process again because you will have started a completely new cycle.
You push yourself and tear down muscle fibers, so why does the continual stress make you stronger? The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 67, 587-598.
Your physique will deteriorate as you lose muscle and gain fat while your performance is in a slump. And, when you do hypertrophy training again, you'll stack on size faster than you've ever dreamed.
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