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admin | Natural Weight Loss Supplement | 14.07.2014
Human Growth Hormone (hGH) also known as somatotrophin is classified as a polypeptide hormone. In above figure purple portion indicates the alpha helical structure, while yellow signifies beta helical structure. The mechanism works by negative feedback mechanism Due to disruption in the endogenous rhythms the neurotransmitter stimulates the pituitary gland .This causes the release of either of the factors depending upon the need of GH. Mechanism of action takes place by binding of GH molecule in between the receptor molecules.
Recombinant hGH or Pit-hGH is given by Subcutaneous route.This is so because when it was given by IV route it got rapidly cleared from the body and half life was very less and frequent dosing was required to achieve desired effect.
In another study an ideal sustained release formulation was made of PLGA microspheres using double emulsion method.
Alternative approach is by either changing the delivery route of the product or by making some structural or formulation changes in the product. In one such study, Pluronic surfactant was used to stabilize the rhGH during microencapsulation.
This offers the advantage of ease of administration, larger surface area and no first pass metabolism. The main advantage of using this route is that there is no metabolic or chemical degradation of the drug and the drug also dodges the first pass metabolism. Other approach is the preparation of a sustained release product which is done by reaction of the drug with the polymer. This type of approaches involve in making devices which are needle free and people who have hGH deficiency and take their medicine without visiting the hospital. Children with short stature caused by GH deficiency, Turner syndrome, idiopathic short stature, SHOX deficiency, and failure to catch up in height after small for gestational age birth. Adult Patients: Treatment of adults with either childhood-onset or adult-onset GH deficiency. A study of clinical trial is completed which shows the use of GH helps immune function in patients with HIV. There are many other clinical trials being conducted to either study the off label uses of hGH or to study the effects of hGH on other metabolic pathways. Galit Levin, 1,3 Amikam Gershonowitz, 1 Hagit Sacks, 1 Meir Stern, 1 Amir Sherman, 1 Sergey Rudaev, 1 Inna Zivin, 1 and Moshe Phillip.
It gives rise to an internal environment conducive to disease, as opposed to a pH balanced environment which allows normal body function necessary for the body to resist disease. The essay will make you understand the brief idea about the developments taking place in the Pharmaceutical field regarding hGH.
In case there is need of GH in body then, the pituitary gland causes a decrease in secretion of GHRIH and increase in secretion of GHRH because of which secretion of GH increases. This binding occurs in the extracellular region and due to this there is receptor dimerization.
Peptides are contaminated by viruses, host derived proteins, endotoxins, glycosylation variants. Here the crude isolated from the other components is purified further to obtain initial product.
Hence there is a need to formulate new products which can last for longer period of time in the body and hence reduce the frequency of the dose.
The results showed a greater residence of activity compared to normal rhGH (Neutropin was used as control). This is due to gastric enzyme activity on the drug and secondly a large molecule like hGH cannot pass through mucosal barrier. However the area to which it gets exposed is small hence this can reduce the absorption of the drug. For example the residence time of the rhGH was increased by using C-Terminally PEGylated hGH-derivatives. One such study uses Dextran T40 which was oxidized with periodate to form aldehyde groups to which recombinant human growth hormone (rhGH) was attached.
This is cured by giving adjuvant therapy of hGH along with the drugs used to cure renal disorder. The aim of the study is to study the effect of GH on glucose and protein metabolism in children with GH deficiency. Hence a vast amount of research is being carried out in this field but still we are searching for a formulation which decrease dose frequency and would be needle free.
Effects of Growth Hormone on Glucose and Protein Metabolism in Children With Growth Hormone Deficiency.
Margaret Dyer, Inderjit Jabbal-Gill, Michael Hinchcliffe, Richard Nankervis, Alan Smith, Peter Watts *. The focus of the essay is on the development occurring on the various alternative delivery routes used to deliver the drug to body without use of injections.
The GH then gets transported to the liver and then it is supplied to the effector organ or cell.  The high levels of GH is later are brought back to normal by increase in secretion of GHRIH.
Many studies have been carried out to see whether a controlled or sustained release formulation can be made which will drastically reduce dose intervals.
But in vivo testing was carried out in animal models and there was not that significant increase in residence time of dose in the body of animals.
Let us look at the various alternative routes and their ability to incorporate rhGH safely and without causing any toxicity. Hence to solve this problem the drug has to be small in size and has to be properly protected.


This study further states that by using this complex the release rates of rhGH from microspheres are increased compared to PLGA microspheres. Hence in the following study the transdermal delivery of rhGH is done through micro channels using radiofrequency.
However human clinical trials are not conducted but the study showed a rapid increase in body growth of the rats. Stabilization of recombinant human growth hormone against emulsification-induced aggregation by Pluronic surfactants during microencapsulation. Sustained release of recombinant human growth hormone from dextran via hydrolysis of an imine bond. Development of a novel sustained release formulation of recombinant human growth hormone using sodium hyaluronate microparticles. When excess acids must be neutralized our alkaline reserves are depleted leaving the body in a weakened condition. Hence taking into consideration the patient compliance as well seeing that a good bioavailability is obtained and there is a considerable amount of decrease in dose frequency of the drug.
Helix 4 and 1 has primary sites for binding of the growth hormone receptor (Reference 13.)  The expression hGH genes present in the body are of 2 types viz.
In one such study a sustained release formulation of recombinant human growth hormone (SR-rhGH) was developed as a once-a-week injection formulation using sodium hyaluronate. In one such study the intranasal delivery of rhGH was done in sheeps using chitosan based powders. Intranasal delivery of recombinant human growth hormone (somatropin) in sheep using chitosan-based powder formulations. A pH balanced diet, according to many experts, is a vital key to health maintenance.                                                        —By permission of Dr. Along with alternative routes, this essay will also provide some information about the newer developments made in the current drugs so that the frequency of dose is reduced. Hence interest in curing the disorders caused by this hormone attracted many scientists and vast amount of research has been conducted in finding medicines to cure them. Due to this there limited availability of hGH in the body and again frequent dosing is required. The peptide is lyophilized and then it mixed with suitable polymer so that its half life increase and then it is mixed with diluents and packed in single use vials. Such purification techniques should be used which account for less amount of loss of yield.
Additional to this new instruments (automated injector with or without needles) are invented so that patient can easily take their daily doses.
In current market the recombinant somatropin (is a term used for hGH produced by recombinant technology) injections are used for treating disorders related to hGH. The variant hGH is found in pregnant women’s placenta and is responsible for growth of the fetus.
This essay will also throw some light on the various clinical trials taking place regarding the concerned topic. Eating a healthy diet and staying alkaline has been known to reduce the itching sensations caused by Morgellons.
Hence this essay provided a review of critical developments taking place regarding the delivery of hGH. By this route the drug may enter the systemic circulation via blood capillaries or lymphatic vessels. If you had a swimming pool, you'd want to raise the pH above 7, otherwise bacteria would thrive in it. When the same test was repeated with alkaline urine he saw micro fibers in it, the difference being was that these micro fibers did not grow any further. Having run these tests numerous times and achieving the same results we can deduce that maintaining an alkaline state will slow fiber growth way down. He gets into all the specifics needed to understanding pH balance such as the proper proportions of foods to prepare and what happens to a body when it is acidic, as well as how much protein your body needs based on your weight. You might be pleased to find out that getting proper Vitamin D and balancing your pH will impact your health in ways you never imagined such as minimizing arthritis, decreasing the risk of diabetes, heart disease and cancer.This from Dr. A chronically over-acidic pH corrodes body tissue, slowly eating into the 60,000 miles of veins and arteries like acid eating into marble.
If left unchecked, it will interrupt all cellular activities and functions, from the beating of your heart to the neural firing of your brain. There is even a device called a pH meter that one can use with urine.Each kit has its own color chart. By comparing your sample to the color chart, you will be able to determine easily your current state of pH balance.At first, you'll want to do this 4-5 times a day (I try to test with each bathroom run) to get a sense of how fast the body is affected after eating and to correct any shifts so you stay as evenly as possible in an alkaline zone. Although we are aiming for an alkaline body, that does not mean that you should eat only alkaline foods.
It's all about finding a balance between the two.Some people have difficulties maintaining proper pH just using diet. Include high alkaline foods like lemon, apple, kale, watermelon along with other alkaline fruit and veggies.Another way to attain alkalinity is with the 'biofilm buster'.
It will begin fizzing and rising—do not stir, otherwise it will react like warm champagne in a shaken bottle, foaming out of the cup!
You can see my live blood microscopy page for some of Rick Panson's (health coach and microbiologist) recommendations as well.What foods can I eat?Keep it simple.
Many processed foods contain genetically modified (GMO) ingredients and they are not labeled, so you can't know if you're ingesting them.


You'll want to eliminate your exposure to these GMOs as there is enough evidence to show they are bad for one's health.
Read Jeffrey Smith's "Seeds of Deception" or watch his documentary "Genetic Roulette – The movie." He is pretty much the go to source for current info on genetic modification which little as it's been tested, is being linked to all kinds of health issues. More on GMOs below.If you have Candida or a fungus problem, you might want to monitor how much, if any, fruit you consume. In a healthy state you can shift the balance to 70% fruit and vegetables to 30% protein.Eat organic if you can. Many Morgellons sufferers are dealing with oxidative stress and trapped toxins in the body that they can't get rid of. While they are good for you if you are not allergic, too much will bring your body into acidity.
Make sure if you are buying pre-packaged organic beef that the label includes grass finished, since the animal may have been grass fed, but fattened before going to market with GMO corn. Additionally, it is anti-viral, anti-fungal, anti-bacterial and anti-parasitic, touching on all things Morgellons sufferers are dealing with. Unlike other oils it tolerates higher heat without causing oxidation and free radicals (which are cancer causing).An added benefit is that coconut oil is converted to energy immediately and is not stored as fat like other oils. Coconut oil has no cholesterol and is a great source of medium chain fatty acids which helps lower the risk of atherosclerosis and heart disease and one study found it to help with dementia. It is also a rich in the antioxidant beta-carotene and the essential fatty acid gamma linolenic acid (GLA) that is found mostly in plant-based oils.
Omega-6 fatty acids play a crucial role in brain function as well as normal growth and development. It is high in Chlorophyll which is believed to soothe inflammation and normalize digestion of amino acids.It comes in two forms, powdered and pills. Seaweed and KelpKelp is a good source of protein along with potassium, iron, B6 and dietary fiber. Mercola pointed out that kelp, like fish, might be carrying heavy metals—a point I hadn't thought of.
It contains 18 amino acids, 8 essential amino acids, essential fatty acids, and is high in vitamin C and beta-carotene. In fact, chia seeds have the highest known whole-food source levels of Omega-3 acids, as measured by percent of weight.• ?Rich In Antioxidants. Chia is a great natural source of antioxidants, including chlorogenic acid, caffeic acid, myricetin, quercetin and flavonols.• Full of Important Nutrients. Chia is an excellent source of calcium, phosphorus, magnesium, potassium, iron, zinc and copper. About five percent of this fiber is soluble, which can help reduce cholesterol.•  Builds Endurance.
Chia builds stamina and endurance because it steadily releases slow-burning glucose into the bloodstream.• ?Gluten-Free.
Since essential amino acids are not produced by the body, it's important to get amino acids from nutrient-rich sources like chia seeds. Research suggests leucine may help regulate blood sugar levels and aid in muscle recovery after exercise.• ?Stays Fresh. Chia seeds stay fresh for24-36 months when stored in proper conditions (cool and dry).?  Gut Health?From Dr.
Moreover, your gut literally serves as your second brain, and even produces more of the neurotransmitter serotonin—known to have a beneficial influence on your mood—than your brain does, so maintaining a healthy gut will benefit your mind as well as your body.Fermented foods are also some of the best chelators and detox agents available, meaning they can help rid your body of a wide variety of toxins, including heavy metals. Caroline recommends beginning with very small servings and working your way up to the quarter- to half cup serving size.
The innate intelligence of their bodies tells them to eat more cultured foods because they're in such a state of dysbiosis. For those that have limited budgets and can't afford high-end probiotics, this is a great way to get beneficial bacteria into your system. To weight it down, I'm using a ball shaped crystal, but a glass paperweight would work too.
If using a metal screwtop on the jar, make sure that the liquid covering the vegetables stays 1 inch below the lid, otherwise it might corrode the lid. Remember, fermenting vegetables give off a gas that needs to escape, so lightly screw on the top which will allow trapped gas to leave. Mercola suggests opening a probiotic pill into the mixture or using juiced celery instead of salt to ferment. These beneficial bacteria produce helpful enzymes as well as antibiotic and anti carcinogenic substances.
Most of the processed food in supermarkets contains some derivatives of corn or soy—yet another reason to eat unprocessed food. To learn more about genetically modified seed and why it is so bad for you read, Seeds of Deception or Genetic Roulette, by Jeffrey Smith. Occasionally they run it for free on his site so it pays to get on his mailing list and they will notify you. Wahl who was crippled and in a wheelchair from Multiple Sclerosis shares what she learned about diet and how she was able to reverse and heal her illness.
If she could accomplish such a spectacular feat as this, what might this diet do for the Morgellons sufferer?



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