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admin | Best Abs Workout For Women | 15.04.2016
A popular and controversial sports supplement widely sold in the USA and other countries is secretly spiked with a chemical similar to methamphetamine that appears to have its origins as an illicit designer recreational drug, according to new tests by scientists in the USA and South Korea.
The test results on samples of Craze, a pre-workout powder made by New York-based Driven Sports and marketed as containing only natural ingredients, raise significant health and regulatory concerns, the researchers said. An attorney for Driven Sports, Marc Ullman, said the company had no comment on the latest findings that the compounds are actually more closely related to methamphetamine.
Cohen said researchers informed the FDA in May about finding the new chemical compound in Craze.
Driven Sports has issued repeated statements in recent months that Craze does not contain any amphetamine-like compounds, including posting test results on its website that it says prove the product is clean. The newspaper's investigation, which focused on several products sold over the years by Cahill's changing series of companies, reported that tests by the U.S. A month after USA TODAY published its report about Cahill and Craze, a team of South Korean scientists published an article in a journal of the Japanese Association of Forensic Toxicology saying they had found a methamphetamine-like compound in samples of Candy Grape flavor and Berry Lemonade flavor Craze. The researchers, from the National Forensic Service in South Korea and the National Institute for Public Health and the Environment in the Netherlands, noted that the compound found in Craze was the same as that found in a crystalline powder seized by narcotics agents in December 2011 as a suspected illicit designer drug. The researchers noted that the compound had been patented in 1988 by Knoll Pharmaceuticals with claims of psychoactive effects, such as enhancing mental activities and pain tolerance. Although not part of the journal article being published today, NSF International announced that in separate testing they also have detected the same methamphetamine-like compound in the weight-loss supplement Detonate sold by Gaspari Nutrition. Last year Driven Sports posted a series of blog items on its website alerting customers that counterfeit versions of Craze were being sold. Craze v2 contains an innovative combination of ingredients to support improved performance, strength, and muscle growth. As a dietary supplement, take 1 scoop with 8oz of cold water 15-30 minutes prior to training. Als je het pre-worksupplement Craze van het Amerikaanse Driven Sports gebruikt, dan is je misschien opgevallen dat webwinkels het spul niet meer verkopen. Detonate van Gaspari Nutrition, een amfetamine-analoog gevonden die nooit is getest op mensen, en in omloop is als recreatieve drug. De val van Craze is ingeluid door onderzoek in laboratoria van Harvard Medical School, de Amerikaanse FDA, het Nederlandse RIVM en de Zuid-Koreaanse National Forensic Service. In het artikel dat we hierboven als tweede noemen [integraal beschikbaar] kun je lezen dat berichten van de WADA de aanleiding waren voor het gezamenlijke onderzoek.
Omdat betrapte sporters vertelden dat ze het pre-workout-supplement Craze hadden gebruikt, kochten onderzoekers een paar potten Craze, en analyseerden de inhoud in het lab. Op het label van Craze staat dat het product enkele analogen van beta-phenylethylamine bevatte. De bad guys van de supplementenindustrie hebben er een handje van om obscure anabolen of amfetamines in hun producten te stoppen, en die dan in een verbasterde vorm op het label te zetten. De stof in Craze zou misschien een analoog kunnen zijn van metamfetamine, dachten de onderzoekers.

Toen de onderzoekers gingen zoeken naar meer informatie over N,alpha-di-ethylphenylethylamine, stuitten ze op een publicatie uit 2011. Driven Sports, de maker van Craze, heeft laten weten dat de stof waar zoveel ophef over is van nature aanwezig is in de Dendrobium-orchidee, waarvan extracten in Craze aanwezig zijn. A USA TODAY investigation published in July reported on other tests detecting amphetamine-like compounds in Craze. In recent weeks, Driven Sports' website, which offers Craze for sale, has said the product is out of stock. Food and Drug Administration, which oversees dietary supplements, could not be reached for comment. The team found the compound - N,alpha-diethylphenylethylamine - has a structure similar to methamphetamine, a powerful, highly addictive, illegal stimulant drug.
In July, a USA TODAY investigation revealed that a top Driven Sports official - Matt Cahill - is a convicted felon who has a history of selling risky dietary supplements, including products with ingredients linked to severe liver injury and at least one death. Anti-Doping Agency in June 2012 and a government-affiliated forensic lab in Sweden in April 2013 had detected undisclosed amphetamine-like compounds in samples of Craze. In that case the powder was found in an unclaimed lost package shipped from Vietnam to South Korea, according to an earlier journal article published by the team in late 2012. While it was never developed into a medicine, the patent described tests on animals and suggested an intended oral dose of 10 mg to 150 mg, with a target of 30 mg.
Instead it says the product contains dendrobium orchid extract that was concentrated for different phenylethylamine compounds.
Driven Sports has reformulated its original lineup to deliver cutting-edge results with this new formula. Betaine supports performance by helping to counteract the effects of lactate to postpone muscular fatigue. According to studies, citrulline elevates arginine levels in the body more efficiently than arginine supplements.
Research on Galangal suggests that it may impede fatty acid synthase, an enzyme that aids the production of fatty acids. Als je precies wilt weten waarom, en waarom je zo goed kon trainen na een dosis Craze, dan moet je dit stukje beslist even lezen. WADA's dopingjagers hadden in de urine van sporters analogen van metamfetemine gevonden die nog niet eerder in dopingtests waren opgedoken.
Beta-Phenylethylamine structuurformule hieronder] is een onschuldige stimulerende stof die van nature in chocolade en andere voedingsmiddelen voorkomt, en die je dus in supplementen kunt tegenkomen. Zou N,N-diethyl-phenylethylamine in werkelijkheid N,alpha-di-ethylphenylethylamine kunnen zijn?
Eentje die onstaat als je niet 2 methylgroepen, maar 2 ethylgroepen vastplakt aan beta-phenylethylamine.
Op basis van die dierstudies berekende Knoll dat de effectieve humane doses van N,alpha-di-ethylphenylethylamine tussen de 10 en 150 mg lagen.

They believe the new compound is likely less potent than methamphetamine but greater than ephedrine.
The team said it began testing Craze in response to several failed urine drug tests by athletes who said they had taken Craze. Cahill is currently facing federal charges in California involving his introduction of another supplement, Rebound XT, to the market in 2008 that contained an estrogen-reducing drug, and this spring a grand jury was also investigating, USA TODAY has reported. Phenylethylamines include a variety of chemicals "that range from benign compounds found in chocolate to synthetically produced illicit drugs," according to the U.S. By elevating argininine levels, it promotes nitric oxide production to help intensify pump and vascularity.
2013, 31, 54.] Daarin beschreven Zuid-Koreaanse collegaonderzoekers hoe ze N,alpha-di-ethylphenylethylamine hadden aangetroffen in een grote partij grondstoffen, die de politie in beslag had genomen.
There is a possibility that this chemical will be widely abused for recreational use in the near future," they wrote at the time.
Je hebt dan trouwens het onschuldige beta-phenylethylamine omgetoverd in de harddrug amfetamine. Waarschijnlijk realiseerde Knoll zich dat N,alpha-di-ethylphenylethylamine na introductie in no-time het stempel van harddrug zou krijgen. En verhip, toen de onderzoekers in een paar potten Craze de concentratie N,alpha-di-ethylphenylethylamine bepaalden, bleek dat die schommelde tussen de 21 en 35 mg per aanbevolen dosis. Tyrosine and Velvet Bean help to keep you motivated, so you can accomplish your training goals. Too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heartbeat. Plak je niet 1 maar 2 methylgroepen vast aan beta-phenylethylamine, dan krijg je het nog sterkere - en nog gevaarlijkere - metamfetamine. Choline Bitartrate is a precursor to the neurotransmitter acetylcholine, which plays a significant role in memory. Chlorogenic Acid acts as an agonist of Peroxisome proliferator-activated receptor alpha, which plays a major role in regulating lipid metabolism in the liver. One serving of this product contains about the same amount of caffeine as one and one half (1.5) cups of coffee. Do not take this product if you have any pre-existing medical conditions or if you are using any prescription or over-the-counter medication. Discontinue use and consult your health care professional if you experience any adverse reaction to this product. User accepts all risks, liabilities, and consequences in regards to the use of this product.

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