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admin | Natural Testosterone Replacement | 07.09.2014
You must have JavaScript enabled in your browser to utilize the functionality of this website. When we start our patients on a hormone-balancing regimen, it's crucial to be mindful of mitochondrial function. Receptors for estrogens, androgens and thyroid hormones are found in the mitochondria from many cell types. Estrogen and testosterone play a protective role in the mitochondrial processes implicated in aging.
Estrogens have a beneficial effect on mitochondrial function in the vascular system while muscle repair also is dependent on hormonal interaction with the mitochondria. Post-menopausal obesity and insulin resistance may be due to skeletal muscle mitochondrial dysfunction caused by a drop in estrogen levels. Researchers have detected estrogen receptors in mitochondria of rat uterine and ovarian cells, MCF-7 breast cancer cells, cultured human lens epithelial cells and rat hippocampus and neuronal cells. Researchers have found androgen receptors in mitochondria of LNCaP cells and human sperm cells. In one study, researchers tested the effects of progesterone and 17β-estradiol on mitochondrial function in the brain.
Brain mitochondria from rats given the hormones had enhanced functional efficiency and increased metabolic rates. Delayed response accuracy was linked to the number of total and straight mitochondria in the dlPFC. Thyroid hormones trigger substantial modifications in mitochondrial inner membrane proteins and lipids.
Another iodothyronine known as 3,5-diiodo-L-thyronine (3,5-T2) also may impact mitochondrial function. Hormone-balancing regimens will be most effective when they also take into account mitochondrial health.
Test patients' thyroid function with a blood test measuring free T3, free T4, reverse T3 and TSH. Consider introducing CoQ10 into patients' supplement regimen to protect mitochondrial health. Read the third part of this article series appearing in the September 2014 newsletter to learn more about the best lifestyle measures and nutritional supplements for enhancing mitochondrial health. The first step is to determine hormone levels in your patients by ordering a salivary hormone test and a thyroid test that includes free T3, free T4, TSH and reverse T3. Indole-3-carbinol (I3C) and diindolylmethane (DIM) are two options for balancing estrogen metabolism. Supporting the health of the mitochondria while balancing hormone levels also is essential. A combination of iodine and iodide also can be used to support thyroid health, depending on the results of the thyroid test. The health of hormonal tissues and that of the mitochondria are interwoven in a complex tapestry that indicates hormonal health can't exist without mitochondrial health and vice versa.


With the onset of my gym’s new strength program, I am noticing a bit more muscle soreness than I am used to. When I feel sore more often, I get proactive because I know there is no need to be in pain all the time.
Before I delve further, I have the following words to say: I am in no way affiliated with Explore Asian, the company that makes theses pastas. The first thing I thought of making when I decided to up my protein a bit was a green + grain + bean bowl using this pasta as a grain. The mitochondria are hugely in influential in fueling hormone cells that make up the tissue of each organ. 17β-estradiol and testosterone trigger a complex molecular mechanism that involves crosstalk between the mitochondria, nucleus and plasma membrane of the cell. Mitochondria play an important role in the accumulation of oxidative damage to cells and tissues.
Progesterone and estrogen have neurotrophic and neuroprotective effects, supporting both reproductive function and cognitive health. The hormone-treated mitochondria also were marked by increased respiratory function and increased expression and activity of the electron transport chain complex IV. On the other hand, delayed response accuracy was inversely associated with the frequency of donut-shaped mitochondria in the dlPFC. Aged ovariectomized monkeys treated with a control experienced significantly impaired working memory and an increase in presynaptic donut-shaped mitochondria.
These results are consistent with the idea that thyroid hormones activate the uncoupling of oxidative phosphorylation through various mechanisms involving inner membrane proteins and lipids. Mitochondrial dysfunction may be involved in the development of vascular disease, while hormonal effects on the mitochondria protect the vascular system. The estrogen-related receptor-alpha (ERRa) regulates mitochondrial biogenesis during differentiation in skeletal myocytes. I will go into more detail about lifestyle and nutritional support to enhance mitochondrial health in the third part of this article series. If we don't support the health of patients' mitochondria at the same time as balancing hormone levels, we risk unraveling the fabric of cellular health. After four months of doing more reps with lighter weights, I am back to the heavy barbell work and it is amazing and challenging and although my muscles are clearly more defined these days I can definitely see that I have lost strength when my focus shifted away from Olympic Lifts.
Her Whey is a great-tasting, high-quality whey protein powder supplement that can be used any time of the day. Supplementing with HER WHEY immediately before workouts will give you the nutrients you need to make it through the most grueling workouts. We are your personal trainer, your nutritionist, your supplement expert, your lifting partner, your support group.
When talking with my patients, I make the comparison that the cells in the human body are like flashlights and the mitochondria act like flashlight batteries. However, other processes besides oxidative stress are involved in mitochondrial-related aging.


Scientists looked at the number and shape (straight, curved, or donut-shaped) of mitochondria in the dlPFC of rhesus monkeys then compared the mitochondria shape to delayed response accuracy, a measure of dlPFC-dependent working memory. Donut-shaped mitochondria had some flaws compared to straight or curved mitochondria, including smaller active zone areas and fewer docked synaptic vesicles. The first is a rapid stimulation of respiration, which occurs within minutes or hours after hormone treatment. See the article in this newsletter about hypothyroidism and cholesterol for more information about thyroid testing.
Eurycoma longifolia has been shown to restore serum testosterone levels and to have significant positive effects on bone health and physical condition of patients. However, one supplement that is foundational for optimized mitochondrial performance is coenzyme Q10 (CoQ10). My heaviest lifts are lighter than they once were, and the day after I go for it, my body definitely feels it. It has a balanced mix of fast and slow digesting proteins so you get a slow release of nutrients when you don't need them immediately absorbed, and a quick release of nutrients when you're body needs them fasta€”after workouts, for example.* I supplement with Her Whey three times per daya€”right when I wake up, immediately post workout and right before bed. Allergen Statement - Manufactured in a facility and equipment that handles: Eggs, Wheat, Soy, Milk, Tree Nuts, Peanuts, Soybeans, Shellfish and Fish. We provide the technology, tools, and products you need to burn fat, build muscle, and become your best self. The strength of these mitochondrial "batteries" determines how brightly the cells shine in their designed functions.
As noted earlier in this article, after menopause, when estrogen levels drop, cognitive health also diminishes. Right when I wake up my body utilizes most the quick digesting proteins after a long night of fasting.
Researchers created a model of this menopause-related cognitive decline by studying mice that underwent ovariectomies. Immediately after a workout my body also utilizes the quick digesting proteins and also the large dose of glutamine for recovery included in every serving. The activity of mitochondrial electron transport chain components as well as other markers of mitochondrial health significantly declined in the brain of ovariectomized mice.
Before bed my body utilizes the slow digesting protein to release protein for several hours after I've gone to sleep.
I haven't been able to find a protein that is sugar and gluten free, has the proteins I need, tastes amazing AND has glutamine!



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