Type 2 diabetes drugs market share worldwide,difference between insulin resistance and type 2 diabetes yahoo,free download diabetes miracle cure review,what are the major differences between type 1 and type 2 diabetes in related to insulin - New On 2016

Joining the open health data community is the health IT company Practice Fusion, which is sharing with the public aggregated data on some 81 million patients collected through over 100,000 active users every month recording patient data in the company’s cloud-based electronic health records system. I spent time on the phone and online this week with Chris Hogg, Associate Vice President – Data Science, who leads the Insight project at Practice Fusion. We also looked at Type 2 Diabetes with respect to prescription drug share (that is, which drugs were most prescribed to patients for managing T2 Diabetes). Beyond this story, the Insight platform can also look at prescription drug patterns in groups of patients.
I asked about how representative these data are, knowing that many millions of patient information is recorded in Practice Fusion’s system. Another very practical use for public health will be anticipating seasonal flu trends migrating from region to region in the U.S. Chris anticipates that Insight will continue to add functionality and different categories for analyzing aggregated patient data.
Jane will be addressing CxOs at the Illinois Health and Hospital Association 2016 Leadership Summit in Lombard, IL, discussing The New Health Economy - Consumers at the Center.
Jane's talk with the Minnesota Hospital Association will be "Health Is Everywhere: Consumers and the New Retail Health," meeting at Madden's on Gull Lake, Brainerd, MN. I've participated in the annual Health 2.0 Conference every year since its inception in 2007, and I'll do the same this year.
AboutFounded in 2007, the Health Populi website has over 2,000 posts, along with a library of Jane's writings and media mentions.
Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. FDA Advisory Panel votes 8-2 in favor of an insulin dosing label update for Dexcom's G5 CGM! Exubera never caught on, but several powerhouse companies are still betting on inhaled insulin.
The bottom line, in our view, is that Pfizer was trying to introduce a consumer product that wasn't friendly to the consumer at all. The inhaler was first-generation and imperfect - like many "first" generation medical devices. The actual benefits were outweighed by drawbacks and were not broadly characterized as "breakthrough." For patients with "needle-phobia," Exubera did provide some relief from needles in administering rapid-acting insulins. Pfizer was actually co-developing a second generation of inhaled insulin with Nektar called Next Generation Inhaled (NGI) insulin, but announced it would discontinue that effort as well. We cannot stress enough that insulin initiation is hard enough with the fear of hypoglycemia, weight gain and healthcare provider reimbursement. These drug manufacturers know that many diabetes patients say that, all things being equal, they would rather receive insulin by inhalation than injection. Our mission is to help individuals better understand their diabetes and to make our readers happier & healthier.
Our mission is to help individuals better understand their diabetes and to make our readers happier and healthier. There are numerous supplements available to help control your blood sugar levels naturally, and listed below are the 12 best. Cinnamon acts to significantly improve blood glucose control, and makes fat cells much more responsive to insulin. Green Tea is a powerful anti-oxidant, and contains a variety of enzymes and amino acids essential to increased metabolism and the lowering of cholesterol. This supplement will help lower your fasting sugar level, as well as lower your cholesterol levels. There is no direct correlation between Magnesium and diabetes, but Magnesium helps to lower blood pressure and reduces risk factors for stroke and heart failure.
Taurine is essential for cardiovascular function, as well as the function of skeletal muscle, the retina and the central nervous system. Vitamin C helps to stop the attachment of sugars and advanced carbohydrates to lipid proteins and other organic molecules.
The Afrezza “Patient Savings Card” indicates that “depending on your insurance coverage,” the first prescription of Afrezza will cost $0, followed by no more than $30 for each additional refill (each refill supplies two inhalers and a month’s supply of cartridges).
Before receiving a prescription for Afrezza, patients will be required to undergo a breathing test (“spirometry”) to verify their lung health (Afrezza is not approved for people with chronic lung disease, including asthma and COPD). In our call with Sanofi management, we discussed how Afrezza compares to Exubera – the first approved inhaled insulin in the US that was later taken off the market due to issues with its design, cost, dosing complications, and long-term safety concerns. There are no concrete plans to submit Afrezza for approval outside of the US yet, though Sanofi is currently assessing the possibility of entering Afrezza into a global market. Sanofi and MannKind's ultra rapid-acting inhaled-insulin Afrezza for type 1 and type 2 diabetes is now available in some US pharmacies! From speaking with pharmacists, it seems that Afrezza’s cash price costs are comparable to those of Novolog and Humalog insulin pens. Afrezza could be an especially good option for type 2 patients that are not achieving their goals on pills, as well as any patient that dislikes injections, those struggling to manage mealtime blood sugars, and those who experience lots of hyperglycemia after meals.
Kelly Close has been on the scene covering the Afrezza news, check out this video below of Sam Finta using Afrezza! As of February 2014, Abbott Laboratories is a Fortune 200 company that operates in more than 150 countries, with approximately 90,000 employees worldwide.
The company has a very strong worldwide presence as most of its employees work outside the US and the majority of its sales are outside the US too. In 2013, Abbott split into two separate companies: Abbott and AbbVie (a biopharmaceutical company). Abbott has four main businesses focuses, including: diagnostics, medical devices, nutritional products, and branded generic pharmaceuticals. Nutritional products – products formulated that promote healthy growth and development as well as managing the nutritional needs of patients with diseases such as cancer or diabetes. No part of this website or any of its contents may be reproduced, copied, or modified, without prior consent, unless otherwise indicated for stand-alone materials. FREE NEWSLETTER: Econintersect sends a nightly newsletter highlighting news events of the day, and providing a summary of new articles posted on the website. Just as some types of governmental spending are more "productive" than others, some portions of GDP spending contribute more to ongoing GDP growth than others.
We're making an economic argument here, not one addressing the fairness or efficacy of the U.S. From a demographic perspective the question takes on a much sharper focus: can future generations afford to support increasingly expensive Medicare entitlements to a growing portion of the population? If we are looking for ways to grow the economy by an excess 3% per annum without running further Federal deficits, and if the costs of the U.S. This specific variety of "Health Care Reform" is directed solely at reducing the cost of providing unaltered levels of coverage and care. It should be noted that many members of the commission also favored statutory caps on punitive and non-economic damages, although that topic seems to have been a little too "unthinkable" to receive a full commission recommendation.
A critical part of patent pool arrangements is automatic cross licensing, preventing the patent holder from maintaining a legal monopoly by withholding production rights from other manufacturers.


Extended patent protection within the confines of the pool, providing some additional income to the patent developer even after the original patent has lapsed.
It is generally estimated that the current process adds $500 million to $2 billion to the cost of developing a new drug.
Allowing patient access to unapproved drugs after informed (and recourse waiving) acknowledgement of the risks involved. Most currently proposed FDA reforms target the general coziness between the agency and the major pharmaceutical firms that the FDA is meant to regulate. The premise behind such separations would be to prevent conflicts of interest that might cause unnecessary diagnostic or institutional services, the crux of the "defensive medicine" cited in the Simpson-Bowles report.
Health care reform has recently proven to be politically divisive, largely because the reform agenda was not primarily cost reduction, but rather extended coverage.
Maybe it's now time to rekindle the whole health care reform debate, but this time tightly focused on cost-cutting opportunities -- reforms that will appeal to the vast majority of American voters, while having as as happy medical side effect the avoidance of a Simpson-Bowles induced depression. The growing use of ad blocking software is creating a shortfall in covering our fixed expenses.
Analyzing data sets across lots and lots of people can help researchers identify medical cures, anticipate epidemics, and solve knotty problems where social and behavioral issues complicate clinical questions and solutions. Insight, the searchable database, is freely available to people, researchers, policymakers, and anyone who wants to look at top line aggregated data organized in several categories: disease states and conditions, prescribed drugs, BMI, and age cohorts, in this first phase of the launch.
We looked at trending diagnoses and the top conditions clinicians saw in the past week, literally. Data gets updated on a weekly basis, with the top findings this week in terms of patients seen presenting with hypertension, high cholesterol, diabetes, depression, arthritis, GI issues, obesity, among others in the top 100. The second chart illustrates the raw truth that as BMI increases, so too does incidence of diabetes, and especially over the age of 35. Chris’s team looked at the pattern of prescribed anti-diabetic drugs in patients with Type 2 Diabetes. Looking forward to learning about the latest digital health innovations, and moderating a panel or two. We don't think Pfizer should have advertised Exubera as "simple and trouble-free as an asthma inhaler" because the reality was far different. Exubera caused a tiny decrease in the amount of that could be blown out in one second (FEV1), and also decreased some patient’s ability to pass oxygen from the lungs to the blood (DLCO). Whereas injected insulin is traditionally prescribed in international units - no complicated conversion required - Exubera was prescribed in milligrams. Nevertheless, certain patients still needed to inject basal insulin in addition to taking Exubera. Although Pfizer developed Exubera with another company, Nektar Therapeutics, we didn't have the impression that Pfizer took full advantage of this collaboration - Nektar likely could have advised Pfizer better than anyone. The inhaled insulin market is now completely open, and some manufacturers - MannKind, Novo Nordisk, and Eli Lilly (partnering with Alkermes) - continue to pursue their own inhaled insulins. So far, over 3,000 patients have been treated with TI, and MannKind plans to launch this by late 2009 or 2010. MannKind has previously announced that TI insulin will be dosed in units (not in milligrams) - this should be easier! Taking an Omega-3 Fatty Acid supplement will help with absorption of glucose, and slow down the process, keeping us from getting hungry too fast. Regular use of aged garlic extracts lower blood homocysteine levels and may help to prevent some complications of diabetes mellitus.[49][50] Insulin dependent diabetics should not consume medicinal amounts of garlic without consulting a physician first. They are also rich in calcium, phosphorus, and manganese, all good for their dietary health benefits.
In the structure of a cell, taurine keeps potassium and magnesium inside the cell, while keeping excessive sodium out, making it work like a diuretic. But Biotin is the one B vitamin that most effectively metabolizes carbohydrates and sugars in the blood. This enzymatic process can create diabetic complications in various organs in the human body. The most commonly used herbs for Blood Sugar control should include Gymnema Sylvetstre, Chromium Picolinate, Turmeric with Bioperine, and a few others. We are curious what insurance plans will qualify for this savings plan, but as of now details about Afrezza’s insurance coverage are not available.
Afrezza is also not recommended in patients who smoke or who have recently stopped smoking. Though Sanofi has not officially announced its availability, Afrezza can now be picked up at retail outlets like CVS and Walgreens – for now, a special pharmacy order may be required, meaning you can pick it ~1-2 days after you turn in the prescription.
While it’s still unclear exactly how much patients with insurance will need to pay for Afrezza, we expect most patients with insurance to have co-pays of around $30. Kelly also got the chance to interview Sam in a panel this week for those working with managed care officials and pharmacy leaders. The inhaled insulin only comes in two sizes right now: equivalent to 4- or 8-units of injected rapid-acting insulin – it will be interesting to see how it is used in type 1. Or perhaps more analytically: at what percentage of GDP do health care expenses pass a "tipping point" of sustainability?
At first glance the highly risk-averse FDA might appear to be acting in the public's best interest.
And that scale of cost also removes incentives to create pharmaceuticals with limited market potential -- while excluding innovative smaller drug firms entirely from the process. And if increased coverage was the overall objective, making end-user costs more affordable would seem to have been a reasonable first step to accomplishing that.
The Consumer Metrics Institute (CMI) provides timely and quality information about the consumer economy in the United States. Please consider a donation to Econintersect to allow continuing output of quality and balanced financial and economic news and analysis. The market for anti-diabetic prescription drugs is very competitive; the most popular one is Januvia from Merck. For those people who want to get more micro, Insight is available for querying specific questions that can be tactically very useful. These visit reasons are recorded in the EHR, and as viruses emerge in one region, Insight can predict their emergence in another and prepare physicians and patients in advance in near real-time. At this point, all we know is that Exubera's was one of the costliest flops in the history of the pharmaceutical industry. Although Exubera’s short-term safety was well documented (we had seen some eight-year data at EASD in Amsterdam last fall), and in most cases the breathing changes could be reversed when it was discontinued, long-term safety concerns about Exubera lingered. A single milligram of Exubera was equivalent to about three units of insulin, but this relationship was not linear.
Almost every state's Medicare program as well as many private insurers placed Exubera in their most expensive tier. There really wasn't precedence for people to go on mealtime insulin before long-acting analogs - perhaps more studies should have been done on this front. In fact, Nektar, which received royalties from Exubera sales, was not even warned by Pfizer that the drug was going to be pulled from the market!
Since Exubera's demise, MannKind has made notable attempts to differentiate TI, arguing that it will offer clinical advantages over vial insulin.


Now, it's somebody else's turn to give us an inhaled insulin product that a good number of patients will want to use and that insurers will pay for at a reasonable rate. The diaTribe team got an exclusive call with Sanofi executives (Andrew Purcell, Vice President and Head of Sanofi’s US Diabetes Business Unit and Stefan Schwarz, Sanofi’s Head of US Marketing for Afrezza) to discuss the details of the launch and plans moving forward. We have heard anecdotally that Humana insurance will likely make a decision about covering Afrezza within 3-6 months.
Spirometry is a simple and common examination used to measure how much air the lungs can inhale and exhale, as well as how fast they can exhale.
If interested, please call your doctor to find out the steps necessary to get access to Afrezza. There will be a discount for those paying out-of-pocket, but it will still be expensive (similar to other insulins).
The word so far is certainly very positive (from the other patients she interviewed too!) and we expect the product’s ease of use will appeal to doctors and nurses as well – “ease of use” means it’s more likely that patients will take insulin when they should! Some may choose to use it for particularly high carb meals or to correct a very high blood sugar; others may want to move to it for more of their insulin needs, especially if they do not experience hypoglycemia, which anecdotally we hear is pretty rare with Afrezza (though this is not on the label). And one might also conclude that rapid expansion of health care expenses did not commensurately expand the rest of the economy. Investments in health care infrastructure clearly create new jobs and new economic "product." Our question is whether the macro economic consequences of that investment on the net overall growth rate of the economy are positive, neutral or negative. The premise behind this is that shifting monies from health care expenses to the rest of the economy would not be a zero-sum-game, and instead would provide businesses (and consumers) with increased margins that should ultimately result in at least some excess aggregate economic growth. Extending the tort reforms listed above to drug manufacturers would help, but even more would be needed to dramatically reduce the costs of this portion of the health care dilemma.
But Milton Friedman pointed out that the regulatory process is inherently biased politically against the approval of drugs, since mistaken approvals of harmful drugs are highly publicized while the consequences of wrongfully banning a truly useful drug will remain forever unknown -- meaning that a politically conscious FDA will take the action that will result in the least public condemnation, regardless of the health consequences.
Time has proven that Senator Glass and Representative Steagall were correct, since the full demise of their act in 1999 (at the hands of the Gramm-Leach-Bliley Act) was credited by the "Financial Crisis Inquiry Commission" (FCIC, aka the "Angelides Commission") as the single most critical cause of the 2007-2009 Financial Crisis.(Click on chart for fuller resolution)If conflicts of interest can become real in finances, we should expect nothing less in health care. Sadly, one consequence of the enacted health care reform package is that an opportunity to potentially stimulate the economy was lost -- and very probably the exact reverse was accomplished: an increased parasitic drag was lashed onto an already weakening economy. Underneath that macro number, the age cohorts tell an important story — that depression prevalence increases to the highest levels between ages 40 and 59, and also grows in direct proportion to BMI.
With the introduction of Invokana in March 2013, Januvia took a market share hit, as the third graph illustrates.
For example, a pharmaceutical marketer can learn, in near-real-time, how the launch of a new drug is faring with respect to new prescriptions written for patients substituting existing competitive drugs for dealing with, say, Type 2 Diabetes as discussed or high cholesterol or any of the 100 or more conditions captured in the platform. Exubera had been in development for over 10 years, and its manufacturer (Pfizer) believed that it would be a very successful drug that would revolutionize the treatment of diabetes.
The inhaler resembled a bulky stapler, making it troublesome to carry around - perhaps if Pfizer had acknowledged this and discussed how it was working to make improvements, that would have helped (the next version would definitely have been better!). Moreover, patients were required to undergo lung-function testing both before using Exubera and after six months of use – this was also seen as “high hassle factor”.
For example, three milligrams of Exubera were equal to eight units of insulin rather than nine.
Exubera cost about $5 per day, compared to about $2-3 for insulin taken using a syringe and vial or a pen.
Additionally, the needles for insulin have shrunk so significantly over the last decade that the burden of injections has decreased - as has the perception of the burden of diabetes! Optimal communication between two parties is always difficult, but here it seemed particularly absent. Whereas Exubera peaked about an hour after administration and was therefore no more rapid than other available rapid-acting insulins, MannKind claims that TI will be absorbed in the blood stream almost instantaneously and will peak in only 12-14 minutes - much faster than other available rapid-acting insulins.
From our understanding, primary care physicians (PCPs) may be more familiar with spirometry testing than endocrinologists (as PCPs use it for patients with asthma and other breathing problems). We also hear that Afrezza works pretty quickly – this also is not on the label and is again more anecdotal.
We could take that argument a step further and assert that increasing health care expenses -- however necessary or defining as a measurement of a nation's "quality of life" -- are at best only marginally productive for (and at worst parasitic on) the overall growth of the economy. If the added investments in health care are prolonging or improving the productive careers of U.S. It is a political issue with strong appeal to the electorate, even as it would face strong opposition from the health care industry's entrenched players. One "unthinkable" option would be to modify the entire framework of patent law in the health care industry, similar to what was done in 1917 by a young Franklin Roosevelt. The data also showed a relationship between physicians prescribing Invokana more among patients who were younger with higher BMI. These are the diseases that are most amenable to consumers’ self-care and -intervention. However, in spite of high expectations and heavy promotion, Exubera failed to gain market traction - its sales amounted to less than one third of one percent of the insulin market. Sad to say, lung function testing presented an inconvenience to patients as well as to overworked physicians who sometimes didn’t even know where to advise patients to go for the tests, though the tests themselves only took 15 minutes or less.
Similarly, the National Health Service in the UK recommended against the use of Exubera because it had not been proven to be more effective than existing treatments. This, the company says, will help to normalize post-prandial glucose levels and will lower the risk of hypoglycemia.
Although lung-function testing will most likely still be mandated for TI users, the lung "sparing" of TI may help to convince patients and physicians of its long-term safety. For more on Afrezza, please see our coverage of its FDA approval and partnership with Sanofi; we’ll have a Test Drive on it soon!
At that time, as Assistant Secretary of the Navy, he pressured the struggling aviation industry to pool their patents into the Manufacturer's Aircraft Association, with cross licensing for the use of those patents in the production of new aircraft designs critical to the war effort. One look at the simple chart on BMI increasing risk for Type 2 Diabetes could help a segment of people who are pre-diabetic start walking a little more and shopping for healthier food. Pfizer pulled Exubera from the market in October, less than two years after the drug was first approved, citing poor sales and little faith in the products' future. Furthermore, physicians felt encumbered in prescribing Exubera due to its complex dosing and lung function tests. In other times of national emergency (notably during World War II) the government has imposed similar patent pool arrangements to restrict intellectual property rights for the greater good -- essentially an "eminent domain" argument applied to intellectual property. National statistics show that over 60 percent of type 2 patients are not at A1c goal but only 29 percent of type 2 patients are on insulin. Ironically, insulin carries a stigma that deters many type 2 patients from its use, and many physicians are also not eager to introduce the therapy either because they are poorly reimbursed for their time and training or because they are pooly trained themselves and don't understand it well enough to help patients.



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