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ANN ARBOR—A tool that helps determine if someone with diabetes could manage it better with drugs or diet and exercise.
A 3-dimensional printer that created a personalized implantable tracheal splint for a baby who stopped breathing every day.
Massive genetics studies to better understand diseases like diabetes, obesity and macular degeneration that involve the coordination of hundreds of scientists and thousands of participants across the globe. These are among the life-saving and life-changing contributions by University of Michigan scientists that highlight U-M's leadership in a growing field known as precision medicine. Using data about lifestyle, medical history, environment and genetics, precision medicine essentially works to prevent and treat disease one person at a time.
A national Precision Medicine Initiative announced in January 2015 by President Barack Obama and funded last week by the National Institutes of Health, dedicates $55 million to create four program areas: a Data and Research Support Center, Participant Technologies Centers, a Healthcare Provider Organizations network, and a Biobank. The U-M School of Public Health was named one of four sub-awardees that will work with the Data and Research Support Center at Vanderbilt University to mine and organize data, and create the tools to analyze it, while protecting those who share it. The nationwide goal is to obtain the DNA and relevant health information from 1 million people.
Currently, a few major academic medical centers, including U-M, gather this information from patients who consent to share it for research.
The NIH announcement comes as U-M is developing its own strategy around how to advance precision medicine work across its campuses.

Among Kheterpal's contributions to the group was sharing what U-M has been doing for 3-4 years in precision medicine.
Michigan's current areas of expertise include precision oncology, drug development and targeted therapies, obesity research, health outcomes research and analysis, social research and new approaches to big data. Abecasis, his lab and other faculty in SPH and across U-M, have been involved with hundreds of genetic studies—either directly or as researchers have used the software and other tools for genetic analysis that were developed here. Abecasis was a leader of the well-known 1000 Genomes Project, an international effort to catalogue human genetic variation. Announcing the awards last week, NIH Director Collins said: "Over time, data provided by participants will help us answer important health questions, such as why some people with elevated genetic and environmental risk factors for disease still manage to maintain good health, and how people suffering from a chronic illness can maintain the highest possible quality of life. A 67-year-old woman presented with new bilateral leg swelling and was diagnosed with bilateral deep vein thromboses. To read this article in its entirety and to view additional images please visit our website. This article originally appeared in the June 2014 issue of The American Journal of Medicine. Despite Advances, DVT Rates Remain HighDespite advances in identification, prophylaxis, and treatment between 1985 and 2009, the annual event rate of venous thromboembolism has increased and remains high.
Michigan has a bank of information from about 35,000 people collected through its Michigan Genomics Initiative, which asks patients in the U-M Health System to provide data on their health.

President Mark Schlissel has asked several U-M scientists to take a look at how the various schools and colleges currently doing this work might collaborate and expand precision medicine at U-M.
Sachin Kheterpal, associate professor of anesthesiology whose research focuses on medical informatics, was appointed by NIH Director Dr. He has made contributions to better understanding conditions such as heart disease, diabetes, psoriasis and macular degeneration.
Two years ago he also established Genes for Good, a public data bank of genetic and health information, which to date has enrolled 13,000 individuals across the country. Ten days later, the patient experienced increased right foot swelling, pain, and cyanosis (Figure). On admission, a right leg arterial ultrasound was normal, but a compression venous duplex ultrasound revealed extensive venous thrombosis of the entire leg. Hypercalcemia, vertebral fracture, and chest computed tomography showing probable metastatic disease were consistent with active cancer.
Rivaroxaban was discontinued and intravenous unfractionated heparin was initiated with target-activated partial thromboplastin time of 55-90 seconds (reference range 28-38 seconds).

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