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Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is used to treat many patients with acute ischemic stroke, but typically not those aged over 80 years or reporting for care more than 3 hours after symptom onset; mainly because these populations were never studied in clinical trials. This entry was posted in Geriatrics, Neurology, Neurology Featured 2, Non-Communicable Disease, Pharmacology, Primary Care and tagged acute stroke, geriatrics, ischemic stroke, NCDs, neurology, pharmacology, primary care, rt-PA, stroke, thrombolysis. Drugs prescribed to treat diabetes could cure Alzheimer’s disease, a pioneering new study has found.
Scientists believe that the two conditions are so similar that medications already used to control levels of glucose and regulate diabetes could also halt the onset of dementia.
A new study using a computer model of Alzheimer’s disease has found that complications within the brain can lead to changes in glucose, which ultimately leads to diabetes. The current medical consensus is that diabetes begins with a malfunction in the pancreas, or through sufferers consuming a high fat, high sugar diet. However, the new research suggests that Alzheimer’s can lead to diabetes, whereas previous studies suggest that the latter is the first to occur. The research, published in the journal Diabetologia, was aimed at finding out why the two diseases are so commonly found together in elderly patients. It also found increased levels of a gene involved in the production of toxic proteins in the brain not only led to Alzheimer’s-like symptoms, but also to the development of diabetic complications.
Cutting the amount of sugar in sweetened drinks by 40% could prevent 300,000 cases of diabetes and one million cases of obesity, research suggests. Tests in mice genetically engineered to develop a rodent form of Alzheimer’s found their brain function improved dramatically when administered with the drug.
Liraglutide is a relatively new, injectable drug with users taking a 1.2 mg dose once a day to treat Type 2 diabetes. Originally developed to stimulate insulin production, scientists believe it could play a key role in activating brain signalling mechanisms which are destroyed when Alzheimer’s takes grip. If they are successful it would become the first new dementia treatment in a decade and could be available for use within five years. New estimates show more than two million people in the UK will be struck down with dementia by 2050.
It commonly occurs in those over 65 and its hallmarks include the rapid deterioration of behaviour, language skills and personality. A Phase III study evaluating Tolerx and GlaxoSmithKline’s (GSK) otelixizumab in the treatment of type 1 diabetes has failed to meet its primary endpoint, prompting the firms to suspend a second, confirmatory Phase III study.
Tolerx licensed otelixizumab from BTG and subsequently teamed up with GSK for worldwide development of the autoimmune diseases candidate back in 2007. Otelixizumab is currently in various stages of clinical development as a potential treatment for a range of autoimmune diseases, including Graves eye disease, rheumatoid arthritis, and myasthenia gravis.
Under the terms of the agreement between GSK and Tolerx, the latter has been responsible for conducting the Phase III clinical program and regulatory submission for the type 1 diabetes indication in the U.S.
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Researchers with the Janssen Pharmaceutical Companies of Johnson & Johnson recently announced a plan to prevent type 1 diabetes by intercepting the disease in its earliest stages and stopping its development before the onset of symptoms. The group focused on diabetes, and potentially other diseases before they fully develop, through a venture called the Disease Interception Accelerator, or DIA. Hedrick further added that the team recognizes that insulin is a life-saving treatment and that advances in glucose control can and will dramatically improve the lives of those affected by type 1 diabetes, but ultimately DIA wants to intercept disease and see people maintain an insulin-independent state.
While ambitious, the approach as it applies to type 1 diabetes has garnered early support from JDRF.
One key to intercepting type 1 diabetes is to understand what triggers it in the first place, according to Hedrick. Hedrick said the first priority for the DIA team is to “identify and prioritize critical pathways that drive the onset and progression to” type 1 diabetes. Rebalancing the immune system includes targeting cells that present as an autoantigen to the immune system, targeting so-called accessory cells of the immune system that might play a role in the early initiation of diabetes, and introducing an antigen-specific tolerance to the immune system, such as a tolerogenic vaccine that might help intercept the progression of the disease.
Maintaining the functionality of beta cells (the cells that secrete stored insulin) is critical to the success of forestalling the development of type 1 diabetes, Hedrick said. The last factor the DIA team will focus on is identifying and intercepting possible environmental factors that may lead to type 1 diabetes, such as viruses and other causative agents. Wiegand added that the effort was in its very early stages, having been launched only one month ago, and many questions still needed to be addressed. Additionally, there are questions about how a screening process to test for diseases before they develop might operate. The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. The Diabetes Forum - find support, ask questions and share your experiences with 209,001 people. It automatically adjusts pressure levels to fit your changing needs to ensure you’re receiving the lowest pressure necessary.
Consistent humidification throughout the night with the integrated HumidAira„? humidifier can provide a more comfortable experience.
Built-in wireless connectivity enables you to opt-in to connect your device to ResMed’s new securely hosted cloud-based system, AirViewa„?.
A built-in ambient light sensor adjusts the brightness of the screen based on the light in the room. Easy-Breathea„? motor is whisper-quiet, offering you and your bed partner a more peaceful night's sleep.
Enter the competition below before midnight on Sunday 15th February and we’ll select one winner at random. By taking part in this promotion all participants will be deemed to have accepted and be bound by these terms and conditions.
To enter the prize draw entrants must enter the competition prize draw above from a valid email address with valid contact details.


Please note that this product is a medical device and we require written confirmation that you have had a formal Sleep Study within the UK before we can send you a device.
By entering the competition you are agreeing to be contacted by ResMed with information about the 10% discount.
Find support, ask questions and share your experiences with 209,001 members of the diabetes community. 10 week (free) low-carb education program developed with the help of 20,000 people with T2D and based on the latest research.
The first comprehensive, free and open to all online step-by-step guide to improving hypo awareness. Now, a new trial published online and ahead-of-print in The Lancet provides data supporting rt-TPA use in a wider range of patients up to 6 hours after stroke onset. The Defend-1 study showed that treatment using the humanized anti-CD3 monoclonal antibody did not change C-peptide levels at one year when used to treat patients with new-onset autoimmune type 1 diabetes. According to BTG, GSK will continue to look into additional dosing regimens for otelixizumab to help in the decision-making process for other clinical development programs.
Launched in February, the new research platform seeks to reimagine how healthcare should work. While no specific model for screening has been developed, Hedrick suggested that such screenings might simply become part of a regular pediatric visit. For this new model of healthcare to have a chance at succeeding, Janssen will need to work closely with many different research scientific, social, governmental, and corporate groups.
Once asleep, your device comfortably ramps up the pressure to ensure the prescribed level is delivered the moment you need it.
Then your care provider can seamlessly and securely review your therapy data, adjust your device settings, check that your device is working properly and troubleshoot any issues to ensure you get the right treatment without delay. So if you need to get up during the night, the screen’s back light won't disrupt your bed partner. The AirSense 10 AutoSet for Her device is part of the first complete sleep therapy solution tailored for women a€” combining cutting edge device technology with masks designed for women, giving you all you need for a great night's sleep.
We will then draw one name randomly from a hat and announce the winner during week commencing 16th February 2015. New patient recruitment and dosing in the confirmatory Defend-2 study has been suspended pending review of the Defend-1 data.



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