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In a report commissioned by the World Health Organisation and the Food and Agricultural Organisation, a team of global experts identified the excessive consumption of sugar from snacks, processed foods and drinks as one of the major factors causing worldwide increases in cardiovascular diseases, along with cancer, diabetes, and obesity.
A recent study published in The Journal of the American Medical Association (JAMA) – Internal Medicine found that the more added sugar you consume the higher your risk is of dying from heart disease. The fact that this appears to be completely independent of other factors – such as weight, calories consumed, smoking, blood pressure, cholesterol level, and physical activity – indicates that there’s something specific about the relationship between sugar and the heart.
Unlike trans fats and salt, there is no upper limit to how much sugar food companies can add to their products; it is on a “generally recognised as safe” list.
We can conclude that excess sugar is not only bad for our weight, our teeth and insulin level, but also has a direct effect on our heart.
During the month of February FirstMed offers a special price on a cardiovascular risk assessment designed to give a basic result of your heart health and uncover possible risks which may require additional monitoring. The pancreas has many islets that contain insulin-producing beta cells and glucagon-producing alpha cells. Since diabetes is a disease that affects your body's ability to use glucose, let's start by looking at what glucose is and how your body controls it. When you eat food, glucose gets absorbed from your intestines and distributed by the bloodstream to all of the cells in your body. To maintain a constant blood-glucose level, your body relies on two hormones produced in the pancreas that have opposite actions: insulin and glucagon.
Insulin is made and secreted by the beta cells of the pancreatic islets, small islands of endocrine cells in the pancreas.
As such, insulin stores nutrients right after a meal by reducing the concentrations of glucose, fatty acids and amino acids in the bloodstream. Type 2 diabetes: What is it?Diabetes is a chronic condition that affects the body's ability to convert sugar into energy. To provide even greater transparency and choice, we are working on a number of other cookie-related enhancements.
The ice cream truck flashes its lights and plays Yankee Doodle as it pulls up next to the playground. The sugar found in candies and ice cream is called Glucose: A simple sugar used by cells in the body (Lundstrom and Rossini, 2004). The β-cells make up about 70 - 80% of Islet cells and are responsible for the production of insulin. Insulin is the most famous of the pancreatic hormones that control blood glucose levels, but it does not work alone. He began to test his hypothesis using non-obese diabetic mice (NOD mice), which are the most commonly used Animal Model: An animal that exhibits a disease or condition similar to that of humans.
The next step for the Unger lab was to determine why leptin had such a profound effect on both the mice and rats. To determine if something else (specifically, an insulin-like hormone) might be mimicking insulin, Dr. Given the astounding results of reversing hyperglycemia in rats and mice, it is possible that one day leptin may be an alternative to insulin injections. Please follow Healthy & Natural World on Facebook to be updated every time we publish a new article on how to improve your health and on a how to make natural products using natural ingredients.
In 2013, over 382 million people around the world had diabetes, and 90% of them had type 2 diabetes. Further reading: You can also read my previous article about 6 reasons you are tired all the time, in which health issues are one of them.
Further reading: find here more health warnings your eyes may be sending and how to protect your eyes. Further reading: Read my article about the top 15 causes of headaches and how to get rid of them naturally. Further reading: read my precious articles about top signs that you have candida infection and what to do about it, and how to treat vaginal yeast infection naturally.
If you are experiencing some of these symptoms, see your doctor so you can have a blood test and establish if you are indeed suffering from type 2 diabetes.
Remember that type 2 diabetes is, to some degree, a preventable disease, and that the complications can be avoided with the right approach to life and health. Being overweight – People with belly fat (visceral obesity) are especially at risk (find how to lose stubborn belly fat for good without counting calories in my ultimate e-book guide Blast Your Belly Fat).
Eating an unhealthy diet rich in red meat, unhealthy fats, sugars and processed food – One can of sugary soda a day increases your risk of diabetes by 22% (read my article about what happens to your body when you drink soda). Generally speaking, you will do a lot if you try to eat healthy, exercise moderately, keep your stress levels under control and avoid bad habits. REALLY good list of symptoms that is all compiled in one place…even ones I had, but was never associated with the developing problem by doctors. This website is designed for educational and informational purposes only, and the content herein should not be mistaken for professional health advice. There is a strong link between sugar intake and a higher risk of obesity, type 2 diabetes, dementia and high blood pressure. For people whose added sugar intake made up over 21% of their daily calories, their risk of death doubled. Therefore it is the individual’s responsibility to keep an eye on added sugar content of each (processed) food, which is not easy to track. Since sugars often are hidden in processed foods, it is more difficult to keep its level to a minimum than just cutting it from our daily morning coffee. Your body tries to keep a constant supply of glucose for your cells by maintaining a constant glucose concentration in your blood -- otherwise, your cells would have more than enough glucose right after a meal and starve in between meals and overnight. This allows sugar levels to build up in the blood, which can lead to heart disease, blindness and other serious complications. It is intended for general information purposes only and does not address individual circumstances. This may be due to the lack of insulin Receptor: A protein embedded in the plasma membrane that binds to a molecule to initiate a specific cellular response.
Roger Unger saw hundreds of patients with type-1 diabetes in the VA North Texas Health Care System and at the University of Texas Southwestern Medical Center. Unger came across was the hormone Leptin: A hormone produced by fat cells that plays a role in weight regulation. Unger and his team repeated these experiments in rats in which type-1 diabetes had been chemically induced.
Insulin acts by binding to something called The insulin receptor The insulin receptor mechanism is not trivial to understand. Unger measured the Protein: Molecules made up of strings of amino acids, proteins are critical in almost all body functions. Roger Unger is a Professor of Internal Medicine at the University of Texas Southwestern Medical Center and the VA North Texas Health Care System, as well as a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
Unger emphasizes that none of his research would have been possible without his dedicated team of researchers at both the Dallas VA Medical Center and UT Southwestern Medical Center. Beta-cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy. Roger Unger has shown in rodents that leptin, a hormone produced by the body's fat cells, lowers blood glucose levels.
Frequent urination (polyuria): If you notice that you have to urinate more often, and you wake up during the night (sometimes several times) to empty your bladder, this could be a warning sign. Increased hunger (polyphagia): Due to extreme highs and lows in blood sugar levels, the body develops a sudden urge to eat. Dry mouth: You experience a lack of moisture in the mouth, which can be both unpleasant and dangerous. Unexplained weight loss or weight gain: As insulin can’t get glucose into the cells, the body reacts as if it would be starving and starts using proteins from the muscles.


Fatigue: Excessive tiredness can develop when body constantly compensates for the lack of glucose in the cells. Headaches – A headache can develop due to elevated blood sugar levels and is considered an early sign of hyperglycemia (high blood glucose).
Infections, cuts and bruises that do not heal: This classic sign of diabetes is a consequence of blood vessel damage. Yeast infections: Since bacteria and fungi thrive in a sugary environment, infections can become more common. Skin changes: Velvety dark skin, known as achantosis nigricans, can appear on the neck, groin and armpit. Sexual dysfunction: Diabetes also damages blood vessels and nerves in the sex organs, which can lead to different sexual problems.
As we get older, the risk of diabetes increases, so it’s even more important to promote a healthy lifestyle and stay active. If you have a medical problem you should seek advice from a doctor and other health care professional. Recently medical professionals have been raising even stronger warnings about the relationship between high blood sugar levels and increased heart disease as repeatedly documented by numerous studies.
The cells take in glucose from the blood and break it down for energy (some cells, like brain cells and red blood cells, rely solely on glucose for fuel).
So, when you have an oversupply of glucose, your body stores the excess in the liver and muscles by making glycogen, long chains of glucose. Insulin is required by almost all of the body's cells, but its major targets are liver cells, fat cells and muscle cells. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. The Romans called it diabetes mellitus form the Latin words diabetes meaning to pass through and mellitus meaning honey or sweet.
The β-cells are destroyed by the immune system and cannot produce insulin, resulting in the condition of high blood sugar and diabetes. For unconscious patients who had overdosed with insulin, he would sometimes prescribe glucagon to restore consciousness by correcting the low glucose level. The treated rats were given leptin by adenovirus gene transfer and the control group was not. The discovery may lead to a treatment option other than insulin for humans with type-1 diabetes. Production of insulin – a pancreatic hormone that usually deals with balancing blood sugar levels – is either reduced or the cells don’t respond to it properly. As you lose more fluids, the body will try to replenish them, hence the constant need to drink. Dry mouth can become a breeding ground for bacteria and cause different oral and dental problems. Rapid, unexplained weight loss (10 to 20 pounds over a couple of months) is not healthy and requires further investigation. Excessive amounts of sugar harm the veins and arteries, so they become less able to transport blood to where it is needed to repair and heal the damage. The most frequent ones are yeast infections, such as candida, especially vaginal candida infections in women.
You can also observe other unusual skin changes and itchiness, especially around the vaginal or groin area.
It is quite clear: increased sugar intake leads to a greater risk of dying of cardiovascular disease. In general, the closer sugars are to the top of the list of ingredients, the more the food contains. Diabetes UK estimates that over 600,000 people with type 2 diabetes don't know they have it. Never ignore professional medical advice in seeking treatment because of something you have read on the BootsWebMD Site.
Diabetes mellitus is a group of diseases all characterized by hyperglycemia, or high blood sugar levels.
Type-2 diabetes has been associated with Obesity: The state of having too much fat on the body. NOD mice have dangerously high blood sugar levels because their beta cells have been destroyed.
The rats that received leptin injections improved to a normal state and remained that way for several months. Unger wondered whether leptin altered blood glucose levels by changing the amount of glucagon in the blood. While he is excited about his new findings, he is reluctant to speak of any new treatments. As diabetes is a serious condition that can cause dangerous complications – including cardiovascular and neurological damage – it is important to detect it as soon as possible. If sugar levels are not brought down, the nerve damage can become permanent and presents a serious complication of diabetes. The entire content of this website is copyrighted and should not be copied without permission.
Because parents know that when their children eat too much sugar they get hyped up and bounce off the walls for a while: then they crash. The two most common forms of diabetes mellitus are type-1 and type-2, but there are other forms of the disease as well.
Unger saw how cumbersome and painful the treatment is for this disease, and he began looking for alternatives to the classic treatment of insulin injections. He and his colleagues injected some NOD mice with a leptin-adenovirus while others served as the Control Group: The group in an experiment that does not receive treatment.
To test this hypothesis, the researchers measured the amount of glucagon in each blood sample. Without insulin present to bind to its receptor and allow glucose into cells, it was unclear how leptin could lower blood glucose levels. Unger began his career as a practicing physician working with diabetes patients before he began research in the field. With the right diet, exercise regimen and, if necessary, medications, diabetes can be kept under control, and the person can continue to live a fulfilling life.
Diabetes may not have symptomsIn most cases type 2 diabetes doesn't cause any symptoms, or the symptoms are mild, which is why many people have it for years without knowing it, and why it's important to get tested.
While rodent and human biology are similar in many ways, they are also very different.” Similar tests would have to be done in larger mammals and if leptin succeeded in normalizing blood glucose levels in those animals, it would move through rounds of clinical trials.
His work over the years has included research on insulin and glucagon mechanisms of function and most recently his research has focused on the role of leptin in the body. Find out about some of the early warning signs of diabetes, so you can act on it and protect your health. If you have been diagnosed as prediabetic, read my article about the 7 effective steps to prevent diabetes.
Warning sign: ThirstOne of the first symptoms of type 2 diabetes may be an increase in thirst.
If left untreated, people without insulin would not survive, because high levels of blood glucose cause many harmful effects.
He concluded that leptin brought blood glucose levels back to normal by inhibiting glucagon.
However, if sugar levels stay high for a long period of time, this can cause permanent damage and can even lead to eyesight loss. This is often accompanied by additional problems, including dry mouth, increased appetite, frequent urination – sometimes as often as every hour -- and unusual weight loss or gain.


But recently, more and more children are being diagnosed with type-2 diabetes, possibly due to an increase in the rate of childhood obesity. Unger’s findings have turned diabetes research upside down and opened the field to a whole new range of possibilities. Warning sign: Blurred visionAs blood sugar levels become more abnormal, additional symptoms may include headaches, blurred vision and fatigue. Warning sign: InfectionsIn most cases, type 2 diabetes is not discovered until it takes a noticeable toll on health. He found that leptin is produced by fat cells and plays a key role in body weight regulation. Unger is conducting more experiments to determine the leptin pathway and figure out exactly how leptin works to exert its insulin-like effects.
To measure blood glucose levels, people with diabetes prick their finger to get a drop of blood, which is then put in a machine that measures the blood glucose level.
Diabetes can cause damage to blood vessels and nerve endings in the genitals, leading to a loss of feeling and making orgasm difficult.
If their blood glucose levels are too high, they give themselves an insulin injection to stimulate the uptake of glucose from the blood. Risk factors you can controlYour habits and lifestyle can affect your odds of developing type 2 diabetes.
Risk factors for womenHaving gestational diabetes when you're pregnant puts you seven times at greater risk of developing type 2 diabetes later on. For example, insulin is needed after eating so the body can use the sugar that has just been consumed, but not before or during exercise. Having a history of polycystic ovary syndrome (PCOS) can also cause insulin resistance that can lead to diabetes. Type 2 diabetes in childrenAlthough older people have a higher risk of getting type 2 diabetes, the condition is affecting more young people. Diabetes UK says around 35,000 children and young people in the UK have diabetes, with around 700 of these having type 2 diabetes. The leading risk factor for children is being overweight, often connected with an unhealthy diet and lack of physical activity. Once children are overweight, their chances of developing type 2 diabetes more than doubles. Often a urine test is carried out first, and if it contains glucose, or a person is at risk of diabetes, one or more blood tests to check levels of glucose in the blood are performed.
How does insulin work?In healthy people, after a meal, food is broken down into a sugar called glucose, which is carried by the blood to cells throughout the body.
Cells use the hormone insulin, made in the pancreas, to help them process blood glucose into energy. People develop type 2 diabetes because the cells in the muscles, liver and fat cannot use insulin properly, called insulin resistance. Type 2 Diabetes: Metabolism mishapsIn type 2 diabetes, the cells cannot absorb glucose properly. If you've developed a condition called insulin resistance, the body makes insulin, but the muscle, liver and fat cells cannot use insulin, or do not respond to the insulin, properly.
With long-standing, uncontrolled type 2 diabetes, the pancreas will reduce the amount of insulin it produces. Managing diabetes: DietFortunately, people with type 2 diabetes can significantly reduce the risk of damage to their bodies, including damage to the heart, kidneys, eyes and feet.
People with type 2 diabetes should carefully monitor carbohydrate consumption, as well as total fat and protein intake and reduce calories. Managing diabetes: ExerciseModerate exercise, such as strength training or walking, improves the body's use of insulin and can lower blood sugar levels in people with type 2 diabetes. Being active also helps reduce body fat, lower blood pressure and protect against heart disease. Try to do at least 150 minutes of exercise a week, with some exercise on most days of the week.
It can also increase glucose levels in your blood as part of your "fight or flight" response. Instead of letting stress take its toll, try relaxation techniques such as deep breathing, meditation or just talking to a friend or relative. Managing diabetes: MedicationWhen people with type 2 diabetes are unable to control blood sugar sufficiently with diet and exercise, medication can help. There are many types of diabetes medicines available and they are often used in combination. Some work by stimulating the pancreas to make more insulin, while others improve the effectiveness of insulin, or reduce the liver's production of glucose, or block the digestion of starches. Managing diabetes: InsulinMany people with type 2 diabetes eventually develop 'beta-cell failure'. This means the cells in the pancreas no longer produce insulin in response to high blood sugar levels.
In this case, insulin therapy – injections or an insulin pump – must become part of the daily routine. Whereas insulin pulls glucose into the cells, these medications cause the body to release insulin to control blood sugar levels.
Glucose testingTesting your blood glucose level will let you know how controlled your blood sugars are and if you need to take action to change your treatment plan.
How often and when you test will be based on how controlled your diabetes is, the type of therapy used to control your diabetes and whether you are experiencing symptoms of fluctuating sugars. Your diabetes team will suggest how often you should use a glucose meter to check your blood sugar. Common testing times are first thing in the morning, before and after meals and exercise and before bedtime.
Long-term damage: ArteriesOver time, untreated type 2 diabetes can damage many of the body's systems. People with diabetes are likely to develop plaque in their arteries, which reduces blood flow and increases the risk of clots. People with diabetes are up to five times more likely to develop heart disease or have a stroke.
Long-term damage: KidneysThe longer you have untreated diabetes, the greater the risk of developing kidney disease or kidney failure. Long-term damage: EyesHigh blood sugar can damage the tiny blood vessels that bring oxygen and nutrients to the retina, a critical part of the eye. This is known as diabetic retinopathy and it can cause progressive, irreversible vision loss. People with diabetes are up to 20 times more likely to go blind than those without diabetes.
Long-Term Damage: Nerve PainOver time, uncontrolled diabetes and elevated blood sugars create a very real risk of nerve damage. Symptoms can include tingling, numbness, pain and a pins and needles sensation -- often in the fingers, hands, toes or feet. Preventing type 2 diabetesOne of the most astonishing things about type 2 diabetes is that such a life-altering condition is often preventable.




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