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In development for the last 13 years, Invokana employs a “novel mechanism of action” to lower blood sugar in type 2 diabetics, Bloomgarden says.
Invokana works by inhibiting sodium glucose co-transporter 2, a carrier that aids in the reabsorption of glucose into the bloodstream through the kidneys, which occurs during the process in which blood is filtered through the kidneys. Because Invokana is such a powerful diuretic, it can help lower a person’s systolic blood pressure, which made some clinical trial subjects feel dizzy and even faint in the first three months while taking the drug.
Additionally, because Invokana blocks absorption of glucose, it could reduce a person’s weight. This method of reducing blood sugar by blocking glucose absorption in the kidneys proved safe and effective through nine clinical trials involving 10,285 participants, according to Janssen Pharmaceuticals.
Even though the FDA voted 10 to five to approve Invokana, the jury is still partially out on the drug’s complete safety and the long-term effects of the new class of medication.
Even though Invokana is a creative and apparently effective new way of reducing blood sugar, Bloomgarden says that metformin, or Glucophage is, and will most likely remain, the primary drug for treating type 2 diabetes. The FDA said Invokana can be used in conjunction with other drugs, such as metformin, in patients as long as they do not have suffer from any kidney function impairment.
Patients won’t have to wait long to get their hands on Invokana if their doctor prescribes it for them. I am taking Invokana alone, as I am allergic to all othet medications for type 2 diabeties it works well keeping my sugars controlled, just have to drink a lot of water, but that is ok. Just started with Invokana about 2 weeks now (taking in addition to other type 2 meds and have seen a considerable drop in blood sugar readings.
After I eat breakfast and take my blood sugar two hours after eating it is actually lower than when I take it first thing in the morning before I take my medications. I know that the price of this medication is high in cost but I really feel if it works for me which it is my life is more important to me than the money. Have been taking Invokana 100 mg for 4 weeks now and have just started to have cramps and diarrhea every day. I have been on Invokana for 1 week now and have had the best results I have had in 2 years.
I can’t tell how much of my positive result was caused by Invokana and how much to attribute to Weight Watchers. I have been taking Invokana for 2 months now after struggling for 2 years to get my blood sugars under control.
The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes.
The “stevia” used as sweetener is Stevia rebaudiana—one species of many in the stevia plant family. Traditionally, indigenous populations of South America brewed whole stevia as tea—not as a sweetener, but as a contraceptive.


It appears to lower blood glucose and to help with post-meal glucose clearance without increasing appetite. Plus, in addition to blood sugar regulation, studies point to other benefits (for an annotated summary, see Mark Sisson’s great post here). More to the point for most who ask whether it’s okay…stevia has zero calories and is naturally sweet (though often with a bitter aftertaste). They’re using highly processed versions, whether in the form of white powders or liquid extracts.
The white powders contain other ingredients as well, often including maltodextrin (corn, most likely genetically modified) along with mysterious, undisclosed “natural flavors.” Meanwhile, the liquid extracts may be made from the whole plant…or from refined, highly processed stevia. And if you’re trying to break a sugar habit (or working with other sorts of cravings), you may find my Free Guide to Overcoming Sugar Addiction helpful.
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It is a handy way to add a touch of sweetness, and I will continue to use but with caution.
But you’ve got the right idea when you caution to be aware if you are using it to keep your sweet tooth. Yeah, the green unprocessed stevia is much harder to find on grocery store shelves, that’s for sure.
Food and Drug Administration means diabetics have a significant new tool for treating the disease, as well as for losing weight and improving their overall health.
The excess glucose is then flushed out of the body, which is why Invokana also acts as a “potent diuretic,” Bloomgarden said. It also worked with about the same effectiveness as sitagliptin, or Januvia, which inhibits enzymes and increases pancreatic function, Ren added.
For extended periods, however, reducing blood pressure in a population of patients with typically higher than normal blood pressure as a result of their diabetes is a positive side effect. According to Janssen Pharmaceuticals, clinical trials subjects taking the drug experienced a 3 percent weight loss compared to subjects taking a placebo. The most common side effects experienced were vaginal yeast infections and urinary tract infections, according to the company. A drug called dapagliflozin, from Bristol-Myers Squibb and AstraZeneca, that also works as a SGLT2 inhibitor, for instance, was rejected for approval by the FDA in 2012 because of concerns it increased rates of bladder and breast cancers in subjects.
However, Invokana can be taken by those already taking metformin and other medications, according to the FDA. According to company spokesperson Christina Holden, Invokana is already being manufactured and field sales agents are already taking order from doctors. With the prescription she gave me a card to give to the pharmacy, now I get a year for free. I was taking Metformin only, but when it alone wasn’t controlling my glucose level my doctor put me on glimepiride.


Made up of the plant and its leaves, stevia in its natural form is green—whether whole or dried and powdered.
But so, for most people, are moderate amounts of caloric whole-food sweeteners, such as raw honey. But, as with any sweetener, more than that feeds a sugar habit and gets in the way of re-sensitizing your taste buds to the natural, less extreme sweetness of foods such as carrots (and even meat!). Most things are ok or good in moderation, but I think moderation is the hardest thing to make a habit of when it comes to diet.
When I first tried stevia, more than 10 years ago, it was in the form of dried leaves in a jar sitting on the table in a cute cafe in Chang Mai, Thailand. I used to really struggle with it when it came to sweets, but after eating a paleo diet for a while, that issue resolved for me.
Financial analysts are predicting that the drug will bring in more than $100 million in sales this year and top out at more than $660 million in annual sales by 2016. I was switched to Invokana after I had a seriously bad reaction with Toujeo ugh it didn’t work for me. Because I was getting dangerously low readings on the glimepiride, I decided to get a referral to an endocrinologist. Since going off sugar my taste has adjusted, to the point where I find food sweetened with other things is just too sickly for me. Maple syrup and honey are excellent choices, and because the cane sugar is added before the kombucha fermentation process, that’s fine too. My doctor put me on Invokana and also gave me a card so I can get a year’s free supply. Since then I’ve discovered the white powder but was unaware that it was so highly processed. I was served a dessert recently at a retreat centre that was sweetened with coconut sugar (heavily), and it was interesting that eating it seemed to awaken an old sugar memory, if I can put it that way. Now if I check right after I eat, I might see like 250~300 but if I eat and wait like 2 hours and check, its back down in the 150 range normally. Looking to to me so far other than I’ve gotten dizzy a few times for a couple seconds and I checked, my sugars were not too low. Invokana has certainly helped and I will continue to take it until I no longer need it for control.



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