Diabetes mellitus type 2 treatment options natural,samsung galaxy s plus i9000,gi joe 2 for free - Tips For You

Type 2 diabetes is triggered by multiple causes interacting with one another, such as genetic predisposition and environmental factors.
Among the environmental factors that may favor the development of diabetes there are overweight and obesity (especially excess of belly fat) and an unbalanced diet, rich in saturated fats and simple sugars.
Often , diabetes is associated with other metabolic diseases, such as hypertension and dyslipidemia.
The main characteristic of diabetes is the presence of elevated blood glucose levels in the blood; hyperglycemia may be asymptomatic or present with nonspecific symptoms (such as persistent thirst or increased sense of hunger associated with weight loss).
It 's very important to diagnose and treat diabetes the best way you can, because over time this disease can cause very serious complications, especially regarding retina and kidney.
Type 2 diabetes must be treated by a healthcare professional with appropriate pharmacotherapy . For lunch and dinner eat full meals composed of bread, pasta or rice (preferably cooked "al dente", using in about 50% of cases whole grains) plus a second course (meat or fish or cheese or cold meats or eggs or legumes) plus vegetables plus fruit. Limit sugary fruit: bananas, figs, persimmons, grapes, tangerines and clementines, dried fruit, dried and canned. Limit as much as possible the consumption of sweets (cookies, cakes, snacks, desserts) and carbonated soft drinks. Patients with type 2 diabetes treated with insulin may need personalized type 2 diabetes diet that is generally provided by the Diet and Nutrition Clinic Services. Enter your email address to subscribe to this blog and receive notifications of new posts by email.
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What is Insulin Resistance?Insulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Tanzeum (albiglutide), developed by GlaxoSmithKline (GSK), is a GLP-1 receptor agonist indicated for treatment of type 2 diabetes.
Tanzeum's mechanism of actionTanzeum contains Glucagon-like peptide-1 (GLP-1) receptor agonist, which is a recombinant protein made by combining two tandem copies of modified human GLP-1 genetically merged in tandem with human albumin. The symptoms of type 2 diabetes include frequent urination, constant appetite and excess thirst.
I became a fitness passionate during the last 10 years, where I learned a lot by studying and also through personal experience.
Cookies are files stored in your browser and are used by most websites to help personalize your web experience. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. GSK received approval for Tanzeum from the US Food and Drug Administration (FDA) as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus in April 2014.Albiglutide received marketing authorisation from the European Medicines Agency (EMA) for treatment of type 2 diabetes in adult patients in March 2014. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. It is available in 50mg dose that can be administered through injection for subcutaneous (SC) use.Clinical trials of TanzeumFDA approval for Tanzeum was based on results obtained from comprehensive Phase III study known as Harmony programme that consisted of eight clinical trials, which enrolled more than 5,000 patients and treated more than 2,000 of them with Tanzeum.


Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production.
The symptoms of the disease include frequent urination, constant appetite and excess thirst. Elevated blood fatty-acid concentrations (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose concentration.
The patients were randomised to receive Tanzeum 30mg SC once weekly, Tanzeum 30mg SC once weekly uptitrated to 50mg once weekly at Week 12, or placebo.The study results demonstrated that the patients who were treated with Tanzeum 30mg or 50mg showed statistically significant reductions in HbA1c from baseline at Week 52.
Other medications available for the treatment of type 2 diabetes include Forxiga (dapagliflozin) developed by AstraZeneca and Bristol-Myers Squibb, and Invokana (canagliflozin) manufactured by Janssen Pharmaceuticals and Mitsubishi Tanabe Pharma Corporation.
In an ''insulin-resistant'' person, normal levels of insulin do not have the same effect on muscle and adipose cells, with the result that glucose levels stay higher than normal. To compensate for this, the pancreas in an insulin-resistant individual is stimulated to release more insulin. The elevated insulin levels have additional effects (see insulin) which cause further biological effects throughout the body.The most common type of insulin resistance is associated with a collection of symptoms known as metabolic syndrome. This is often seen when hyperglycemia develops after a meal, when pancreatic I?-cells are unable to produce sufficient insulin to maintain normal blood sugar levels (euglycemia). The inability of the I?-cells to produce sufficient insulin in a condition of hyperglycemia is what characterizes the transition from insulin resistance to Type 2 diabetes mellitus.Various disease states make the body tissues more resistant to the actions of insulin. Recent research is investigating the roles of adipokines (the cytokines produced by adipose tissue) in insulin resistance. Exercise reverses this process in muscle tissue, but if left unchecked, it can spiral into insulin resistance.Elevated blood levels of glucose a€” regardless of cause a€” leads to increased glycation of proteins with changes (only a few of which are understood in any detail) in protein function throughout the body. With respect to visceral adiposity, a great deal of evidence suggests two strong links with insulin resistance. First, unlike subcutaneous adipose tissue, visceral adipose cells produce significant amounts of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-a), and Interleukins-1 and -6, etc. In numerous experimental models, these proinfammatory cytokines profoundly disrupt normal insulin action in fat and muscle cells, and may be a major factor in causing the whole-body insulin resistance observed in patients with visceral adiposity. Second, visceral adiposity is related to an accumulation of fat in the liver, a condition known as nonalcoholic fatty liver disease (NAFLD). In this case, the production of antibodies against insulin leads to lower-than-expected glucose level reductions (glycemia) after a specific dose of insulin. In vitro and in vivo studies have demonstrated that insulin may modulate the shift of Mg from extracellular to intracellular space.
Intracellular Mg concentration has also been shown to be effective in modulating insulin action (mainly oxidative glucose metabolism), offset calcium-related excitation-contraction coupling, and decrease smooth cell responsiveness to depolarizing stimuli. Poor intracellular Mg concentrations, as found in Type 2 diabetes mellitus and in hypertensive patients, may result in a defective tyrosine-kinase activity at the insulin receptor level and exaggerated intracellular calcium concentration. Both events are responsible for the impairment in insulin action and a worsening of insulin resistance in noninsulin-dependent diabetic and hypertensive patients.
By contrast, in T2DM patients daily Mg administration, restoring a more appropriate intracellular Mg concentration, contributes to improve insulin-mediated glucose uptake. The benefits deriving- from daily Mg supplementation in T2DM patients are further supported by epidemiological studies showing that high daily Mg intake are predictive of a lower incidence of T2DM.


An American study has shown that glucosamine (often prescribed for joint problems) may cause insulin resistance.Insulin resistance has also been linked to PCOS (polycystic ovary syndrome) as either causing it or being caused by it. Insulin resistance has certainly risen in step with the increase in sugar consumption and the substantial commercial usage of HFCS since its introduction to the food trades; the effect may also be due to other parallel diet changes however. CellularAt the cellular level, excessive circulating insulin appears to be a contributor to insulin resistance via down-regulation of insulin receptors. Since the usual instances of Type 2 insulin resistance are distinct from pathological over production of insulin, this does not seem to be the typical cause of the insulin resistance leading to Type 2 diabetes mellitus, the largest clinical issue connected with insulin resistance. The presence of insulin resistance typically precedes the diagnosis of Types 2 diabetes mellitus, however, and as elevated blood glucose levels are the primary stimulus for insulin secretion and production, habitually excessive carbohydrate intake is a likely contributor. Additionally, some Type 2 cases require so much external insulin that this down-regulation contributes to total insulin resistance.Inflammation also seems to be implicated in causing insulin resistance. PKC Theta inhibits Insulin Receptor Substrate (IRS) activation and hence prevents glucose up-take in response to insulin.
MolecularInsulin resistance has been proposed at a molecular level to be a reaction to excess nutrition by superoxide dismutase in cell mitochondria that acts as a antioxidant defense mechanism. It is also based on the finding that insulin resistance can be rapidly reversed by exposing cells to mitochondrial uncouplers, electron transport chain inhibitors, or mitochondrial superoxide dismutase mimetics.GeneticIndividual variability is a cause with an inherited component, as sharply increased rates of insulin resistance and Type 2 diabetes are found in those with close relatives who have developed Type 2 diabetes. DiseaseSub-clinical Cushing's syndrome and hypogonadism (low testosterone levels) seem to be the major insulin resistance causes .Recent research and experimentation has uncovered a non-obesity related connection to insulin resistance and Type 2 diabetes. It has long been observed that patients who have had some kinds of bariatric surgery have increased insulin sensitivity and even remission of Type 2 diabetes. This suggested similar surgery in humans, and early reports in prominent medical journals (January 8) are that the same effect is seen in humans, at least the small number who have participated in the experimental surgical program.
The speculation is that some substance is produced in that portion of the small intestine which signals body cells to become insulin resistant. If the producing tissue is removed, the signal ceases and body cells revert to normal insulin sensitivity. Both metformin and the thiazolidinediones improve insulin resistance, but are only approved therapies for type 2 diabetes, not insulin resistance, ''per se''.
By contrast, growth hormone replacement therapy may be associated with increased insulin resistance.Metformin has become one of the more commonly prescribed medications for insulin resistance, and currently a newer drug, exenatide (marketed as Byetta), is being used. Exenatide has not been approved except for use in diabetics, but often improves insulin resistance by the same mechanism as it does diabetes. It also has been used to aid in weight loss for diabetics and those with insulin resistance, and is being studied for this use as well as for weight loss in people who have gained weight while on antidepressants. The ''Diabetes Prevention Program'' showed that exercise and diet were nearly twice as effective as metformin at reducing the risk of progressing to type 2 diabetes.Many people with insulin resistance currently follow the lead of some diabetics, and add cinnamon in therapeutic doses to their diet to help control blood sugar.



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