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In contrast to mean values, the variability in SBP and DBP between visits was associated with cognitive and verbal decline. In a systematic review and meta-analysis of 17 studies, the short-term and long-term exposure to air pollutants was significantly associated with increased risk for hypertension. Morning home BP measurements were strong predictors of both CAD risk and stroke in HONEST study. ACC 2016 HOPE-3 study shows that statins may significantly reduce adverse cardiovascular events in people with average cholesterol and blood pressure (BP) levels who are considered to be at intermediate risk for cardiovascular disease, while the use of BP-lowering medications may be beneficial only in hypertensive patients.

A large meta-analysis shows that dietary interventions lead to clinically significant net BP reductions, but effects vary between types of diet, and within different patient subgroups.
A large systematic review and meta-analysis shows that antihypertensive treatment provides no benefit and increases the risk of CV death in patients with DM and SBP < 140 mm Hg. In patients with a history of stroke or TIA, the SBP target of <130 mmHg rather than 140 mmHg yielded only a small additional reduction in BP. The beneficial effect of BP-lowering on various CV outcomes, also in individuals with lower baseline systolic BP, was broadly similar among populations with different comorbidities. 2014 Evidence-Based Guideline For The Management Of High - Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated .

Bryan Williams, an expert in the management of hypertension, discusses the updated NICE guidelines on the management of hypertension.
Clinic SBP and evening SBP may underestimate risk, as well as diastolic BP in either setting. Salim Yusuf discusses the results of the HOPE-3 study, which indicates that statins are effective in all patients with intermediate CVD risk, whereas blood pressure lowering is only effective in hypertensive patients.

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