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Pyoderma gangrenosum or gangrenosum pyoderma refers to serious but rare disease of the skin in which painful pustule or nodule breaks down and then forms ulcer that enlarges progressively. The name, Pyoderma gangrenosum is related to that way in which the ulcers appear and look like. About 30% of the patients that develop this condition have history of serious trauma on the skin. In most cases, the gsngrenosum pyoderma develops at the site of provisos injury, cut or other skin trauma. Because the causes of pyoderma gangrenosum are not very well known, it is not possible to prevent or avoid it.
Generally speaking, pyoderma gangrenosum is rare in the United States.  It occurs in only one among 100,000 people in a year. Death from pyoderma gangrenosum is very rare but this does not mean that it cannot cause it.  The death may not be directly caused by pyoderma gangrenosum but because of the diseases or complications that are associated with the disease. Death may also occur as a result of the therapy treatments that may sometimes involve the use of complex or simultaneous medical procedures and drugs.  Most patients complain of pain and they may be tempted to take narcotics to reduce it. Pyoderma gangrenosum can attack any person of any age but it is very common in the persons that are aged 40 years and older. In most cases, pyoderma gangrenosum symptoms begin and develop as though it is a reaction to an insect bite. The pyoderma gangrenosum may also develop as a result of an underlying condition like diabetes or lupus.
Pyoderma gangrenosum is closely related but not caused by Crohn disease, ulcerative colitis, regional enteritis and inflammatory bowel disease. Once you show or experience any symptoms of this condition you should consult a dermatologist as soon as possible.  Early pyoderma gangrenosum diagnosis and proper medical intervention measures are the surest ways of dealing with the condition. Though you may find some suggested home therapies for treating the condition over the internet, it is highly recommended that you take the long and of course the expensive option of seeking proper medical care.  You should not take gamble with your health. There are two main variants of the pyoderma gangrenosum; the classic pyoderma gangrenosum and the atypical pyoderma gangrenosum. This form of gangrenosum pyoderma can also occur on the genital parts.  It is occurs on the male penis it is referred to as penile pyoderma gangrenosum.
There is an intraoral form of gangrenosum pyoderma that is commonly referred to as pyostomatitis vegetans. There may the involvement of other systems of organs in the patients suffering from pyoderma gangrenosum and this will manifest as sterile neutrophilic abscesses.  There may also be involvement of the gastro intestinal tract, heart, eyes and the central nervous system.
Even though pyoderma gangrenosum is not life threatening in most cases, patients are advised to consult a dermatologist for advice on pyoderma gangrenosum diagnosis and the best treatment.. Biopsies may be required for pyoderma gangrenosum diagnosis or out rule other conditions that in most cases accompany the condition.


If there is infection that is accompanying the pyoderma gangrenosum then the patients should be put on the right treatment for that condition.
Surgery: Surgery may also be used in Pyoderma gangrenosum treatment but it poses the risk of redeveloping Pyoderma Gangrenosum. Skin grafts: skin grafts may also be used to repair or replace the damaged tissues as result of this condition. If left untreated pyoderma gangrenosum wounds and lesions are likely to increase in size and become deeper.
The patient may also experience severe pain and the wound may bring out offensive smell.  After the healing, the scars that will be left may be patient. The patient may sometimes be put on antibiotics after treatment to prevent the risk of infection by bacteria.  Though it is very rare, the pyoderma gangrenosum may also tend to affect and bring problems of the heart, eyes and other organs of the body. Though it rarely affects children, if it happens the child is at risk of developing complications or dying than an adult. The duration or success of treatment of pyoderma gangrenosum is dependent on very many factors.  The doctors will assess and treat each individual case separately. Medical data tends to show that there is recurrence in about 50% of the patients that undergo treatment for gangrenosum pyoderma. They have surface that is purulent (pyoderma) and edge that is blue-black in color (gangrenosum).
Pyoderma gangrenosum may be easily confused with some other conditions that present similar symptoms.
It is however believed that immune system deregulation in general and alterations of the neutrophil chemotaxis in particular are the major pyoderma gangrenosum causes. Most patients are very able to notice that there is something unusual once the pyoderma gangrenosum begins to develop because the wounds and lesions associated with the condition are very slow to heal. This condition may cause problems of healing of wound especially after invasive surgery like for example breast construction or face lift. Children may also be affected but it is very rare because their total cases combined account for between 3 and 4% of all the total cases. It may develop as a lesion that has a small red pustule or papule but it may change in to   bigger lesion that is ulcerative pyoderma gangrenosum.  Most patients think that they might have been bitten a poisonous insect like a scorpion or spider.
The patients may also experience general unwell feeling (malaise) and arthralgias (severe pain of the body joints). If the pyoderma gangrenosum is as result of underlying condition, the pyoderma gangrenosum treatment should involve treating the lesions as well as treating the condition that is causing or aggravating it.
Before going in to the details, it is good to know that the classic pyoderma gangrenosum mostly develops on the legs while the atypical pyoderma gangrenosum mostly develops on the hands. Peristomal pyoderma gangrenosum may be confused with wound infection or irritation resulting from the appliance.


The ulcers and lesions of can be cultured or swabbed so as to test for any infections that may be present. If for example the condition is caused by bacteria the patient should be put on antibiotics.
They have the effect of preventing the development of new lesions.  At the first few days (or weeks depending on the severity of the condition), high doses of prednisolone may be needed. Pulse therapy by use of (IV) methylprednisolone that is administered intravenously at doses of 1 gram per day for a duration of between 3 and 5 days may also be used in the treatment. That may also trigger swelling of the adjacent tissues of the part in which they have affected.
It may take weeks months or even several years (when there is recurrence) to completely treat and cure the problem. Most of the patients that develop complications from pyoderma gangrenosum treatment have an underlying condition like diabetes, high blood pressure or lupus that aggravates the condition. These other conditions include skin infections, vasculitis, trauma, diabetes skin complications, malignancy, and collagen vascular diseases.
Trauma on the skin oaf people suffering from this condition may lead to the development of wounds and lesions that are difficult to heal. The condition also affects people of all sexes but there seem to be some higher prevalence in women.
Most patients suffering from this condition develop systemic illness either before, during or after the positive diagnosis of the same. This condition is very different from the sexually transmitted diseases and it may be confused with them in most cases. Upon ocular examination, there may be evidence of extracutaneous neutrophilic disease and this has also been reported in the liver, bones and the lungs. It is however very important to note that pyoderma gangrenosum is not solely caused by bacteria and antibiotics so should not be used for treatment of pyoderma gangrenosum unless there is another infection by bacteria.
Patients may also experience swelling of the lymph nodes and numbness of the hand or leg that is affected. Another potential complication is the development of secondary infection after Pyoderma gangrenosum treatment. Asian countries,[18] United States (including Hawaii), Canada ,[19] and Scotland)[20] due to bacterial resistance.



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