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Les femmes secretant des taux faibles de melatonine ont un risque accru de presenter un diabete de type 2 comparees a celles ayant des valeurs elevees de cette hormone. Des recepteurs a la melatonine ont ete trouves dans plusieurs organes dont les cellules ?-pancreatiques et plusieurs travaux suggerent que cette hormone peut jouer un role dans le metabolisme du glucose. Certaines etudes, mais sur peu de patients, suggerent aussi que la melatonine aurait un effet protecteur sur le developpement du diabete sucre.
La melatonine fera-t-elle demain partie de la prevention et du traitement du diabete de type 2 chez l’homme ? Defaut d’oxydation des acides gras dans les cellules tubulaires renales : role majeur dans le developpement de la fibrose renale.
La dominance chez le chien domestique revisitee : habitude usuelle et habitude construite ? La tetrahydrobiopterine diminue l’activite des nerfs sympathiques musculaires et ameliore l’augmentation de l’index chez les patients avec maladie renale chronique. Management avec hydrocortisone de l’hypocorticisme aigue chez le chien : serie retrospective de 30 cas. Regeneration du cristallin par ses propres cellules souches : un changement de paradigme dans la chirurgie cristallinienne ! L’effet de la selection genetique et de la consanguinite sur l’incidence de deux maladies auto-immunes majeures chez le caniche standard, l’adenite sebacee et la maladie d’Addison. Les journaux scientifiques devraient creer une nouvelle rubrique appelee “les minutes de la science”.
Concentrations de bupivacaine dans le liquide synovial apres une seule injection intra-articulaire dans des genoux normaux ou arthrosiques. Consensus europeen sur le traitement medical de l’epilepsie chez le chien (trois articles). Evaluation de la maladie coronoide mediale chez 180 coudes douloureux de chiens : sensibilite et specificite comparative entre radiographie, scanner et arthroscopie.
Association entre age, sexe, poids corporel et l’epaisseur des glandes surrenales determinee par echographie chez le chien avec maladie non surrenalienne.
Evolution du comportement de chatons de refuge adoptes apres gonadectomie realisee a un age precoce et a l’age traditionnel. Effets d’un supplement alimentaire a base de chitosan pour reduire la probabilite de deces par crises uremiques chez des chiens souffrant d’IRC.
Pesquisadores britanicos descobriram que um gene ligado a diabetes tipo 2 e niveis de colesterol e na verdade um gene “regulador”, que controla o comportamento de outros genes encontrados dentro da gordura no corpo. A boa noticia e que a gordura desempenha um papel-chave na suscetibilidade a doencas metabolicas como obesidade, doencas cardiacas e diabetes, portanto a descoberta do gene regulador o torna um possivel alvo para futuros tratamentos para combater essas doencas.
Os pesquisadores examinaram mais de 20.000 genes em biopsias de gordura subcutanea de 800 voluntarias gemeas, e mais tarde uma amostra independente de 600 biopsias de gordura subcutanea de individuos islandeses. O nome do gene encontrado, KLF14, ja era ligado a diabetes tipo 2 e niveis de colesterol, mas, ate agora, como ele fazia isso e seu papel no controle de outros genes era desconhecido. Os outros genes controlados por KLF14 sao de fato ligados a um conjunto de caracteristicas metabolicas, incluindo indice de massa corporal (que determina a obesidade), colesterol, insulina e niveis de glicose, o que destaca a inter-relacao de caracteristicas metabolicas.
O KLF14 parece agir como um controlador mestre de processos que contribuem para a diabetes e outras condicoes. Esse e o primeiro grande estudo que mostra como pequenas alteracoes em um gene regulador podem causar uma cascata de outros efeitos metabolicos em outros genes.
Ola tambem soudiabetica tipo2 por enquanto Gracas A Deus, so uso remedios nao presisei de insulinainjetavel, assim espero ate chegar a cura tenho 53 anos, gostaria de me candidatar pela cura muito obrigado e nao esquecam de mim nesta batalha quero muito ficar curada.Dulcemara Martins. Meu Pai Esta diabetico a 5 anos, ele tem 52 anos de idade e se coloca a disposicao para qualquer pesquisa para a cura do diabetes, pois realmente sofre com tanta preocupacao com isso. Sou diabetica tipo 2, apos ter diabetes gestacional , isso faz pelo menos uns 15 anos, sinto piorar muito, ja tomo insulina regular e a humana.
Ola,tenho diabetes tipo 2,tomo remedios e tomo insulina e gostaria de ser voluntario para testar novos medicamentos para a cura do diabetes, tenho 47 anos. Meu filho de 21 anos adquiriu a doenca e ja faz uso de remedio para diminuir a taxa de acucar no sangue, eu tenho 48 anos e nao tenho diabetes mas infelizmente apareceu nele a pouco mais de um mes, tendencia era obvio ja que os dois lados da familia teve.. Ola,tenho diabetes tipo 2, gostaria de ser voluntario para testar novos medicamentos para a cura do diabetes, tenho 57 anos sou aposentado.


Diagnosticada desde 2006 com tipo 2,aposentada,55 anos,quero ser voluntaria para a vacina contra o diabetes. Tenho acompanhado as materias sobre Diabetes 2, e com uma imensa satisfacao recebo esta noticia. Parabens a equipe de Hypescience pela qualidade desta reportagem que traz dados e informacoes objetivas raramente vistos em artigos cientificos. Tambem gostaria de me candidatar tbm sou tipo 2,se alguem souber onde sao feitos estes testes me avisem. Envie um comentario Cancelar respostaVoce precisa fazer o login para publicar um comentario.
About Speaking of DiabetesSpeaking of Diabetes is produced by Joslin Diabetes Center for people with diabetes and those who care for them.. Joslin Diabetes Center, a teaching and research affiliate of Harvard Medical School, is a one-of-a-kind institution on the front lines of the world epidemic of diabetes - leading the battle to conquer diabetes in all forms through cutting-edge research and innovative approaches to clinical care and education. This entry was posted in Diabetes Day2Day, Insulin and tagged exercise and insulin injections, injection sites, insulin injections. When it comes to injecting insulin, the stomach, the buttocks, the back of the arm and the thigh have something in common. If injected directly into muscle, aside from being painful, it will be absorbed much too rapidly. Each of these approved areas absorbs insulin at a slightly different rate, and knowing this can help you make the best decision about where to inject depending on your blood glucose. For example if your blood glucose is low before a meal, you may want to inject into the buttock area because insulin is absorbed most slowly here.
Injecting insulin into the same site over and over again can lead to the fat below the skin becoming hard and lumpy. Inject at least 4 inches (or approximately one hand-width) above the knee and at least 4 inches down from the top of the leg. Inject into the fatty tissue in the back (not the side) of the arm between the shoulder and the elbow.
To make sure that your insulin is absorbed consistently, it may be best to give all injections in one or two areas of the body and rotate where you inject the insulin within that site for a period of time.
Hot temperatures tend to increase insulin absorption, while cold temperatures can decrease absorption.
To the Point: Six Simple Tips to Overcome a Fear of NeedlesAsk Joslin: Lumps Near Injection SitesIs There A Better Way To Give an Insulin Injection?
A clinical trial for a Type 1 diabetes vaccine has resulted in promising findings, suggesting there may be a future where we can prevent people from getting the disease.
Researchers completed a 12-week trial on a DNA-based vaccine on 80 subjects with Type 1 diabetes. In Type 1 diabetes, the immune system attacks its own beta cells, a cell found in the pancreas. The experimental vaccine works by targeting and suppressing a set of immune cells called CD8, which are thought to attack insulin-producing beta cells.
Since C-peptide remains in the body longer than insulin, it can serve as a good intermediary between beta cells and further insulin production.
A DNA-based vaccine has never been approved by the Food and Drug Administration (FDA), and many more trials with more subjects need to occur, the researchers said. Diabetes is a serious and chronic disease that occurs when the body does not have the ability to produce insulin, or enough insulin, to metabolize glucose.? There is no known cure for the disease but research continues to make progress. Os cientistas descobriram uma associacao entre o gene KLF14 e os niveis de expressao de varios genes encontrados no tecido adiposo, o que significa que ele controla esses genes. Cada pessoa herda um conjunto de genes de ambos os pais, mas, neste caso, a copia do KLF14 do pai e desligada, o que significa que a copia da mae e o gene ativo. O proximo passo da pesquisa e entender esses processos e como eles podem ser usados para melhorar o tratamento dessas condicoes. Agradeco por nos dar dias melhores por estas informacoes, nao esquecam dele e muito obrigado.
Gostaria de me candidatar para ser voluntaria em pesquisas de cura dessa doenca tao primitiva, mas que mata aos poucos.


Este leitor agradece e espera que seja este um exemplo a ser seguido por outros jornalistas e outros veiculos de divulgacao.
The insulin may reach your blood stream before your digestive system has the time to release glucose from the food you eat. In general, insulin is more quickly absorbed from the stomach followed by the arm, the thigh, and the buttocks. On the other hand, if you are hyperglycemic the stomach may be the best choice as it has the fastest absorption rate. Aside from being unsightly, it can change the way your insulin is absorbed so you won’t easily know when the insulin will start working or peak.
For example, inject your morning insulin in your stomach and your evening insulin in your thigh.
It’s best not to inject in your arm or thigh if you have just exercised or plan to exercise (your arms would absorb insulin quickly if you were doing a set of bicep curls, for instance). Be careful about injecting insulin after taking a hot shower, a bath or being out in the cold. The patients were able to maintain levels of a blood-borne intermediary that can stimulate insulin production, and some subjects were able to increase levels. Lawrence Steinman, professor of pediatrics and neurological sciences at Stanford University in Calif., said in a press release.
While it isn’t as common as Type 2 diabetes, it typically manifests at an earlier age and requires multiple daily injections of insulin throughout life. The proinsulin-targeting CD8 cells then attack the beta cells that the proinsulin is resting on. When the body processes the vaccine, it sends an anti-inflammatory signal to only the CD8 cells. C-peptide has also been shown to stop or reduce some of the long-term effects of diabetes including eye, kidney and nerve damage.
In addition, the vaccine’s effectiveness dropped after the 12-week period, so the current formula may not offer long-term protection. According to the American Diabetes Association, diabetes affects 25.8 million children and adults in the United States. Le groupe avec des valeurs basses de melatonine presente un risque double de diabete compare a celui a valeurs hautes ! Alem disso, a capacidade de KLF14 de controlar outros genes tambem era totalmente dependente da copia do KLF14 herdada da mae (a copia herdada do pai nao tinha efeito algum). This variability is most prominent with NPH and regular insulin and not as much a factor with the rapid acting insulins.
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That suggests the cellular changes that occur in patients with Type 1 diabetes may be shut down.
CD8 ignores most peptides on healthy cells, but when a peptide looks out of the ordinary, it attacks the cell.
Researchers measured the levels of C-peptide, a portion of proinsulin that gets removed when insulin is made, in the patients’ blood stream. Experts say a working vaccine is still years away, but this trial’s results are promising and a good start. Levels were measured during the fifth and 15th weeks and then six, nine, 12, 18 and 24 months after starting on the vaccination regimen.
L’etape logique suivante est de mener des etudes pour voir si l’augmentation des valeurs de melatonine (endogene en prolongeant la periode de vie dans le noir soit exogene via une supplementation) peut augmenter la sensibilite a l’insuline et diminuer l’incidence de diabete de type 2. You may not alter or remove any trademark, copyright or other notice from copies of the content. Each time, researchers took blood samples 30, 60, 90 and 120 minutes after patients drank a modified milkshake.



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