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In what could be the biggest breakthrough in years toward a cure for type 1 diabetes, researchers at Harvard University say they have developed a way of transforming stem cells to help diabetics produce their own insulin. The researchers say the stem cells can create hundreds of millions of beta cells, which produce insulin.
While in 15 years of testing the group has been able to develop insulin-producing cells from cadavers, they weren’t able to generate the quantity needed.
Melton had a personal interest in the project because both of his children were diagnosed with the disease as youngsters.
The next steps include moving to clinical trials in humans, possibly in as few as three years.
Researchers have achieved a major breakthrough in the search for a cure for type 1 diabetes in humans.
The team of researchers, consisting of scientists from MIT, Harvard, and other institutions, announced in the journal Nature Medicine on Monday that they have successfully implanted mass-produced pancreatic beta cells into mice genetically bred to suffer type 1 diabetes. The latest breakthrough follows the successful use of human embryonic stem cells in 2014 to create insulin-producing beta cells in large quantities in the laboratory. Harvard’s Professor Doug Melton, who led the team that made the 2014 breakthrough, was also part of the team that achieved the latest breakthrough. The researchers also announced they were able to prevent the cells from being rejected by the immune system of the mice.
The scientists reported that following the transplant of the TMTD-encapsulated pancreatic beta cells, the mice were able to produce insulin to regulate blood sugar levels at normal healthy ranges during the 174-day period of the study without requiring daily injections of insulin. Type 1 diabetes is a condition in which the pancreas is unable to produce insulin, the hormone that helps to regulate glucose levels in the blood. Thus, people with type 1 diabetes need daily injections of insulin to prevent the build-up of sugar in their bloodstream. The latest breakthrough has been hailed as having the potential to provide a functional cure for type 1 diabetes.
He said that human trials would commence soon and that if the procedure proves successful in humans, type 1 diabetes patients would no longer require daily injections of insulin, but only booster transfusions of the pancreatic beta cells once in a few years. According to Julia Greenstein, the vice president of Juvenile Diabetes Research Foundation (JDRF) which funded the study, “Encapsulation therapies have the potential to be groundbreaking for people with type 1 diabetes. When these compounds were tested in trials involving animals with type 1 diabetes, their blood glucose levels and beta cell counts were properly restored! BioInformant is the only research firm that has served the stem cell sector since it emerged. Perfect for stylishly storing jewelry and mementos, this hardwood box showcases a ceramic tile.
A Type 1 diabetes cure through promising stem cell treatment is currently in the clinical trial stage and could eliminate blood glucose monitor and insulin injections, according to Fortune magazine.

ViaCyte Inc., the company conducting the clinical trial, announced Thursday it was joining forces with Janssen Biotech Inc. If the clinical trials are successful, the stem cell treatment could be available in several years with a similar treatment for Type 2 diabetes to follow, according to The Associated Press. Fortune said the implanted capsule essentially acts as an artificial pancreas, making insulin in diabetic patients. Derek Rapp, president of JDRF, formerly the Juvenile Diabetes Research Foundation, said in a ViaCyte statement that the stem cell therapy could make a difference in the quality of treatment and management for diabetes patients. ViaCyte said its work with Janssen, part of Janssen Pharmaceutical Companies of Johnson & Johnson, and consolidating assets of Janssen's BetaLogics group, will help make advances in the stem cell treatments. A Type 1 diabetes cure through promising stem cell treatment is currently in the clinical trial stage and could eliminate blood glucose monitor and insulin injections.
When the cells are transferred to diabetic mice, they behaved as healthy cells do and regulated blood sugar. A team of scientists have been able to halt type 1 diabetes in mice for six months by implanting into the mice insulin-producing pancreatic beta cells generated in the laboratory from human embryonic stem cells. He has been working on a cure for type 1 diabetes since his son Sam was diagnosed with the condition, according to the Daily Mail. When the body’s immune system rejects transplanted cells, it attacks and destroys them, rendering them non-functional. It is thought that the condition is caused by genetic factors or the destruction of insulin-producing cells in the pancreas by an autoimmune reaction possibly triggered by viral infections. High blood sugar levels have a damaging effect on vital body organs, leading to cardiovascular ailments and damage to the kidneys, eyes, and nerves. The only available therapy for type 1 diabetes for many years involves daily injections of insulin which causes patients significant discomfort. Bryan Laffitte, Director of Drug Discovery Pharmacology at the Genomics Institute of the Novartis Research Foundation, talks about progress his lab is making in producing an effective treatment for type 1 diabetes in the video below.
Our management team comes from a BioInformatics background – the science of collecting and analyzing complex genetic codes – and applies these techniques to the field of market research. The cells were able to restore normal insulin function in mice, thus eliminating the need for daily injections of insulin. That is because, in diabetes type 1, the immune systems destroy insulin-producing cells located in the pancreas.
BioInformant research has been cited by major news outlets that include the Wall Street Journal, Nature Biotechnology, CBS News, Medical Ethics, and the Center for BioNetworking. Fortune said the therapy includes implanting a capsule with insulin-producing cells from embryonic stem cells under the skin of patients suffering from diabetes.
Insulin-producing cells in question are beta cells.In normal conditions, the immune system will attack and fortify the body from bacteria and viral substances or who infiltrate into the body.

Serving Fortune 500 leaders that include GE Healthcare, Pfizer, Goldman Sachs, and Becton Dickinson, BioInformant is your global leader in stem cell industry data. However, in diabetes type 1, with no definite reason, the immune system attacks the pancreas and destroys the beta cells and causes inhibition of the production of the hormone insulin.Diabetes type 1 occurs when the body lacks insulin, so the glucose (blood sugar) rises above normal. Insulin serves to absorb nutrients and sugars in the blood, and then circulate it to the various cells of the body to be used as an energy source.People with diabetes type 1 produce insulin only in very few or even none at all. As a result, increasing blood glucose (hyperglycemia) and the body’s cells do not get enough energy intake. High levels of sugar in the blood will increase the frequency of urination in response to lowering blood sugar.
When blood sugar is out with urine, the body will lose a lot of water, causing dehydration.Losing weight.
Glucose is wasted with urine also contains many nutrients and calories needed the human body. Therefore, people with diabetes type 1 will also lose weight drastically.Damage to the body. The risk of developing diabetes type 1 be inherited through genetics.Also, several other supporting factors in the environment can lead to the development of this type of diabetes. This condition will cause minor scratches on the feet quickly turn into a serious injury and infection.
In severe cases, foot infection must be amputated in order to wound not continue to spread.Retinal damage. Keeping glucose levels remain normal will reduces the risk of damage to the retina.Kidney damage. This risk will continue to increase over time, especially after suffering from diabetes for 15-25 years. These complications can lead more serious conditions such as kidney failure or heart attack.
Share on: Twitter Facebook Google +Posts Related to Type 1 Diabetes Causes Symptoms Treatment4 Differences Between Diabetes Type 1 and Type 2Most people do not understand what the difference between diabetes type 1 and type 2. Most people think that diabetes is just one disease that occurs due to high sugar levels in the blood.
This condition (prediabetes) almost always comes before a person has type 2 diabetes that more severe.

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