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The amino acid called GABA (Gamma Aminobutyric Acid) is the principal INHIBITORY neurotransmitter in the mammalian central nervous system, ¬† sending chemical messages through the brain and nervous system and helping regulate communication between brain cells. Pharmaceuticals called benzodiazepines bind to the same receptors as GABA, mimicking GABA’s natural calming effects. Glutamate (also called L-glutamate or glutamic acid)) is another important amino acid neurotransmitter released by nerve cells in the brain.
An earlier experiment, in 2011, demonstrated that a different type of gut bacteria, Lactobacillus rhamnosus, dramatically altered GABA activity in the brains of mice as well as affected how well they responded to stress.
When the researchers surgically removed the vagus nerve, the communication pathway between the gut and the brain, the effect on the mice disappeared Рmore evidence on how gut bacteria influence the brain. The research team, led by Philip Strandwitz at Northeastern University in Boston, is now searching for other gut bacteria that consume or even produce GABA.
Researchers are just at the beginning of looking into the many ways the gut microbiome influences, if not regulates, many bodily processes and how unbalance in the gut microbiome eventually leads to poor health.


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It is involved in most aspects of normal brain functioning, including cognition, memory and learning. They found that a type of recently discovered gut bacteria, called KLE1738, can survive and reproduce only if it has GABA molecules to feed on. In order to post comments, please make sure JavaScript and Cookies are enabled, and reload the page. Research suggests that GABA helps control fear and anxiety when neurons become overexcited.
The researchers tried providing KLE1738 with other types of neurotransmitters but the bacteria couldn’t survive on anything but GABA.


Such work may eventually lead to new treatments for mood disorders like depression or anxiety. Neurotransmitters and specific microbes may become the treatment of choice for mood disorders – or, even better, for preventing mood disorders in the first place.
Below normal GABA levels in the brain have been linked to depression, anxiety, sleep disorders, and schizophrenia.



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