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While the FTC appears to have dialed back somewhat on this interpretation, it’s understandable that it initially set industry back on its heels. But there’s a reason the National Institutes of Health (NIH), the FDA, and other august bodies deem RCTs the gold standard of clinical research—several reasons, in fact. Rice and others share their candidates for some of the most notable human clinical trials of the year. Consumers have long turned to botanical preparations to prevent or alleviate flu symptoms, but the clinical evidence supporting such preparations’ efficacy hasn’t always been ironclad.
More people die each year from cardiovascular diseases (CVD) than from any other cause of death, according to the World Health Organization (WHO). One study (2), published earlier this year in Thrombosis and Haemostasis, is helping to raise vascular health’s profile, as well as that of a form of vitamin K2 particularly suited to promoting it. While earlier population-based studies revealed an association between vitamin K2 consumption and cardiovascular risk, “this is the first study showing that long-term use of vitamin K2 in the form of MK-7 beneficially affects cardiovascular health,” noted Cees Vermeer, the study team leader and a researcher at Maastricht University in the Netherlands, in a press release.
Stomach distress can seem like an inevitability in a modern era of plentiful stressors and even more plentiful occasions to eat (often not very well).
One hundred subjects with gastroesophageal reflux disease (GERD)—56 men and 44 women ranging in age from 18 to 70—were treated with the PPI pantoprazole for six months and then randomized to receive either two daily doses of the probiotic Lactobacillus paracasei F19 (LP-F19) three days per week for six months, a similarly administered placebo, LP-F19 for the first three months followed by the placebo, or the placebo for the first three months and LP-F19 thereafter. Additionally, Brown finds it “interesting” that the probiotic was only administered twice daily for three days per week during the study. The long-chain omega-3 fatty acid docosahexaenoic acid (DHA) has a reputation as a brain-health powerhouse—a logical conclusion, given its importance as a constituent of brain phospholipids.
Scientists know that omega-3 and omega-6 fatty acids are chemical precursors to endocannabinoids, eicosanoid compounds similar to the active component in marijuana.
According to GOED’s Rice, “The number of people who’ve told me that they modified their omega-3 and omega-6 intake and no longer suffer any or as many debilitating headaches is staggering.
SIBO stands for small intestine bacterial overgrowth and it’s responsible for many common conditions that conventional medicine has no solid answers for.
The small intestine is where most of our nutrients are absorbed and, unlike the large intestine, is considered to be relatively sterile. Our small intestine has many important functions including digestion, nutrient absorption, immunity, and brain health.
Additionally, pathogenic bacteria are known to rob our body of key nutrients, leading to vitamin, mineral, and amino acid deficiencies. Unfortunately, SIBO is under-diagnosed and not well understood by the majority of healthcare practitioners. History and Exam: As a functional medicine practitioner, listening to the patient and performing a kinesiological exam will often reveal that SIBO is present. Additionally, manual correction of the iliocecal valve by a trained chiropractor or kinesiologist can be very helpful, both to lessen the acute symptoms and in the longterm recovery of SIBO. For reasons we don’t fully understand yet, SIBO often recurs in some susceptible patients. Enter your email address to subscribe to this blog and receive notifications of new posts by email. Turns out, there are a few different methods in use by health professionals to assess the nature of our bacterial microflora. The hydrogen breath test is a way of measuring the amount of hydrogen present in our breath when we breathe out. This procedure, known as an esophagogastroduodenoscopy, or EGD, is performed by passing a long, flexible tube with a camera (an endoscope) through the mouth, esophagus, stomach, and into the small intestine.
During my dietetic internship to become a registered dietician, I spent the better part of a year working in various units in a hospital.
The point is that despite bacterial cultures being considered the gold standard when testing for the presence of bacteria, invasive procedures are not something that you’ll see many people lining up for (at least not voluntarily).
One reason is that feces only contain a fraction of the millions of types of bacteria present in the gut. Other than the hydrogen breath test, these methods are generally inaccessible or unrealistic for most people unless there’s something more serious at work. Stay tuned for next time, when I’ll be addressing probiotics and their role in reestablishing balance to the microflora of the gut.
Although active in several sports from a young age, Peter struggled with being overweight through high school and into college. Nature's Secret Digestive Bliss Probiotic combines a proprietary blend of lactobacillus and other friendly bacterial organisms. Ingredients: Proprietary Probiotic Blend 4 Billion CFU (125mg), Lactobacillus Acidophilus, Bifidobacterium Bifidum, Lactobacillus Rhamnosus, Lactobacillus Salivarius, Bifidobacterium Longum, Bifidobacterium Infantis, Lactobacillus Bulgaricus, Lactobacillus Plantarum, Lactobacillus Casei, Lactobacillus Paracasei, Streptococcus Thermophilus, Lactobacillus Brevis, Lactobacillus Reuteri, Lactococcus Lactis, Lactococcus SP Lactis, Lactococcus Fermentum, Lactococcus Helveticus, Enterococcus Faecium, Lactococcus Keferi, and Fructo Oligosaccharides (FOS) (25mg).
After all, as any researcher will attest to, even one well-controlled human clinical study—to say nothing of two—is incredibly complex, time-intensive, not to mention expensive to do. Some consider such large-scale, randomized, controlled human studies indispensable for revealing consistent, unbiased information about a supplement’s effects, allowing us better to determine appropriate dosing, understand a mechanism of action, and elucidate benefits.

A randomized, double-blind, placebo-controlled clinical trial (1) comparing the effects of a product containing Echinacea (Echinacea purpurea) herb and root extract plus European elderberry (Sambucus nigra) juice or extract against the common prescription flu treatment oseltamivir (Tamiflu) adds one more mark to the pro-botanical column.
And the relationship linking CVD, diet, and circulating triglycerides and cholesterol levels is almost common knowledge among health-aware consumers and the medical and scientific communities alike.
The three-year study involved 244 healthy postmenopausal women aged 55 to 65 who took 180 mcg of a menaquinone-7 form of vitamin K2 (MenaQ7 natural vitamin K2 MK-7; NattoPharma, Oslo, Norway) or a placebo daily. No surprise, then, that use of proton-pump inhibitors (PPIs)—drugs that reduce gastric-acid production—has grown. The results of the multicenter trial “suggest that concomitant use of probiotics—most likely Lactobacilli strains—may reduce bowel symptoms such as bloating and flatulence but not abdominal pain in patients taking PPIs long-term,” says Donald J Brown, ND, managing director, Natural Product Research Consultants (Seattle). But the brain can’t synthesize DHA from scratch, which suggests that our bodies need to shuttle the fatty acid across the blood-brain barrier. But two subsequent studies (5,6) published in 2015 involved human subjects and significantly moved the ball forward in explaining how DHA makes its way into cerebral tissue, and what happens when that transport is stymied.
Nguyen LN et al., “Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid,” Nature, vol. Guemez-Gamboa et al., “Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome,” Nature Genetics, vol. Alakbarzade V et al., “A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome,” Nature Genetics, vol. As such, the fatty acids have demonstrated pain- and anxiety-fighting, as well as neurogenic, properties in previous studies.
Obviously, for some, this may be nothing more than a placebo effect, but the results of Dr. Ramsden CE et al., “Diet-induced changes in n-3- and n-6-derived endocannabinoids and reductions in headache pain and psychological distress,” The Journal of Pain, vol. An ever-growing number of ailments such as chronic fatigue syndrome, fibromyalgia, autoimmune conditions, irritable bowel disease, leaky gut, and multiple food sensitivities are frequently the result of SIBO. That means, under normal circumstances, there are only a few bacteria present in the small bowel. It is also home to friendly bacteria (probiotics) that are an essential part of our overall health. Because these bad bacteria are not normally present in the intestines in significant amounts, they can’t interfere with absorption. The valve that divides the small intestine from the large intestine, called the ileocecal valve, can become dysfunctional and allow bacteria from the large intestine to migrate into the small intestine. The overgrowth of bacteria causing SIBO give off hydrogen and methane gases (which are what cause the bloating) and these gases can be detected in one’s breath.
Normally, these byproducts are not found in the urine, and when present, predict SIBO or yeast overgrowth.
There was a great response to the article, and one of the comments was a question asking how we assess whether or not our gut bacteria are healthy. Unfortunately, there are a few things that can affect the accuracy of the hydrogen breath test. This is because the presence of bacteria in the small intestine is a compelling sign of gut bacteria imbalance and small intestinal bacterial overgrowth. During one of my stints, I had the esteemed opportunity to observe a day of endoscopic procedures. Try eliminating refined sugars and other processed and highly inflammatory foods and see if there’s a change. He wears many hats in his professional life, as resident sports dietitian for Portland State University Athletics, independent nutrition consultant, and personal trainer at Premier Sport & Fitness in Happy Valley, Oregon.
A healthy digestive tract contains a variety of friendly bacteria, which it must maintain in proper balance for overall health. Such randomized controlled trials (RCTs) take a long time and a large number of participants to carry out. And, for those who require them, RCTs burnish the legitimacy of an industry that often finds itself on the defensive.
Rice PhD, vice president of regulatory and scientific affairs, GOED (Global Organization for EPA and DHA Omega-3s; Salt Lake City). The results of the trial—involving 473 patients spread across 29 medical practices in the Czech Republic—showed the herbal extract (Echinaforce Hotdrink; A.
But the role of vascular health in the onset and development of CVD hasn’t been as well known, until now. Using pulse-wave velocity and ultrasound—measurements that indicate the blood’s ability to flow through the vessels—researchers determined that the vitamin K2 inhibited age-related arterial stiffening and improved vascular elasticity to a statistically significant degree. But PPIs have appeared in some studies to encourage small-intestine bacterial overgrowth (SIBO) that leads to diarrhea, abdominal pain and bloating. Just how that happens has been something of a mystery until recently, when several studies identified the protein MFSD2A as the major transporter for DHA uptake into brain.

The results: among the study’s 55 participants, the dietary intervention increased levels of omega-3 derivatives while reducing those of omega-6, with the changes in omega-3 derivatives—but not omega-6 derivatives—correlating with reductions in physical pain and psychological distress. Occasionally, however, healthy bacteria from the large intestine can make their way into the small intestine, or the few bacteria normally present in the small intestine can multiply out of control. These bacteria synthesize several important nutrients including folic acid, vitamin K, and butyric acid (known to improve metabolism and protect against inflammation and insulin resistance), and aid in the absorption of many other nutrients.
However, as their numbers increase, they selfishly absorb nutrients for their own needs leaving less available for us.
The enzymes that digest and sterilize food can become low, and some foods and beverages can feed the unwanted organisms. The standard tests used by most doctors to evaluate the digestive tract will not detect SIBO. This includes continuing to follow a relatively low carb, ancestral diet, including fermented foods and resistant starch, limiting stress and stimulants (coffee and alcohol), and adopting a restorative exercise plan (yoga, tai chi, energizing hikes, or progressive relaxation exercises). First, not all bacteria in the body produce hydrogen, in which case they would be missed by the test. Bacteria further upstream in the stomach and small intestine are not generally accounted for in the feces. Methodology and indications of H2-breath testing in gastrointestinal diseases: the Rome Consensus Conference.
Lactobacillus organisms are considered friendly bacteria as they play an important role in digestive function and immune health of the small intestine.
And they aren’t even always appropriate—or necessary—for answering the questions or establishing the knowledge that researchers or industry seeks. Vogel Bioforce AG, Roggwil, Switzerland) to be effectively equal to the prescription treatment in its therapeutic effects, with a similar number of participants in both the botanical and prescription groups exhibiting mild or no symptoms after one, five, and 10 days of treatment. A randomized, double-blind, placebo-controlled trial (3) recently looked at the role of probiotic bacteria in ameliorating those symptoms. Another important job of these healthy microorganisms is to limit the growth of the unfriendly or pathogenic bacteria, yeast, and parasites. Substances like undigested food particles, bad bacteria, intestinal toxins, and protein complexes such as gluten pass through the “leaky” intestine into the bloodstream activating the immune system. Besides eating our food, pathogenic microorganisms have been found to excrete toxic byproducts that can congest the liver, irritate joints, and affect hormone balance.
Colonoscopies, endoscopies, ultrasounds, blood tests, etc., will all be negative and may leave one feeling discouraged or crazy. Second, disorders of carbohydrate metabolism such as celiac disease, can produce false positives.
Sedatives are often used to help people relax during these procedures, and you can imagine why.
And if you’re more proactive, taking a probiotic supplement or increasing your intake of fermented foods can potentially be a very beneficial step in the right direction.
These small microbes coat the intestinal wall and play a key role in the proper breakdown of food. The body’s natural response to these foreign invaders is to trigger inflammation and immune reactions resulting in allergies, food reactions, muscle and joint pain, autoimmunity and depression. When not at adequate levels, the digestive system is less able to digest food properly and low levels of friendly bacteria may lead to gas, bloating and abdominal discomfort. A patient suffering with digestive issues goes to see their primary doctor or a specialist and all the tests are normal. The proprietary blend of probiotics in this formula contains Lactobacillus Reuteri to support the body's natural defenses and to help maintain healthy equilibrium in the gastrointestinal tract.
The doctor discounts the patient or may blame the symptoms on stress, hormone imbalance, depression, or just getting older.
This probiotic strain secretes reuterin, a substance with beneficial properties to promote a healthy balance of "good" bacteria.
The key breakthrough of Digestive Bliss Probiotic is its patented delivery system which is designed to deliver live probiotic bacteria into the gastrointestinal tract. Each patented technology tablet of Digestive Bliss Probiotic forms a gel barrier around the tablet as soon as it is ingested. This barrier helps protect the delicate probiotic organisms inside as they travel to the low acid environment of your small intestine. Take a look at the way our medical system is organized-from cardiologists to dermatologists, we have a doctor for nearly ever body part.

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Category: Flora Probiotics | 26.12.2015

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