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Abstract In this study, we investigated the influence of ?-asarone, the major ingredient of Acorus tatarinowii Schott, on depressive-like behavior induced by the chronic unpredictable mild stresses (CUMS) paradigm and to clarify the underlying mechanisms. The results show that ?-asarone treatment partially reversed the CUMS-induced depression-like behaviors in both the forced swim and sucrose preference tests.
We did not observe a complete reversal of depression-like behaviors to control levels by ?-asarone. To our knowledge, the present study is the first to demonstrate that adult neurogenesis is involved in the antidepressant-like behavioral effects of ?-asarone, suggesting that ?-asarone is a promising candidate for the treatment of depression.
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