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Treating acute tinnitus, ringing ears dizzy - Review

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Auris Medical, Basel, Switzerland, is about to start the planning phase for a clinical trial of its new tinnitus drug. Emerging evidence suggests that NMDA receptors in the cochlea play a major role in the occurrence of tinnitus following inner ear excitotoxicity, which is characterized by excessive synaptic release of glutamate, the principal neurotransmitter in the auditory system. Of them, 300 will be patients at the acute stage (up to 3 months from tinnitus onset) and 300 will be at the post-acute stage (4 to 12 months from tinnitus onset).

Inner ear tinnitus may be provoked by various injuries to the cochlea, the organ of hearing, such as overexposure to noise or inflammation. It will be designed to confirm the efficacy and safety of the product in the treatment of acute peripheral tinnitus following traumatic cochlear injury or otitis media. As of today, there exists neither a universal standard of care for acute inner ear tinnitus, nor a truly proven, effective treatment method.

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