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07.06.2015

Tinnitus drug trials 2013, lipoflavonoid side effects benefits - For Begninners

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UT Dallas researchers have demonstrated that treating tinnitus, or ringing in the ears, using vagus nerve stimulation-tone therapy is safe and brought significant improvement to some of the participants in a small clinical trial.
For the study, a stimulation electrode was implanted directly on the vagus nerve of 10 tinnitus sufferers. Henry Ford Health System, Detroit, Mich, is one of many institutions around the world seeking participants for two clinical trials investigating tinnitus, a chronic ringing of the ears affecting more than 600 million people worldwide.
Tinnitus affects more than 12% of American troops who have been exposed to acoustic trauma from machinery and explosive devices. Tinnitus in the inner ear is often a consequence of an acoustic trauma, barotrauma, operation on the middle ear, traumatic perforation of the eardrum or middle ear infection.


Henry Ford is one of 70 sites worldwide involved in this National Institutes of Health-supported study and it is currently recruiting patients aged 18-75, and have been diagnosed within the past three months or less with acute inner ear tinnitus brought on by acoustic trauma, barotrauma, operation on the middle ear, traumatic perforation of the eardrum or middle ear infection. Eligible participants are ages 22-65, who have been diagnosed with subjective tinnitus due to hearing loss with sensorineural aspects and at least some tonal quality of the tinnitus. Sven Vanneste and Michael Kilgard of the School of Behavioral and Brain Sciences used a new method pairing vagus nerve stimulation (VNS) with auditory tones to alleviate the symptoms of chronic tinnitus. While the tinnitus often goes away after a short period in these circumstances, it can persist in some cases even after the injury has healed.
Participants must have experienced tinnitus (unilateral or bilateral) for at least one year.


Investigators are seeking to determine the drug’s safety and effectiveness in lessening the excessive signaling to the brain that occurs with acute inner ear tinnitus, most often caused by noise trauma or infection. The company intends to secure a CE mark for both systems next year, and then raise more funds to support a clinical trial for a pre-market approval in the U.S. AM-101 inhibits certain receptors in the inner ear that are thought to play a key role in the development of tinnitus.



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