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14.04.2015

Tinnitus cure potassium, best treatments for depression and anxiety - Try Out

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Neurophysiologists at the University of Connecticut (UConn) have discovered a new drug that may prevent tinnitus and treat epilepsy by selectively affecting potassium channels in the brain.
In 2013, Tzingounis began collaborating with Thanos Tzounopoulos, PhD, a tinnitus expert at the University of Pittsburgh, to create a new drug candidate.
The co-authors explain in their article that KCNQ potassium channels are found in the initial segment of axons, long nerve fibers that reach out and almost touch other cells. In some types of epilepsy, the KCNQ potassium channels have trouble opening and shutting down runaway electrical potentials in the nerve synapse.
While exact statistics on tinnitus are not easy to determine, the American Tinnutus Association estimates that two million people in the US suffer from disabling tinnitus. They first had to determine if SF0034 worked on KCNQ potassium channels the same way retigabine does, and if so, if it would be better or worse.


It appeared to open only KCNQ2 and KCNQ3 potassium channels, and to not affect the KCNQ 4 or 5 potassium channels. I have Chronic Tinnitus causing almost deafness in my right ear and I have Tinnitus in my left ear which is affecting my hearing.
But for others it can become chronic and almost intolerable.There are currently no drugs available to treat or prevent tinnitus. Originally developed by SciFluor, the company wanted to know whether the compound had promise for treating epilepsy and tinnitus. According to the authors, there are five different kinds of KCNQ potassium channels in the body, but only two are important in epilepsy and tinnitus: KCNQ2 and KCNQ3.
When the Tinnitus (sometimes pulsatile) gets really loud and I cannot hear well I have to wear my hearing aid.


When that electrical potential goes on too long, or gets overactive, the KCNQ potassium channel kicks in.
The result is that it opens, potassium ions flood out, and the sodium-induced electrical potential shuts down.



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