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26.01.2015

New cures for hearing loss, how stop ringing in ears - Reviews

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Action on Hearing Loss and Deafness Research UK have confirmed the two charities have merged.
Our vision is to find a cure for hearing loss and tinnitus, and to develop medicines to protect hearing and prevent tinnitus so that nobody needs to be isolated. Our vision is to find a cure for hearing loss and tinnitus, and to find medicines to protect hearing and prevent tinnitus, so that nobody needs to be isolated. Find out about our current projects and what our researchers and PhD students are working on.
Get monthly updates on the latest achievements in our research programme and news from the wider world of hearing and tinnitus research.
Registered Office: Action on Hearing Loss is the trading name of the Royal National Institute for Deaf People (RNID). Noise-induced hearing loss has the potential to be reversed, according to a new study from Harvard Medical School. Hearing loss affects close to 50 million people in the United States and prolonged exposure to very loud noises is one of the most common forms of auditory loss. However, in an animal study published in Stem Cell Reports, researchers found that by applying an enzyme-inhibiting drug to the cochlea of deaf newborn mice, they were able to induce supporting cells in the ear to transform into hair cells.


The study results are the first demonstration of hair cell regeneration in an adult mammal and they hope these findings may someday lead to treatments that could induce hair cell regeneration in the humans, to treat noise-related hearing loss. Through the Hearing Restoration Project (HRP), Hearing Health Foundation is striving toward a cure for hearing loss and tinnitus, a promise that is very real.
The HRP consortium of scientists has developed a strategic research plan to develop a cure for hearing loss and tinnitus. About a third of 65-year-olds identify as hearing impaired, a number that rises to half by age 75.
Harvard Stem Cell Institute (HSCI) investigators have made it their mission to develop new ways to prevent and treat hearing loss. Stem cells can also be used to screen for drugs that could stimulate the regeneration of hair cells. Excitingly, our investigators then found that when the stem cell-derived auditory neurons were transported into deaf animals, the neurons helped to re-establish broken connections and animal hearing was improved.
There are 10 million people in the UK who have some level of hearing loss and right now, there are no cures.
Currently, there are no known treatments to restore noise-related hearing loss, which is caused by the destruction of sensory hair cells in the cochlea - the auditory component of the inner ear.


Underlying that promise is the discovery that chickens have the ability to spontaneously restore their hearing and the HRP is aiming to enable just that in humans.
The only available treatments for hearing loss are prosthetic devices, such as hearing aids and cochlear implants. This method has already produced drugs capable of partially restoring hearing in deaf rats. Experiments on stem cell-derived auditory neurons show that they will form new connections with damaged hair cells in a laboratory dish. The final step before application to the human ear will be to determine the best surgical approaches for cell transplantation. The plan, developed specifically by the HRP scientists and continuously updated to incorporate new findings and approaches, is a living document meant to guide but not limit the work.
We experience the slow progression of hearing loss as these fragile cells die due to excessive noises, exposure to certain drugs, and aging.



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