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Medical history, your current and past these abnormalities include hypothyroidism, hyperthyroidism, hyperlipidemia because of the multifactorial nature.

02.06.2014

Muscle fatigue and heart disease, does lipoflavonoid work - Reviews

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The library is an integral part of a project being developed by FAPESP - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, in partnership with BIREME - the Latin American and Caribbean Center on Health Sciences Information. The Project envisages the development of a common methodology for the preparation, storage, dissemination and evaluation of scientific literature in electronic format.
The interface also provides access to the full text of articles via author index or subject index, or by a search form on article elements such as author names, words from title, subject, words from the full text and publication year. One of the most frequent causes of hospital admissions in older adults is the devastating condition known as congestive heart failure. Fortunately, scientists have discovered that the mitochondrial energizer coenzyme Q10 (CoQ10) can offer powerful assistance to those challenged with congestive heart failure, improving the heart’s pumping ability and even reducing the need for medications.
Since CoQ10 levels are depleted by aging and statin medications and tend to be low in those with congestive heart failure, achieving optimal blood levels of CoQ10 may be an important strategy for safeguarding cardiac health. It has been 50 years since Fred Crane discovered CoQ10 in 1957.1 Since that time, scientists have discovered what this extraordinary molecule is and what it does in settings of both health and disease.
In the late 1960s and early 1970s, it became clear that patients suffering from congestive heart failure had measurable deficiency of CoQ10 in both blood and heart muscle, and that the degree of deficiency correlated with the severity of heart failure. This demonstrates the simultaneous drop in plasma CoQ10 level and ejection fraction in a 70-year-old female patient started on statin therapy. Congestive heart failure is a condition in which there is weakening of heart muscle function so that fluid or congestion backs up and causes swelling or edema in the liver, lungs, the lining of the intestine, and the lower legs and feet. In the course of this six-year study, the 126 patients were followed very closely with measurement of blood CoQ10 levels and heart function every three months.4 We unexpectedly came across the detrimental effect of the cholesterol-lowering drugs known as HMG-CoA reductase inhibitors, or more simply as statins. All statin drugs block the biosynthesis of both cholesterol and CoQ10, which explains statins’ common side effects of fatigue, muscle pain and muscle weakness, and a worsening of heart failure (see figure 2). All statin drugs (HMG-CoA reductase inhibitors) block the biosynthesis of both cholesterol and CoQ10, which explains their common side effects of fatigue, muscle pain, and a worsening of heart failure. When CoQ10 levels are lowered by statin drug therapy, one of the first changes to occur is a weakening of heart muscle function, known as diastolic dysfunction. In 2004, a study published in the American Journal of Cardiology showed that diastolic dysfunction (heart muscle weakness) occurred in 70% of previously normal patients treated with 20 mg a day of Lipitor® for six months.
All 50 patients were found to have one or more side effects from statin therapy, so we discontinued their statin drugs and began supplemental CoQ10.
A high prevalence of skeletal muscle pain and weakness at 64% on initial visit was reduced to 6% in follow-up. There were no adverse effects from stopping statin drug therapy with no cases of heart attack or stroke during follow-up.
In the early years of our experience with CoQ10 therapy, no one knew the therapeutic or ideal plasma level of CoQ10 for the treatment of heart failure.
Out of a total of 22 controlled trials of supplemental CoQ10 in congestive heart failure, only three have failed to show significant benefit. Heart symptoms may not always be explicit so do not ignore any potential cardiac warning signs.
When chest pain is heart-related it is often centered under the breastbone, slightly to the left of center.
In heart failure, fluid may accumulate in the lungs, causing a persistent cough or wheezing. Heart attacks and heart rhythm abnormalities called arrhythmias can cause dizziness, lightheadedness, and even fainting.


Fatigue is one of those symptoms that can be attributed to many different medical conditions. During a heart attack or heart failure, fluid may leak into the lungs, causing shortness of breath.
Breaking out into a sudden sweat for no reason is actually a common symptom of a heart attack. When the heart is weakened it pumps blood less effectively, and this can lead to fluid retention that results in swelling (edema) of the lower extremities or abdomen. Characterized by disabling symptoms of difficulty breathing, fatigue, and swelling of the extremities, congestive heart failure also increases the risk of early demise. It is the only fat-soluble antioxidant that is synthesized by our body and is capable of regeneration back to its reduced or antioxidant form through normal cellular enzyme systems. Much of this work was performed as a collaborative effort between Professor Karl Folkers, PhD, Gian Paolo Littarru, MD, and Denton Cooley, MD.2 In 1980, my father, cardio-logist Per H. It was our initial concern that CoQ10 may have been acting as a stimulant that could bring about short-term improvement in heart muscle function but actually increase mortality over time. The first statin drug, lovastatin (Mevacor®) came on the market in 1987, and five of our heart failure patients were started on this drug by their primary care physicians. This heart muscle dysfunction was reversible with supplemental CoQ10.7 Heart failure that develops after years of statin drug therapy can be termed statin cardiomyopathy and may well be playing a role in the epidemic of congestive heart failure in the United States. Overall, there was an improvement in heart muscle function on discontinuation of statin therapy and addition of supplemental CoQ10. Many factors more important than cholesterol—such as stress, smoking, hypertension, insulin resistance, high triglycerides, diabetes, and low testosterone (in men)—contribute to atherosclerosis and cardiovascular disease.17-19 Despite this, the theory that cholesterol is the dominant villain responsible for atherosclerosis has been promulgated for over 60 years, making the pharmaceutical industry’s anti-cholesterol campaign the most profitable medical myth of all time. But heart disease can be deadly because many people don't recognize some early signs and symptoms and they don't seek treatment until it may be too late.
Some warning signs not to ignore include: shortness of breath, heartburn, muscle soreness, painful hiccups, neck or upper back pain, or other symptoms discussed in this slide show. Don't ignore them or wait for them to go away – see your doctor for testing and diagnosis.
You may feel as if you are having a panic attack and experience shortness of breath, palpitations, chest pain, and dizziness. Many different conditions can cause these kinds of symptoms, so see a doctor to find out if heart disease is the cause of your dizziness. Sometimes women in particular to experience unusual fatigue during and in the days prior to a heart attack.
Sometimes the poor circulation due to a weak heart or blocked arteries can cause these symptoms.
Many people experience heart attacks as pain that begins in the chest and spreads to the shoulders, arms, back, neck, jaw, or abdomen.
But if you have a rapid or irregular heart rate this could be a symptom of a heart attack, heart failure, or an arrhythmia. If you have any risk factors for heart disease it is especially important to pay attention to your body and get any symptoms checked out by a doctor. It is intended for general informational purposes only and does not address individual circumstances.
Its location in the lipid mitochondrial membranes is particularly important, as mitochondria are the major site of free-radical production, and CoQ10 is an excellent free-radical scavenger.


All five of these stabilized patients had a significant decline in their blood CoQ10 levels and a decline in their heart function and clinical status. After heart muscle contracts, it takes a great deal of cellular energy, or ATP, to re-establish the calcium gradients such that muscle fibers may relax. However, due to powerful propaganda surrounding both cholesterol and statin drug therapy, many patients and physicians are afraid to stop statin therapy. By 2006, there were a total of 22 randomized, controlled trials involving a total of 1,605 patients evaluating the therapeutic benefit of supplemental CoQ10 in congestive heart failure.22-24 The majority of studies were favorable, showing significant improvement in heart muscle function. People with known heart disease or significant risk factors such as people over age 65, strong family history of heart disease, obesity, smokers, high cholesterol, high blood pressure, or diabetes should pay extra attention to any possible cardiac symptoms. In addition, chest pain can be a result of other conditions that are not related to the heart.
Men may experience pain in their left arm during a heart attack; women may experience pain in either arm or between the shoulder blades. Shortness of breath can be due to other conditions such as chronic obstructive pulmonary disease (COPD) but it can also be a sign of heart attack or heart failure. Blood gets diverted to the most critical organs such as the heart, lungs, and brain, and away from the muscles. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. By following these 126 heart failure patients for six years, it became clear that the improvement in heart function was sustained and that overall mortality was one third of expected.4 It was at this time that we realized CoQ10 represented a major advance in the treatment of a disease that previously could be only palliated and never cured. Their heart failure worsened to such a degree that two patients became critically ill and one went on to require a heart transplant. Furthermore, there have been 34 open-label trials involving 4,221 patients evaluating the clinical utility of CoQ10 in heart failure, and again clear benefits were observed without any adverse effect or drug interaction.
If you have any cardiac disease risk factors, including being male, over age 65, have high cholesterol or high blood pressure, are obese, a smoker, diabetic, or have a family history of heart disease you need to pay extra attention to any potential heart disease symptoms. Seek medical attention immediately – some arrhythmias can lead to stroke, heart failure, or death without prompt medical intervention.
Because the heart muscle uses more energy than any other tissue and normally has the highest concentration of CoQ10, it is very sensitive to CoQ10 deficiency. Despite these studies, CoQ10 remains obscure to most physicians and is not routinely used in the treatment of congestive heart failure. One patient in particular showed a simultaneous drop in plasma CoQ10 level and ejection fraction when started on statin therapy, with improvement after the statin was discontinued (see figure 1).
This is in part due to the pervasive anti-nutrient bias in conventional medical practice, medical literature, and medical education. Unfortunately, these patents have never been acted on and to this day, the vast majority of physicians and patients are completely unaware of statin-induced CoQ10 depletion.



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