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02.08.2015

Chronic fatigue syndrome virus, natural remedies for sleep deprivation - Plans Download

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The journal Science has decided to put that link to rest by officially retracting the original research paper that first suggested chronic fatigue syndrome was caused by the virus "XMRV" typically found in mice. The journal declared in May that the paper's validity was "seriously in question" after two studies suggested the viral link may have been due to contaminated lab samples.
The news that scientists are no closer to finding a cause for the syndrome may disappoint some of the million-plus Americans who suffer from chronic fatigue.
Then in September, a new study found no link between XMRV and chronic fatigue syndrome and concluded lab tests used in the original study were unreliable, CBS Newsreported. The disease is characterized by overwhelming fatigue for at least six months despite ample rest.
Abnormalities in the central and autonomic nervous systems, possibly linked to a viral trigger and ongoing immune system dysregulation, may play a role in the pathophysiology of the disorder.
A two-year follow-up study of chronic fatigue syndrome comorbid with psychiatric disorders. Determinants of health care use in chronic fatigue syndrome patients: a cross-sectional study. Comparative epidemiology of chronic fatigue syndrome in Brazilian and British primary care: prevalence and recognition. Etiology of chronic fatigue syndrome: testing popular hypotheses using a national birth cohort study.


The nosology of sub-acute and chronic fatigue syndromes that follow infectious mononucleosis. The xenotropic murine leukemia virus-related retrovirus debate continues at First International Workshop.
Chronic fatigue syndrome can't be diagnosed with a simple test, so doctors diagnose it by ruling out other diseases. Although no laboratory findings are specific for CFS, the pattern of certain laboratory results and clinical presentation can support the diagnosis in patients with cognitive dysfunction in whom other diseases have been excluded as a cause of fatigue.
Three conditions characterized by chronic fatigue that should initially be ruled out in the workup are fibromyalgia, hypothyroidism, and Lyme disease.
Many patients with CFS report that their illness followed an infection.12-16 A wide variety of viral infections—including glandular fever, hepatitis, meningitis, and parvovirus and enterovirus infections—are known to trigger CFS. Although infections are a common trigger, most current evidence suggests that persistent viral infection is not part of the ongoing pathology.
There is evidence, some of it replicated, to indicate that abnormalities in the central and autonomic nervous systems, possibly linked to a viral trigger and ongoing immune system dysregulation, play a key role in the pathophysiology of CFS.14Recently, scientists identified a virus in 68 of 101 patients who had received a diagnosis of CFS. Whether the virus known as xenotropic murine leukemia virus (XMRV) causes the syndrome is still unclear.17DIAGNOSTIC CRITERIACDC criteria. The Oxford criteria differ slightly from the CDC criteria in that they emphasize the presence of mental fatigue.15,16,18,19 The major inclusion criterion is severe disabling fatigue of at least 6 months’ duration that affects both physical and mental functioning and is present more than 50% of the time.


These tests can be used to exclude other diseases associated with fatigue.12-16 The most consistent laboratory abnormality in patients with CFS is an extremely low erythrocyte sedimentation rate (ESR), which approaches zero. A normal ESR or one that is in the upper reference range suggests another diagnosis.Thyroid function tests—chiefly, measurement of thyroid-stimulating hormone—are useful in ruling out other disorders that may be associated with fatigue. Conditions that are characterized by chronic fatigue should initially be ruled out; these include fibromyalgia, hypothyroidism, and Lyme disease. Acute Lyme disease usually has a neurological component, but chronic neuroborreliosis is distinctly uncommon. Patients with chronic neuroborreliosis do not have the same cognitive defects as patients with CFS and usually do not present with fatigue as their chief complaint.18,22Gulf War syndrome. It is estimated that 1 in 4 of the 697,000 US Gulf War veterans has this condition.23The syndrome is characterized by disabling fatigue, intermittent fever, night sweats, arthralgia, myalgia, headache, rashes, intermittent diarrhea, abdominal bloating, chronic bronchitis, photophobia, transient visual scotomata, short-term memory impairment, confusion, irritability, and depression.



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