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09.05.2014

Adrenal fatigue and ms, tinnitus clinical trials - For Begninners

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Many people question whether a total and complete recovery from adrenal fatigue is possible. Most people have a mistaken belief that the hallmark of a successful recovery program has an early onset of increased energy and fatigue removal. Overtime, the body starts to decompensate, and with a stressful event, a crash is triggered and the recovery process goes backwards down a few steps. This Web Site and all content and materials included on this Web Site, including without limitation all information, text, graphics, illustrations, photos, video, sound and software (collectively the "Content"), are copyrighted and protected under U.S.
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For fast reading, scan through the topic headings in BOLD BLACK, important conclusions in BOLD BLUE, and "Must Know" in BOLD RED. Symptoms of hypoglycemia include hunger, nausea, headache, rage, lethargy, daydreams, confusion, amnesia, dizziness, fatigue, irritability, anxiety, jittery feelings, adrenaline rush, elevated heart rate, memory loss, and in severe cases, fainting, coma, and seizures. Key hormones regulating blood sugar in the body include insulin, cortisol, and growth hormone.
Sub-clinical hypoglycemia secondary to Adrenal Fatigue requires a systematic and comprehensive approach to be prevented and reversed due to its chronic nature. Take protein (such as nuts, meat, beans, cottage cheese, whole milk yogurt) and fat (nut, extra virgin olive oil, coconut, whole milk yogurt, avocado) with each meal or snack. The key to a successful Adrenal Recovery Exercise Program involves a well thought-out strategy that helps you regain control of the core functions of the body. Those in early Adrenal Fatigue (Stages 1 and 2) may only feel tired intermittently and tend to recover from any low energy state quickly, Those in advanced Adrenal Fatigue (Stage 3 and 4) are characterized by a constant low energy state and fatigue, only to worsen over time. It is important to provide and have a consistent and maintained energy stream for vital organs to overcome low energy state. A properly designed Adrenal Recovery Exercise Program needs to factor in the following technical components as well: breathing, muscle toning, stretching, strength training, motion fluidity, control, and systemic circulation. As with any exercise program, always consult and seek approval of your personal treating physician prior to beginning. Three main sets of muscles are active when you breathee normally: the intercostal muscles, the abdominal muscles, and the respiratory diaphragm. The ANS is broadly divided into the Sympathetic Nervous System (SNS), which is responsible for adrenaline release and the fight or flight response on one side, and the Parasympathetic Nervous System (PNS), which is responsible for rest and relaxation of the body's internal function. Adrenal Fatigue, especially in the advanced state, is invariably tied to overstimulation of the SNS. Proper adrenal breathing releases tension from the body, clears the mind, reconnects the body to the mind, reduces fatigue, and improves both physical and mental wellness. Bear in mind that in Eastern cultures, breathing is also used as an effective modality to enhance energy and alertness by stimulating the body's Sympathetic Nervous System (SNS). Beginning students and those with advanced Adrenal Fatigue (Stage 3 or higher) and weak constitutions should be very careful in the inhalation and exhalation intensity. If properly done, Adrenal breathing Exercise using the diaphragm helps to restore adrenal health by enhancing parasympathetic tone, improving lymphatic circulation and clearing up toxic metabolites. Adrenal breathing Exercise takes as little as a few minutes to complete and can be done anywhere at anytime. In addition to adrenal hormones, the use of thyroid replacement to overcome fatigue brought on by Adrenal Fatigue is a common practice.
Clearly, hormone replacement therapy in a setting of Adrenal Fatigue requires careful attention and the use of adrenal hormones needs to be put into perspective. Medical science is just beginning to find out that a person can feel horrible and function poorly even with a minimal to moderate hormone deficiency that is clinically undetected by routine blood tests. The adrenal glands are two small glands; each about the size of a large grape and their role in producing hormones required for optimal living is crucial.
In addition to output considerations, we need to pay attention to how these hormones are broken down and metabolized. A steroid is a chemical substance with four carbon ring structures attached to each other in a very specific and unique fashion.
Each hormone produced acts as part of an overall orchestra of hormones where proper balance is essential for optimal adrenal function.
This paper will examine some of the most common steroidal hormone replacements and their clinical ramification in the Adrenal Fatigue setting and these hormones are: Pregnenolone, DHEA, cortisol, melatonin, testosterone, estrogen, and progesterone. Back in the 1940's, when researchers started experimenting with the use of pregnenolone, they realized that it could be helpful for people who were under stress and that it could also increase energy in those who were fatigued. During periods of stress, the output of adrenal steroids such as cortisol will increase, which will put a great demand on pregnenolone production.
Some with Adrenal Fatigue find pregnenolone replacement improves their energy, vision, memory, clarity of thinking, well being, and often sexual enjoyment or libido.
The cells of the adrenal glands, as well as the central nervous system, synthesize pregnenolone.
Taking pregnenolone for adrenal fatigue can therefore be challenging for multiple reasons as paradoxical reaction is a major concern.
Pregnenolone is converted in the body to progesterone and these two hormones have some overlapping similarities. Over stimulation and insomnia - low doses can be helpful for sleep when taken in the morning.
Pregnenolone may cause disturbances in the endocrine system, including changes in the menstrual cycle and problems associated with hormone sensitive diseases, or it may interact with hormone therapy such as oral contraceptives. This usually follows immediately after the preparation period and can last a few days to 12 weeks if the preparation period is carried out properly. Though the most dramatic improvement often comes in the first few cycles, one accumulates more energy with time, and fatigue becomes less pronounced. They crash right from the beginning and never fully recover from it, as illustrated in line C. Lam was first to coin the term, ovarian-adrenal-thyroid (OAT) hormone axis, and to describe its imbalances. She received her Bachelor of Science degree in Dietetics, holds a Master’s Degree in Public Health in Nutrition, and a Master of Science degree in Nutrition from Loma Linda University, in Loma Linda, California.
Compared to a normal person or even one with compromised insulin control, those with Adrenal Fatigue tend to have symptoms of hypoglycemia even though the serum blood sugar may be within the normal range. Conditions associated with Adrenal Fatigue that might also play a part in sugar regulation include PCOS, metabolic syndrome, drug effects, adrenal insufficiency, and diabetes.
This will lead to slower release of sugar in the body and thus extend the time you become hypoglycemic between meals.
While these are beneficial to general good health and promotes circulation and muscle strength, it is not the best solution when it comes to Adrenal Fatigue. It needs to take into consideration the state of adrenal function (Stage of Adrenal Fatigue), the amount of reserve remaining, the biological constitution, age, metabolic issues, past medical history, and injuries. In quiet times when there is less need for air, the PNS mildly constricts the smooth muscle that surrounds the airways, especially the smaller bronchioles, and thereby impedes the flow of air to and from the alveoli. Extensive experiments have shown that Type A high strung personalities have about threefold more plasma norepinephrine responses and fourfold larger adrenaline responses during exposure to various laboratory and clinical stressors than compared to Type B individuals who are laid back and relaxed. Abnormal breathing patterns in an Adrenal Fatigue setting can over-stimulate the SNS, trigger panic attacks, and contribute to adrenal crashes.
This is seen frequently in certain types of yoga breathing and is usually accomplished by various techniques involving breathe holding that gradually increases intensity and performing quick breathing exercises with high frequency (belly breathing). All sympathetically driven and oriented breathing techniques should therefore be restricted and not be deployed until the adrenals are well healed or unless directed by your health care professional. Forcing more air in and out of the lungs beyond what the body can tolerate may drain the body of reserve and potentially have a negative effect of activating the SNS.
The activity also improves vital capacity, supports healthy ANS balance, improves tissue oxygen saturation, and effects gentle rhythmic massage on the GI track and internal organs including the adrenals, and optimizes musculo-skeletal tone.
In fact, many people with Adrenal Fatigue with symptoms of low thyroid function are prescribed thyroid medications as if they suffer from primary hypothyroidism. In the right situation and using the right dose, hormone replacement can be of great benefit.


The outer adrenal cortex comprises eighty percent of the adrenal gland and is responsible for producing over 50 different types of hormones in three major classes-glucocorticoids, mineral corticoids and androgens.
Hormones can be over-produced or under produced, depending on the state of fatigue of the adrenals, and also on each person's intrinsic body constitution.
Cortisol, DHEA, testosterone, pregnenolone, progesterone, and estrogen are all steroid-based hormones that chemically look very similar to each other in terms of their basic molecular structures. However, at about the same time, cortisol, another closely related hormone, was discovered and it stole the limelight, as it was far more potent. This may lead to pregnenolone deficiency, which in turn may lead to reduction of both glucocorticosteroids and mineralocorticoids such as cortisol and aldosterone respectively. In normal people, pregnenolone will boost energy, elevate mood and improve memory and mental performance.
Some women report lessening of hot flashes or premenstrual symptoms and this is likely due to the rise of progesterone (the biological daughter of pregnenolone) reduction in estrogen dominance. In Adrenal Fatigue, pregnenolone level usually stays high in early stages, but tends to be low as adrenal weakness progresses due to a phenomena known as “pregnenolone steal” as the pregnenolone level drops because the body bypasses pregnenolone production in favor of producing more down-stream hormones such as DHEA and cortisol. Pregnenolone should be derived from a pharmacologically pure product and not a yam-derived "precursor.” Oral pregnenolone pills work well.
Pregnenolone is also converted into DHEA, which, in turn may convert into androstenedione, testosterone, and estrogens. Pregnenolone converts into DHEA, which in turn converts into testosterone and possibly onto DHT.
Do not rely on blood or saliva tests alone to determine how much pregnenolone should be taken as the clinical correlation is unreliable in Adrenal Fatigue. This ideal situation only occurs in a minority of cases where the fatigue is very mild and under expert guidance. Lam received his Bachelor of Science degree from Oregon State University, and his Doctor of Medicine degree from the Loma Linda University School of Medicine in California. He was first to scientifically tie in Adrenal Fatigue Syndrome (AFS) as part of the overall neuroendocrine stress response continuum of the body. If you have a specific health concern and wish my personalized nutritional recommendation, write to me by clicking here. When this demand is not being met, as in Adrenal Fatigue, the body will turn to existing protein and fat as resources of energy. In fact, wrong exercises may make Adrenal Fatigue worse and can trigger adrenal crashes easily.
Think of a car that is running low on gas, has a steering wheel problem, a sticky gas pedal that continues to accelerate at will, and a brake pedal that malfunctions intermittently. You can have fuel in the car and still be unable to get to where you want to go if the steering system is not functioning. Over utilization of energy for exercise, even if it is good for circulation and has other health benefits, may trigger adrenal crashes.
The amount of exercise must be adjusted to avoid over-stimulation of the sympathetic nervous system and trigger adrenaline release. After a comfortable level of reserve is accomplished and built up in the body, a gradual progression is effected so that the body can reverse its catabolic state into an anabolic state where muscles start to rebuild and strengthen. Improper use of exercise, whether it be too much, too little, or wrong timing can make Adrenal Fatigue worse, and trigger adrenal crashes, especially if the body's reserve is low. As a result, the vast majority of people simply do not breathee properly while in a normal healthy state, not to mention any state of body weakness such as Adrenal Fatigue. But in times of emergency or increased physical activity, the SNS opens the airways and allows air to flow more easily.
These chemical transmitters of the SNS flood the body in Type A individuals, resulting in a body that is on constant alert, leading to a viscous downward spiral of compensatory responses and ultimately adrenal burnout.
Another technique involves using the chest wall only to affect breathing and this is called thoracic or paradoxical breathing. It is one of the easiest and most effective exercises anyone with Adrenal Fatigue can do at anytime and anyplace to support adrenal recovery.
Hormone replacement is commonly prescribed by physicians when presented with a patient's symptoms suggestive of adrenal insufficiency.
Adrenal hormones are under the control of the hypothalamus-pituitary-adrenal axis where over 50 hormones are involved, and dysregulation of any one can produce unpleasant symptoms.
For example, cortisol output in the body usually rises in Stages 1 and 2 but will subsequently fall when a person enters into Stage 3 and beyond.
In addition to recognizing the sequential cascade of hormonal synthesis, it is very important to understand that pro-hormones such as pregnenolone and DHEA, which are placed naturally at the top of the cascade, are gentler as compared to down-stream hormones such as testosterone and cortisol.
It is also the precursor in the synthesis of female hormones such as estrogen and progesterone, mineralocorticoids such as aldosterone that is responsible for sodium regulation, glucocorticoids such as cortisol that suppresses inflammation and helps to reduce stress, and androgens such as testosterone.
Others, however, may find pregnenolone worsen existing fatigue and may even trigger adrenal crashes. The U-shaped distribution describes a benefit associated with low dose pregnenolone, a loss of effect with increasing dose of pregnenolone, and a second peak of benefit with higher doses of the steroid. Sublingual administration is an excellent option by bypassing the initial liver metabolism that occurs after swallowing an oral pill but it tends to be "spiky" and not well tolerated by those who are sensitive or in advanced s adrenal fatigue state. Pregnenolone supplementation may increase progesterone levels and consequently other hormones in the body (testosterone and estradiol).
Generally speaking, the earlier the adrenal fatigue stage, the longer this period can last. For most cases, due to internal derangement of the adrenals, the road to recovery is laden with pot holes and crashes.
He systematized the clinical significance and coined the various phases of Adrenal Exhaustion.
After a meal, those with advanced Adrenal Fatigue tend to have a faster dip in serum blood sugar below the Hypoglycemic Symptoms Threshold (HSL) level compared to normal.
Reactivation and restoration of normal cell function require extra amounts of energy beyond what is normally required for maintenance of normal energy burn.
Because all functions of the body require energy, the most prominent outcome in those with Adrenal Fatigue is low energy. Risk of adrenal crash must be carefully monitored and preventive steps must be taken at the right time consistently. The PNS, by way of release of its neurotransmitter, acetylcholine, works in a dynamic balance with the SNS, by releasing its neurotransmitter, norepinephrine, to modulate and maintain homeostasis in our body. The chest wall expands while the abdominal wall is drawn inward towards the back during inhalation and outward during exhalation.
The intensity level may need to be titrated downwards significantly in times of adrenal crashes. In the early days of adrenal hormone replacement, researchers had little clue of the proper dosage or the toxicity complications.
In the early days of thyroid hormone replacement, patients received up to many times the usual dose of thyroid hormone as well and as a result, the toxic effects could be severe. For example, low aldosterone level can lead to blood pressure irregularities and fatigue, high estrogen can trigger PMS and anxiety, and low cortisol output can lead to sugar dysregulation, hypoglycemia and sluggishness.
Hormones required for recovery from Adrenal Fatigue need to be considered not only their absolute quantity.
However, their actions differ markedly, with enormous differences in how they function and in the roles they play in the various chemical factories of our bodies.
The more gentle the hormone, the more nurturing it is for the adrenal to make its own down-stream hormone and the less will be the side effects. Furthermore, pregnenolone has a host of other benefits, which include the ability to influence cerebral function, the female reproductive cycle, immune defenses, inflammation, mood, skin health, sleep patterns, stress tolerance, and wound healing. It is unknown what dosage range is represented in either part of the U-shaped curve for humans and whether or not this curve is altered by disease. The weaker the adrenals, the more tendency for this period to be short-lived unless under professional guidance. In early stages of adrenal fatigue, this period can go on for years and totally asymptomatic.


He has written five books: Adrenal Fatigue Syndrome - Reclaim Your Energy and Vitality with Clinically Proven Natural Programs, The Five Proven Secrets to Longevity, Beating Cancer with Natural Medicine (Free PDF version), How to Stay Young and Live Longer, and Estrogen Dominance. He has written five books: Adrenal Fatigue Syndrome - Reclaim Your Energy and Vitality with Clinically Proven Natural Programs, The Five Proven Secrets to Longevity, Beating Cancer with Natural Medicine (Free PDF version), How to Stay Young and Live Longer, and Estrogen Dominance. Her personal research and writing focuses on the metabolic aspect of Adrenal Fatigue Syndrome. Without adequate cortisol levels to elevate blood sugar levels by facilitating the conversion of glycogen, fats, and proteins to new glucose supplies, this increased demand is difficult or impossible to meet. Many hormones are dysregulated, and as a result, in addition to having low energy, the body suffers from hypoglycemia (too little gasoline in the gas tank), feelings of being "wired" (sticky gas pedal that stays down), foggy thinking (driver who texts while driving), and depression (brake pedal is burned out). This involves a total mind-body approach incorporating lifestyle, diet, mental, nutritional, and physical components. Doing this might help avoid one of the most common recovery errors among those self-navigating as well as inexperienced clinicians - over zealous exercise leading to retarded adrenal recovery. Shallow breathing limits oxygen intake and adds further stress to the body, creating a vicious cycle. While these breathing techniques are empowering and increase energy flow, they can also drain the body of the already low energy state of Adrenal Fatigue.
This is often referred to as abdominal breathing, or belly breathing, because this is where movement can be seen and felt. Because the wrong inhale and exhale intensity can trigger an adrenal crash, this exercise should be done under professional guidance. Misled by improvement in their patients' symptoms, they gave patients many times more adrenal hormone than the normal amount. Pro-hormones are less potent but contrast this with the cortisol, which is the most potent, and has the greatest potential side effects. As an anti-aging tool, taking pregnenolone will therefore rejuvenate the entire adrenal cascade.
Time is a great healer when the body is given the proper nutrients along with proper lifestyle and dietary protocols. She is married to Michael Lam and is an integral part of the telephone-based nutritional coaching team helping people overcome Adrenal Fatigue Syndrome. The more advanced the Adrenal Fatigue, the more the blood sugar curve is shifted towards the left. The internal thermostat of the body is broken and it is no wonder that the adrenals crash with each little stressor. Adrenal breathing influences the autonomic circuits that slow the heartbeat and reduce blood pressure, producing calm feelings and a sense of stability. Holding one's breathe either at the end of inhalation or exhalation stimulates the sympathetic nervous system, aggravating adrenal weakness if the body is already in a state of low adrenal reserve. Unfortunately, laboratory tests and other investigative tools are not very helpful when it comes to Adrenal Fatigue due to inconsistent clinical correlation. Pregnenolone output also tends to rise in early stages of Adrenal Fatigue just like cortisol before it starts to fall due to a phenomenon known as pregnenolone steal.
Hormone replacement therapy for people suffering from Adrenal Fatigue, whether it is in synthetic or bio-identical form, is therefore difficult and challenging.
Those who demand a quick recovery invariably become disappointed because the body is not a light switch that can be turned on and off at will. If this happens at the same time as demand for glucose increases, the stage becomes set for an adrenal crisis. Adrenal breathing Exercises can break this negative cycle by rebalancing the ANS and gently delivering more oxygen to the body for natural energy generation without over-stimulating the SNS. Paradoxical reactions may arise during this time and adjustments of nutrients may be needed. Blood pressure starts to stabilize, brain fog starts to dissipate, and functional sleep returns. Overtime, they have forgotten what it feels like to be in optimum health and indeed often have given up, especially if adrenal function during this plateau phase is below the adrenal symptoms threshold level, where they are constantly suffering. He utilizes optimum blends of nutritional supplementation that manipulate food, vitamins, natural hormones, herbs, enzymes, and minerals into specific protocols to rejuvenate cellular function. For this reason, it is common for those with Stage 3 and beyond Adrenal Fatigue to require sugar replenishment every 2-3 hours. Others would do the opposite, forcing themselves to do more, and thinking that it is beneficial.
Long term and excessive use of cortisol have many negative side effects as well so much, so that its use as a performance enhancer in competitive sports has now been universally banned. Paying close attention to the signs and symptoms of Adrenal Fatigue is perhaps the most effective way to assess whether or not there is the need for hormone replacement. In other words, adrenal hormone replacement should not be considered as a first line remedy until better and gentler compounds that can get the job done without the risk of side effects, has failed.
Proper nutrients administered here strengthen the adrenals and cushions the mini-crashes and setbacks so frequently experienced by all. Provided free as a public service, he has answered countless questions through the website on alternative health and AFS. Because of these bad experiences, researchers became frightened and avoided prescribing adrenal hormones such as cortisol whenever possible. The ultimate decision as to whether or not to use hormone replacement as an Adrenal Fatigue recovery tool is best left to the professional.
Premature use of adrenal hormonal replacement is common in most self-navigation programs, is a common mistake, and can be a major cause of recovery delay or failure. Supporting the body may involve increasing or decreasing the dose of nutrients, depending on the body type and sensitivity level. If the adrenal function is already at its maximum, one can be stuck at this period for a very long time without upward progress. The key is not to avoid exercise totally, but to have a personalized program designed specifically for the level of adrenal function. Due to poorly understood patho-physiological mechanisms, some trial and error in administering hormone replacement will be inevitable even in the best of hands.
Improper use of adrenal hormonal replacement in fact can make the condition worse due to toxicity, paradoxical effects, addiction, and withdrawal complications. Many on self-guided programs would not be able rise to the next cycle due to the lack of foresight and planning.
Those having frequent infections will find that recovery is faster, and frequency of infection is reduced. Most interpret the lack of continuation and sustained improvement as failure and become disappointed.
She received her Bachelor of Science degree in Dietetics, holds a Master’s Degree in Public Health in Nutrition, and a Master of Science degree in Nutrition from Loma Linda University, in Loma Linda, California. This is of vital importance to those with advanced Adrenal Fatigue when the Autonomic Nervous System is invariably dysfunctional.
There should be sustained energy to carry out normal daily activities, and social activities returns.
Others might start to take more nutrients, thinking that it will help speed up the process and forcing the adrenals to work harder at a time when it is not capable of doing just that. If there is concurrent thyroid illness, many will note the returning thyroid function and that less medications are required. Forcing the body to accelerate instead of allowing it time to rebuild itself is a grave mistake and often leads to unexpected and severe crashes at the end. Any female hormonal imbalance such as PMS is reduced and menstrual cycles become more regular.



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