10.03.2014

Pubmed indexed dental journal uk

The Baker Research Lab’s current interests concern the welfare of people who are unable to produce adequate saliva either due to genetics, autoimmunity or side effects from treatments. Salivary gland bioengineering: We utilize various approaches to facilitate the creation of clinically safe transplantable salivary glands. Salivary gland tight junctions: We are interested in the functional significance of tight junctions in salivary gland epithelium. Effects of radiation treatment on salivary gland function: Radiation therapy is commonly used to treat patients with head and neck cancer.
Image Caption: Mouse submandibular gland cell clusters were grown for 6 days on Laminin-1 and fed with human hair follicle-derived mesenchymal stem cell conditioned medium. I was drawn out of my dental practice by the realization that many of my patients could not be aided by existing treatments. I developed an interest in the field of molecular cytogenetics during my senior year in college. Below is a Google map photo showing the approximate location of the Baker Research Lab at the University of Utah Health Sciences Center (383 Colorow Drive). Health report will be faxed to the veterinarian of the receiving institution and any additional requirements will be discussed between institutions. Dental ‘silver’ fillings present a time-release poison – indeed they are the major cause of mercury poisoning in humans.
Mercury has been found to accumulate in vital organs and tissues, such as the liver, brain, and heart muscle. Recent studies have found that substantial amounts of mercury vapor are released from dental amalgam after chewing gum for just ten minutes. No governmental agency has established safe standards for mercury intake from dental amalgams. Of course, our readers, may have a nagging question here – if mercury is so toxic, what is it doing in my mouth?
How is it possible that we ban the thermometers filled with mercury from use, and we warn people to be extremely cautious during disposal of fluorescent tubes, which are full of mercury, and then we say that to put it in our teeth and into vaccines is perfectly fine. To understand what is really going on in politics of medicine, you may want to visit at some stage our page ‘Shocking Truth’ and watch many documentaries online, which address this issue.
A: A new research indicates that amalgam fillings do not perform as well as it was previously believed. Secondly, just because clear symptoms are not visible at the moment, it  does not mean that Mercury has not affected some functions in the body. Q: Where can I find additional proves that mercury dental fillings are detrimental to my health? Q:  My dentist still insists on putting ‘silver’ fillings into my mouth despite the fact that he admits that mercury is toxic. Q: I heard that amalgam (mercury) ‘silver’ fillings can release mercury during the time of chewing food.
A: The straight forward answer is YES, although many dentists deny this fact, because they never seen the evidence or just because they are affraid to admit .
As expected, stimulation produced no measureable mercury vapour from the tooth without the amalgam filling. Medical textbooks state that mercury from dental fillings is a potential hazard to both dental patients and the staff working in the dentist’s office.
A comprehensive approach to hyposalivation involves not just treatment but also preventative aspects, which are both warranted and viable. Specifically, we culture salivary cell lines and primary cells on different extracellular matrices, seeking to improve survival rates, cell differentiation, and secretory function. Interactions between different combinations of tight junction proteins define tissue specificity and function during physiological and pathological processes. In these treatments, the parotid, submandibular, and minor salivary glands become irradiated. Localization of filamentous-actin, tight junctions and nuclei was determined using a phalloidin stain (red); an anti zonula-occludens-1 antibody (green) and a propidium iodide stain (blue) respectively.


This administrative supplement will perform studies targeting specific proteins involved in RvD1 biosynthesis and RvD1-mediated signaling pathways in genetically modified mice. This administrative supplement will perform studies targeting gender differences during RvD1 treatment in mice. The goal of this research program is to enhance acinar differentiation in parotid glands using fibrin hydrogels. Zonula Occludens-1, Occludin and E-cadherin Expression and Organization in Salivary Glands with Sjögren's Syndrome. Growth factors polymerized within fibrin hydrogel promote amylase production in parotid cells.
Current cell models for bioengineering a salivary gland: a mini-review of emerging technologies. P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells. Interleukin-1beta enhances nucleotide-induced and alpha-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y(2) receptor.
PKC{alpha}{beta}{gamma}- and PKC{delta}-dependent endocytosis of NBCe1-A and NBCe1-B in salivary parotid acinar cells. Proinflammatory cytokines tumor necrosis factor-alpha and interferon-gamma alter tight junction structure and function in the rat parotid gland Par-C10 cell line. P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecule-1 [corrected] expression and enhances lymphocyte adherence to a human submandibular gland cell line. My PhD study mainly focused on characterizing critical bioadhesive components, and its formation mechanism from underwater sandcastle worm and caddisfly larvae. For information about Living in Utah (housing, recreation, transportation & more), please click here. Be prepared for a shock, because mercury is found in all the people with so called amalgam (metal) tooth fillings put in by ‘old school’ dentists.
Patients don’t realize that the “silver” amalgam dental fillings actually consist of 40 to 55% mercury. The typical adult has ten amalgam fillings containing about 5 grams of mercury. Major symptoms of mercury toxicity include Emotional Instability, tremors, gingivitis, and kidney failure. Our friendly and very experienced dentist showed us new composite materials which bind perfectly to enamel. There are dentist who not only do not encourage patients to get these type of filings, but they would never put them in anybodies mouth. Also please check the List of Symptoms of Mercury Toxicity to see if these health issues are relevant in your case. He argues that the amalgam is very hard, stable and stays only in my teeth so there is no danger from it to the rest of my body. And by the way, most of the dentists are not familiar with new and shocking  information regarding instability of mercury and its highly volatile nature . In fact, Mercury vapour released from new and old teeth has been captured for the first time few years ago, during various experiments which were  filmed.
Brushing the tooth with amalgam resulted in the highest mercury vapour measruements, followed by coffee (95.5*C) and then water. A potential treatment could involve the use of resolvins, which are highly potent endogenous lipid mediators that are synthesized during the resolution of inflammation to restore tissue homeostasis. Consequently, a common side effect is a reduction in salivary function (xerostomia), which leads to multiple problems, including a predisposition to oral infections, sleep disturbances, oral pain, difficulty in chewing and swallowing, and an overall reduction of the patient’s quality of life.
Cell clusters demonstrated organized lumen formation, as seen by the apical expression of filamentous-actin. I enrolled in a doctoral program in Biochemistry in my home country of Venezuela to work in research and to gain experience in the pathobiology of salivary gland disorders. Thus, I am working to find alternative scaffolds to support salivary cell growth in vitro, which will circumvent this obstacle. The understanding of natural adhesive has been a valuable model for development of synthetic adhesives for underwater bonding applications, including medical adhesives.


The research that we have found clearly shows that amalgam fillings pose serious hazard over time (scroll down for more evidence). 1) size and amount of dental fillings one has, 2) age of first filling and duration of exposure, 3) individual anti-oxidant profile, 4) ability to detoxify heavy metals, 5) kidney function , 6) diet and lifestyle, 7) and even improper use of mobile phone .
They still believe and follow the old teachings from their Dental schools, which pushes amalgam on people.
It has been found that not only chewing the food causes this, but consumption of hot drinks also triggered the release too! However, amalgam filling removal CAN be done safely and effectively done by a dentist trained in the correct techniques. Our ongoing studies aim to more deeply understand the biosynthetic pathways and signaling mechanisms of resolvins to promote resolution of inflammation in salivary glands. We are currently analyzing the regulatory components of the tight junctions that could potentially affect secretory functions of the salivary epithelium.
And then I worked in the areas of biological materials and drug delivery system for 4 years.
And if it is in the mouth, it will be in the organs, tissues and cells throughout the body.
Further, its affect on the body’s immune system is potentially devastating, possibly contributing to diseases such as leukemia and hematopoietic dycrasias. In order to develop new treatments, we need to understand how radiation treatments affect different tissues involved in salivary secretion. Development and Regeneration -Advances in Research and Clinical Approaches to Functional Restoration Springerlink online book, Editor Cha S. My post-doctoral work included building high-resolution comprehensive ovine whole-genome RH maps. Therefore, we currently collect human submandibular glands from patients who have been exposed to head and neck radiation.
I took advantage of my background in molecular genetics and genomics to develop a dense single nucleotide polymorphism (SNP) map for the ovine genome. Currently, I'm interested in the artificial salivary gland on various extracellular matrices especially Fibrin Hydrogel. Further, I am also interested in combining bioadhesive field with the current studied disease model, hoping to develop a stable and nontoxic matrix for salivary gland regeneration. The glands from these patients are being used to understand the effects of radiation on tissue integrity. My current interests mirror past concerns for the well-being of people who do not produce adequate saliva, either due to genetics or treatment side effects. I was offered a two-year fellowship position at the Huntsman Cancer Institute to learn and understand the molecular mechanisms of lung and colorectal cancers. When I am not in the lab, you probably can find me at the ski resorts, golf courses, and unleashed dog parks.
I feel that a comprehensive approach to the problem, involving not just treatment but preventative aspects, is both warranted and viable.
These research experiences have shaped and redefined my research interests as well as my career goals. As such, I currently work in the areas of clinically applicable implants (using new biomaterials) and resolution of inflammation (using resolvins), which I believe to be the most efficacious treatment available.
I believe that this research will bring tangible benefits to those who suffer from hyposalivation and look forward to bringing these research programs to fruition.



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