New therapy for lung cancer

RT Magazine’s annual Product Focus features information on 70 of the latest respiratory and critical care products. A look at three offerings in medical disinfection and sterilization from Sunset Healthcare and Cenorin. RT highlights seven patient monitoring devices from leading manufacturers such as Nonin, Hill-Rom, Medtronic, and EarlySense. Information on 11 of the latest products in airway management from leading manufacturers like Dale, Neotech, and Hollister. Merck announced new data evaluating KEYTRUDA, an anti-PD-1 therapy, in advanced non-small cell lung cancer and malignant pleural mesothelioma. Merck, known as MSD outside the United States and Canada, today announced that new data evaluating KEYTRUDA (pembrolizumab), the company’s anti-PD-1 therapy, in both advanced non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma will be presented as part of the Clinical Trials Plenary Session on Sunday, April 19 at the American Association for Cancer Research (AACR) Annual Meeting in Philadelphia, April 18 – 22.
The NSCLC data will be the first presentation of new efficacy and safety findings for KEYTRUDA from 495 patients, including validation of PD-L1 expression (abstract #CT104). Recent research has discovered that the innermost layer of cells that line blood vessels, endothelial cells, are not uniform throughout the body. Proteins have been discovered in lung endothelial cells that promote the metastasis and invasion of the lung by other tumors, such as breast cancer. The endoarterial biopsy catheter will provide a tool to obtain samples of endothelial and subendothelial cells from blood vessels lining lung cancer tumors safely and effectively in a minimally invasive fashion. Pulmonary endoarterial biopsy samples can also be obtained from cancer patients at risk for secondary lung cancer metastasis. Knowledge of a patient’s endothelial cell protein and receptor patterns could also be used to deliver individualized therapies by creating therapeutic agents to specifically target those receptors and proteins.
November is National Lung Cancer Awareness Month - Southeast Radiation Oncology Group, P.A.
CaroMont Health contributes $45,000 towards lung cancer screening, for those people that fit the national lung cancer screening protocol criteria, $50 low radiation CT scans for screening are now available. An estimated 224,210 new cases of lung cancer are expected in 2014, accounting for about 13% of all cancer diagnoses. Cigarette smoking is by far the most important risk factor for lung cancer; risk increases with both quantity and duration of smoking.

CaroMont Cancer Staff celebrate at US National Whitewater Center for the second year in a row.
Social strains and lack of social competence are common in children recovering from malignant brain tumors.
A:  Although survival rates for children with brain tumors have greatly improved, many survivors report ongoing cognitive, physical, and social problems after treatment has ended.
A: We examined a peer-mediated intervention that was initially developed for children with autism spectrum disorders and adapted it to children who are recovering from brain tumors. A:  The study was not designed to assess whether the peer intervention helped the brain tumor survivor, but rather it was an exercise to see if the method of intervention was acceptable to survivors’ families and feasible to carry out in a public school setting.
A: A large multi-center trial  is needed to determine if a peer-mediated intervention can improve social competence outcomes for childhood brain tumor survivors. These data are from the largest, multi-center Phase 1b (KEYNOTE-001) study of an anti-PD-1 therapy. Advanced proteomic techniques have been employed to illustrate the differences in endothelial cell proteins and receptors lining blood vessels in different organs, and between blood vessels lining normal tissues and cancerous tumors.
Differences in endothelial cell proteins and receptors between ethnic groups have been noted, and differences that extend to the level of individuals have been proposed. The information would allow physicians to diagnose and stage disease, as well as customize therapy according to each patient’s potentially unique pattern of endothelial cell protein expression. An estimated 159,260 deaths, accounting for about 27% of all cancer deaths, are expected to occur in 2014. Sharp Discusses Breast Cancer Basics Dr.
Rutgers Cancer Institute of New Jersey behavioral scientist Katie Devine, PhD, MPH and colleagues from universities across the U.S. Social competence, including how well a child interacts with and is liked by peers, is a critical aspect of normal child development.
The intervention was designed to encourage peer leaders to include children who are socially isolated through small group instruction. Future work should examine if such an intervention works differently for children with late health effects, at different ages, or with neurocognitive problems.

With the mesothelioma findings (abstract #CT103), data evaluating KEYTRUDA will have been presented in eight different types of cancer. Identifying protein and receptor signatures in endothelial cells lining blood vessels adjacent to tumors would provide oncologists with a powerful tool to diagnose and customize treatment for lung cancer and prevent lung metastasis from other cancers. Please consult with your physician or other medical care provider regarding any medical questions you may have. Childhood brain tumor survivors are at risk for low social competence but there are very few interventions available to support these kids. We enrolled 12 childhood brain tumor survivors in 1st through 8th grade and 217 of their classmates. The few available tend to focus on teaching the survivor social skills, and have not examined whether any improvements in skills lead to improvements in peer relationships. Preliminary results suggested that survivors in intervention classrooms had a non-significant increase in friendships and classroom levels of social rejection and victimization were significantly lower in intervention classrooms post-intervention.
Therefore, attacking the growth source of the tumor, the so-called neovasculature or “new blood vessels”, has become the new method of fighting cancer – a technique generally known as “anti-angiogenic therapy”. In the eight intervention classrooms, two to three children chosen by peers to be leaders were taught skills to engage classmates in five to eight small group sessions over the course of four to six weeks. Overall, this study was novel in focusing on training peers rather than survivors and including peer reports of social functioning. The sessions focused generally on including kids who are not socially connected including the brain tumor survivor who was never identified in order to protect the their privacy. Results support the need for a larger randomized trial to determine if the intervention is efficacious. The findings may also be relevant for other groups of children who have had medical trauma or diseases that impact the brain.

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