11.01.2014

Journal cancer pharmacology 6th

The social wasp Polybia paulista protects itself against predators by producing venom known to contain a powerful cancer-fighting ingredient.
Beales and co-senior study author JoA?o Ruggiero Neto of SA?o Paulo State University in Brazil suspected that the reason might have something to do with the unique properties of cancer cell membranes.
In future studies, the researchers plan to alter MP1's amino acid sequence to examine how the peptide's structure relates to its function and further improve the peptide's selectivity and potency for clinical purposes. We've come a long way in cancer treatments a€“ we have powerful, effective drugs for many types of cancer and we're moving toward ever more specific, less invasive therapies. Scientists from the Institute for Biomedical Research (IRB Barcelona) have carried out successful in vitro tests using wasp venom to kill tumour cells.
Extra virgin olive oil (EVOO), long-known for its heart health benefits, has now been identified for its rapid destruction of cancer cells.
Scientists are planning for a future in which superbugs gain the upper hand against our current arsenal of antibiotics.
One of the hottest new materials is a class of porous solids known as metal-organic frameworks, or MOFs. Fans of Superman surely recall how the Man of Steel used immense heat and pressure generated by his bare hands to form a diamond out of a lump of coal.


Research at ANSTO has helped to reveal insights into a molecular mechanism for harvesting light in extreme conditions.
Turning carbon dioxide into stored energy sounds like science fiction: researchers have long tried to find simple ways to convert this greenhouse gas into fuels and other useful chemicals. Science fiction is inching closer to reality with the development of revolutionary self-propelling liquid metalsa€”a critical step towards future elastic electronics. Cancer cells are more dependent on a cellular garbage disposal unita€”the proteasomea€”than healthy cells, and cancer therapies take advantage of this dependency. Interesting how some people have tried "bee sting therapy" for cancer - maybe they were on the right track but the wrong insect! A 69-year-old man with a past history of non-melanoma skin cancer presented for a total body skin check.
A Biophysical Journal study published September 1 reveals exactly how the venom's toxina€”called MP1 (Polybia-MP1)a€”selectively kills cancer cells without harming normal cells.
Serendipitously, the antimicrobial peptide shows promise for protecting humans from cancer; it can inhibit the growth of prostate and bladder cancer cells, as well as multi-drug resistant leukemic cells. In healthy cell membranes, phospholipids called phosphatidylserine (PS) and phosphatidylethanolamine (PE) are located in the inner membrane leaflet facing the inside of the cell.


They used a wide range of imaging and biophysical techniques to characterize MP1's destructive effects on the membranes. MP1 interacts with lipids that are abnormally distributed on the surface of cancer cells, creating gaping holes that allow molecules crucial for cell function to leak out. However, until now, it was not clear how MP1 selectively destroys cancer cells without harming normal cells.
But in cancer cells, PS and PE are embedded in the outer membrane leaflet facing the cell surroundings.
Strikingly, the presence of PS increased the binding of MP1 to the membrane by a factor of 7 to 8. The differential diagnosis usually consists of: epidermal cyst, lipoma, and cutaneous metastases.
On the other hand, the presence of PE enhanced MP1's ability to quickly disrupt the membrane, increasing the size of holes by a factor of 20 to 30.



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