15.04.2015

Journal cancer clinical oncology uk

Daily aspirin use, even at low doses, may reduce mortality among men with high-risk non metastatic prostate cancer, according to research published online Oct.
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Combined treatment with a BRAF inhibitor and a MEK inhibitor resulted in modest clinical efficacy in a group of patients whose melanoma had progressed after prior treatment with a BRAF inhibitor, results of a new study published in the Journal of Clinical Oncology show. Preliminary data from a combination trial of vemurafenib plus PX-866, a nonreversible pan-PI3 kinase inhibitor were presented at the 10th International Congress of the Society for Melanoma Research (SMR) held in Philadelphia. People who eat lots of red meat may have a higher risk of some types of kidney cancer, according to a U.S.
Researchers writing in the American Journal of Clinical Nutrition found that middle-aged adults who ate the most red meat were 19 percent more likely to be diagnosed with kidney cancer than those who ate the least.
A higher intake of chemicals found in grilled or barbecued meat was also linked to increased risk of the disease. Previous studies examining the link between red meat and kidney cancer arrived at mixed conclusions, so Daniel and her colleagues used data from a study of close to 500,000 U.S. The group was surveyed on their dietary habits, including meat consumption, and then followed for an average of nine years to track any new cancer diagnoses. During that time, about 1,800 of them -- less than half a percent -- were diagnosed with kidney cancer. On average, men in the study ate two to three ounces (57 to 85 grams) of red meat a day, compared to one or two ounces among women. That was after accounting for other aspects of diet and lifestyle that could have influenced cancer risks, including age, race, fruit and vegetable consumption, smoking and drinking, and other medical conditions such as high blood pressure and diabetes. The association between red meat and cancer was stronger for so-called papillary cancers, but there was no effect for clear-cell kidney cancers.
People who ate the most well-done grilled and barbecued meat -- and therefore had the highest exposure to carcinogenic chemicals that came out of the cooking process -- also had an extra risk of kidney cancer compared to those who didn't cook much meat that way.
The study doesn't prove that eating red meat, or cooking it a certain way, causes kidney cancer.


Daniel said that more research is needed to figure out why eating red meat is linked to some cancers but not others.
But for now, she said, meat-related cooking chemicals can be reduced by reducing the cooking time for meat, by avoiding direct exposure of meat to an open flame or hot metal surface, and by using a microwave oven to partially cook meat before exposing it to high temperatures. In the August 2015 issue of The American Journal of Medicine, Sayuk and Gyawali detail modern concepts about  irritable bowel syndrome and offer management options. Hospital Readmissions Increase after Changes in Physician Call SystemFollowing house staff physician schedule changes in the US and Canada in recent years, the Sunnybrook Health Sciences Centre in Toronto changed its physician call system from the concentrated (bolus) system to the distributed (drip) system. CSCs are also multipotent and can give rise to the diverse set of cells that make up a given tumor.
Jacobs, of the American Cancer Society in Atlanta, and colleagues analysed data for men diagnosed with non metastatic prostate cancer to assess the association between daily aspirin use and prostate cancer-specific mortality (PCSM). The combined used of BRAF and MEK inhibitors has also been explored in patients who are treatment-naive, with study results published recently in Lancet Oncology and presented at the 2014 ESMO Congress.“BRAF inhibitors are a highly active therapy in the 50% of melanomas that harbor BRAF mutations,” said Douglas B. The patient cohort included 19 patients with metastatic melanoma and a single patient with gastrointestinal stromal tumor—all patients had either V600E or V600K BRAF-positive disease. Participants with the highest consumption of red meat -- about four ounces (113 grams) per day -- were 19 percent more likely to be diagnosed with kidney cancer than those who ate less than one ounce per day. And, said Mohammed El-Faramawi, an epidemiologist from the University of North Texas Health Science Center in Fort Worth, some people who eat lots of red meat won't develop kidney cancer, while others who hardly eat any will. Irritable bowel syndrome is thought to be a multifactorial disorder, deriving from a potential multitude of etiopathogenic factors, including environmental, psychologic, and physiologic factors. New research published in the American Journal of Medicine revealed that following this change, there was a 26% increase in readmissions.
Inherent within this hypothesis is the assumption that current treatments for cancer can considerably diminish tumor burden, but have a decreased effect on CSCs, which are later capable of driving tumor recurrence and regrowth. The men were enrolled in the Cancer Prevention Study-II Nutrition Cohort between 1992 or 1993 and June 2009, and followed up through 2010.
Patients with NSGCT CS II A or B and an elevation of tumor markers should be treated by chemotherapy according to IGCCCG risk group recommendations.


Thirty-five percent of patients (7 of 20) had previously been treated with either a BRAF or a MEK inhibitor. This model highlights the complex, often bidirectional interplay of these factors in the experience of irritable bowel syndrome symptoms.
Nontumorigenic cancer progenitor cells are capable of cell division, but their capability to divide is limited, and they are unable to match the rates of tumor cell apoptosis and senescence. In cases of detection of residual retroperitoneal tumor ≥1 cm, a residual tumor resection is mandatory. To achieve cancer remission or cure, therefore, it will be necessary to develop novel therapies that are cytotoxic to CSCs.PowerPoint slides for teachingDownloading may take up to 30 seconds. The four responding patients had partial response and 13 additional patients (50%) had stable disease at 8 weeks. Alpert discusses the new research and the drawbacks in current physician scheduling systems.
Patients in Group C had an overall response rate of 13%, including one complete response and five partial responses.
Alternatively to RLA, a surveillance strategy with a 6-week follow-up examination is indicated.
Thus far, one patient has been enrolled into this cohort, and the goal is to enroll two more. In patients with rapidly growing lesions and rising tumor markers, the tumor should not be resected but treated with a chemotherapy strategy according to IGCCCG recommendations.
In cases of progressive or stable disease with negative tumor markers, a teratoma or a growing, undifferentiated malignant tumor is suspected and a RLA is indicated.
We need to understand whether there are patients who may benefit more from BRAF plus PI3K inhibition,” Gangadhar told Cancer Network.Both longer follow-ups of these patients as well as additional larger studies are needed to understand whether this combination could overcome resistance to monotherapy treatment with a BRAF or MEK inhibitor, and to find out whether this combination could result in durable responses when given to patients as a first-line metastatic treatment.



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