11.12.2014

Cancer oxygen therapy treatment

Breathing in 100% (pure) oxygen under increased pressure, called HBOT, allows extra oxygen to be taken up by the bloodstream and dissolved at a far greater rate. HBOT has been shown to improve oxygenation, new blood cell formation (angiogenesis) and new nerve growth (neurogenesis) in the brain (7). A 2006 study in Japan involving patients with brain tumors receiving radiation and chemotherapy experienced much longer survival times and reduced side effects when using HBOT as a complimentary treatment (15).  Another 2009 study showed extended survival times and reduced side effects using HBOT with radiation treatment in patients with glioma tumors (16). The world’s top researchers (Angela M Poff, Csilla Ari, Thomas N Seyfried and Dr Dominic P D?Agostino)  in ketogenic diet and HBOT agree that HBOT alone has no effect on cancer growth and progression.  However, when it is combined with the ketogenic diet it has a significant complementary effect at inhibiting tumor growth and increasing survival time. By increasing the oxygen environment to the cancer cells, it makes them less virulent and in many instances destroys them. Most patients do not experience any symptoms immediately after HBOT and can return to work the day of treatment. Contraindications for HBOT include high fever, untreated seizure disorder and untreated air or gas in the pleural space of the lung, which causes the lung to collapse (pneumothorax).
If you are looking for a hyperbaric oxygen chamber for your home, I recommend the Vitaeris 320, which is what we use in our health clinic. Conconi MT, Baiguera S, Guidolin D, Furlan C, Menti AM, Vigolo S, Belloni AS, Parnigotto PP, Nussdorfer GG. Heyboer M 3rd, Milovanova TN, Wojcik S, Grant W, Chin M, Hardy KR, Lambert DS, Logue C, Thom SR.
Chungpaibulpatana J, Sumpatanarax T, Thadakul N, Chantharatreerat C, Konkaew M, Aroonlimsawas M. Rossignol DA, Rossignol LW, Smith S, Schneider C, Logerquist S, Usman A, Neubrander J, Madren EM, Hintz G, Grushkin B, Mumper EA. Hey Michelle, it looks like there are several places that are offering it when I did a google search. In Hospitals here they are only use HyperBaric chamber to treat the damage after Radiation. Cancer is a group of diseases in which the body's normal self-regulatory mechanisms no longer control the growth of some kinds of cells. Targeted gene therapy is using corresponding medicines against the specific carcinogenic sites (those sites could be a protein molecule or a genetic segment in tumor cells). Some viruses have been changed in the laboratory so that they target cancer cells and unhealthy cells.
Gendicine's functional component is the p53 gene, a naturally occurring tumor suppressor gene that has been under research in the United States, Europe and Asia for 20 years. Targeted gene therapy gets the characteristics of non-cytotoxic, effective, harmfulness and high tolerance. Medicine combines with routine therapies (like chemotherapy and radiotherapy), can be given separately or jointly, thus better results would be achieved.
Reactive oxygen species (ROS) are generated in cells not only under the influence of xenobiotic agents (peroxides, photosensitizers, other oxidants) and radiation (UV, X-rays), but also endogenously, e.g. In this area of research, we analyse the type and extent of the cellular oxidative DNA damage that is induced by various drugs (photosensitizers, radiomimetic drugs, oxidants) and correlate the DNA damage with those consequences that are relevant for carcinogenesis, such as induction of mutations and DNA repair.
The balance between generation of oxidative DNA modifications (most probably by endogenously generated reactive oxygen species) and their removal by specific repair enzymes results in steady-state levels of these lesions that can be detected in apparently all types of cells under physiological conditions (see Fig.
Oxidative DNA basemodifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are repaired predominantly by base excision repair. PDT is one of those new alternative cancer therapies - except it has been around for over 100 years! The principle behind it is that oxygen kills cancer cells - Otto Warburg won a Nobel Prize for this discovery in 1932. Firstly, can there be an agent which can achieve this tight targeting and exclusively lock onto cancer cells? Secondly, it is easy to see how Aloe Vera, or mangostein, or similar local cancer remedies might have been used by ancient civilisations to treat superficial skin conditions when exposed to sunlight. Fortunately, in the last 20 years there have been significant developments with lasers and other delivery systems for energy of the specific frequencies needed to activate the newer agents. We have much more on this web site about PDT and important developments and treatments. One of the issues with PDT is trying to develop a system that can tackle deep-seated cancers. The Dove did publish a paper in the journal Current Drug Research, covering 115 patients treated over the last 5 years.
Sonodynamic Photodynamic Therapy (SPDT) utilises a new light and ultrasound sensitive medicine, (commonly called the agent) Sonnelux-1 that is administered under the tongue. Photodynamic Therapy involves the conversion of light energy into chemical energy by using the characteristics of the photosensitive medicine (agent).
Ultrasound is used widely in diagnostic imaging for its excellent tissue penetration and safety profile. No photosensitivity from normal light, artificial or natural, has been noted but as a precaution patients are advised not to stay in direct sunlight for periods over half an hour for one week following Sonnelux -1 administration. Light and ultrasound activation is repeated on three consecutive days and the same process of Sonnelux 1 administration followed by light and ultrasound exposure is repeated after one week to complete the treatment cycle. Ozone Autohaemotherapy is administered immediately before light bed exposure, aiming to further increase singlet oxygen levels (p02) at the tumour site. A course of oral Dexamethasone is administered to tumour patients depending on tumour type, background, physical status and total tumour volume along with the SPDT protocol.
This 50 year old female patient first came to The Dove in April 2008, with a massive Ependymoma first diagnosed in April 2003.
She had been complaining since December 2005 of a persistent troublesome cough and recurrent chest infections. This case shows sustained symptomatic improvement following SPDT, stable lung disease and improved adrenal pathology on follow up imaging 2 years after diagnosis. This 56 year old female patient was diagnosed with squamous cell carcinoma of the anus in April 2006. In August 2007 a CT scan revealed a 16 mm liver lesion, this increased to 3 cm in October 2007. She has recently developed a recurrence, again as in the previous case, with an almost straight-line division between the ultrasound treated area and the areas above and below it in which the recurrences are currently situated. There seems little doubt that SPDT warrants further investigation as a non-invasive, well-tolerated and highly targeted cancer treatment capable of killing cancer cells at both superficial and deep malignant sites. Sign up for icon Our icon magazine is available free in over 500 UK hospitals, cancer centres and libraries.
An extension of Healing Touch for People, Healing Touch for Animals also involves a heart-centered, intentional way of using gentle, light, or near-body touch to promote healing. This extra oxygen can help where healing is slowed down by infection or where blood supply is limited by damage to the tissues. Other rare side effects include temporary short-sightedness (myopia) and pulmonary oxygen toxicity. Some patients, however, may experience temporary changes in vision when completing more than 20 HBOT sessions. Hyperbaric oxygen induces endogenous neural stem cells to proliferate and differentiate in hypoxic-ischemic brain damage in neonatal rats. Hyperbaric oxygen therapy improves neurogenesis and brain blood supply in piriform cortex in rats with vascular dementia.


Attenuating inflammation but stimulating both angiogenesis and neurogenesis using hyperbaric oxygen in rats with traumatic brain injury. Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial.
Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomas. The effect of hyperbaric oxygen treatment on squamous cell cancer growth and tumor hypoxia. The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer. I have a cousin that is 44yo and has sickle cell and has had frequent episodes and more recently. I have taken this product and noticed an increased feeling of energy and wonder if it would have similar helpful effects? Genes determine obvious traits, such as hair and eye color, as well as more subtle characteristics, like the ability of the blood to carry oxygen. Cells are frequently exposed to a variety of agents, from both external and internal sources, which damage DNA. The medicine would take effect by specially combining carcinogenic sites after entering human body, thus tumor cells would die specifically without affecting normal cells around. The p53 gene exists ubiquitously in normal cells and is one of the most prevalent tumor suppressor genes in the human body. If you find our website useful, please follow our FaceBook and YouTube, health information will be updated regularly. For this end, the the pattern of DNA modifications, the repair and the induction of mutations are determined in cultured mammalian cells.
However, our results indicated an unexpected relevance of other proteins, in particular Cockayne Syndrome B protein (CSB) and poly(ADP-ribosyl)polymerase 1 (Parp1). On the one hand, DNA directly absorbs radiation in the UVC and UVB range of the spectrum (up to ~320 nm).
PDT traditionally uses an active agent, which passes around the body and locks onto cancer cells. But singlet oxygen is even more dangerous than that and can in theory kill any cell in which to which it is attached. If it doesnt then obviously the whole treatment might miss a few cancer cells, which would divide and take you back to square one in no time at all. Agents such as Photofrin, a product from pigs blood, have been approved and used with limited success. Scientists are exploring modern light forms including lasers and ultrasound to activate the agent.
Sonnelux-1 is developed from chlorophyll, the green coloured light-sensitive molecule in plants that allows photosynthesis.
Light energy of a specific wavelength is absorbed by the photosensitiser causing an excited electron state capable of transferring energy to Oxygen (O2) within the cancer cell. Ultrasound has the capacity to activate the photosensitiser within deep tumour tissue that is otherwise inaccessible to light. This diagram shows tumours excised after Sonnelux administration only (top line), ultrasound only (second line) and a control group with no active treatment. This provides sustained low plasma concentration and accumulation of the agent in the tumour tissue. Light bed exposure time varies, with shorter exposure duration in cases with large tumour load, to try and reduce the inflammatory response which occurs following tumour cell necrosis. Clinically, this has been observed as significantly increased tumour cytotoxic effect of SPDT, and we have an objective study showing that this use of ozone normalises the p02 levels in tumour tissue. At first consultation her clinical state was poor, with a predicted median survival time of 6 months. She had a previous history of right-sided breast cancer in 2002 treated by lumpectomy with no chemotherapy or radiotherapy. A chest X ray was performed in January 2006 which revealed a 1.8cm soft tissue density in the left upper lobe.
She had been complaining of a persistent cough over the previous 10 months with a 40 pack-year smoking history.
Radiotherapy was not offered due to her previous treatment and she was offered a partial hepatectomy with neoadjuvant chemotherapy. She went on to have a partial hepatectomy, and histology confirmed extensive tumour cell necrosis and showed 3 tumours in the resected section, each tumour having extensive central necrosis.
She had a right sided breast cancer diagnosed in 2002 followed by a right mastectomy followed by chemotherapy and radiotherapy. She had had a right sided breast cancer in November 2004 for which she had a mastectomy, the tumour was oestrogen receptor positive.
Full of great articles and the very latest cancer information, you can have it sent to your own home. Whether an animal is recovering from illness, injury or surgery, the use of Healing Touch, in conjunction with other modalities, does a great deal to facilitate the healing process. Because HBO treatment can increase stem cells it may have a role in stem cell transplantation – a treatment sometimes used in haematological (blood) cancers.
The removal of these oncogenes reprograms the cell to its normal state, preventing tumor growth and the spread of cancer. Complex characteristics, such as physical strength, may be shaped by the interaction of a number of different genes along with environmental influences.
Even minor DNA damage can have profound effects, causing certain genes to become overactive, to undergo partial or complete inactivation, or to function abnormally. ROS are generated in cells both endogenously (oxygen metabolism) and exogenously (drugs, radiation). The influence of the chromatin structure on the damage generation and mutagenesis is of specific interest. Since several of the oxidative DNA modifications are known to be mutagenic, increased steady-state levels should be associated with higher mutation rates and therefore more frequent tumor development. The absorption gives rise to characteristic photoproducts, especially the formation of pyrimidine dimers.
Suitable photosensitizers should absorb efficiently in the red range of the spectrum, generate singlet oxygen in high yields after excitation, not be toxic in the absence of light and accumulate in tumor cells.
The agent is then activated by light of a specific frequency to produce singlet oxygen which kills the cancer cells. Or worse, you dont want the singlet oxygen killing healthy cells around the cancer tumour either, because it has not been specific enough to just lock onto cancer cells. They state that It is a non-invasive, well-tolerated and clinically effective, targeted cancer treatment capable of killing cancer cells on both the surface of the body and in deep tissue. Uniquely, it is preferentially taken up by cancer cells rather than healthy cells and is safe and non-toxic.
This breaks down O2 into singlet oxygen and other reactive oxygen species, inducing necrosis and cancer cell death.
SPDT uses low-intensity ultrasound applied via a probe placed on the skin over known tumour sites and creates further singlet oxygen production and cancer cell membrane changes (sonoporation) leading to cancer cell death (necrosis) and immune activation.
There is no significant difference when applied individually compared to the no treatment control group.


48 hours after the administration of the agent the patient is exposed to a light bed containing 48 panels of Light Emitting Diodes emitting a combination of visible and infrared light at the frequencies 660 nm and 940 nm. She was subsequently referred urgently for further investigation and was given the diagnosis of a breast cancer secondary or a non-small cell lung cancer primary. After recurrent courses of antibiotics she had a chest X ray which revealed a 6cm left upper lobe mass. No evidence of recurrent local or distant metastatic disease was seen on two follow up scans. She only had a small number of tumour cells in each secondary, the vast majority consisted of necrotic tissue. By inducing deep relaxation, Healing Touch stimulates an animal’s circulation, allowing more oxygen, nutrients, and hormones to flow through the body. Genes control a number of protective pathways in cells that prevent cells from becoming cancerous. Targeted gene therapy is against disease roots: abnormal genes, this is the fundamental solution for cancer.
The most common types of carrier used in gene therapy are viruses because they can enter cells and deliver genetic material.
The DNA modifications contribute to the spontaneous mutation frequency of the cells during replication, which can activate tumor genes and thereby initiate carcinogenesis. In our projects we want to test this hypothesis and thus assess the role of ROS for the initiation of carcinogenesis.
In addition, the influence of changes of the chromatin structure on the repair mechanisms and kinetics are currently of specific interest . Hitherto, with some of the chemical agents approved for use in PDT, twenty five per cent of the cells killed were actually healthy. They studied algae, chlorella and spirulina because the chlorophyll molecule (the molecule that makes plants green) resembles the haemoglobin molecule except the former has magnesium at its centre whilst the latter has iron.
She was diagnosed following a scan and her biopsy as having a non-small cell lung cancer in the left lung. She had a local recurrence along the scar 9 months after the mastectomy and spread into the neck lymphatics. Once the harmony and balance in an animal’s energy system is restored, the animal can begin to self-heal. For example, pathways that transmit signals for a cell to divide have on-off switches to control cell division. In addition, we want to identify both cellular constituents and exogenous compounds that influence the steady-state levels of oxidative modifications in cultured cells and in vivo. On the other hand, some so far unidentified cellular constituents (probably porphyrins or flavins) act as endogenous photosensitizers that react directly with DNA or give rise to the formation of ROS. This similarity allows the chlorophyll molecule to pass reasonably freely within the blood system. The respiratory physicians felt that biopsy was not possible due to the location of the tumour and the associated bleeding risk.
When she came to see us she had widespread tumour in both sides of the chest, with glands in the right supraclavicular fossa. All he gets are pain med scripts, epidural so, tons of green box BC Powders, Ibuprophen and on the sofa all day then to bed at night.
Cells also have mechanisms that allow them to determine if their DNA has been damaged, and they have pathways to repair that damage or eliminate the cell. Therefore, the cellular generation of ROS constitutes a serious threat to the integrity of the cellular genome, despite of the existence of efficient defense mechanisms (antioxidants, specific DNA repair), and it is supposed to be causally involved in the generation of cancer and other age-correlated diseases (Fig. And as most schoolboys will be able to tell you, shine light onto chlorophyll and you produce oxygen, the enemy of the cancer cell.
Subsequently she underwent a follow up chest X ray which revealed the mass had doubled in size between January and May 2006. On clinical examination at the time of presentation she had no breath sounds detectable in the left lung. Opiates that Dr prescribed reduced pain and my hearts hurts so much seeing my precious Son’s life fade away. The contribution of the indirect (photosensitizer mediated) mechanisms to the cancer risk induced by direct sun light is, as yet, not known and is therefore being investigated in this research field.
In addition, it is planned to attach the photosensitizers to carrier systems that allow specific targeting to tumor cells.
We saw her in August 2008 and she had several involved lymph nodes in the right and left supraclavicular fossae and widespread tumour across the right side of the chest, clearly extending deeply, together with a fungating lesion in the centre of the chest.
Our research aims at a better understanding of the genotoxicity of ROS and its role for the induction of cancer and other diseases. It is anticipated that the indirect mechanisms will not be as effective as direct DNA excitation, but that they will make an important contribution to the genotoxicity of sunlight in the longer wavelength range where DNA has little or no absorption. We did this under Dexamethasone cover, but she still got a marked inflammatory response to the area treated with ultrasound. Her cough cleared up and breath sounds were detectable again in the lung approximately 2 months after the SPDT. She developed a marked inflammatory response which as in the previous case lasted for approximately 3 months. She requested a further scan at that time but due to there being no conventional active treatment this request was refused. All tumour cleared from the treated area of the chest, but she eventally developed some recurrence above and below the ultrasound treated area. This resulted in complete resolution of the tumour in the treated area which was replaced by fibrous tissue. Her chronic cough cleared up after the SPDT and she stopped having regular chest infections.
She developed a cough again towards the end of 2007, also air entry was again reduced on the left lung at that time and she was experiencing marked right loin pain from the adrenal metastasis. Of interest was the clearly observable fact that no tumour recurred in the ultrasound treated area. She has undergone regular chest X rays since the SPDT which show that the previously enlarging mass is stable and has remained so. The delineation between the ultrasound treated areas and the areas where recurrence was occurring was most impressive in this patient, and almost had the precision of a straight-line division. This time she had some pain in the left chest and tiredness associated with the SPDT although this was controlled symptomatically and resolved over 4-6 weeks.
The pain she had experienced in the right loin fully settled post SPDT and has not returned. She has had a follow-up scan in the Autumn of 2009, following developing visual symptoms, and this showed a solitary brain metastasis. It also showed that the lung primary was stable from previous imaging and that the previous pleural effusion had fully resolved.



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