04.06.2014

Breast cancer chemotherapy no hair loss

Despite the fact that advancements in cancer treatment have improved survival rates among patients for certain cancers, the risk of developing treatment-related leukemia still persists, finds a study. Chemotherapy is often a highly effective treatment for cancer, but certain drugs have also been shown in a range of studies to increase a patient’s risk of developing therapy-related acute myeloid leukemia (tAML), a rare but frequently fatal condition.
To examine how the risk of tAML has evolved over time among cancer patients treated with chemotherapy, Dr. As the team compared tAML risks with trends in cancer treatment over time, they analyzed several factors that likely contributed to the differences in risk between patients, including the type of cancer initially diagnosed and the year of diagnosis.
A similar decline in risk was observed among ovarian cancer patients, possibly linked to a shift in ovarian cancer chemotherapy treatment in the 1970s from melphalan, a type of chemotherapy that has been shown to trigger leukemia, to a less toxic platinum-based chemotherapy.
The database analysis also found that relative tAML risk for many patients tended to decline with increasing time since initial cancer diagnosis. The United States Preventive Services Task Force (USPSTF), a panel appointed during the George W. To support its proclamations, the panel used a computer model to create new, non-peer-reviewed data extrapolated from previously published studies on mammography screening. It has been estimated that if the USPSTF recommendations are followed as clinical guidelines, 20% of breast cancer deaths will occur in women who could have been saved.  We have excellent data on mortality reduction as a result of screening women in their 40’s from numerous sources, including Dr. The authors of this most recent study also found that cancers in women in their 40’s that were detected by mammograms required less invasive surgery (more lumpectomies rather than mastectomies; less lymph nodes removed), and these patients needed chemotherapy less frequently. Higher likelihood of being a candidate for breast-conserving surgery, with a better cosmetic outcome.  Don’t let anyone shame you into thinking that you are shallow and vain if you believe this is an important consideration. Less likely need for complete removal of lymph nodes under the arm (axillary dissection), avoiding the potential lifelong misery of a chronically swollen and painful arm (lymphedema).


Any useful discussion regarding the value of screening for breast cancer must consider morbidity as well as mortality.  It is severely unfair to women if these factors are left out of the debate, as they invariably have been until now.
Needle biopsies are a needle in a haystack and surgical biopsies destroy the tissue sample. Thanks to significant advancements in therapy resulting in improved patient survival rates for certain cancers over the last several decades, researchers and clinicians now aim to design treatment regimens that maximize patient survival while minimizing short- and long-term complications.
However, no recent large-scale studies have evaluated how the risk of treatment-related leukemia has evolved with the changing treatment strategies,” said Lindsay Morton, PhD, of the National Cancer Institute (NCI) and lead author of the study. Morton’s team confirmed 801cases of tAML, nearly five times more than the number of cases expected in the general population. For example, trends in risk for breast cancer patients (which comprised roughly one-third of tAML cases in the study) correlated to changes in breast cancer treatment protocols over the last several decades, suggesting that the decrease in tAML risk observed among breast cancer survivors in the 1980s might be attributable to an increased use of cyclophosphamide-based chemotherapy, which is less likely to cause leukemia than earlier treatment options. In contrast, tAML risks increased over the last several decades among patients treated with chemotherapy for non-Hodgkin lymphoma (NHL), possibly as a result of improvements in survival for patients who received multiple courses of treatment. For those with non-hematologic malignancies, there was no evidence of elevated tAML risks more than 10 years following diagnosis, whereas risks persisted more than 10 years after diagnosis for patients with Hodgkin lymphoma (HL), NHL, and myeloma.
Bush Administration and supported by the federal Agency for Healthcare Research and Quality, a branch of the U.S. Surveillance, Epidemiology, and End Results (SEER) Program, identifying adult patients ages 20-84 who were diagnosed with cancer (any type) between 1975 and 2008 and who were treated with chemotherapy. To help explain the changes in relative risk over time, investigators compared the trends in the data with evolving treatment recommendations and major therapeutic discoveries as described in the medical literature.
Patients diagnosed with myeloma today still face some of the highest risks for tAML, possibly due to the ongoing use of melphalan to fight the aggressive disease.


Heightened tAML risk among these patients could be linked to the higher intensity and longer duration of their treatment. Hendrick and Helvie’s study, and research presented from the Elizabeth Wende Breast Center in November 2011, to support the assertion that the USPSTF guidelines should be revised. Research has proved that chemo only works for certain tumor types and has little to do with tumor size or even staging.
SEER data files were reviewed to determine tAML risk based on first type of cancer, time since diagnosis, age at diagnosis, and year of diagnosis.
While patient information in the SEER database did not include data on specific drugs or doses, the incidence trends were consistent with changing treatment practices and the toxicities associated with certain chemotherapies. Instead of being applauded as one of the few interventions in the healthcare system that actually saves people, with a 30% reduction in breast cancer mortality in the U.S. In addition, this month’s edition of the journal Radiology published important original research concluding that mammography screening for 40- to 49-year-old women significantly decreases mortality. Notably, the proportion of patients receiving chemotherapy, both with or without radiotherapy, increased during the study period for many malignancies.



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