11.02.2015

Alternative treatment brain cancer zodiac

The FDA (US Food and Drug Administration) has approved a new treatment for patients as an alternative to chemotherapy.
According to Novocure, TTF therapy has several important aspects that distinguish it from existing cancer treatment methods. There is no evidence of cumulative damage to healthy tissues in the body when exposed to TTF therapy. The Novocure device, which weighs about six pounds (three kg), is to be used continuously throughout the day by the patient.
Tumor Treating Fields are discussed by Novocure executive, Bill Doyle at the TEDMed event this year. Anterior pituitary hormones are regulated by hypothalamic releasing and inhibitory hormones and by negative feedback of the target glandular hormones at the pituitary and hypothalamic levels (Table 1).
Pituitary adenomas arise from adenohypophyseal cells and are almost always benign (Table 2). Pituitary adenomas are rarely associated with parathyroid and neuroendocrine hyperplasia or neoplasia as part of the multiple endocrine neoplasia type I (MEN I) syndrome. Pituitary tumors can manifest with signs and symptoms of pituitary hypofunction, hormone hypersecretion, or mass effect. The goals for treatment of a pituitary tumor include reduction or complete removal of the tumor, elimination of mass effect, normalization of hormone hypersecretion, and restoration of normal pituitary function.
Pituitary adenomas are the most common cause of hypopituitarism, but other causes include parasellar diseases, pituitary surgery, radiation therapy, inflammatory and granulomatous diseases, and head injury.
Random measurements of GH and gender- and age-adjusted insulin-like growth factor-1 (IGF-1) levels are not reliable to diagnose GH deficiency because GH secretion is pulsatile, and up to 65% of patients with GH deficiency have a normal IGF-1 level. In reproductive-aged women, gonadotropin deficiency causes infertility and oligomenorrhea or amenorrhea. Patients with ACTH deficiency maintain their mineralocorticoid secretion because aldosterone is regulated primarily by the renin-angiotensin system and serum potassium concentration. An ACTH stimulation test and early morning (8 am) plasma cortisol level measurement are reasonable initial tests for evaluating the corticotropin axis. The symptoms of thyrotropin (TSH) deficiency are similar to those in patients with primary hypothyroidism, including malaise, fatigue, leg cramps, dry skin, and cold intolerance. The diagnosis cannot be established only through measurement of TSH because these patients might have a normal TSH level. Prolactinomas are pituitary adenomas that secret prolactin in varying degrees and account for about 30% of all pituitary adenomas.
Clinical features of prolactinomas may be related to excess prolactin and associated secondary hypogonadism or mass effect. Dopamine agonists are the therapy of choice for most patients, and they are effective in decreasing adenoma size and restoring normal prolactin level in most patients. Acromegaly is a rare disease caused by a GH-secreting pituitary adenoma in more than 99% of patients. Because of the pulsatile nature of GH secretion, random GH levels can overlap in acromegalic patients and normal persons. Surgery is the treatment of choice for most patients presenting with acromegaly even if a cure cannot be achieved.
Cushing’s syndrome (CS) comprises symptoms and signs associated with prolonged exposure to inappropriately high levels of plasma free glucocorticoids (Box 3). Surgical removal of the ACTH-secreting pituitary tumor is the treatment of choice.10 Availability of an experienced neurosurgeon is crucial, and the long-term remission rate is about 60 to 80% following surgery. Thyrotropin (TSH)-secreting pituitary adenomas account for less than 1% of all pituitary tumors.
Nonfunctional and glycoprotein-secreting pituitary tumors account for about 25% to 30% of all pituitary adenomas. Patients with small nonfunctional pituitary adenomas are usually observed; however, the standard treatment for those with mass effect is surgery, mainly through the trans-sphenoidal approach. Lymphocytic hypophysitis is a rare inflammatory lesion of the pituitary gland, commonly affecting young women during late pregnancy or in the postpartum period. The empty sella is defined as a sella that, regardless of its size, is completely or partly filled with cerebrospinal fluid.
Pituitary apoplexy is a rare endocrine emergency resulting from hemorrhagic infarction of a preexisting pituitary tumor (Fig. Diabetes insipidus by itself is usually well tolerated and results in few symptoms, including polydipsia and polyuria. Once diabetes mellitus and hypercalcemia have been excluded, patients should have their 24-hour urinary volume measured during ad libitum fluid intake. The therapy of choice for central DI is the administration of the ADH analogue desmopressin (DDAVP). Casanueva FF, Molitch ME, Schlechte JA, et al: Guidelines of the pituitary society for the diagnosis and management of prolactinomas. Ezzat S, Serri O, Chik CL, et al: Canadian consensus guidelines for the diagnosis and management of acromegaly. Krikorian A, Aron D: Evaluation and management of pituitary incidentalomas-revisiting an acquaintance. Schade R, Andersohn F, Suissa S, et al: Dopamine agonists and the risk of cardiac-valve regurgitation. Nachtigall LB, Valassi E, MCarty D, et al: Cardiac valvular function in hyperprolactinemic patients receiving cabergoline.
Luckily, non-drug ADHD treatments have emerged within the last year, and among them, the most prominent and safe is called neurofeedback treatment.  Using electroencephalography (also known as EEG) to record electrical activity within the brain, people can learn to become aware of their physiological responses to ADHD and exercise better control over their frontal lobe – which is the center of executive functioning in the brain. Studies have shown that neurofeedback for ADHD is just as effective as a regimen of 30 milligrams of Ritalin (methylphenidate) – a psychostimulant drug – per day.  After the treatment regimen is finished (usually between five and twenty total hours of therapy) there are no drugs to take – only relief from this frustrating and sometimes debilitating  mental disorder.
Dissociative drugs blog certain signals within the brain and result in various hallucinogenic effects. DXM is a main ingredient in many over the counter cough syrups such as NyQuil, Vicks and Robitussin, among others. PCP and Ketamine are both illegal, however Ketamine is the most dangerous of the dissociative drugs, considered more dangerous than all the Hallucinogenics as well as Ecstasy.
Neuropathy which arises out of Charcot Marie Tooth Disease or CMT impairs both the motor as well as sensory nerves.
The symptoms of Charcot Marie Tooth Disease or CMT generally begin with adolescence but there have been cases where an individual has developed symptoms in adulthood. To understand the causes of Charcot Marie Tooth Disease or CMT, one must know how information is transmitted to brain by the nerves.
The main reason behind CMT is the mutation of genes resulting in malfunction of the peripheral nerves and over time the nerves start losing their capacity to interact or communicate with the limb and back to the brain, which results in weakness of the muscle and loss of muscle bulk as well as sensory impairment. CMT1-A: It is an autosomal dominant disorder which is caused due to duplicating genes in chromosome 17. CMT1-B: This is also an autosomal dominant disorder which is due to gene mutation of genes that carry instruction for producing protein P0, another important part of the myelin sheath.
CMT1-C, CMT1-D, and CMT1-E are rare disorders and have symptoms which are similar to CMT1-A.
CMT-2: This is different from CMT1 in that this disease is due to abnormality in the axons that are present in the cells of the peripheral nerves and not the myelin sheath. CMT-3: It is a demyelinating neuropathy of a severe nature that starts with infancy with infants having severe muscle weakness and sensory impairments. CMT-4: This type of CMT contains several subsets of autosomal recessive motor and sensory neuropathy of a demyelinating nature with each subset being caused by a different gene mutation. CMT-X: This disorder is caused by the mutation of the gene called connexin-32 on chromosome-X. To diagnose Charcot Marie Tooth Disease or CMT, the physician conducts an initial examination comprising of a detailed medical history, family history, and a comprehensive neurological evaluation.


If all of the above testing does not give a definite diagnosis of CMT, then a nerve biopsy is performed to confirm the diagnosis. No clear-cut treatment is available for Charcot Marie Tooth Disease or CMT but the use of physical therapy, occupational therapy, AFOs, and other assistive devices can be used to diminish the symptoms, which are often disabling.
NOTE: The latest CPR procedure does NOT make use of mouth-to-mouth breathing as a part of the protocol for children over 8 years old and adults. This is called the recovery position, but it should not be used if you suspect there might be a neck or spinal injury.
The promising new non-invasive treatment by Novocure uses "Tumor Treating Fields" (NovoTTF) to treat cancerous growths and is now available for adult patients with recurring brain tumors (recurrent glioblastoma or GBM). Tests indicate that the devices can slow and reverse tumor growth by inhibiting mitosis, the process by which cancerous cells divide and replicate.
Among pituitary hormones, only the secretion of prolactin is increased in the absence of hypothalamic influence, because it is mainly under tonic suppression by dopamine, the main inhibitory factor. Pituitary carcinomas are extremely rare, but metastases from other solid malignancies (mainly breast and lung) can occur. Impingement on the chiasma by a pituitary tumor results in visual field defects, most commonly bitemporal hemianopia (Fig. Once a pituitary adenoma is found, it is necessary to determine the type of adenoma (secretory vs. Some patients, especially those with large tumors, require several therapeutic modalities, including medical, surgical, and radiation therapies.
The sequential loss of pituitary hormones secondary to a mass effect is in the following order: growth hormone (GH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), and prolactin. Patients with GH deficiency have increased body fat and decreased lean body mass, and they might have decreased bone mineral density. Measurement of gonadotropin and estradiol levels in reproductive-aged women with irregular menstruation is usually not informative. Symptoms usually include chronic malaise, fatigue, anorexia, low-grade fever, and hypoglycemia. Patients should be instructed to carry a medical alert, double their replacement dosage for 2 to 3 days in case of an acute disease, and should be covered by stress doses of hydrocortisone if undergoing surgery.
For this reason, if secondary hypothyroidism is clinically suspected, TSH and free thyroxine (T4) should be measured together.
The levothyroxine replacement dose should be adjusted according to the patient’s clinical status and free T4 and free triiodothyronine (T3) levels, but not TSH. They are seen in all age groups but are more common in women, with a peak incidence during the childbearing years. Women of reproductive age mainly present with oligomenorrhea, amenorrhea, galactorrhea, or infertility. Dopamine agonists usually restore visual field defects to an extent similar to surgery.4 Therefore, visual field defects associated with prolactinomas are not a neurosurgical emergency.
IGF-1 has a longer plasma half-life than GH and is the best single test for the diagnosing acromegaly (Fig. Even a subtotal resection of the tumor will improve the efficacy of subsequent adjuvant therapy.
Cyclic CS is characterized by periods of excess alternating with intervals of normal or decreased cortisol production, which occurs in some patients with CS. Radiotherapy is indicated in those with residual pituitary tumor following surgical debulking or in those who are not surgical candidates.
It is important to monitor patients with varying degrees of hypopituitarism, because some have partial or full recovery of their pituitary axes.
The true prevalence of DI is unknown, but it is usually underdiagnosed because the symptoms and signs are benign and many patients ignore them or are unaware of them. Nocturia of a large urine volume is often the primary reason for which patients seek medical attention. One particular feature is that the muscles of the lower leg become weak leading to frequent falls and an impaired gait. This communication between the nerves and the brain takes place by a part of cell called as the axon, and for better and faster communication it is protected by myelin that is formed by a cell called as Schwann cell. This chromosome is responsible for carrying instructions to produce PMP22 protein, which is a very important part of myelin sheath. When conducting the neurological examination, the physician observes for signs of weakness in the muscles of the extremities, loss of muscle bulk, decrease in the deep tendon reflexes, or any form of impairment in sensation of the individual. This study is helpful in determining the involvement of the peripheral nerves and to which severity they are involved. Once pulse and respiration resume role the person onto his side taking care to move the body as a whole unit. The treatment delivers electric fields to a patient utilizing a portable, wearable device that permits the patient to maintain normal daily activities without down time. The NovoTTF treatment involves placing pads onto the patient's skin that creates a low intensity and alternating electric field within the tumor. The results from a 237-patient trial indicated that NovoTTF treated patients achieved comparable median overall survival times to patients treated with chemotherapy but had fewer side effects, and reported an improved quality of life. Cavernous sinuses are located laterally on each side of the sella, inclusive of the internal carotid artery and cranial nerves III, IV, V1, V2 and VI (Fig. Antidiuretic hormone (ADH, vasopressin) is produced by the supraoptic and paraventricular nuclei of the hypothalamus and travels in the axons through the pituitary stalk to the posterior pituitary gland. Autopsy studies suggest that up to 20% of normal persons harbor pituitary microadenomas.1 Pituitary tumors discovered by computed tomography (CT) or magnetic resonance imaging (MRI) examination, in the absence of any symptoms or clinical findings, are referred to as pituitary incidentalomas.
The most important factor in pituitary surgery is the availability of an experienced neurosurgeon.
In men, hypogonadism is diagnosed less often, because decreased libido and impotence may be considered functions of aging. The presence of normal menstruation is the best indicator of the integrity of the gonadotropin axis in women of reproductive age.
The serum prostate-specific antigen (PSA) level, hematocrit, and lipid profile should be monitored in men during testosterone replacement therapy.
Patients might present with hyponatremia, which is secondary to inappropriate ADH secretion.
In general, one should try to keep the free T4 level in the upper normal range while the free T3 level stays in the normal range. Men and postmenopausal women usually come to medical attention because of mass effect, such as headaches and visual field defects.
Biochemical analysis to evaluate renal and hepatic function and the TSH determination should be carried out.
Cabergoline and bromocriptine are potent inhibitors of PRL secretion and often cause tumor shrinkage. Medical treatment of acromegaly has gained significance since the limitations of radiation and surgical therapy have become evident. Symptoms secondary to hyperthyroidism and goiter are the initial complaints in most patients, followed by pituitary mass effect if the disease remains undiagnosed.
Somatostatin analogues are effective in most patients for control of excess TSH production leading to improvement in hyperthyroidism and possibly to a decrease in tumor size.11 Beta blockers should be initiated in patients with uncontrolled hyperthyroidism, and antithyroid medications may be used only for a short period before surgery (if somatostatin analogues cannot be used) because long-term use can stimulate tumor growth.
The use of high-dose dopamine agonists has been associated with a decrease in tumor size in only about 10% of patients. An empty sella is called secondary when it is seen after surgery, irradiation, or medical treatment for a pituitary pathology. The clinical manifestations are related to rapid expansion of the tumor secondary to hemorrhage, with compression of the pituitary gland and the perisellar structures leading to headache, hypopituitarism, visual field defect, and cranial nerve palsies.13 Headache is the most prominent symptom in most patients with clinically evident pituitary apoplexy.
There are four major types of DI: central (neurogenic) DI, nephrogenic DI, primary polydipsia, and gestational DI.


In most patients, DI is not associated with any abnormality on the physical examination or routine laboratory evaluation, except a low urine osmolality. Patients with DI who are conscious usually have sufficient thirst to maintain a normal serum sodium level in spite of polyuria.
The spray or oral form of desmopressin is usually started at bedtime and is gradually titrated for the desired antidiuretic effect.
Charcot Marie Tooth Disease or CMT is also knows as hereditary sensory and motor neuropathy.
In Charcot Marie Tooth Disease or CMT, the axon and the myelin sheath is disturbed and hence the nerves are not able to send the signals from the limb to the brain. The electric field prevents the normal mitotic process and causes cancer cell death prior to division without harming healthy cells.
Patients with sellar mass pressing on the optic chiasma should have a Humphrey visual field test.
Hypogonadism is often diagnosed retrospectively in men and postmenopausal women when patients present with mass effect.
Estrogen replacement is necessary in hypogonadal women of reproductive age to prevent osteoporosis and to treat hot flushes, decreased libido, and vaginal dryness. It is important to evaluate the corticotropin axis before initiating levothyroxine replacement, because therapy in those with underlying undiagnosed ACTH deficiency can result in an adrenocortical crisis secondary to an increase in metabolic demand.
All patients with macroprolactinomas and most patients with microprolactinomas require treatment. The drug history is an important part of the initial evaluation, because some medications are associated with hyperprolactinemia and their discontinuation for at least 3 days, if possible, will prevent any further and often expensive workup (Fig. Dopamine agonists should be initiated slowly, because side effects often occur at the beginning of treatment. Clinical features of acromegaly may be related to excess GH or IGF-1 or to associated mass effect including hypopituitarism, because most patients present with pituitary macroadenomas (Box 2 and Fig.
Somatostatin analogues inhibit GH secretion mainly by binding to somatostatin receptors and result in normalization of IGF-1 in up to 65% of patients.
In contrast to pale striae that occur postpartum or with weight gain, the striae in CS are usually red-purple, more than 1 cm wide, and located on the abdomen, upper thighs, breasts, and arms (Fig. The most important biochemical feature is elevation of serum thyroid hormone levels (T4 and T3), with an inappropriately normal or elevated TSH level.
Most patients have no pituitary dysfunction, but partial or complete pituitary insufficiency has been reported.
Central DI is secondary to inadequate ADH secretion that is insufficient to concentrate the urine. Overt disturbances in fluid and electrolytes are uncommon unless other factors interfere with the normal compensatory mechanism of polydipsia, such as loss of consciousness.
One additional deformity which can arise due to loss of muscle bulk in the lower extremities is called "champagne bottle deformity." As the disease progresses, the weakness progresses to the upper extremities as well resulting in impairment of fine motor functions in the upper extremities.
The pain severity can be mild to fairly severe to the point that some individuals need assistive devices in order to remain mobile.
People with CMT1A start having weakness in the lower extremities in their adolescence which progresses to upper extremity weakness and subsequently sensory loss.
A typical sign of CMT in individuals is the enlargement of the nerves which can be clearly observed from the skin. Whilst chemotherapy treatments can often be debilitating, the most commonly reported side effect from the NovoTTF treatment is a mild-to-moderate rash beneath the electrodes. Lateral extension of the pituitary mass to the cavernous sinuses can result in diplopia, ptosis, or altered facial sensation. Diabetes insipidus is almost never seen in patients with pituitary adenomas at presentation. Osteopenia is a consequence of long-standing hypogonadism and responds to hormone replacement therapy. Some indications for treatment of patients with microprolactinomas include bothersome galactorrhea, oligomenorrhea or amenorrhea, infertility, and sexual dysfunction. The most common side effects include nausea, headache, dizziness, nasal congestion, and constipation. The most common side effects are gastrointestinal, including diarrhea, abdominal pain, and nausea. Medical therapy for Cushing’s syndrome has limited value because of the associated toxicity and gradual decrease in efficacy. The chronologic association with pregnancy or the postpartum period and isolated ACTH deficiency is a diagnostic clue. The discovery of an empty sella needs to be followed by an endocrine evaluation to determine whether there is any associated pituitary dysfunction. Patients with mass effect benefit from tumor and blood clot debulking, which leads to resolution of visual field defects and improvement of cranial nerve palsies in most patients. A water deprivation test may need to be performed by an experienced endocrinologist to differentiate among types of partial DI.
Braces and other devices are used to provide stability to the joints, which become weak due to the disease. There is no specific headache pattern associated with pituitary tumors and, in some patients, the headache is unrelated to pituitary adenoma. Bromocriptine is the drug of choice in women planning pregnancy because there is considerable worldwide experience with the drug.
Excess growth hormone before the fusion of the epiphyseal growth plates results in gigantism. Gallbladder sludge and cholelithiasis have been reported in up to 25% of patients on long-term therapy with somatostatin analogues, but most patients were asymptomatic. Cabergoline is more potent, may be taken only twice a week, and is better tolerated by most patients.
Acromegalic patients probably carry an increased risk of malignancy such as premalignant adenomatous colon polyps and colon cancer, although published data vary greatly in their findings.
Dopamine agonists have variable efficacy in patients with acromegaly but may be an attractive first-line therapy, especially in those with cosecretion of prolactin and GH. Supraclavicular and dorsocervical fat pads (buffalo hump) and moon face are nonspecific and are seen in many patients of obesity clinics.
Pegvisomant has higher affinity to GH receptors than native GH but inhibits its dimerization, which is necessary for the action of GH.
Women complain of menstrual irregularity (84%) and hirsutism (especially vellous hypertrichosis of the face), and men and women exhibit loss of libido (≤100%). Radiation therapy may be considered for patients who poorly tolerate dopamine agonists and cannot be cured by surgery.
It is administered once daily and is usually reserved for patients not responding to other medical therapies. Psychiatric abnormalities occur in 50% of patients, with agitated depression and lethargy being the most common manifestations. A high clinical suspicion, attention to suggestive clinical features (see Box 3), and an appropriate screening test are the keys to early diagnosis of CS (Fig. 7).9 Because of the challenging nature of diagnosing CS, it is important to follow a stepwise evaluation, know the limitations of each test, and avoid shortcuts. Radiotherapy is reserved for patients who cannot be cured by surgery and do not respond to or tolerate medical therapy.



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