Alternative medicine metastatic breast cancer 2014

Women with early-stage breast cancer for whom chemotherapy was indicated and who used dietary supplements and multiple types of complementary and alternative medicine (CAM) were less likely to start chemotherapy than nonusers of alternative therapies, according to latest research led by Heather Greenlee, ND, PhD, associate professor of Epidemiology at Columbia University's Mailman School of Public Health.
Use of alternative therapies was reported by the large majority of the women studieda€”87 percent. Not all women initiate adjuvant treatment for breast cancer despite the survival benefits associated with it.
Complementary and alternative therapy use among patients with breast cancer has increased in the past two decades.
Greenlee suggests that it is important to consider possible alternative explanations for their findings.
A new study has shed light on how cancer patients' attitudes and beliefs drive the use of complementary and alternative medicine. It is well documented that black, Hispanic, and Asian women typically develop advanced-stage breast cancer more often than white women.
New data analyses found no association between anthracycline chemotherapy and greater risk of cognitive decline in breast cancer survivors, according to an article published online by JAMA Oncology.
Cancer is a disease of our genes - yet our understanding of how our genetic makeup affects our risk of cancer is still rudimentary. Scientists at Lancaster University have shed light on the metabolic switch observed in abnormal cells like cancer. Here's one more reason to consider cutting back on the soda: drinking too many sugary drinks on a daily basis has been linked to gallbladder cancer. Lung cancer is the most common cause of cancer deaths, accounting for about a third of all tumor-related deaths. A team of Mayo Clinic researchers has identified evidence of bacteria in sterilely-obtained breast tissue and found differences between women with and without breast cancer. Umass researchers using salmonella in fight against cancer, The researchers set out to see if the salmonella protein would disable the transporters so a common chemotherapy drug could accumulate and kill the cell.
How to grow amazing salad microgreens at your campsite, You may choose to grow mustard, cabbage, radish according to the u.s. Researchers succeed in growing breast tissue in a petri dish, Founded in 2013, tech gen mag offers in-depth coverage of the latest news in tech, science and space.
Researchers grow breast tissue in a lab - Scientists can grow pretty much anything in a petri dish. Umass researchers using salmonella in fight against cancer - The researchers set out to see if the salmonella protein would disable the transporters so a common chemotherapy drug could accumulate and kill the cell.
How to grow amazing salad microgreens at your campsite - You may choose to grow mustard, cabbage, radish according to the u.s. Researchers succeed in growing breast tissue in a petri dish - Founded in 2013, tech gen mag offers in-depth coverage of the latest news in tech, science and space. Top 10 foods that prevent breast cancer - The indian council of medical research (icmr) too, concluded that over the last two decades there has been a steep rise in the statistics pertaining to women being diagnosed with breast cancer or make a side dish out of it by boiling and simmering.
INDIAPOST – Bollywood actors Tusshar Kapoor, Sunny Leone and Vir Das have wrapped the first schedule of their upcoming film MASTIZAADE, directed by Milap Zaveri. SubscribeEnter your email address below to receive updates each time we publish new content. INDIAPOST – All India Anna Dravida Munnetra Kazhagam (AIADMK) chief J Jayalalithaa suffered another setback on Wednesday as the vacation bench of the Karnataka High Court adjourned her petition seeking bail till October 7, Zee News reports.
Engineering at Dartmouth is non-departmental and most projects crosscut traditional engineering disciplines to address critical human needs.
In the following, Dartmouth engineers explain some of the many projects they are working on with colleagues at Dartmouth Medical School and Dartmouth-Hitchcock Medical Center to give doctors new tools for better care.
SMALL IS BIG: Professor Ursula Gibson fabricates materials tiny enough to carry drugs directly into tumors. If we can structure materials on a very fine scale, we can give them a plethora of functionalities for targeting cancer. HOT IRON: Professor Ian Baker is developing iron nanoparticles that be inserted into tumors and heated to destroy them. The ultimate goal is to tag these nanoparticles with tumor-specific antibodies, and put them into the bloodstream to find their way to a tumor and attach to it.
POWER SOURCE: Professor Kofi Odame streamlines circuits so medical devices can be small, light, and long-lived. Low-power electronics are crucial for medical devices that need to be portable or implantable. But a fully internal cochlear implant, with all of its parts surgically placed inside the patient’s head, will never become a reality unless the implant is made to consume so little power that batteries would only need to be changed once every several years, if at all. We look at the problems orthopedists and patients have with hip and knee implants and figure out how to solve them. Orthopedic surgeon Michael Mayor thought that if we’re putting implants into patients, we ought to examine the devices when they come out. Even with a sophisticated prosthetic device, surgeons can get into difficulty if they haven’t done many implant procedures. We’re building a special brain imaging lab at Thayer that will allow us to run three different noninvasive neuroimaging techniques simultaneously. Our instruments will allow us to explore neurovascular relationships with more precise timing and better specificity to neural currents than can be done with an MRI. Once all the instruments are functioning, we’ll start studying the neurovascular coupling relationships in healthy normal controls.

ANTIBODY HUNTER: Professor Karl Griswold wants to find proteins capable of curing deadly lung infections for people with cystic fibrosis. Seeing proteins as next-generation antibiotics, I wanted to develop enzymes to treat bacterial infections. Most CF patients die from complications associated with Pseudomonas aeruginosa bacterial infection of the lungs. SHARED VISION: A few of the Thayer professors who work on imaging gather in the Advanced Imaging Center at Dartmouth-Hitchcock Medical Center.
MIS and EIS measure the ability of different regions of the breast to hold or conduct electricity.
MRE uses an MRI scanner and specialized coils to vibrate breast tissue and measure whether it is elastic or stiff. All four technologies differ from mammography in another way as well: computational complexity. We’re developing a fluorescence signature to guide surgeons in removing brain tumors. If you’re using heat to destroy a tumor, you want to monitor the temperature during the treatment. A big problem with screening for prostate cancer is that the prostate-specific antigen (PSA) test is not specific to just cancer.
This is one of the first studies to evaluate how complementary and alternative medicine use affects decisions regarding chemotherapy. Greenlee and colleagues studied a group of 685 women with early-stage breast cancer who were recruited from Columbia University Medical Center, Kaiser Permanente Northern California, and Henry Ford Health System and enrolled 2006-2010.
By 12 months, chemotherapy was initiated by 89 percent of women for whom chemotherapy was indicated.
The decision to start chemotherapy involves psychosocial factors, belief systems, and clinical, demographic and provider characteristics. The most commonly used complementary and alternative therapies were dietary supplements and mind-body practices.
However, dietary supplements usage and a higher simultaneous use of multiple complementary and alternative therapies among women for whom chemotherapy was indicated were associated with a lower likelihood to initiate chemotherapy than nonusers, according to the results. For example, it is unclear whether the association between complementary and alternative medicine use and chemotherapy non-initiation reflects long-standing decision-making patterns among study participants. A cautious interpretation of results may suggest to oncologists that it is beneficial to ascertain use of complementary and alternative medicine therapy among their patients, especially dietary supplement use, and to consider use of alternative treatment as a potential marker of patients at risk of not initiating clinically indicated chemotherapy," Greenlee said.
Every medical device represents a collaboration between doctors eager for better ways to treat patients and engineers eager to push technological boundaries. We’re using knowledge of self-assembly of small-scale materials to try to make therapeutic substances that will interact with diseased tissue. They essentially have little pores in them that are about 300 nanometers in diameter — a scale at which people have started to gain control over what they can fabricate. We could incorporate a drug into a polymer structure, add some magnetic nanoparticles that can absorb energy from an externally applied field, and attach an antibody to the outside of the polymer to help it find the cancer or bind preferentially to the cancer for a multiplicative effect.
Then, using a technique like MRI to ensure the particles are at the tumor, we’ll magnetically heat the tumor to destroy it without damaging surrounding tissue.
I’m currently working on an algorithm and designing an electronic circuit that will imitate a healthy cochlea. Loosening is no longer a problem [thanks largely to a porous coating Collier developed in the 1980s]. Polyethylene is a long-chain monomer; you can improve its wear resistance by connecting the chains to one another. The device might not be exactly the right size or it might not be tensioned or positioned exactly. With functional MRI, you get an image stack of the whole brain about every two seconds, and you can see how the stack evolves over time due to the cerebral blood dynamics.
With that data as a foundation, we can then begin the pilot clinical work, measuring people who are at risk for developing Alzheimer’s or who are in the early stages of it. Knowing how well proteins work in their natural context, engineers and scientists have envisioned ways in which we can use these molecules to enable practical applications. We’re identifying natural enzymes that have infection-fighting potential, outlining their limitations, and then developing improved versions in the lab. Clockwise from lower left, veterinarian Jack Hoopes (who conducts animal studies for the technologies), Brian Pogue, John Weaver, Ryan Halter, Paul Meaney, Keith Paulsen, and Shudong Jiang (who evaluates the effectiveness of neoadjuvant treatments of metastatic cancer). That’s why Thayer School engineers and Dartmouth Medical School (DMS) researchers have been working together for a decade on four alternative imaging technologies to detect and help treat breast cancer.
Pritzker Professor of Biomedical Engineering, and Dartmouth Medical School radiology professor Dr. Part of what defines a tissue as cancerous is how its cells and blood vessels are organized. Penetrating deep into tissue, NIR reveals information about hemoglobin and oxygen saturation levels, which can indicate a tumor. Since mammography utilizes X-rays, which penetrate the body in more or less a straight path, constructing an image from X-ray data is a relatively easy linear problem. And while researchers elsewhere are working on their own versions of the technologies, no program is as comprehensive and well developed as the Dartmouth collaboration. We’ve found that high-grade tumors fluoresce, so the fluorescence can be used as a kind of surgical road map.

The most problematic parts of a tumor cannot be seen structurally because they’re a microscopic invasion. We use an injectable agent that isn’t FDA-approved yet, but would be a good candidate for future clinical use. Rather than immediately removing the primary cancer, the oncologist leaves it in place and attacks it with a mix of chemotherapies. The remaining group of women for whom chemotherapy was discretionary had a much lower rate of initiationa€”at 36 percent. On average, the women used two such therapies, although nearly 40 percent of the women reported using three or more complementary and alternative therapies. There was no association between starting chemotherapy and using alternative medicine among women for whom chemotherapy was discretionary. It is possible that women who did not initiate treatment and who were alternative therapy users were long-time users of CAM and chose complementary medicine as an alternative to conventional chemotherapy. Dartmouth engineers have focused on medical technologies since the 1960s, when Professor John Strohbehn started a biomedical engineering program at Thayer.
An external part contains a microphone, microprocessor, and batteries, which need to be replaced or recharged every 24 hours or so.
We do in-vitro simulations, but when a new material is put in the body, we commonly get surprised. Since the 1970s he has evaluated nearly 10,000 retrieved implants for corrosion and other damage. You can tell what part of the brain was active when the subject saw a certain stimulus or performed a particular task. The background work could take five years, but I envision early clinical work at the pilot level starting in two to four years. However, when you yank proteins out of their natural context, they frequently lose some or all of their desirable qualities. By growing inside this complex matrix, bacteria gain protection from the human immune system and antibacterial drugs.
But the electromagnetic waves used in MIS, EIS, and NIR and the mechanical waves generated during MRE travel through the breast in complex patterns. We hope to be able to make low-grade tumors fluoresce, too, so they can be treated before they get worse. With better molecular tracers and optical imaging, though, we’ve been able to detect them. We need to do phase-one trials with new drugs and imaging systems to make sure they don’t harm the patient.
If the chemotherapies shrink the primary tumor, you can assume that they also attack unseen metastases.
Ultrasound-guided biopsy is used to definitively diagnose prostate cancer in men with elevated PSA, but it misses some malignant lesions and doesn’t accurately characterize the extent of the disease. Nearly half (45 percent) were clinically indicated to receive chemotherapy per National Comprehensive Cancer Network guidelines. However, the study did not assess prior complementary and alternative medicine use and therefore cannot rule out this possibility. Collaborating with clinicians at Dartmouth Medical School, Strohbehn directed his inventive skills to a wide range of medical applications, including mathematical models for X-ray tomography, an interactive image processor for clinical use, hyperthermia techniques for destroying cancer cells with heat, and a frameless stereotactic operating microscope for neurosurgeons.
Others have resulted in new companies, such as GlycoFi, the protein engineering start-up that professors Tillman Gerngross and Charles Hutchinson sold to Merck in 2006 for $400 million, or Gerngross’ latest bioengineering venture, Adimab. But nano-sized iron particles exposed to air quickly form an oxide and produce so much heat that they catch fire.
Together they lead a team of some 40 engineers, radiologists, pathologists, computer programmers, data analysts, and other collaborators who are refining the technologies and conducting clinical trials at Dartmouth-Hitchcock Medical Center. This is very exciting, because we can now demonstrate that we can see something that standard clinical imaging doesn’t capture. We’ve integrated a microwave imaging system into it, allowing us to continuously image the patient while the heating occurs.
We’re incorporating electrical impedance spectroscopy (EIS) sensors into standard biopsy needles and ultrasound probes to improve this detection and disease characterization. I had the idea of using iron particles for their heating effect and coating them with iron oxide to make them safe and make them visible in magnetic resonance imaging. The device would be doing wireless transmission of electroencephalogram (EEG) data, which consumes a lot of power. We take natural protein sequences as a starting point and redesign them to meet our own performance criteria.
We’re also developing EIS-enhanced probes that surgeons can use during surgery to ensure clear margins. I’m designing circuits that selectively transmit only the important portions of EEG data in a low-power fashion.
More recently another post-doc, Guandong Zhang, managed to tweak the processing so that now our particles range from 8 to 20 nanometers, heat well, have a biocompatible coating, and have good MRI contrast.

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