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Pathogenesis of atherogenic dyslipidaemia in the setting of hypertriglyceridaemia, insulin resistance, and hepatic steatosis; central obesity and type 2 diabetes mellitus are common clinical phenotypes.
Oversecretion of VLDL and chylomicrons by the liver and intestine, coupled with decreased catabolism, increases the plasma pool of TRLs, including remnant lipoproteins; increased heteroexchange of neutral lipids between TRLs and LDLs and HDLs via CETP results in remodelling of LDLs and HDLs to form correspondingly smaller, denser particles.
Lipid Disorders Clinic and Metabolic Research Centre, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia, PO Box X2213, Perth, WA 6847, Australia. Kropps- vikt Kropps-langd Arterioskleros Behandlad hypertoni Type 2 diabetes HDL cholesterol Urinsyra Insulin Vitamin D BMI Lean Body mass Ostrogen Fritt. Fysiskt aktiva individer loper lagre risk att drabbas av bland annat benskorhet, blodpropp, fetma och psykisk ohalsa. Epidemiologisk forskning inom allmanmedicin Susanna Calling, Med dr, Allmanlakare Centrum for Primarvardsforskning.
Behandling av typ 2 diabetes Bodil Eckert och Tomas Kanter Terapigrupp Endokrinologi 140828. Visste du att… Fysiskt aktiva individer loper halften sa stor risk att do av hjart-karlsjukdom som sina stillasittande jamnariga. Livet efter gastric bypass Anders Kyleback OL Kir Klin Skaraborgs Sjukhus Skovde Bariatric Center Skane, Lund. Synpunkter pa utredning och behandling av testosteronbrist i primarvarden Catarina Canivet DL, St Lars VC, Lund. Sjalvevaluering Hyperlipidemi, T3 Susanne Hilke, Klinisk Kemi Bakgrund Struktur och funktion Diagnostik. Svenska Kommunforbundet och Landstingsforbundet i samverkan 1 Diagnoskriterier vid beroende och missbruk Edy Welander Overlakare Beroendecentrum Orebro. Claude Marcus 2010-11-25 Prevalens av cardiometabola riskfaktorer bland obesa barn i Sverige Claude Marcus. Risk- och friskfaktorer for demens och Alzheimers sjukdom Miia Kivipelto, MD, PhD Professor Aging Research Center, Karolinska Institutet and Karolinska. The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors.
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Possible Link Between Body Mass Index (BMI),Type 2 Diabetes Mellitus T2DM) And Coronary Artery Disease(CAD).FFA-Free fatty acid10.
The subjects were graded into I,II,III based on severity Statistical analysis was done by Chi square test. It is sacred Greek text that has withstood the test of time as an understanding that practicing medicine should be governed by ethics, principles, and above all else empathy and compassion for those that need to be cared for.

We understand that in most cases, the proper information about a medical condition is the best deterrent for the condition becoming unmanageable. Om du vill ladda ner presentationen var vanlig rekommendera den till dina vanner i vilket socialt natverk som helst. Befintlig patient Diabetes typII Hjart-karlsjukdom Hypertoni Langvarig smarta i viktbarande leder Vissa cancerformer Gallsten Kvinnlig. While some of these factors are under personal control, such as diet and obesity, other factors are not, such as increasing age, female gender, and genetics.
According to the International Journal of Diabetes in developing Countries India is labelled as the diabetic capital of the world.
Statistical analysis was done by Chi square test.According to the percentage of stenosis and involvement of coronary vessels, severity of CAD was assessed and classified as Grade I(mild), Grade II(Moderate) and Grade III(Severe). Watts, DSc, PhD, DM, FRACP, FRCP is a graduate of Imperial College in the University of London, UK.
Dr., Handlaggare Miljomedicinska Enheten Centrum for Arbets- och Miljomedicin Stockholms Lans.
The International Diabetes Federation estimates that the number of diabetic patients in India more than doubled from 19 million in 1995 to 40.9 million in 2007.
Coronary angiography and grading of CAD patients The coronary angiogram was assessed by two cardiologists who were unaware of the current study. Analysis on frequency of distribution has revealed that severity was significantly high in CAD WDM. He is a senior consultant physician in cardiometabolic medicine, a Past-President of The Australian Atherosclerosis Society and current Chair of The Familial Hypercholesterolaemia-Australasia Network. He is Director of the Metabolic Research Centre and Lipid Disorders and Hypertension Clinics at Royal Perth Hospital and Professor of Cardiometabolic Medicine, School of Medicine and Pharmacology Unit in The University of Western Australia. Patients with type II diabetes have 2 - 4 times higher risk of experiencing cardiovascular disease(CVD) than adults without diabetes (Fox et al. The severity of coronary atherosclerosis was estimated by calculating the coronary atherosclerotic score (CAS). 21% of CAD WDM patients had Grade II (moderate) compared to 29% in CAD WNDM.16% of CAD WDM had Grade I (mild) disease compared to 46% in CAD WNDM. A significantly high percentage of multivessel atherosclerosis was observed in CAD WDM when compared to CAD WNDM. Body Mass Index (BMI)Body mass index (BMI) is a simple index of weight-for-height that is commonly used to classify overweight and obesity in adults. Professor Watts is actively involved in undergraduate and postgraduate teaching and supervisors PhD students and postdoctoral fellows.
2005), much of which may be preventable with appropriate treatment of dyslipidemia.The elevated CVD risk affecting patients with Type II diabetes may be attributed to a combined dyslipidemia characterized by elevated triglycerides, elevated triglyceride rich remnant lipoproteins(TGRLP), elevated apolipoprotein (apo) B and low levels of HDL cholesterol, with a predominance of small, dense low density lipoprotein(LDL) particles amid relatively normal LDL Cholesterol levels (Chih-yuan wang et al.
The WHO defines a BMI greater than or equal to 25 is overweight and a BMI greater than or equal to 30 is obesity(World Health Organization,2007). The level of total cholesterol was significantly high in CAD WDM and CAD WNDM) when compared to control. He has authored over 380 published works and is on the editorial board of Atherosclerosis, Clinical Science, Metabolism, Practical Diabetes, and International Journal of Evidence-Based Medicine.Contact Gerald F.

The association of low plasma levels of high-density lipoprotein (HDL) with states of impaired glucose metabolism and type 2 diabetes mellitus is well established, but the mechanistic links remain to be fully elucidated. Recent data suggests that HDL directly influences glucose metabolism through multiple mechanisms. OoiDr Esther Ooi, PhD is an National Health and Medical Research Council Postdoctoral Research Fellow at the University of Western Australia (UWA), School of Medicine and Pharmacology in Perth.
Biochemical estimationsRoutine biochemical investigations were done using serum and plasma.
She gained her PhD with Distinction from UWA in 2007 and subsequently, undertook her overseas training at Harvard and Tufts Universities in Boston, MA, USA.
Serum was used for the determination of insulin and blood glucose on the same day of sample collection.
Her research interest is in the pathogenesis, diagnosis, and treatment of dyslipidaemia, atherosclerosis, and cardiovascular disease. Materials and methodsStudy was done on 109 subjects aged 40-75 years from HIGH-Tech Hospital, Cardiology Unit, Vinayaka Missions, Salem, India. Determination of Homeostasis Model Assessment (HOMA) — IR The Homeostasis Model Assessment (HOMA) estimates steady state beta cell function (%B) and insulin sensitivity (%S), as percentages of a normal reference population.
Since 2005, she has published 45 papers and has been the recipient of 11 competitive grants and fellowships, and 29 awards for merit, scholarship and travel. Subjects were selected by simple random technique from the group of patients who were referred to the department of cardiology for coronary angiography and who met the inclusion criteria set out above. From all patients a written informed consent was obtained All data collected during a regular visit to the hospital included, anthropometric parameters including weight, height and waist circumference were measured using standard protocols Also a completed questionnaire regarding their medical history, coronary artery disease(CAD) and its complications, hypertension, age of onset of diabetes mellitus, chronic diseases other than CAD and diabetes mellitus, medications, socio-economic factors, dietary habits as well as the family medical history.3.
ChanDr Dick Chan, PhD is a Research Assistant Professor at the School of Medicine & Pharmacology, University of Western Australia in Perth. He has a strong research interest in the pathophysiology of lipid disorders and the role of interventions on lipoprotein metabolism and other related cardiovascular risk factors such as obesity, insulin resistance, and proinflammatory state. Biochemical studiesSerum samples taken were subjected to estimations of glucose, Glycated hemoglobin, insulin, lipid profile including apo A 1 and apo B. In 2010, Dr Chan was granted a fellowship status from The Royal College of Pathologists, UK on the basis of published work. ResultStudy was done on 109 subjects who were selected by simple random technique from the group of patients referred to the department of cardiology for coronary angiography and who met the inclusion criteria.
Study subjects were 39% control subjects(n=71), 29% coronary artery disease patients without type 2 DM (CAD WNDM, n=52) and 32 % were coronary artery disease patients with type 2 DM (CAD WDM, n=57). He has a strong background in developing biomedical analytical techniques such as ultracentrifugation, electrophoresis, GCMS, HPLC, RIA, ELISA and tissue cultures. Among the CAD WNDM patients 88% were males and 12% were female and in CAD WDM 82% were male and 18% were female.The base line characteristics of study subjects are shown in Table 1. Statistically no significant difference in SBP and DBP was observed in CAD WDM when compared to CAD WNDM.

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